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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:40710
Term: ICI-164384
Definition: A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.
Chemical ID: MESH:C051781
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOEsr1 (Mus musculus)6480464CTDICI 164384 binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDICI 164384 binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; ICI 164384 binds to and results in increased activity of ESR1 proteinPMID:11174852
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