|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
decreases activity decreases expression
|
ISO
|
tetrandrine results in decreased activity of ABCB1A protein tetrandrine results in decreased expression of ABCB1
|
CTD |
PMID:17273824 PMID:19840446 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:17201889 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
multiple interactions
|
ISO
|
AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]
|
CTD |
PMID:26640276 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
|
|
G
|
Aifm1
|
apoptosis inducing factor, mitochondria associated 1
|
increases expression
|
ISO
|
tetrandrine results in increased expression of AIFM1 protein
|
CTD |
PMID:26822499 |
|
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases phosphorylation decreases phosphorylation
|
ISO
|
tetrandrine results in increased phosphorylation of AKT1 protein tetrandrine results in decreased phosphorylation of AKT1 protein
|
CTD |
PMID:30549224 PMID:31255635 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Atg12
|
autophagy related 12
|
increases expression
|
ISO
|
tetrandrine results in increased expression of ATG12 protein
|
CTD |
PMID:26822499 |
|
NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261
|
|
G
|
Atg5
|
autophagy related 5
|
increases expression decreases expression
|
ISO
|
tetrandrine results in increased expression of ATG5 protein tetrandrine results in decreased expression of ATG5 protein
|
CTD |
PMID:25266202 PMID:26822499 |
|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
|
|
G
|
Atg7
|
autophagy related 7
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of ATG7 protein
|
CTD |
PMID:25266202 |
|
NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319
|
|
G
|
Bak1
|
BCL2-antagonist/killer 1
|
increases expression
|
ISO
|
tetrandrine results in increased expression of BAK1 protein
|
CTD |
PMID:26822499 |
|
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression
|
ISO
|
tetrandrine results in increased expression of BAX protein
|
CTD |
PMID:26822499 PMID:31255635 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
affects response to substance increases expression multiple interactions decreases expression
|
ISO
|
BCL2 protein affects the susceptibility to tetrandrine tetrandrine results in increased expression of BCL2 protein CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein] tetrandrine results in decreased expression of BCL2 mRNA; tetrandrine results in decreased expression of BCL2 protein
|
CTD |
PMID:18495333 PMID:26302866 PMID:26822499 PMID:31255635 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of BCL2L1 protein
|
CTD |
PMID:26822499 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
|
|
G
|
Becn1
|
beclin 1
|
increases expression multiple interactions decreases expression
|
ISO
|
tetrandrine results in increased expression of BECN1 protein [sodium arsenite co-treated with tetrandrine] results in increased expression of BECN1 protein tetrandrine results in decreased expression of BECN1 protein
|
CTD |
PMID:25266202 PMID:26822499 PMID:30123091 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
|
|
G
|
Bid
|
BH3 interacting domain death agonist
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of BID protein
|
CTD |
PMID:26822499 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
affects binding decreases expression
|
ISO
|
tetrandrine binds to BIRC5 promoter tetrandrine results in decreased expression of BIRC5 mRNA
|
CTD |
PMID:17968851 PMID:18495333 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
|
|
G
|
Casp12
|
caspase 12
|
increases cleavage
|
ISO
|
tetrandrine results in increased cleavage of CASP12 protein
|
CTD |
PMID:26822499 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442
|
|
G
|
Casp3
|
caspase 3
|
increases expression increases cleavage multiple interactions
|
ISO
|
tetrandrine results in increased expression of CASP3 protein tetrandrine results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]; tetrandrine results in increased cleavage of and results in increased activity of CASP3 protein
|
CTD |
PMID:25266202 PMID:26302866 PMID:26822499 PMID:31255635 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions increases expression increases cleavage
|
ISO
|
tetrandrine results in increased cleavage of and results in increased activity of CASP8 protein tetrandrine results in increased expression of CASP8 protein tetrandrine results in increased cleavage of CASP8 protein
|
CTD |
PMID:25266202 PMID:26822499 PMID:31255635 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases cleavage
|
ISO
|
tetrandrine results in increased cleavage of and results in increased activity of CASP9 protein tetrandrine results in increased cleavage of CASP9 protein
|
CTD |
PMID:25266202 PMID:26822499 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Ccna2
|
cyclin A2
|
increases expression
|
ISO
|
tetrandrine results in increased expression of CCNA2 protein
|
CTD |
PMID:31255635 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
|
|
G
|
Ccnb1
|
cyclin B1
|
increases expression
|
ISO
|
tetrandrine results in increased expression of CCNB1 protein
|
CTD |
PMID:31255635 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
|
|
G
|
Ccnd1
|
cyclin D1
|
multiple interactions decreases expression affects expression
|
ISO
|
[sodium arsenite co-treated with tetrandrine] affects the expression of CCND1 protein; [sodium arsenite co-treated with tetrandrine] results in decreased expression of CCND1 protein tetrandrine results in decreased expression of CCND1 protein tetrandrine affects the expression of CCND1 protein
|
CTD |
PMID:30123091 PMID:31255635 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cdh1
|
cadherin 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of CDH1 protein
|
CTD |
PMID:30549224 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
|
|
G
|
Cdh2
|
cadherin 2
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of CDH2 protein
|
CTD |
PMID:30549224 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression affects expression multiple interactions
|
ISO
|
tetrandrine results in increased expression of CDKN1A tetrandrine affects the expression of CDKN1A protein [sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A protein
|
CTD |
PMID:19840446 PMID:30123091 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Cdkn1b
|
cyclin-dependent kinase inhibitor 1B
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with tetrandrine] results in increased expression of CDKN1B protein tetrandrine results in increased expression of CDKN1B protein
|
CTD |
PMID:30123091 |
|
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
|
|
G
|
Chuk
|
component of inhibitor of nuclear factor kappa B kinase complex
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]
|
CTD |
PMID:17201889 PMID:22001142 |
|
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of COL1A1 mRNA
|
CTD |
PMID:27235791 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
|
|
G
|
Col2a1
|
collagen type II alpha 1 chain
|
multiple interactions
|
ISO
|
[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]
|
CTD |
PMID:26640276 |
|
NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions increases expression
|
ISO
|
[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein
|
CTD |
PMID:26640276 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
increases glutathionylation
|
ISO
|
