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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Berbamine
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Accession:CHEBI:3063 term browser browse the term
Definition:A bisbenzylisoquinoline alkaloid that has formula C37H40N2O6.
Synonyms:related_synonym: Formula=C37H40N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1;   InChIKey=DFOCUWZXJBAUSQ-URLMMPGGSA-N;   SMILES=COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5cc(C[C@H]6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5O)cc4
 xref: CAS:478-61-5;   KEGG:C09357;   KNApSAcK:C00001817
 xref_mesh: MESH:C027870


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Berbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO berbamine results in decreased expression of BCL2L1 protein CTD PMID:19960011 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO berbamine results in decreased expression of BID protein CTD PMID:19960011 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
affects binding		 ISO berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein
berbamine binds to BIRC5 promoter		 CTD PMID:17531122 PMID:17968851 PMID:19960011 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity ISO berbamine results in increased activity of CASP3 protein CTD PMID:17531122 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO berbamine results in decreased expression of CCND1 protein CTD PMID:19960011 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO berbamine results in decreased expression of CHUK protein CTD PMID:19960011 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO berbamine results in decreased phosphorylation of NFKBIA protein CTD PMID:19960011 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO berbamine affects the localization of RELA protein CTD PMID:19960011 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO berbamine results in increased expression of TNFAIP3 protein CTD PMID:19960011 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            alkaloid 7826
              isoquinoline alkaloid 1195
                benzylisoquinoline alkaloid 220
                  bisbenzylisoquinoline alkaloid 119
                    Berbamine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organonitrogen compound 18812
                                alkaloid 7826
                                  isoquinoline alkaloid 1195
                                    benzylisoquinoline alkaloid 220
                                      bisbenzylisoquinoline alkaloid 119
                                        Berbamine 9
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