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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bisbenzylisoquinoline alkaloid
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Accession:CHEBI:133004 term browser browse the term
Definition:A type of benzylisoquinoline alkaloid whose structures are built up of two benzylisoquinoline units linked by ether bridges. Various structural patterns resulting from additional bridging between the two units by direct carbon-carbon bridging or by methylenedioxy groups are common.
Synonyms:related_synonym: bis-benzylisoquinoline alkaloid;   bis-benzylisoquinoline alkaloids;   bisbenzylisoquinoline alkaloids
 xref: PMID:1955879;   PMID:2191354;   PMID:3323421



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(+)-Tetrandrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression
ISO tetrandrine results in decreased activity of ABCB1A protein
tetrandrine results in decreased expression of ABCB1
CTD PMID:17273824 PMID:19840446 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:17201889 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA] CTD PMID:26640276 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO tetrandrine results in increased expression of AIFM1 protein CTD PMID:26822499 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO tetrandrine results in increased phosphorylation of AKT1 protein
tetrandrine results in decreased phosphorylation of AKT1 protein
CTD PMID:30549224 PMID:31255635 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg12 autophagy related 12 increases expression ISO tetrandrine results in increased expression of ATG12 protein CTD PMID:26822499 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 increases expression
decreases expression
ISO tetrandrine results in increased expression of ATG5 protein
tetrandrine results in decreased expression of ATG5 protein
CTD PMID:25266202 PMID:26822499 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 decreases expression ISO tetrandrine results in decreased expression of ATG7 protein CTD PMID:25266202 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO tetrandrine results in increased expression of BAK1 protein CTD PMID:26822499 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrandrine results in increased expression of BAX protein CTD PMID:26822499 PMID:31255635 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
increases expression
multiple interactions
decreases expression
ISO BCL2 protein affects the susceptibility to tetrandrine
tetrandrine results in increased expression of BCL2 protein
CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]
tetrandrine results in decreased expression of BCL2 mRNA; tetrandrine results in decreased expression of BCL2 protein
CTD PMID:18495333 PMID:26302866 PMID:26822499 PMID:31255635 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tetrandrine results in decreased expression of BCL2L1 protein CTD PMID:26822499 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
decreases expression
ISO tetrandrine results in increased expression of BECN1 protein
[sodium arsenite co-treated with tetrandrine] results in increased expression of BECN1 protein
tetrandrine results in decreased expression of BECN1 protein
CTD PMID:25266202 PMID:26822499 PMID:30123091 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO tetrandrine results in decreased expression of BID protein CTD PMID:26822499 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding
decreases expression
ISO tetrandrine binds to BIRC5 promoter
tetrandrine results in decreased expression of BIRC5 mRNA
CTD PMID:17968851 PMID:18495333 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp12 caspase 12 increases cleavage ISO tetrandrine results in increased cleavage of CASP12 protein CTD PMID:26822499 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
ISO tetrandrine results in increased expression of CASP3 protein
tetrandrine results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]; tetrandrine results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:25266202 PMID:26302866 PMID:26822499 PMID:31255635 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
increases cleavage
ISO tetrandrine results in increased cleavage of and results in increased activity of CASP8 protein
tetrandrine results in increased expression of CASP8 protein
tetrandrine results in increased cleavage of CASP8 protein
CTD PMID:25266202 PMID:26822499 PMID:31255635 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO tetrandrine results in increased cleavage of and results in increased activity of CASP9 protein
tetrandrine results in increased cleavage of CASP9 protein
CTD PMID:25266202 PMID:26822499 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 increases expression ISO tetrandrine results in increased expression of CCNA2 protein CTD PMID:31255635 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO tetrandrine results in increased expression of CCNB1 protein CTD PMID:31255635 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
affects expression
ISO [sodium arsenite co-treated with tetrandrine] affects the expression of CCND1 protein; [sodium arsenite co-treated with tetrandrine] results in decreased expression of CCND1 protein
tetrandrine results in decreased expression of CCND1 protein
tetrandrine affects the expression of CCND1 protein
CTD PMID:30123091 PMID:31255635 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO tetrandrine results in decreased expression of CDH1 protein CTD PMID:30549224 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO tetrandrine results in decreased expression of CDH2 protein CTD PMID:30549224 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
affects expression
multiple interactions
ISO tetrandrine results in increased expression of CDKN1A
tetrandrine affects the expression of CDKN1A protein
[sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A protein
CTD PMID:19840446 PMID:30123091 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [sodium arsenite co-treated with tetrandrine] results in increased expression of CDKN1B protein
tetrandrine results in increased expression of CDKN1B protein