CYP3A4 protein results in increased glutathionylation of tetrandrine
|
CTD |
PMID:21992520 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
|
|
G
|
Cyp3a9
|
cytochrome P450, family 3, subfamily a, polypeptide 9
|
increases glutathionylation increases response to substance multiple interactions
|
ISO
|
CYP3A5 protein results in increased glutathionylation of tetrandrine CYP3A5 protein results in increased susceptibility to tetrandrine CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione]; CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased abundance of Reactive Oxygen Species]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]
|
CTD |
PMID:21992520 PMID:26302866 |
|
NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression
|
ISO
|
tetrandrine results in increased expression of DDIT3 protein
|
CTD |
PMID:26822499 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Egfr
|
epidermal growth factor receptor
|
decreases phosphorylation
|
ISO
|
tetrandrine results in decreased phosphorylation of EGFR protein
|
CTD |
PMID:30549224 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
|
|
G
|
Endog
|
endonuclease G
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of ENDOG protein
|
CTD |
PMID:26822499 |
|
NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573
|
|
G
|
Erbb2
|
erb-b2 receptor tyrosine kinase 2
|
multiple interactions decreases expression
|
ISO
|
[arsenite co-treated with tetrandrine] results in decreased expression of ERBB2 protein tetrandrine results in decreased expression of ERBB2 protein
|
CTD |
PMID:31934280 |
|
NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
|
CTD |
PMID:10072926 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Foxo3
|
forkhead box O3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein; [sodium arsenite co-treated with tetrandrine] results in increased expression of FOXO3 protein; tetrandrine affects the expression of and affects the phosphorylation of FOXO3 protein
|
CTD |
PMID:30123091 |
|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845
|
|
G
|
Foxp3
|
forkhead box P3
|
multiple interactions increases expression
|
ISO
|
[tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]; resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]
|
CTD |
PMID:26640276 |
|
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894
|
|
G
|
Grb2
|
growth factor receptor bound protein 2
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of GRB2 protein
|
CTD |
PMID:30549224 |
|
NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of GSK3B protein modified form
|
CTD |
PMID:25266202 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
increases expression
|
ISO
|
tetrandrine results in increased expression of HSPA5 protein
|
CTD |
PMID:26822499 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions increases expression
|
EXP ISO
|
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] tetrandrine results in increased expression of ICAM1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tetrandrine results in increased expression of ICAM1 protein]; [arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein; [arsenite co-treated with tetrandrine] results in increased expression of ICAM1 protein
|
CTD |
PMID:17201889 PMID:31934280 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]
|
CTD |
PMID:26640276 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions increases expression
|
ISO
|
[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]
|
CTD |
PMID:26640276 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions decreases expression
|
ISO
|
resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein] tetrandrine results in decreased expression of IL17A mRNA
|
CTD |
PMID:26640276 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP ISO
|
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]
|
CTD |
PMID:22001142 PMID:26640276 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]
|
CTD |
PMID:26640276 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
decreases phosphorylation
|
ISO
|
tetrandrine results in decreased phosphorylation of JUN protein
|
CTD |
PMID:30549224 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Lmna
|
lamin A/C
|
increases expression
|
ISO
|
tetrandrine results in increased expression of LMNA protein
|
CTD |
PMID:31255635 |
|
NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072
|
|
G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
increases expression
|
ISO
|
tetrandrine results in increased expression of MAP1LC3B
|
CTD |
PMID:26822499 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358 Ensembl chr16:66,574,407...66,584,358
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions increases phosphorylation
|
EXP ISO
|
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] tetrandrine results in increased phosphorylation of MAPK1 protein [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK1 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK1 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:22001142 PMID:31934280 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions increases phosphorylation
|
EXP ISO
|
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] tetrandrine results in increased phosphorylation of MAPK3 protein [arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:22001142 PMID:31934280 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mcl1
|
MCL1 apoptosis regulator, BCL2 family member
|
increases expression
|
ISO
|
tetrandrine results in increased expression of MCL1 protein
|
CTD |
PMID:31255635 |
|
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
tetrandrine results in decreased expression of and results in decreased activity of MMP2 protein
|
CTD |
PMID:30549224 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions decreases expression
|
EXP ISO
|
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein] tetrandrine results in decreased expression of MMP9 protein
|
CTD |
PMID:22001142 PMID:30549224 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions decreases expression
|
ISO
|
[sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine results in decreased expression of and results in decreased phosphorylation of MTOR protein tetrandrine results in decreased expression of MTOR protein; tetrandrine results in decreased expression of MTOR protein modified form
|
CTD |
PMID:25266202 PMID:26822499 PMID:30123091 PMID:31255635 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:17201889 PMID:22001142 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]
|
CTD |
PMID:22001142 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
tetrandrine results in increased cleavage of PARP1 protein
|
CTD |
PMID:26822499 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
affects phosphorylation multiple interactions
|
ISO
|
tetrandrine affects the phosphorylation of PRKAA1 protein [sodium arsenite co-treated with tetrandrine] affects the phosphorylation of PRKAA1 protein
|
CTD |
PMID:30123091 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions increases phosphorylation
|
EXP ISO
|
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein] tetrandrine results in decreased expression of and results in decreased activity of RELA protein tetrandrine results in increased phosphorylation of RELA protein
|
CTD |
PMID:17201889 PMID:30549224 PMID:31255635 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Rorc
