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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flutriafol
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Accession:CHEBI:81923 term browser browse the term
Definition:A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops.
Synonyms:exact_synonym: rac-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
 related_synonym: (+-)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol;   (RS)-2,4'-difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol;   Formula=C16H13F2N3O;   PP 450;   R 152450;   alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol;   rac flutriafol;   rac-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol
 xref: CAS:76674-21-0;   KEGG:C18734
 xref_mesh: MESH:C543009
 xref: PMID:18178235;   PMID:20533452;   PMID:21740052;   PMID:22885544;   PMID:22983725;   PMID:23208429;   PMID:24611465;   PMID:25300182;   PMID:25376483;   Patent:EP15756;   Pesticides:76674-21-0;   Pesticides:flutriafol;   Reaxys:7141682


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flutriafol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP flutriafol results in increased expression of BAX protein CTD PMID:34200939 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP flutriafol results in decreased expression of BCL2 protein CTD PMID:34200939 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP flutriafol results in increased expression of and results in increased cleavage of CASP3 protein CTD PMID:34200939 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO
EXP		 Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP1A2 mRNA] CTD PMID:34200939 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression
multiple interactions		 ISO flutriafol results in increased expression of CYP2C19 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2C19 mRNA]		 CTD PMID:34200939 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions		 ISO flutriafol results in increased expression of CYP2E1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2E1 mRNA]		 CTD PMID:34200939 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO
EXP		 flutriafol results in increased expression of CYP3A4 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP3A4 mRNA]
flutriafol results in increased expression of CYP3A2 mRNA		 CTD PMID:34200939 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP51A1 mRNA] CTD PMID:34200939 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTO2 mRNA] CTD PMID:34200939 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO flutriafol results in increased expression of GSTP1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTP1 mRNA]		 CTD PMID:34200939 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
increases localization
multiple interactions		 EXP
ISO		 flutriafol results in decreased expression of NFE2L2 protein
flutriafol results in increased localization of NFE2L2 protein
Acetylcysteine inhibits the reaction [flutriafol results in increased localization of NFE2L2 protein]		 CTD PMID:34200939 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO flutriafol results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO1 mRNA]		 CTD PMID:34200939 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO2 mRNA] CTD PMID:34200939 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      chemical substance 14408
        mixture 13725
          racemate 12102
            flutriafol 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  heteroarene 17169
                                    monocyclic heteroarene 14995
                                      azole 14515
                                        triazoles 8436
                                          1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 13
                                            (R)-flutriafol 13
                                              flutriafol 13
paths to the root