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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoquinoline alkaloid
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Accession:CHEBI:24921 term browser browse the term
Definition:Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine.
Synonyms:related_synonym: isoquinoline alkaloids



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(+)-Tetrandrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression
ISO tetrandrine results in decreased activity of ABCB1A protein
tetrandrine results in decreased expression of ABCB1
CTD PMID:17273824 PMID:19840446 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:17201889 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA] CTD PMID:26640276 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO tetrandrine results in increased expression of AIFM1 protein CTD PMID:26822499 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO tetrandrine results in increased phosphorylation of AKT1 protein
tetrandrine results in decreased phosphorylation of AKT1 protein
CTD PMID:30549224 PMID:31255635 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg12 autophagy related 12 increases expression ISO tetrandrine results in increased expression of ATG12 protein CTD PMID:26822499 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 increases expression
decreases expression
ISO tetrandrine results in increased expression of ATG5 protein
tetrandrine results in decreased expression of ATG5 protein
CTD PMID:25266202 PMID:26822499 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 decreases expression ISO tetrandrine results in decreased expression of ATG7 protein CTD PMID:25266202 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO tetrandrine results in increased expression of BAK1 protein CTD PMID:26822499 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrandrine results in increased expression of BAX protein CTD PMID:26822499 PMID:31255635 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
increases expression
multiple interactions
decreases expression
ISO BCL2 protein affects the susceptibility to tetrandrine
tetrandrine results in increased expression of BCL2 protein
CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]
tetrandrine results in decreased expression of BCL2 mRNA; tetrandrine results in decreased expression of BCL2 protein
CTD PMID:18495333 PMID:26302866 PMID:26822499 PMID:31255635 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO tetrandrine results in decreased expression of BCL2L1 protein CTD PMID:26822499 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
decreases expression
ISO tetrandrine results in increased expression of BECN1 protein
[sodium arsenite co-treated with tetrandrine] results in increased expression of BECN1 protein
tetrandrine results in decreased expression of BECN1 protein
CTD PMID:25266202 PMID:26822499 PMID:30123091 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO tetrandrine results in decreased expression of BID protein CTD PMID:26822499 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding
decreases expression
ISO tetrandrine binds to BIRC5 promoter
tetrandrine results in decreased expression of BIRC5 mRNA
CTD PMID:17968851 PMID:18495333 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp12 caspase 12 increases cleavage ISO tetrandrine results in increased cleavage of CASP12 protein CTD PMID:26822499 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
ISO tetrandrine results in increased expression of CASP3 protein
tetrandrine results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]; tetrandrine results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:25266202 PMID:26302866 PMID:26822499 PMID:31255635 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
increases cleavage
ISO tetrandrine results in increased cleavage of and results in increased activity of CASP8 protein
tetrandrine results in increased expression of CASP8 protein
tetrandrine results in increased cleavage of CASP8 protein
CTD PMID:25266202 PMID:26822499 PMID:31255635 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO tetrandrine results in increased cleavage of and results in increased activity of CASP9 protein
tetrandrine results in increased cleavage of CASP9 protein
CTD PMID:25266202 PMID:26822499 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 increases expression ISO tetrandrine results in increased expression of CCNA2 protein CTD PMID:31255635 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO tetrandrine results in increased expression of CCNB1 protein CTD PMID:31255635 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
affects expression
ISO [sodium arsenite co-treated with tetrandrine] affects the expression of CCND1 protein; [sodium arsenite co-treated with tetrandrine] results in decreased expression of CCND1 protein
tetrandrine results in decreased expression of CCND1 protein
tetrandrine affects the expression of CCND1 protein
CTD PMID:30123091 PMID:31255635 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO tetrandrine results in decreased expression of CDH1 protein CTD PMID:30549224 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO tetrandrine results in decreased expression of CDH2 protein CTD PMID:30549224 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
affects expression
multiple interactions
ISO tetrandrine results in increased expression of CDKN1A
tetrandrine affects the expression of CDKN1A protein
[sodium arsenite co-treated with tetrandrine] affects the expression of CDKN1A protein
CTD PMID:19840446 PMID:30123091 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO [sodium arsenite co-treated with tetrandrine] results in increased expression of CDKN1B protein
tetrandrine results in increased expression of CDKN1B protein
CTD PMID:30123091 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein] CTD PMID:17201889 PMID:22001142 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO tetrandrine results in decreased expression of COL1A1 mRNA CTD PMID:27235791 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein] CTD PMID:26640276 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA; [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein; AHR protein affects the reaction [tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein]; AHR protein affects the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 protein]; tetrandrine results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:26640276 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of tetrandrine CTD PMID:21992520 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases glutathionylation
increases response to substance
multiple interactions
ISO CYP3A5 protein results in increased glutathionylation of tetrandrine
CYP3A5 protein results in increased susceptibility to tetrandrine
CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione]; CYP3A5 protein promotes the reaction [tetrandrine results in decreased expression of BCL2 protein]; CYP3A5 protein promotes the reaction [tetrandrine results in increased abundance of Reactive Oxygen Species]; CYP3A5 protein promotes the reaction [tetrandrine results in increased expression of CASP3 protein]
CTD PMID:21992520 PMID:26302866 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO tetrandrine results in increased expression of DDIT3 protein CTD PMID:26822499 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrandrine results in decreased phosphorylation of EGFR protein CTD PMID:30549224 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Endog endonuclease G decreases expression ISO tetrandrine results in decreased expression of ENDOG protein CTD PMID:26822499 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO [arsenite co-treated with tetrandrine] results in decreased expression of ERBB2 protein
tetrandrine results in decreased expression of ERBB2 protein
CTD PMID:31934280 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] CTD PMID:10072926 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein; [sodium arsenite co-treated with tetrandrine] results in increased expression of FOXO3 protein; tetrandrine affects the expression of and affects the phosphorylation of FOXO3 protein CTD PMID:30123091 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]; resveratrol inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA] CTD PMID:26640276 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO tetrandrine results in decreased expression of GRB2 protein CTD PMID:30549224 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tetrandrine results in decreased expression of GSK3B protein modified form CTD PMID:25266202 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO tetrandrine results in increased expression of HSPA5 protein CTD PMID:26822499 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
EXP
ISO
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
tetrandrine results in increased expression of ICAM1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tetrandrine results in increased expression of ICAM1 protein]; [arsenite co-treated with tetrandrine] affects the expression of ICAM1 protein; [arsenite co-treated with tetrandrine] results in increased expression of ICAM1 protein
CTD PMID:17201889 PMID:31934280 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IFNG protein] CTD PMID:26640276 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO [tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]; resveratrol inhibits the reaction [[tetrandrine co-treated with COL2A1 protein] results in increased expression of IL10 protein]; resveratrol inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA] CTD PMID:26640276 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]
tetrandrine results in decreased expression of IL17A mRNA
CTD PMID:26640276 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]
tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]
CTD PMID:22001142 PMID:26640276 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein] CTD PMID:26640276 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO tetrandrine results in decreased phosphorylation of JUN protein CTD PMID:30549224 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lmna lamin A/C increases expression ISO tetrandrine results in increased expression of LMNA protein CTD PMID:31255635 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO tetrandrine results in increased expression of MAP1LC3B CTD PMID:26822499 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]
tetrandrine results in increased phosphorylation of MAPK1 protein
[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK1 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK1 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:22001142 PMID:31934280 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]
tetrandrine results in increased phosphorylation of MAPK3 protein
[arsenite co-treated with tetrandrine] results in increased phosphorylation of MAPK3 protein; arsenite promotes the reaction [tetrandrine results in increased phosphorylation of MAPK3 protein]; tetrandrine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]
CTD PMID:22001142 PMID:31934280 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO tetrandrine results in increased expression of MCL1 protein CTD PMID:31255635 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tetrandrine results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:30549224 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
tetrandrine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP9 protein]
tetrandrine results in decreased expression of MMP9 protein
CTD PMID:22001142 PMID:30549224 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine affects the expression of and affects the phosphorylation of MTOR protein; tetrandrine results in decreased expression of and results in decreased phosphorylation of MTOR protein
tetrandrine results in decreased expression of MTOR protein; tetrandrine results in decreased expression of MTOR protein modified form
CTD PMID:25266202 PMID:26822499 PMID:30123091 PMID:31255635 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17201889 PMID:22001142 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP tetrandrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:22001142 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO tetrandrine results in increased cleavage of PARP1 protein CTD PMID:26822499 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 affects phosphorylation
multiple interactions
ISO tetrandrine affects the phosphorylation of PRKAA1 protein
[sodium arsenite co-treated with tetrandrine] affects the phosphorylation of PRKAA1 protein
CTD PMID:30123091 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
EXP
ISO
tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]
tetrandrine results in decreased expression of and results in decreased activity of RELA protein
tetrandrine results in increased phosphorylation of RELA protein
CTD PMID:17201889 PMID:30549224 PMID:31255635 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
decreases expression
ISO tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]
tetrandrine results in decreased expression of RORC mRNA
