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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloral hydrate
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Accession:CHEBI:28142 term browser browse the term
Definition:An organochlorine compound that is the hydrate of trichloroacetaldehyde.
Synonyms:exact_synonym: 2,2,2-trichloroethane-1,1-diol
 related_synonym: 1,1,1-trichloro-2,2-dihydroxyethane;   1,1,1-trichloro-2,2-ethanediol;   2,2,2-trichloro-1,1-ethanediol;   Aquachloral Supprettes;   Chloralhydrat;   Formula=C2H3Cl3O2;   InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H;   InChIKey=RNFNDJAIBTYOQL-UHFFFAOYSA-N;   Noctec;   SMILES=OC(O)C(Cl)(Cl)Cl;   Somnote;   Trichloracetaldehyd-hydrat;   chloral monohydrate;   knockout drops;   trichloroacetaldehyde hydrate
 alt_id: CHEBI:23105;   CHEBI:3600
 xref: Beilstein:1698497;   CAS:302-17-0;   DrugBank:DB01563;   Drug_Central:586;   Gmelin:101369;   KEGG:C06899;   KEGG:D00265
 xref_mesh: MESH:D002697
 xref: MetaCyc:CPD0-1476;   PPDB:2987;   UM-BBD_compID:c0011;   VSDB:2987


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chloral hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde		 CTD PMID:18272654 PMID:21334317 PMID:21376711 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions ISO Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA] CTD PMID:7513451 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis
multiple interactions		 ISO CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate
[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate		 CTD PMID:1739413 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:15219685 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta 1 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 5:71,815,264...72,306,915
Ensembl chr 5:71,815,456...72,306,380 		JBrowse link
G Gast gastrin multiple interactions ISO Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
increases expression		 ISO Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein
Chloral Hydrate results in increased expression of GJA1 protein		 CTD PMID:21243523 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression
increases expression		 ISO Chloral Hydrate results in decreased expression of GJB2 mRNA
Chloral Hydrate results in increased expression of GJB2 protein		 CTD PMID:21243523 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Chloral Hydrate affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Chloral Hydrate results in increased expression of IL1B mRNA
Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]		 CTD PMID:15207037 PMID:15207038 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 increases expression ISO Chloral Hydrate results in increased expression of IL6 mRNA CTD PMID:15207037 PMID:15207038 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 22192
    role 22177
      biological role 22176
        xenobiotic 19683
          chloral hydrate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      chalcogen 21446
                        oxygen atom 21425
                          oxygen molecular entity 21425
                            hydroxides 20803
                              organic hydroxy compound 19738
                                polyol 11674
                                  diol 3891
                                    ethanediol 162
                                      chloral hydrate 15
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