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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bongkrekic acid
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Accession:CHEBI:77742 term browser browse the term
Definition:A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group. It is produced by the bacterium Burkholderia gladioli and implicated in outbreaks of food-borne illness involving coconut and corn-based products in Indonesia and China.
Synonyms:exact_synonym: (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
 related_synonym: (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyl-2,4,8,10,14,18,20-docosaheptaenedioic acid;   Formula=C28H38O7;   InChI=1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1;   InChIKey=SHCXABJSXUACKU-WUTQZGRKSA-N;   SMILES=CO[C@H](C\\C=C/C=C/CC\\C=C\\C[C@H](C)\\C=C\\C(\\CC(O)=O)=C/C(O)=O)C(\\C)=C/C=C(\\C)C(O)=O;   bongkrek acid
 xref: CAS:11076-19-0;   CBA:366918;   Chemspider:4938689
 xref_mesh: MESH:D001865
 xref: PDBeChem:BKC;   PMID:12034471;   PMID:15919152;   PMID:16430940;   PMID:17123460;   PMID:20237660;   PMID:2037079;   PMID:22050912;   PMID:22998163;   PMID:22999884;   PMID:23315986;   PMID:24522192;   PMID:25786526;   PMID:26032198;   PMID:26126659;   PMID:26548846;   PMID:27798877;   PMID:27823840;   PMID:28105575;   PMID:28769000;   PMID:29155976;   PMID:30611538;   PMID:31517068;   PMID:31518860;   PMID:31524538;   PMID:31642300;   PMID:33246684;   PMID:33459584;   PMID:34019862;   PMID:34079526;   PMID:7164105;   Patent:JP2005068064;   Reaxys:1717902;   Wikipedia:Bongkrek_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:178020


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bongkrekic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Bongkrekic Acid results in increased expression of ADIPOQ mRNA CTD PMID:25786526 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Bongkrekic Acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein] CTD PMID:29427785 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Bongkrekic Acid inhibits the reaction [leflunomide results in increased expression of DDIT3 protein] CTD PMID:29427785 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Bongkrekic Acid inhibits the reaction [N-caproylsphingosine results in increased expression of ICAM1 mRNA] CTD PMID:12952965 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il24 interleukin 24 decreases activity ISO Bongkrekic Acid results in decreased activity of IL24 protein CTD PMID:14678967 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G P2rx1 purinergic receptor P2X 1 increases activity ISO Bongkrekic Acid results in increased activity of P2RX1 protein CTD PMID:34019862 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623 		JBrowse link
G Padi4 peptidyl arginine deiminase 4 increases activity ISO Bongkrekic Acid results in increased activity of PADI4 protein CTD PMID:34019862 NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO Bongkrekic Acid analog results in increased activity of PPARG protein; Bongkrekic Acid results in increased activity of PPARG protein CTD PMID:25786526 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions EXP Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein] CTD PMID:18667415 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO Bongkrekic Acid results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        poison 18589
          toxin 15966
            bongkrekic acid 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      tricarboxylic acid 2485
                                        bongkrekic acid 10
paths to the root