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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity decreases expression |
ISO |
tetrandrine results in decreased activity of ABCB1A protein tetrandrine results in decreased expression of ABCB1 |
CTD |
PMID:17273824 PMID:19840446 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:17201889 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:26640276 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
ISO |
tetrandrine results in increased expression of AIFM1 protein |
CTD |
PMID:26822499 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation decreases phosphorylation |
ISO |
tetrandrine results in increased phosphorylation of AKT1 protein tetrandrine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:30549224 PMID:31255635 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atg12 |
autophagy related 12 |
increases expression |
ISO |
tetrandrine results in increased expression of ATG12 protein |
CTD |
PMID:26822499 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg5 |
autophagy related 5 |
increases expression decreases expression |
ISO |
tetrandrine results in increased expression of ATG5 protein tetrandrine results in decreased expression of ATG5 protein |
CTD |
PMID:25266202 PMID:26822499 |
|
NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg7 |
autophagy related 7 |
decreases expression |
ISO |
tetrandrine results in decreased expression of ATG7 protein |
CTD |
PMID:25266202 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
tetrandrine results in increased expression of BAK1 protein |
CTD |
PMID:26822499 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
tetrandrine results in increased expression of BAX protein |
CTD |
PMID:26822499 PMID:31255635 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
affects response to substance increases expression multiple interactions decreases expression |
ISO |
BCL2 protein affects the susceptibility to tetrandrine tetrandrine results in increased expression of BCL2 protein CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein] tetrandrine results in decreased expression of BCL2 mRNA; tetrandrine results in decreased expression of BCL2 protein |
CTD |
PMID:18495333 PMID:26302866 PMID:26822499 PMID:31255635 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of BCL2L1 protein |
CTD |
PMID:26822499 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions decreases expression |
ISO |
tetrandrine results in increased expression of BECN1 protein [sodium arsenite co-treated with tetrandrine] results in increased expression of BECN1 protein tetrandrine results in decreased expression of BECN1 protein |
CTD |
PMID:25266202 PMID:26822499 PMID:30123091 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
tetrandrine results in decreased expression of BID protein |
CTD |
PMID:26822499 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
affects binding decreases expression |
ISO |
tetrandrine binds to BIRC5 promoter tetrandrine results in decreased expression of BIRC5 mRNA |
CTD |
PMID:17968851 PMID:18495333 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp12 |
caspase 12 |
increases cleavage |
ISO |
tetrandrine results in increased cleavage of CASP12 protein |
CTD |
PMID:26822499 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases expression increases cleavage multiple interactions |
ISO |
tetrandrine results in increased expression of CASP3 protein tetrandrine results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]; tetrandrine results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:25266202 PMID:26302866 PMID:26822499 PMID:31255635 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression increases cleavage |
ISO |
tetrandrine results in increased cleavage of and results in increased activity of CASP8 protein tetrandrine results in increased expression of CASP8 protein tetrandrine results in increased cleavage of CASP8 protein |
CTD |
PMID:25266202 PMID:26822499 PMID:31255635 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases cleavage |
ISO |
tetrandrine results in increased cleavage of and results in increased activity of CASP9 protein tetrandrine results in increased cleavage of CASP9 protein |
CTD |
PMID:25266202 PMID:26822499 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna2 |
cyclin A2 |
increases expression |
ISO |
tetrandrine results in increased expression of CCNA2 protein |
CTD |
PMID:31255635 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
tetrandrine results in increased expression of CCNB1 protein |
CTD |
PMID:31255635 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression affects expression |
ISO |
[sodium arsenite co-treated with tetrandrine] affects the expression of CCND1 protein; [sodium arsenite co-treated with tetrandrine] results in decreased expression of CCND1 protein tetrandrine results in decreased expression of CCND1 protein tetrandrine affects the expression of CCND1 protein |
CTD |
PMID:30123091 PMID:31255635 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of CDH1 protein |
CTD |
PMID:30549224 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
tetrandrine results in decreased expression of CDH2 protein |
CTD |
PMID:30549224 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression affects expression multiple interactions |
ISO |
tetrandrine results in increased expression of CDKN1A tetrandrine affects the expression of CDKN1A protein [sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A protein |
CTD |
PMID:19840446 PMID:30123091 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
[sodium arsenite co-treated with tetrandrine] results in increased expression of CDKN1B protein tetrandrine results in increased expression of CDKN1B protein |
CTD |
PMID:30123091 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein] |
CTD |
PMID:17201889 PMID:22001142 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
tetrandrine results in decreased expression of COL1A1 mRNA |
CTD |
PMID:27235791 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
ISO |
[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein] |
CTD |
PMID:26640276 |
|
NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein |
CTD |
PMID:26640276 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases glutathionylation |
ISO |
CYP3A4 protein results in increased glutathionylation of tetrandrine |
CTD |
PMID:21992520 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases glutathionylation increases response to substance multiple interactions |
ISO |
CYP3A5 protein results in increased glutathionylation of tetrandrine CYP3A5 protein results in increased susceptibility to tetrandrine CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione]; CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased abundance of Reactive Oxygen Species]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein] |
CTD |