CTD PMID:26640276 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO tetrandrine results in decreased expression of RPS6 protein modified form CTD PMID:25266202 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression ISO tetrandrine results in decreased expression of RAPTOR protein CTD PMID:25266202 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Sfn stratifin increases expression ISO tetrandrine results in increased expression of SFN protein CTD PMID:26822499 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO tetrandrine results in decreased expression of SNAI1 protein CTD PMID:30549224 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO tetrandrine results in decreased expression of SOS1 protein CTD PMID:30549224 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO tetrandrine results in decreased expression of SQSTM1 protein CTD PMID:25266202 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; tetrandrine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:17201889 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; tetrandrine inhibits the reaction [TNF protein results in increased localization of RELA protein]; tetrandrine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
resveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]]; tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]
CTD PMID:17201889 PMID:26640276 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
decreases expression
ISO tetrandrine results in increased phosphorylation of ULK1 protein
tetrandrine results in decreased expression of ULK1 protein
CTD PMID:25266202 PMID:26822499 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein
CTD PMID:20674069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:20674069 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
increases expression
decreases expression
multiple interactions
ISO BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein
Noscapine results in decreased expression of BIRC5 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
CTD PMID:20674069 PMID:22848370 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein
CTD PMID:20674069 PMID:22848370 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein
CTD PMID:20674069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein
CTD PMID:20674069 PMID:22848370 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
(RS)-coclaurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA CTD PMID:28843594 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA CTD PMID:28843594 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA CTD PMID:28843594 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA CTD PMID:28843594 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA CTD PMID:28843594 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
(RS)-norcoclaurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA CTD PMID:28843594 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA CTD PMID:28843594 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA CTD PMID:28843594 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA CTD PMID:28843594 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA CTD PMID:28843594 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
(S)-coclaurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA CTD PMID:28843594 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA CTD PMID:28843594 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA CTD PMID:28843594 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA CTD PMID:28843594 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA CTD PMID:28843594 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
(S)-glaucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO glaucine results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
(S)-magnoflorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
6-Acetylmorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases chemical synthesis
multiple interactions
increases degradation
ISO ACHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine
[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine
CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases chemical synthesis
increases degradation
ISO [BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine
BCHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine
CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Ces1d carboxylesterase 1D affects binding
multiple interactions
increases chemical synthesis
ISO 6-O-monoacetylmorphine binds to CES1 protein
Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]
CTD PMID:8930175 PMID:9311626 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis
multiple interactions
increases chemical synthesis
ISO CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]
CTD PMID:8930175 PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
allocryptopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO allocryptopine results in increased expression of CYP1A1 mRNA CTD PMID:21419197 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO allocryptopine results in increased expression of CYP1A2 mRNA CTD PMID:21419197 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
Angoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO angoline inhibits the reaction [monobutyl phthalate results in increased expression of ACSL4 protein] CTD PMID:37121744 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO angoline inhibits the reaction [monobutyl phthalate results in decreased expression of GPX4 protein] CTD PMID:37121744 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Il6 interleukin 6 multiple interactions ISO angoline inhibits the reaction [monobutyl phthalate results in increased expression of IL6 mRNA] CTD PMID:37121744 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO angoline inhibits the reaction [monobutyl phthalate results in increased expression of STAT3 mRNA] CTD PMID:37121744 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO angoline inhibits the reaction [monobutyl phthalate results in increased expression of TNF mRNA] CTD PMID:37121744 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
apomorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy2a3 amylase 2a3 multiple interactions EXP Apomorphine results in increased secretion of and results in increased activity of AMY1A protein; Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532
JBrowse link
G Avp arginine vasopressin increases expression
multiple interactions
ISO Apomorphine results in increased expression of AVP protein
Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein]
CTD PMID:16575035 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form] CTD PMID:25633564 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO Apomorphine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Cck cholecystokinin multiple interactions
decreases activity
EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Apomorphine CTD PMID:11702094 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Apomorphine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Apomorphine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
CTD PMID:8103921 PMID:15985612 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects response to substance
increases response to substance
ISO
EXP