CTD PMID:30123091 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein] CTD PMID:17201889 PMID:22001142 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO tetrandrine results in decreased expression of COL1A1 mRNA CTD PMID:27235791 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein] CTD PMID:26640276 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:26640276 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of tetrandrine CTD PMID:21992520 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases glutathionylation
increases response to substance
multiple interactions
ISO CYP3A5 protein results in increased glutathionylation of tetrandrine
CYP3A5 protein results in increased susceptibility to tetrandrine
CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione]; CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased abundance of Reactive Oxygen Species]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]
CTD PMID:21992520 PMID:26302866 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO tetrandrine results in increased expression of DDIT3 protein CTD PMID:26822499 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrandrine results in decreased phosphorylation of EGFR protein CTD PMID:30549224 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Endog endonuclease G decreases expression ISO tetrandrine results in decreased expression of ENDOG protein CTD PMID:26822499 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO [arsenite co-treated with tetrandrine] results in decreased expression of ERBB2 protein
tetrandrine results in decreased expression of ERBB2 protein
CTD PMID:31934280 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] CTD PMID:10072926 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein; [sodium arsenite co-treated with tetrandrine] results in increased expression of FOXO3 protein; tetrandrine affects the expression of and affects the phosphorylation of FOXO3 protein CTD PMID:30123091 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]; resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA] CTD PMID:26640276 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO tetrandrine results in decreased expression of GRB2 protein CTD PMID:30549224 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tetrandrine results in decreased expression of GSK3B protein modified form CTD PMID:25266202 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tetrandrine results in increased expression of HSPA5 protein CTD PMID:26822499 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
EXP
ISO
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
tetrandrine results in increased expression of ICAM1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tetrandrine results in increased expression of ICAM1 protein]; [arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein; [arsenite co-treated with tetrandrine] results in increased expression of ICAM1 protein
CTD PMID:17201889 PMID:31934280 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein] CTD PMID:26640276 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA] CTD PMID:26640276 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]
tetrandrine results in decreased expression of IL17A mRNA
CTD PMID:26640276 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]
CTD PMID:22001142 PMID:26640276 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein] CTD PMID:26640276 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO tetrandrine results in decreased phosphorylation of JUN protein CTD PMID:30549224 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lmna lamin A/C increases expression ISO tetrandrine results in increased expression of LMNA protein CTD PMID:31255635 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO tetrandrine results in increased expression of MAP1LC3B CTD PMID:26822499 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]
tetrandrine results in increased phosphorylation of MAPK1 protein
[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK1 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK1 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:22001142 PMID:31934280 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]
tetrandrine results in increased phosphorylation of MAPK3 protein
[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]
CTD PMID:22001142 PMID:31934280 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO tetrandrine results in increased expression of MCL1 protein CTD PMID:31255635 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tetrandrine results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:30549224 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]
tetrandrine results in decreased expression of MMP9 protein
CTD PMID:22001142 PMID:30549224 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine results in decreased expression of and results in decreased phosphorylation of MTOR protein
tetrandrine results in decreased expression of MTOR protein; tetrandrine results in decreased expression of MTOR protein modified form
CTD PMID:25266202 PMID:26822499 PMID:30123091 PMID:31255635 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17201889 PMID:22001142 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:22001142 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO tetrandrine results in increased cleavage of PARP1 protein CTD PMID:26822499 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 affects phosphorylation
multiple interactions
ISO tetrandrine affects the phosphorylation of PRKAA1 protein
[sodium arsenite co-treated with tetrandrine] affects the phosphorylation of PRKAA1 protein
CTD PMID:30123091 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]
tetrandrine results in decreased expression of and results in decreased activity of RELA protein
tetrandrine results in increased phosphorylation of RELA protein
CTD PMID:17201889 PMID:30549224 PMID:31255635 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
decreases expression
ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]
tetrandrine results in decreased expression of RORC mRNA
