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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620707
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:40710
Term: ICI-164384
Definition: A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.
Chemical ID: MESH:C051781
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tff1multiple interactionsISOTFF1 (Homo sapiens)6480464CTDICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [phenothrin results in increased expression of TFF1 mRNA]PMID:10064545 PMID:16242299 PMID:8968093
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