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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fidarestat
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Accession:CHEBI:31611 term browser browse the term
Synonyms:related_synonym: Aldos (TN);   Formula=C12H10FN3O4;   SNK 860
 xref: CAS:136087-85-9;   KEGG:D01842
 xref_mesh: MESH:C077139


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Fidarestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 multiple interactions ISO fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions
affects binding		 EXP fidarestat binds to and results in decreased activity of AKR1B1 protein
NADP binds to AKR1B1 protein binds to fidarestat		 CTD PMID:23295227 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 affects binding
multiple interactions		 EXP NADP binds to AKR1B10 protein mutant form binds to fidarestat
fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form		 CTD PMID:23295227 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22253906 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G IL13 interleukin 13 multiple interactions
decreases response to substance		 EXP
ISO		 fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]
fidarestat results in decreased susceptibility to IL13 protein		 CTD PMID:21203431 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:22253906 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22253906 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JAK1 Janus kinase 1 multiple interactions
decreases phosphorylation		 EXP fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]
fidarestat results in decreased phosphorylation of JAK1 protein		 CTD PMID:21203431 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation		 EXP fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]
fidarestat results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21203431 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions		 EXP fidarestat results in decreased phosphorylation of MAPK3 protein
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21203431 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA] CTD PMID:21203431 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22253906 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G SPDEF SAM pointed domain containing ETS transcription factor multiple interactions EXP fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein] CTD PMID:21203431 NCBI chr 6:34,537,802...34,556,329
Ensembl chr 6:34,537,802...34,556,333 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 multiple interactions
decreases phosphorylation		 EXP
ISO		 fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]
fidarestat results in decreased phosphorylation of STAT6 protein		 CTD PMID:21203431 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22253906 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    chemical entity 26483
      atom 26479
        nonmetal atom 25741
          carbon atom 25623
            organic molecular entity 25623
              Fidarestat 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    p-block element atom 26216
                      carbon group element atom 25661
                        carbon atom 25623
                          organic molecular entity 25623
                            Fidarestat 15
paths to the root