[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]
Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]
DRD2 protein affects the susceptibility to Apomorphine
DRD2 protein results in increased susceptibility to Apomorphine
CTD PMID:2571179 PMID:7520908 PMID:8103596 PMID:8103921 PMID:14639100 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 protein results in increased susceptibility to Apomorphine CTD PMID:19497322 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Apomorphine results in increased expression of FOS protein CTD PMID:10904129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO Apomorphine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gh1 growth hormone 1 increases secretion
increases expression
ISO Apomorphine results in increased secretion of GH1 protein
Apomorphine results in increased expression of GH1 protein
CTD PMID:993808 PMID:8889285 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases secretion
decreases expression
ISO Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Apomorphine results in decreased secretion of HAMP protein modified form
Apomorphine results in decreased expression of HAMP mRNA
CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine] CTD PMID:8539317 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 increases response to substance
multiple interactions
EXP HTR6 protein results in increased susceptibility to Apomorphine
Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]
CTD PMID:17920665 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein] CTD PMID:14599342 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO Apomorphine results in increased activity of ODC1 protein CTD PMID:10354516 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Penk proenkephalin multiple interactions EXP Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA] CTD PMID:17719177 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Prl prolactin decreases expression ISO Apomorphine results in decreased expression of PRL protein CTD PMID:8889285 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Pvalb parvalbumin affects expression EXP Apomorphine affects the expression of PVALB protein CTD PMID:15238432 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance ISO RGS9 affects the susceptibility to Apomorphine CTD PMID:15728856 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions EXP SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Apomorphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Syt7 synaptotagmin 7 multiple interactions EXP [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:17719177 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
Berbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO berbamine results in decreased expression of BCL2L1 protein CTD PMID:19960011 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO berbamine results in decreased expression of BID protein CTD PMID:19960011 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
affects binding
ISO berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein
berbamine binds to BIRC5 promoter
CTD PMID:17531122 PMID:17968851 PMID:19960011 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases activity ISO berbamine results in increased activity of CASP3 protein CTD PMID:17531122 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO berbamine results in decreased expression of CCND1 protein CTD PMID:19960011 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO berbamine results in decreased expression of CHUK protein CTD PMID:19960011 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO berbamine results in decreased phosphorylation of NFKBIA protein CTD PMID:19960011 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO berbamine affects the localization of RELA protein CTD PMID:19960011 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO berbamine results in increased expression of TNFAIP3 protein CTD PMID:19960011 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP
ISO
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]
Berberine results in decreased activity of ACHE protein
CTD PMID:29170048 PMID:33844597 PMID:37350525 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of ACTA2 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]
CTD PMID:17973934 PMID:37839514 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of AGER mRNA] CTD PMID:35121005 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity EXP
ISO
Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine results in decreased phosphorylation of AKT1 protein
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465 PMID:30138605 PMID:33325633 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alb albumin multiple interactions EXP Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of BAX mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Cisplatin] results in increased expression of BAX protein; [Berberine co-treated with Niacinamide] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression
ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Becn1 beclin 1 multiple interactions EXP Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BECN1 mRNA] CTD PMID:35439518 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression
ISO [Cisplatin co-treated with Berberine] results in increased expression of BNIP3 protein
Berberine results in increased expression of BNIP3 protein
CTD PMID:36070022 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression
multiple interactions
ISO Berberine results in increased expression of BNIP3L protein
[Cisplatin co-treated with Berberine] results in increased expression of BNIP3L protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
CTD PMID:36070022 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
ISO
EXP
[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]
Berberine increases activity of CASP3 protein in colon epithelial cells
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 mRNA]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD
RGD
PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... RGD:152995489 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO
EXP
Berberine results in increased cleavage of CASP9 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP9 protein]
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103 PMID:26712469 PMID:30138605 PMID:37839514 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]; Berberine inhibits the reaction [Bortezomib results in decreased expression of CAT protein]; Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of CAT protein]
CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 PMID:33460233 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]
