The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.
ICI 164384 binds to ESR1 protein [ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; ICI 164384 binds to and results in increased activity of ESR1 protein
ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Cadmium results in increased expression of PGR protein]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of PGR mRNA]
ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of PRL mRNA]
ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA] ICI 164384 results in decreased expression of SIAH2 mRNA SIAH2 protein affects the susceptibility to ICI 164384
ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [phenothrin results in increased expression of TFF1 mRNA]
ICI 164384 inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TP53 protein]