|
RAR-related orphan receptor C
|
multiple interactions decreases expression
|
ISO
|
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA] tetrandrine results in decreased expression of RORC mRNA
|
CTD |
PMID:26640276 |
|
NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566
|
|
G
|
Rps6
|
ribosomal protein S6
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of RPS6 protein modified form
|
CTD |
PMID:25266202 |
|
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
|
|
G
|
Rptor
|
regulatory associated protein of MTOR, complex 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of RAPTOR protein
|
CTD |
PMID:25266202 |
|
NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413
|
|
G
|
Sfn
|
stratifin
|
increases expression
|
ISO
|
tetrandrine results in increased expression of SFN protein
|
CTD |
PMID:26822499 |
|
NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995
|
|
G
|
Snai1
|
snail family transcriptional repressor 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of SNAI1 protein
|
CTD |
PMID:30549224 |
|
NCBI chr 3:176,667,476...176,671,965
|
|
G
|
Sos1
|
SOS Ras/Rac guanine nucleotide exchange factor 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of SOS1 protein
|
CTD |
PMID:30549224 |
|
NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
|
|
G
|
Sqstm1
|
sequestosome 1
|
decreases expression
|
ISO
|
tetrandrine results in decreased expression of SQSTM1 protein
|
CTD |
PMID:25266202 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP
|
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:17201889 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP ISO
|
tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]
|
CTD |
PMID:17201889 PMID:26640276 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Ulk1
|
unc-51 like autophagy activating kinase 1
|
increases phosphorylation decreases expression
|
ISO
|
tetrandrine results in increased phosphorylation of ULK1 protein tetrandrine results in decreased expression of ULK1 protein
|
CTD |
PMID:25266202 PMID:26822499 |
|
NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746
|
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
decreases expression
|
ISO
|
berbamine results in decreased expression of BCL2L1 protein
|
CTD |
PMID:19960011 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
|
|
G
|
Bid
|
BH3 interacting domain death agonist
|
decreases expression
|
ISO
|
berbamine results in decreased expression of BID protein
|
CTD |
PMID:19960011 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
decreases expression affects binding
|
ISO
|
berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein berbamine binds to BIRC5 promoter
|
CTD |
PMID:17531122 PMID:17968851 PMID:19960011 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
|
|
G
|
Casp3
|
caspase 3
|
increases activity
|
ISO
|
berbamine results in increased activity of CASP3 protein
|
CTD |
PMID:17531122 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression
|
ISO
|
berbamine results in decreased expression of CCND1 protein
|
CTD |
PMID:19960011 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Chuk
|
component of inhibitor of nuclear factor kappa B kinase complex
|
decreases expression
|
ISO
|
berbamine results in decreased expression of CHUK protein
|
CTD |
PMID:19960011 |
|
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
decreases phosphorylation
|
ISO
|
berbamine results in decreased phosphorylation of NFKBIA protein
|
CTD |
PMID:19960011 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
affects localization
|
ISO
|
berbamine affects the localization of RELA protein
|
CTD |
PMID:19960011 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Tnfaip3
|
TNF alpha induced protein 3
|
increases expression
|
ISO
|
berbamine results in increased expression of TNFAIP3 protein
|
CTD |
PMID:19960011 |
|
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
decreases activity
|
ISO
|
cepharanthine results in decreased activity of ABCB1 protein
|
CTD |
PMID:15958061 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Kcnh2
|
potassium voltage-gated channel subfamily H member 2
|
decreases activity
|
ISO
|
cepharanthine results in decreased activity of KCNH2 protein
|
CTD |
PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
|
|
G
|
Mcl1
|
MCL1 apoptosis regulator, BCL2 family member
|
increases expression
|
ISO
|
cepharanthine results in increased expression of MCL1 protein
|
CTD |
PMID:31255635 |
|
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
decreases expression
|
ISO
|
cepharanthine results in decreased expression of MTOR protein
|
CTD |
PMID:31255635 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
decreases expression
|
ISO
|
cepharanthine results in decreased expression of PARP1 protein
|
CTD |
PMID:31255635 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Tp53
|
tumor protein p53
|
increases expression
|
ISO
|
cepharanthine results in increased expression of TP53 protein
|
CTD |
PMID:31255635 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
increases glutathionylation multiple interactions
|
ISO
|
CYP3A4 protein results in increased glutathionylation of dauricine [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine; [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide; CYP3A4 protein results in increased oxidation of and results in increased activity of dauricine; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]
|
CTD |
PMID:19358519 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
|
|
|
G
|
Atf4
|
activating transcription factor 4
|
increases expression multiple interactions
|
ISO
|
fangchinoline results in increased expression of ATF4 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]
|
CTD |
PMID:28754437 |
|
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
decreases expression
|
ISO
|
fangchinoline results in decreased expression of BIRC5 mRNA; fangchinoline results in decreased expression of BIRC5 protein
|
CTD |
PMID:28754437 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
|
|
G
|
Casp3
|
caspase 3
|
increases cleavage
|
ISO
|
fangchinoline results in increased cleavage of CASP3 protein
|
CTD |
PMID:28754437 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
increases cleavage
|
ISO
|
fangchinoline results in increased cleavage of CASP8 protein
|
CTD |
PMID:28754437 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Ccnb1
|
cyclin B1
|
multiple interactions
|
ISO
|
fangchinoline results in decreased degradation of and results in increased expression of CCNB1 protein
|
CTD |
PMID:38876226 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
|
|
G
|
Cdc25b
|
cell division cycle 25B
|
increases phosphorylation
|
ISO
|
fangchinoline results in increased phosphorylation of CDC25B protein
|
CTD |
PMID:38876226 |
|
NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492
|
|
G
|
Ctsd
|
cathepsin D
|
decreases expression
|
ISO
|
fangchinoline results in decreased expression of CTSD protein
|
CTD |
PMID:37689368 |
|
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression multiple interactions
|
ISO
|
fangchinoline results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein]
|
CTD |
PMID:28754437 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
increases expression multiple interactions
|
ISO
|
fangchinoline results in increased expression of HSPA5 protein Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]
|
CTD |
