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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:coumermycin A1
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Accession:CHEBI:3907 term browser browse the term
Definition:A hydroxycoumarin antibiotic that is obtained from Streptomyces rishiriensis and exhibits potent antibacterial and anticancer activity.
Synonyms:exact_synonym: (3-methyl-1H-pyrrole-2,4-diyl)bis[carbonylimino(4-hydroxy-8-methyl-2-oxo-2H-chromene-3,7-diyl)oxy(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2,4-diyl] bis(5-methyl-1H-pyrrole-2-carboxylate)
 related_synonym: Coumermycin;   Formula=C55H59N5O20;   InChI=1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1;   InChIKey=WTIJXIZOODAMJT-DHFGXMAYSA-N;   NSC 107412;   Notomycin;   Notomycin A1;   SMILES=CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4c[nH]c(C(=O)Nc5c(O)c6ccc(O[C@@H]7OC(C)(C)[C@H](OC)[C@@H](OC(=O)c8ccc(C)[nH]8)[C@H]7O)c(C)c6oc5=O)c4C)c(=O)oc3c2C)OC1(C)C;   Sugordomycin D-1a;   coumamycine;   coumamycinum;   cumamicina
 xref: CAS:4434-05-3;   KEGG:C05073;   KEGG:D02333;   KNApSAcK:C00002461
 xref_mesh: MESH:C004628
 xref: PMID:23123663;   PMID:23652970;   PMID:24079980;   PMID:24692538;   Reaxys:5230975;   Wikipedia:Coumermycin_A1



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coumermycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]
coumermycin results in increased expression of BCL2 protein
CTD PMID:34423886 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions
ISO coumermycin results in increased secretion of CCL2 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]
CTD PMID:34423886 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO coumermycin results in increased expression of CCND1 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]
CTD PMID:34423886 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]
coumermycin results in increased expression of HMOX1 protein
CTD PMID:34423886 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]
coumermycin results in increased secretion of IL1B protein
CTD PMID:34423886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]
coumermycin results in increased secretion of IL6 protein
CTD PMID:34423886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases expression
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]
coumermycin results in increased expression of JAK2 protein
CTD PMID:34423886 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
ISO coumermycin results in increased phosphorylation of STAT3 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]
CTD PMID:34423886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]
coumermycin results in increased secretion of TNF protein
CTD PMID:34423886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 20069
    role 20021
      biological role 20020
        antimicrobial agent 17783
          coumermycin A1 9
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  CHEBI ontology 20069
    subatomic particle 20068
      composite particle 20068
        hadron 20068
          baryon 20068
            nucleon 20068
              atomic nucleus 20068
                atom 20068
                  main group element atom 19969
                    p-block element atom 19969
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic molecule 19833
                              organic cyclic compound 19587
                                organic heterocyclic compound 18853
                                  oxacycle 17699
                                    benzopyran 11223
                                      1-benzopyran 10960
                                        chromenes 3031
                                          chromenone 2970
                                            coumarins 2721
                                              coumermycin A1 9
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