CTD PMID:26640276 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO tetrandrine results in decreased expression of RPS6 protein modified form CTD PMID:25266202 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression ISO tetrandrine results in decreased expression of RAPTOR protein CTD PMID:25266202 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Sfn stratifin increases expression ISO tetrandrine results in increased expression of SFN protein CTD PMID:26822499 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO tetrandrine results in decreased expression of SNAI1 protein CTD PMID:30549224 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO tetrandrine results in decreased expression of SOS1 protein CTD PMID:30549224 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO tetrandrine results in decreased expression of SQSTM1 protein CTD PMID:25266202 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:17201889 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]
CTD PMID:17201889 PMID:26640276 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
decreases expression
ISO tetrandrine results in increased phosphorylation of ULK1 protein
tetrandrine results in decreased expression of ULK1 protein
CTD PMID:25266202 PMID:26822499 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
Berbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO berbamine results in decreased expression of BCL2L1 protein CTD PMID:19960011 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO berbamine results in decreased expression of BID protein CTD PMID:19960011 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
affects binding
ISO berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein
berbamine binds to BIRC5 promoter
CTD PMID:17531122 PMID:17968851 PMID:19960011 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases activity ISO berbamine results in increased activity of CASP3 protein CTD PMID:17531122 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO berbamine results in decreased expression of CCND1 protein CTD PMID:19960011 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO berbamine results in decreased expression of CHUK protein CTD PMID:19960011 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO berbamine results in decreased phosphorylation of NFKBIA protein CTD PMID:19960011 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO berbamine affects the localization of RELA protein CTD PMID:19960011 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO berbamine results in increased expression of TNFAIP3 protein CTD PMID:19960011 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
cepharanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO cepharanthine results in decreased activity of ABCB1 protein CTD PMID:15958061 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO cepharanthine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO cepharanthine results in increased expression of MCL1 protein CTD PMID:31255635 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO cepharanthine results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO cepharanthine results in decreased expression of PARP1 protein CTD PMID:31255635 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tp53 tumor protein p53 increases expression ISO cepharanthine results in increased expression of TP53 protein CTD PMID:31255635 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
dauricine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation
multiple interactions
ISO CYP3A4 protein results in increased glutathionylation of dauricine
[CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine; [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide; CYP3A4 protein results in increased oxidation of and results in increased activity of dauricine; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]
CTD PMID:19358519 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
fangchinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO fangchinoline results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]
CTD PMID:28754437 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO fangchinoline results in decreased expression of BIRC5 mRNA; fangchinoline results in decreased expression of BIRC5 protein CTD PMID:28754437 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases cleavage ISO fangchinoline results in increased cleavage of CASP3 protein CTD PMID:28754437 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO fangchinoline results in increased cleavage of CASP8 protein CTD PMID:28754437 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO fangchinoline results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein]
CTD PMID:28754437 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO fangchinoline results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]
CTD PMID:28754437 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO fangchinoline results in increased cleavage of PARP1 protein CTD PMID:28754437 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
tubocurarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] CTD PMID:29618714 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] CTD PMID:16644063 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] CTD PMID:19436947 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G C7 complement C7 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA
CTD PMID:16949557 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] CTD PMID:7808438 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10082212 PMID:10216184 PMID:16931985 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cntn1 contactin 1 increases expression
decreases expression
multiple interactions
ISO Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine results in decreased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD PMID:12588870 PMID:16949557 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA
CTD PMID:12588870 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Eml4 EMAP like 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions
decreases expression
