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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:piclamilast
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Accession:CHEBI:47619 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
Synonyms:related_synonym: 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide;   3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide;   3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide;   Formula=C18H18Cl2N2O3;   InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23);   InChIKey=RRRUXBQSQLKHEL-UHFFFAOYSA-N;   RP 73-401;   RP 73401;   SMILES=COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl;   piclamilastum
 xref: CAS:144035-83-6;   DrugBank:DB01791;   KEGG:D05474
 xref_mesh: MESH:C087566
 xref: PDBeChem:PIL;   PMID:10485818;   PMID:22360706;   PMID:7647982;   PMID:7889300;   PMID:8864527;   PMID:9316851;   Reaxys:6937319;   Wikipedia:Piclamilast


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piclamilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein] CTD PMID:34627785 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX mRNA] CTD PMID:34627785 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 mRNA] CTD PMID:34627785 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 mRNA] CTD PMID:34627785 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein] CTD PMID:34627785 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of piclamilast CTD PMID:12464242 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP piclamilast inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL1B protein] CTD PMID:34627785 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of MTOR protein] CTD PMID:34627785 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:34627785 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of RASGRF1 protein] CTD PMID:34627785 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein] CTD PMID:34627785 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein] CTD PMID:34627785 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          piclamilast 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                arenecarboxamide 8246
                                                  benzamides 8246
                                                    piclamilast 13
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