PMID:28754437 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
|
|
G
|
Map1lc3a
|
microtubule-associated protein 1 light chain 3 alpha
|
increases lipidation
|
ISO
|
fangchinoline results in increased lipidation of MAP1LC3A protein
|
CTD |
PMID:37689368 |
|
NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850
|
|
G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
increases lipidation
|
ISO
|
fangchinoline results in increased lipidation of MAP1LC3B protein
|
CTD |
PMID:37689368 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358 Ensembl chr16:66,574,407...66,584,358
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions
|
ISO
|
[fangchinoline co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein
|
CTD |
PMID:37689368 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
fangchinoline results in increased cleavage of PARP1 protein
|
CTD |
PMID:28754437 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
G
|
Sqstm1
|
sequestosome 1
|
increases expression
|
ISO
|
fangchinoline results in increased expression of SQSTM1 protein
|
CTD |
PMID:37689368 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
|
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
ISO
|
Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
|
CTD |
PMID:10421444 |
|
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
|
CTD |
PMID:29618714 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]
|
CTD |
PMID:16644063 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bglap
|
bone gamma-carboxyglutamate protein
|
multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
|
CTD |
PMID:19436947 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
|
|
G
|
C7
|
complement C7
|
multiple interactions decreases expression
|
ISO
|
Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] Tubocurarine results in decreased expression of C7 mRNA
|
CTD |
PMID:16949557 |
|
NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672
|
|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
|
CTD |
PMID:15231866 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
|
|
G
|
Chrna1
|
cholinergic receptor nicotinic alpha 1 subunit
|
multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]
|
CTD |
PMID:19690163 |
|
NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353
|
|
G
|
Chrna2
|
cholinergic receptor nicotinic alpha 2 subunit
|
multiple interactions
|
EXP
|
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]
|
CTD |
PMID:7808438 |
|
NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144
|
|
G
|
Chrna3
|
cholinergic receptor nicotinic alpha 3 subunit
|
multiple interactions
|
ISO EXP
|
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
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CTD |
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 |
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NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412
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G
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Chrna4
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cholinergic receptor nicotinic alpha 4 subunit
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
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CTD |
PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 |
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NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
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G
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Chrna7
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cholinergic receptor nicotinic alpha 7 subunit
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multiple interactions
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ISO
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Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
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CTD |
PMID:10082212 PMID:10216184 PMID:16931985 |
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NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
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G
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Chrnb2
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cholinergic receptor nicotinic beta 2 subunit
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multiple interactions
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ISO EXP
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Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
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CTD |
PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 |
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NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
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G
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Chrnb4
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cholinergic receptor nicotinic beta 4 subunit
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multiple interactions
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ISO EXP
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Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
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CTD |
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 |
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NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248
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G
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Cntn1
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contactin 1
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increases expression multiple interactions decreases expression
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ISO
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Tubocurarine results in increased expression of CNTN1 mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] Tubocurarine results in decreased expression of CNTN1 mRNA
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CTD |
PMID:12588870 PMID:16949557 |
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NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:125,142,696...125,440,391
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G
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Csf2
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colony stimulating factor 2
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein]
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CTD |
PMID:9606035 |
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NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
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G
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Dhfr
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dihydrofolate reductase
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multiple interactions decreases expression
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] Tubocurarine results in decreased expression of DHFR mRNA
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CTD |
PMID:12588870 |
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NCBI chr 2:25,320,895...25,346,004
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G
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Eml4
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EMAP like 4
