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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,4'-thiodiphenol
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Accession:CHEBI:38957 term browser browse the term
Definition:A phenol that has formula C12H10O2S.
Synonyms:exact_synonym: 4,4'-sulfanediyldiphenol
 related_synonym: 4,4'-Dihydroxydiphenyl sulfide;   Bis(4-oxyphenyl)sulfide;   Formula=C12H10O2S;   InChI=1S/C12H10O2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8,13-14H;   InChIKey=VWGKEVWFBOUAND-UHFFFAOYSA-N;   SMILES=Oc1ccc(Sc2ccc(O)cc2)cc1;   p,p'-Dihydroxydiphenyl sulfide
 xref: Beilstein:2050739;   CAS:2664-63-3
 xref_mesh: MESH:C586730


show annotations for term's descendants           Sort by:
4,4'-thiodiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP bis(4-oxyphenyl)sulfide binds to AR protein CTD PMID:31836225 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases expression		 ISO bis(4-oxyphenyl)sulfide binds to ESR1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]		 CTD PMID:27880919 PMID:31836225 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO bis(4-oxyphenyl)sulfide binds to ESR2 protein CTD PMID:31836225 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression
multiple interactions		 ISO bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein]		 CTD PMID:27880919 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO
EXP		 bis(4-oxyphenyl)sulfide results in decreased activity of HSD11B2 protein CTD PMID:36871355 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein] CTD PMID:27880919 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:27880919 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
temephos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Temefos results in decreased activity of ACHE protein CTD PMID:34382084 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Temefos results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Temefos inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      molecular entity 19839
        polyatomic entity 19797
          heteroatomic molecular entity 19754
            hydroxides 19332
              organic hydroxy compound 18955
                phenols 18637
                  4,4'-thiodiphenol 10
                    temephos 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organosulfur compound 17361
                                  organic sulfide 10112
                                    aryl sulfide 8334
                                      diphenyl sulfide 10
                                        4,4'-thiodiphenol 10
                                          temephos 3
paths to the root