PMID:21992520 PMID:26302866 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
tetrandrine results in increased expression of DDIT3 protein |
CTD |
PMID:26822499 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
tetrandrine results in decreased phosphorylation of EGFR protein |
CTD |
PMID:30549224 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Endog |
endonuclease G |
decreases expression |
ISO |
tetrandrine results in decreased expression of ENDOG protein |
CTD |
PMID:26822499 |
|
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions decreases expression |
ISO |
[arsenite co-treated with tetrandrine] results in decreased expression of ERBB2 protein tetrandrine results in decreased expression of ERBB2 protein |
CTD |
PMID:31934280 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] |
CTD |
PMID:10072926 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
[sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein; [sodium arsenite co-treated with tetrandrine] results in increased expression of FOXO3 protein; tetrandrine affects the expression of and affects the phosphorylation of FOXO3 protein |
CTD |
PMID:30123091 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Foxp3 |
forkhead box P3 |
multiple interactions increases expression |
ISO |
[tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]; resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA] |
CTD |
PMID:26640276 |
|
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
tetrandrine results in decreased expression of GRB2 protein |
CTD |
PMID:30549224 |
|
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
ISO |
tetrandrine results in decreased expression of GSK3B protein modified form |
CTD |
PMID:25266202 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
tetrandrine results in increased expression of HSPA5 protein |
CTD |
PMID:26822499 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions increases expression |
EXP ISO |
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] tetrandrine results in increased expression of ICAM1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tetrandrine results in increased expression of ICAM1 protein]; [arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein; [arsenite co-treated with tetrandrine] results in increased expression of ICAM1 protein |
CTD |
PMID:17201889 PMID:31934280 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein] |
CTD |
PMID:26640276 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
ISO |
[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA] |
CTD |
PMID:26640276 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il17a |
interleukin 17A |
multiple interactions decreases expression |
ISO |
resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein] tetrandrine results in decreased expression of IL17A mRNA |
CTD |
PMID:26640276 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein] |
CTD |
PMID:22001142 PMID:26640276 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein] |
CTD |
PMID:26640276 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation |
ISO |
tetrandrine results in decreased phosphorylation of JUN protein |
CTD |
PMID:30549224 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Lmna |
lamin A/C |
increases expression |
ISO |
tetrandrine results in increased expression of LMNA protein |
CTD |
PMID:31255635 |
|
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
ISO |
tetrandrine results in increased expression of MAP1LC3B |
CTD |
PMID:26822499 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] tetrandrine results in increased phosphorylation of MAPK1 protein [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK1 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK1 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22001142 PMID:31934280 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP ISO |
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] tetrandrine results in increased phosphorylation of MAPK3 protein [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22001142 PMID:31934280 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
increases expression |
ISO |
tetrandrine results in increased expression of MCL1 protein |
CTD |
PMID:31255635 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
tetrandrine results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:30549224 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
EXP ISO |
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein] tetrandrine results in decreased expression of MMP9 protein |
CTD |
PMID:22001142 PMID:30549224 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases expression |
ISO |
[sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine results in decreased expression of and results in decreased phosphorylation of MTOR protein tetrandrine results in decreased expression of MTOR protein; tetrandrine results in decreased expression of MTOR protein modified form |
CTD |
PMID:25266202 PMID:26822499 PMID:30123091 PMID:31255635 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17201889 PMID:22001142 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] |
CTD |
PMID:22001142 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
tetrandrine results in increased cleavage of PARP1 protein |
CTD |
PMID:26822499 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
affects phosphorylation multiple interactions |
ISO |
tetrandrine affects the phosphorylation of PRKAA1 protein [sodium arsenite co-treated with tetrandrine] affects the phosphorylation of PRKAA1 protein |
CTD |
PMID:30123091 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases phosphorylation |
EXP ISO |
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein] tetrandrine results in decreased expression of and results in decreased activity of RELA protein tetrandrine results in increased phosphorylation of RELA protein |
CTD |
PMID:17201889 PMID:30549224 PMID:31255635 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions decreases expression |
ISO |
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA] tetrandrine results in decreased expression of RORC mRNA |
CTD |
PMID:26640276 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Rps6 |
ribosomal protein S6 |
decreases expression |
ISO |
tetrandrine results in decreased expression of RPS6 protein modified form |
CTD |
PMID:25266202 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rptor |
regulatory associated protein of MTOR, complex 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of RAPTOR protein |
CTD |
PMID:25266202 |
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NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
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G |
Sfn |
stratifin |
increases expression |
ISO |
tetrandrine results in increased expression of SFN protein |
CTD |
PMID:26822499 |
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Ensembl chr 5:145,826,201...145,831,314