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]
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CTD |
PMID:12588870 |
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NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439
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G
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Fas
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Fas cell surface death receptor
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]
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CTD |
PMID:16644063 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
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G
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Fez1
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fasciculation and elongation protein zeta 1
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multiple interactions decreases expression
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ISO
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Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] Tubocurarine results in decreased expression of FEZ1 mRNA
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CTD |
PMID:12588870 |
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NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:44,733,300...44,784,097
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G
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Fos
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Fos proto-oncogene, AP-1 transcription factor subunit
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
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CTD |
PMID:11425648 |
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NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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G
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Golga4
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golgin A4
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decreases expression multiple interactions
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ISO
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Tubocurarine results in decreased expression of GOLGA4 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]
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CTD |
PMID:16949557 |
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NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603
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G
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Il1b
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interleukin 1 beta
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]
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CTD |
PMID:22119045 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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G
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Kcnn1
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potassium calcium-activated channel subfamily N member 1
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decreases activity
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ISO
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Tubocurarine results in decreased activity of KCNN1 protein
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CTD |
PMID:10696100 |
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NCBI chr16:18,608,782...18,632,571
Ensembl chr16:18,610,769...18,632,571
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G
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Kcnn2
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potassium calcium-activated channel subfamily N member 2
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decreases activity
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ISO EXP
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Tubocurarine results in decreased activity of KCNN2 protein
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CTD |
PMID:10696100 PMID:10991935 |
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NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045
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G
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Kmt2c
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lysine methyltransferase 2C
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multiple interactions decreases expression
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] Tubocurarine results in decreased expression of KMT2C mRNA
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CTD |
PMID:12588870 |
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NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:10,353,735...10,568,620
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G
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Litaf
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lipopolysaccharide-induced TNF factor
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
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CTD |
PMID:12588870 |
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NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930
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G
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Mapk1
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mitogen activated protein kinase 1
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
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CTD |
PMID:22119045 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
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Mapk3
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mitogen activated protein kinase 3
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
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CTD |
PMID:22119045 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
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Mmp1
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matrix metallopeptidase 1
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multiple interactions
|
ISO
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Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
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CTD |
PMID:17151781 PMID:18986645 |
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NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964
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G
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Nin
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ninein
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multiple interactions decreases expression
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA] Tubocurarine results in decreased expression of NIN mRNA
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CTD |
PMID:16949557 |
|
NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:94,263,206...94,363,610
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G
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Plau
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plasminogen activator, urokinase
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multiple interactions
|
ISO
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Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]
|
