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gypenoside LXXV - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gypenoside LXXV
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Accession:CHEBI:77156 term browser browse the term
Definition:A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Synonyms:exact_synonym: (beta,12beta)-3,12-dihydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
 related_synonym: Formula=C42H72O13;   InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,55-37-35(51)33(49)31(47)25(54-37)20-52-36-34(50)32(48)30(46)24(19-43)53-36)22-11-16-41(7)29(22)23(44)18-27-39(5)15-13-28(45)38(3,4)26(39)12-17-40(27,41)6/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36+,37-,39-,40+,41+,42-/m0/s1;   InChIKey=YIYRCZFIJNGYOG-QINBLQPGSA-N;   SMILES=CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C
 xref_mesh: MESH:C000719168
 xref: MetaCyc:CPD-15460;   PMID:20622122;   PMID:22450790;   PMID:22805203;   PMID:22911093;   PMID:23717145


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gypenoside LXXV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased phosphorylation of AKT1 protein] CTD PMID:35192202 PMID:36325883 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein] CTD PMID:35192202 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCN2 cellular communication network factor 2 increases expression
multiple interactions
ISO gypenoside LXXV results in increased expression of CTGF mRNA
gypenoside LXXV results in increased expression of and results in increased secretion of CTGF protein
CTD PMID:31018484 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein] CTD PMID:33050067 PMID:35192202 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein] CTD PMID:35192202 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IRS1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
ISO gypenoside LXXV results in decreased phosphorylation of IRS1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein
CTD PMID:35192202 PMID:36325883 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
JBrowse link
G LEPR leptin receptor multiple interactions ISO gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein] CTD PMID:35192202 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions ISO gypenoside LXXV binds to and affects the localization of NR3C2 protein CTD PMID:31018484 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO gypenoside LXXV results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV binds to and results in increased activity of PPARG protein]; gypenoside LXXV binds to and results in increased activity of PPARG protein
CTD PMID:35192202 PMID:36325883 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of RELA protein CTD PMID:33050067 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
affects localization
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of SLC2A4 protein] CTD PMID:35192202 PMID:36325883 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression ISO gypenoside LXXV results in decreased expression of TGFB1 protein CTD PMID:33050067 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]; gypenoside LXXV inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:33050067 PMID:35192202 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

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  CHEBI ontology 26506
    role 26329
      biological role 26308
        epitope 7439
          beta-D-glucose 1712
            beta-D-glucoside 1521
              gypenoside LXXV 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 26506
    subatomic particle 26482
      composite particle 26482
        hadron 26482
          baryon 26482
            nucleon 26482
              atomic nucleus 26482
                atom 26482
                  main group element atom 26220
                    p-block element atom 26220
                      carbon group element atom 25665
                        carbon atom 25627
                          organic molecular entity 25627
                            heteroorganic entity 25013
                              organochalcogen compound 24607
                                organooxygen compound 24203
                                  carbohydrates and carbohydrate derivatives 16827
                                    carbohydrate 16827
                                      monosaccharide 5081
                                        aldose 3369
                                          aldohexose 2993
                                            glucose 2946
                                              D-glucose 2944
                                                D-glucopyranose 1865
                                                  beta-D-glucose 1712
                                                    beta-D-glucoside 1521
                                                      gypenoside LXXV 13
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