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of SNAI1 protein |
CTD |
PMID:30549224 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of SOS1 protein |
CTD |
PMID:30549224 |
|
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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G |
Sqstm1 |
sequestosome 1 |
decreases expression |
ISO |
tetrandrine results in decreased expression of SQSTM1 protein |
CTD |
PMID:25266202 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:17201889 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein] |
CTD |
PMID:17201889 PMID:26640276 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
increases phosphorylation decreases expression |
ISO |
tetrandrine results in increased phosphorylation of ULK1 protein tetrandrine results in decreased expression of ULK1 protein |
CTD |
PMID:25266202 PMID:26822499 |
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NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
berbamine results in decreased expression of BCL2L1 protein |
CTD |
PMID:19960011 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
berbamine results in decreased expression of BID protein |
CTD |
PMID:19960011 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression affects binding |
ISO |
berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein berbamine binds to BIRC5 promoter |
CTD |
PMID:17531122 PMID:17968851 PMID:19960011 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
berbamine results in increased activity of CASP3 protein |
CTD |
PMID:17531122 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
berbamine results in decreased expression of CCND1 protein |
CTD |
PMID:19960011 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
decreases expression |
ISO |
berbamine results in decreased expression of CHUK protein |
CTD |
PMID:19960011 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Nfkbia |
NFKB inhibitor alpha |
decreases phosphorylation |
ISO |
berbamine results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:19960011 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization |
ISO |
berbamine affects the localization of RELA protein |
CTD |
PMID:19960011 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
increases expression |
ISO |
berbamine results in increased expression of TNFAIP3 protein |
CTD |
PMID:19960011 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity |
ISO |
cepharanthine results in decreased activity of ABCB1 protein |
CTD |
PMID:15958061 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
cepharanthine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
increases expression |
ISO |
cepharanthine results in increased expression of MCL1 protein |
CTD |
PMID:31255635 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
ISO |
cepharanthine results in decreased expression of MTOR protein |
CTD |
PMID:31255635 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
decreases expression |
ISO |
cepharanthine results in decreased expression of PARP1 protein |
CTD |
PMID:31255635 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
cepharanthine results in increased expression of TP53 protein |
CTD |
PMID:31255635 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases glutathionylation multiple interactions |
ISO |
CYP3A4 protein results in increased glutathionylation of dauricine [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine; [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide; CYP3A4 protein results in increased oxidation of and results in increased activity of dauricine; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine] |
CTD |
PMID:19358519 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
fangchinoline results in increased expression of ATF4 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein] |
CTD |
PMID:28754437 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
fangchinoline results in decreased expression of BIRC5 mRNA; fangchinoline results in decreased expression of BIRC5 protein |
CTD |
PMID:28754437 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
fangchinoline results in increased cleavage of CASP3 protein |
CTD |
PMID:28754437 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
fangchinoline results in increased cleavage of CASP8 protein |
CTD |
PMID:28754437 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
fangchinoline results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein] |
CTD |
PMID:28754437 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
fangchinoline results in increased expression of HSPA5 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein] |
CTD |
PMID:28754437 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
fangchinoline results in increased cleavage of PARP1 protein |
CTD |
PMID:28754437 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] |
CTD |
PMID:10421444 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] |
CTD |
PMID:29618714 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] |
CTD |
PMID:16644063 |
|
NCBI chr13:22,689,783...22,853,920
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G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] |
CTD |
PMID:19436947 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
C7 |
complement C7 |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] Tubocurarine results in decreased expression of C7 mRNA |
CTD |
PMID:16949557 |
|
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] |
CTD |
PMID:15231866 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Chrna1 |
cholinergic receptor nicotinic alpha 1 subunit |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] |
CTD |
PMID:19690163 |
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NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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G |
Chrna2 |
cholinergic receptor nicotinic alpha 2 subunit |
multiple interactions |
EXP |
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] |
CTD |
PMID:7808438 |
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NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
multiple interactions |
ISO EXP |
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] |
CTD |
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 |
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NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] |
CTD |
PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 |
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NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
ISO |
Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] |
CTD |
PMID:10082212 PMID:10216184 PMID:16931985 |
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NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions |
ISO EXP |
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein] |
CTD |
PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 |
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NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions |
ISO EXP |
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] |
CTD |
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 |
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NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
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G |
Cntn1 |
contactin 1 |
increases expression decreases expression multiple interactions |
ISO |
Tubocurarine results in increased expression of CNTN1 mRNA Tubocurarine results in decreased expression of CNTN1 mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] |
CTD |
PMID:12588870 PMID:16949557 |
|
NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] |
CTD |
PMID:9606035 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Dhfr |
dihydrofolate reductase |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] Tubocurarine results in decreased expression of DHFR mRNA |
CTD |
PMID:12588870 |
|
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Eml4 |
EMAP like 4 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] |
CTD |
PMID:12588870 |
|
NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] |
CTD |
PMID:16644063 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fez1 |
fasciculation and elongation protein zeta 1 |
multiple interactions decreases expression |
ISO |
Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] Tubocurarine results in decreased expression of FEZ1 mRNA |
CTD |
PMID:12588870 |
|
NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] |
CTD |
PMID:11425648 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Golga4 |
golgin A4 |
decreases expression multiple interactions |
ISO |
Tubocurarine results in decreased expression of GOLGA4 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] |
CTD |
PMID:16949557 |
|
NCBI chr 8:118,208,200...118,285,003
|
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]] |
CTD |
PMID:22119045 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kcnn1 |
potassium calcium-activated channel subfamily N member 1 |
decreases activity |
ISO |
Tubocurarine results in decreased activity of KCNN1 protein |
CTD |
PMID:10696100 |
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NCBI chr16:18,574,858...18,597,780
Ensembl chr16:18,585,992...18,597,482
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G |
Kcnn2 |
potassium calcium-activated channel subfamily N member 2 |
decreases activity |
ISO EXP |
Tubocurarine results in decreased activity of KCNN2 protein |
CTD |
PMID:10696100 PMID:10991935 |
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NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
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G |
Kmt2c |
lysine methyltransferase 2C |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] Tubocurarine results in decreased expression of KMT2C mRNA |
CTD |
PMID:12588870 |
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NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] |
CTD |
PMID:12588870 |
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NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22119045 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22119045 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] |
CTD |
PMID:17151781 PMID:18986645 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Nin |
ninein |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA] Tubocurarine results in decreased expression of NIN mRNA |
CTD |
PMID:16949557 |
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NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] |
CTD |
PMID:19690163 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases expression multiple interactions |
ISO |
Tubocurarine results in decreased expression of POU5F1 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA] |
CTD |
PMID:15612475 PMID:15749260 |
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NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
decreases expression |
ISO |
Tubocurarine results in decreased expression of PRKN mRNA |
CTD |
PMID:16949557 |
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NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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G |
Ptma |
prothymosin alpha |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] |
CTD |
PMID:16644063 |
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NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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G |
Ptpra |
protein tyrosine phosphatase, receptor type, A |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
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G |
Rbbp6 |
RB binding protein 6, ubiquitin ligase |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
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G |
Sftpa1 |
surfactant protein A1 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA] |
CTD |
PMID:9458815 |
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NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
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G |
Sftpc |
surfactant protein C |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA] |
CTD |
PMID:9458815 |
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NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
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G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] Tubocurarine results in decreased expression of SOS1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] |
CTD |
PMID:11425648 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Stip1 |
stress-induced phosphoprotein 1 |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA] Tubocurarine results in decreased expression of STIP1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
multiple interactions decreases expression |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA] Tubocurarine results in decreased expression of UBE2C mRNA |
CTD |
PMID:16949557 |
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NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Ube3a |
ubiquitin protein ligase E3A |
increases expression multiple interactions |
ISO |
Tubocurarine results in increased expression of UBE3A mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] |
CTD |
PMID:9789800 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Zfp42 |
zinc finger protein 42 |
multiple interactions |
ISO |
Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] |
CTD |
PMID:15749260 |
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NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
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G |
Zfr |
zinc finger RNA binding protein |
decreases expression multiple interactions |
ISO |
Tubocurarine results in decreased expression of ZFR mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
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