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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,3-thiazolidine-2,4-dione
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Accession:CHEBI:50992 term browser browse the term
Definition:A thiazolidenedione carrying oxo substituents at positions 2 and 4.
Synonyms:related_synonym: 2,4(3H,5H)-thiazoledione;   2,4-dioxothiazolidine;   2,4-thiazolidinedione;   Formula=C3H3NO2S;   InChI=1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6);   InChIKey=ZOBPZXTWZATXDG-UHFFFAOYSA-N;   SMILES=O=C1CSC(=O)N1
 xref: CAS:2295-31-0;   Gmelin:101158
 xref_mesh: MESH:C089946
 xref: Reaxys:110700


show annotations for term's descendants           Sort by:
1,3-thiazolidine-2,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 2,4-thiazolidinedione results in increased expression of BAX protein CTD PMID:15916743 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 2,4-thiazolidinedione results in decreased expression of BCL2 protein CTD PMID:15916743 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 2,4-thiazolidinedione results in decreased expression of CCND1 protein CTD PMID:15916743 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 2,4-thiazolidinedione results in decreased expression of CDK4 protein CTD PMID:15916743 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 2,4-thiazolidinedione results in increased expression of CDKN1A protein CTD PMID:15916743 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 2,4-thiazolidinedione results in increased expression of CDKN1B protein CTD PMID:15916743 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO 2,4-thiazolidinedione results in decreased expression of CYP1A1 mRNA CTD PMID:15521013 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO 2,4-thiazolidinedione results in decreased expression of PCNA protein CTD PMID:15916743 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
increases expression
multiple interactions		 ISO
EXP		 2,4-thiazolidinedione binds to PPARG protein
2,4-thiazolidinedione results in increased expression of PPARG mRNA
2,4-thiazolidinedione binds to and results in increased activity of PPARG protein		 CTD PMID:15521013 PMID:15916743 PMID:20724125 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO 2,4-thiazolidinedione results in decreased expression of RB1 protein CTD PMID:15916743 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP 2,4-thiazolidinedione results in increased expression of SLC2A4 mRNA CTD PMID:20724125 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19893
    chemical entity 19891
      atom 19891
        nonmetal atom 19814
          nitrogen atom 18995
            nitrogen molecular entity 18995
              organonitrogen compound 18847
                organonitrogen heterocyclic compound 18169
                  thiazolidines 8123
                    thiazolidine 11
                      1,3-thiazolidine 11
                        1,3-thiazolidine-2,4-dione 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19893
    subatomic particle 19891
      composite particle 19891
        hadron 19891
          baryon 19891
            nucleon 19891
              atomic nucleus 19891
                atom 19891
                  main group element atom 19830
                    p-block element atom 19830
                      carbon group element atom 19771
                        carbon atom 19767
                          organic molecular entity 19767
                            organic molecule 19719
                              organic cyclic compound 19509
                                organic heterocyclic compound 18887
                                  organic heteromonocyclic compound 17812
                                    thiazolidines 8123
                                      thiazolidine 11
                                        1,3-thiazolidine 11
                                          1,3-thiazolidine-2,4-dione 11
paths to the root