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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:38957
Term: 4,4'-thiodiphenol
Definition: A phenol that has formula C12H10O2S.
Chemical ID: MESH:C586730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases expressionISORGD:7365596480464CTD4, 4'-thiodiphenol results in increased expression of ESR1 protein

PMID:27880919
Esr1multiple interactionsISORGD:7365596480464CTD4-(6-bromo-1, 3-benzodioxol-5-yl)-3a, 4, 5, 9b-3H-cyclopenta(c)quinoline inhibits the reaction [4, 4'-thiodiphenol results in increased expression of ESR1 protein], fulvestrant inhibits the reaction [4, 4'-thiodiphenol results in increased expression of ESR1 protein]

PMID:27880919
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.