ISO Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA
CTD PMID:12588870 NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] CTD PMID:11425648 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Golga4 golgin A4 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]
CTD PMID:16949557 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]] CTD PMID:22119045 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases activity ISO Tubocurarine results in decreased activity of KCNN1 protein CTD PMID:10696100 NCBI chr16:18,574,858...18,597,780
Ensembl chr16:18,585,992...18,597,482
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO
EXP
Tubocurarine results in decreased activity of KCNN2 protein CTD PMID:10696100 PMID:10991935 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA
CTD PMID:12588870 NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] CTD PMID:12588870 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:22119045 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:22119045 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] CTD PMID:17151781 PMID:18986645 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Nin ninein multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA
CTD PMID:16949557 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Tubocurarine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Ptma prothymosin alpha multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA] CTD PMID:9458815 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpc surfactant protein C multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA] CTD PMID:9458815 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA
CTD PMID:16949557 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA
CTD PMID:16949557 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA
CTD PMID:16949557 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression
multiple interactions
ISO Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]
CTD PMID:12588870 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
JBrowse link
G Zfr zinc finger RNA binding protein decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]
CTD PMID:12588870 NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            alkaloid 5702
              isoquinoline alkaloid 1156
                benzylisoquinoline alkaloid 218
                  bisbenzylisoquinoline alkaloid 116
                    (+)-Atherospermoline 0
                    (+)-Bebeerine 0
                    (+)-O-Methylthalicberine 0
                    (+)-Tetrandrine 72
                    2'-norberbamunine 0
                    Adiantifoline 0
                    Aromoline 0
                    Berbamine 9
                    Calafatimine 0
                    Cancentrine 0
                    Cycleanine 0
                    Daphnandrine 0
                    Daphnoline 0
                    Fetidine 0
                    Gyrocarpine 0
                    Hernandezine 0
                    Isochondrodendrine 0
                    Isotetrandrine 0
                    Magnoline 0
                    Obaberine 0
                    Obamegine 0
                    Pycnamine 0
                    Thalidasine 0
                    Thalmine 0
                    berbamunine + 0
                    cepharanthine 6
                    dauricine + 1
                    fangchinoline 7
                    guattegaumerine 0
                    oxofangchirine 0
                    oxyacanthan + 0
                    oxyacanthine 0
                    rodiasine 0
                    thalicarpine 0
                    tubocurarine 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      p-block molecular entity 19990
                        carbon group molecular entity 19885
                          organic molecular entity 19909
                            heteroorganic entity 19591
                              organonitrogen compound 18736
                                alkaloid 5702
                                  isoquinoline alkaloid 1156
                                    benzylisoquinoline alkaloid 218
                                      bisbenzylisoquinoline alkaloid 116
                                        (+)-Atherospermoline 0
                                        (+)-Bebeerine 0
                                        (+)-O-Methylthalicberine 0
                                        (+)-Tetrandrine 72
                                        2'-norberbamunine 0
                                        Adiantifoline 0
                                        Aromoline 0
                                        Berbamine 9
                                        Calafatimine 0
                                        Cancentrine 0
                                        Cycleanine 0
                                        Daphnandrine 0
                                        Daphnoline 0
                                        Fetidine 0
                                        Gyrocarpine 0
                                        Hernandezine 0
                                        Isochondrodendrine 0
                                        Isotetrandrine 0
                                        Magnoline 0
                                        Obaberine 0
                                        Obamegine 0
                                        Pycnamine 0
                                        Thalidasine 0
                                        Thalmine 0
                                        berbamunine + 0
                                        cepharanthine 6
                                        dauricine + 1
                                        fangchinoline 7
                                        guattegaumerine 0
                                        oxofangchirine 0
                                        oxyacanthan + 0
                                        oxyacanthine 0
                                        rodiasine 0
                                        thalicarpine 0
                                        tubocurarine 46
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