CTD |
PMID:19690163 |
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NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030
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G
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Pou5f1
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POU class 5 homeobox 1
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decreases expression multiple interactions
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ISO
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Tubocurarine results in decreased expression of POU5F1 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
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CTD |
PMID:15612475 PMID:15749260 |
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NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598
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G
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Prkn
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parkin RBR E3 ubiquitin protein ligase
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decreases expression
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ISO
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Tubocurarine results in decreased expression of PRKN mRNA
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CTD |
PMID:16949557 |
|
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
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G
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Ptma
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prothymosin alpha
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]
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CTD |
PMID:16644063 |
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NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276
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G
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Ptpra
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protein tyrosine phosphatase, receptor type, A
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]
|
CTD |
PMID:12588870 |
|
NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126
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G
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Rbbp6
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RB binding protein 6, ubiquitin ligase
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
|
CTD |
PMID:12588870 |
|
NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:186,934,938...186,966,852
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G
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Sftpa1
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surfactant protein A1
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
|
CTD |
PMID:9458815 |
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NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,042,255...17,045,769
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G
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Sftpc
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surfactant protein C
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
|
CTD |
PMID:9458815 |
|
NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475
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G
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Sos1
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SOS Ras/Rac guanine nucleotide exchange factor 1
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multiple interactions decreases expression
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] Tubocurarine results in decreased expression of SOS1 mRNA
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CTD |
PMID:16949557 |
|
NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
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G
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Spp1
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secreted phosphoprotein 1
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multiple interactions
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
|
CTD |
PMID:11425648 |
|
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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G
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Stip1
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stress-induced phosphoprotein 1
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multiple interactions decreases expression
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ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA] Tubocurarine results in decreased expression of STIP1 mRNA
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CTD |
PMID:16949557 |
|
NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654
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G
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Ube2c
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ubiquitin-conjugating enzyme E2C
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multiple interactions decreases expression
|
ISO
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Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA] Tubocurarine results in decreased expression of UBE2C mRNA
|
CTD |
PMID:16949557 |
|
NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678
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G
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Ube3a
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ubiquitin protein ligase E3A
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increases expression multiple interactions
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ISO
|
Tubocurarine results in increased expression of UBE3A mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]
|
CTD |
PMID:12588870 |
|
NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097
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G
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Xdh
|
xanthine dehydrogenase
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multiple interactions
|
EXP
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Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form]
|
CTD |
PMID:9789800 |
|
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
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G
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Zfp42
|
zinc finger protein 42
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multiple interactions
|
ISO
|
Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]
|
CTD |
PMID:15749260 |
|
NCBI chr16:55,568,903...55,577,883
Ensembl chr16:55,568,093...55,578,170 Ensembl chr 4:55,568,093...55,578,170
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G
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Zfr
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zinc finger RNA binding protein
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decreases expression multiple interactions
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ISO
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Tubocurarine results in decreased expression of ZFR mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]
|
CTD |
PMID:12588870 |
|
NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133
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