CTD PMID:16391493 PMID:35691465 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CCND1 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:33325633 PMID:36822301 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnt1 cyclin T1 multiple interactions EXP Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO Berberine results in increased expression of CD36 mRNA
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 PMID:29408570 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA] CTD PMID:37839514 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CDK4 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:36822301 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions EXP Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA; Berberine results in decreased expression of CEBPA protein
CTD PMID:20564506 PMID:26478571 PMID:37511356 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects phosphorylation
multiple interactions
increases expression
ISO Berberine affects the phosphorylation of CEBPB protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CEBPB mRNA
CTD PMID:28038998 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO Berberine results in increased expression of COL1A1 mRNA
Berberine inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]
CTD PMID:26478571 PMID:37839514 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA] CTD PMID:37839514 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions EXP Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA] CTD PMID:37350525 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in decreased expression of CREB1 protein] CTD PMID:35121005 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D multiple interactions
decreases cleavage
ISO GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSD protein] CTD PMID:36070022 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases cleavage
multiple interactions
ISO Berberine results in decreased cleavage of CTSL protein
Acetylcysteine inhibits the reaction [Berberine results in decreased cleavage of CTSL protein]; GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSL protein]
CTD PMID:36070022 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein] CTD PMID:36070022 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Berberine affects the localization of CYCS protein
[Berberine co-treated with Cisplatin] results in increased expression of CYCS protein
CTD PMID:16505103 PMID:36070022 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO Berberine results in increased expression of CYP2B10 mRNA
Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
CTD PMID:22342832 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832 PMID:25455889 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
decreases activity
EXP
ISO
Berberine results in decreased expression of CYP3A4 mRNA; Berberine results in decreased expression of CYP3A4 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Berberine results in decreased activity of CYP3A4 protein
Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
CTD PMID:21524698 PMID:30086269 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dzip3 DAZ interacting zinc finger protein 3 increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353
JBrowse link
G Egf epidermal growth factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein] CTD PMID:33325633 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Berberine results in decreased expression of EGFR protein CTD PMID:33325633 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Berberine results in decreased expression of ERBB2 protein]; Berberine results in decreased expression of and results in increased ubiquitination of ERBB2 protein CTD PMID:33325633 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
multiple interactions
increases expression
ISO Berberine results in decreased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571 PMID:29408570 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506 PMID:20656010 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of FN1 mRNA]
CTD PMID:30138605 PMID:37839514 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fundc1 FUN14 domain containing 1 increases expression
multiple interactions
ISO Berberine results in increased expression of FUNDC1 protein
[Cisplatin co-treated with Berberine] results in increased expression of FUNDC1 protein; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
CTD PMID:36070022 NCBI chr  X:5,083,635...5,100,293
Ensembl chr  X:5,083,617...5,100,284
JBrowse link
G Gata2 GATA binding protein 2 increases expression ISO Berberine results in increased expression of GATA2 mRNA CTD PMID:37511356 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO Berberine results in increased expression of GATA3 mRNA CTD PMID:37511356 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of GCLM mRNA] CTD PMID:35121005 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of GFAP mRNA] CTD PMID:35121005 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 PMID:33460233 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044 PMID:23954465 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 PMID:33460233 PMID:35439518 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941
JBrowse link
G H2ac18 H2A clustered histone 18 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 2:183,808,398...183,808,992 JBrowse link
G H2ac25 H2A clustered histone 25 decreases expression ISO Berberine results in decreased expression of H2AC25 mRNA CTD PMID:27311644 NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874
JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381
JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions
ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr17:42,485,699...42,486,162 JBrowse link
G H2bc6 H2B clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr17:41,520,775...41,521,238 JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr17:42,708,658...42,709,408 JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr17:42,470,593...42,478,590 JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr13:92,533,289...92,544,902
Ensembl chr13:92,533,298...92,544,908
JBrowse link
G H3f4 H3.4 histone, cluster member decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr10:43,740,702...43,741,262 JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Berberine results in decreased expression of H4C2 mRNA CTD PMID:27311644 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048
JBrowse link
G Hat1 histone acetyltransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression
ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Hgf hepatocyte growth factor increases expression
multiple interactions
ISO Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
CTD PMID:29408570 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hist1h2af histone cluster 1 H2A family member F decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
JBrowse link
G Hist1h2ah histone cluster 1 H2A family member H decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr17:41,384,521...41,385,018 JBrowse link
G Hist1h2al1 histone cluster 1 H2A family like 1 decreases expression ISO Berberine results in decreased expression of H2AC6 mRNA CTD PMID:27311644 NCBI chr17:42,707,954...42,708,420 JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hist1h2bq histone cluster 1 H2B family member Q decreases expression ISO Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Berberine results in increased expression of HMOX1 protein
Berberine results in increased expression of HMOX1 mRNA; Berberine results in increased expression of HMOX1 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of HMOX1 protein]
Berberine inhibits the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 PMID:35121005 PMID:37511356 PMID:37839514 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP
ISO
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319 PMID:25455889 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Ifng interferon gamma multiple interactions EXP Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 multiple interactions
decreases expression
ISO Berberine inhibits the reaction [[Dextran Sulfate co-treated with azomethane] results in increased expression of IGF2BP3 protein]
[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein; Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein]; Cycloheximide promotes the reaction [Berberine results in decreased expression of IGF2BP3 protein]
CTD PMID:36822301 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779 PMID:30138605 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493 PMID:29170048 PMID:30138605 PMID:35121005 PMID:35691465 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression ISO Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]
CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 PMID:34427876 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itgb4 integrin subunit beta 4 increases expression ISO berberine increases expression of ITGB4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
EXP Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
EXP Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kdm1a lysine demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kdm4a lysine demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501
JBrowse link
G Kdm5b lysine demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
JBrowse link
G Kdm6a lysine demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062
JBrowse link
G Kdm6b lysine demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]] CTD PMID:34427876 NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378 PMID:20564506 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases localization
ISO
EXP
[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein; Berberine results in increased expression of and results in increased lipidation of MAP1LC3B protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine results in increased localization of MAP1LC3B protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of MAP1LC3B mRNA]
CTD PMID:35439518 PMID:36070022 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
EXP
ISO
Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404 PMID:20462044 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein] CTD PMID:36070022 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mir142 microRNA 142 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MIR142 mRNA]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]] CTD PMID:34427876 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Mir21 microRNA 21 decreases expression ISO berberine decreases expression of MIR21 RNA in colon epithelial cell RGD PMID:29564000 RGD:152995489 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir92a1 microRNA 92a-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions
decreases expression
EXP arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 PMID:33325633 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
multiple interactions
ISO Berberine results in decreased activity of MMP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]
CTD PMID:33325633 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA] CTD PMID:37350525 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions EXP Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA] CTD PMID:37350525 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions EXP Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA] CTD PMID:37350525 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR mRNA]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR protein] CTD PMID:35439518 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects localization
EXP arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein] CTD PMID:36070022 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein] CTD PMID:36070022 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
increases activity
ISO
EXP
Berberine results in increased expression of NFE2L2 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]
Berberine results in increased activity of NFE2L2 protein
Berberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906 PMID:23954465 PMID:30818834 PMID:35121005 PMID:37839514 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of NFKB1 mRNA] CTD PMID:35121005 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]
CTD PMID:21963898 PMID:34427876 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA] CTD PMID:35121005 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217 PMID:23523906 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions IEP
EXP
Berberine reverses reaction [Carbon tetrachloride decreases Nqo1 mRNA in liver]
Berberine inhibits the reaction [Bortezomib results in increased expression of NQO1 mRNA]
CTD
RGD
PMID:35121005 PMID:31432116 RGD:25823187 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases localization ISO Berberine increases localization of NR1H3 protein in macrophage nucleus RGD PMID:20506155 RGD:401827279 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
decreases expression
EXP arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]
CTD PMID:16505103 PMID:26712469 PMID:36070022 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Berberine increases expression of PDCD4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Berberine results in increased expression of PDK4 mRNA CTD PMID:37511356 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity
increases expression
ISO Berberine results in increased activity of PPARD protein
Berberine results in increased expression of PPARD mRNA; Berberine results in increased expression of PPARD protein
CTD PMID:37511356 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression
increases response to substance
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
Berberine results in decreased expression of PPARG mRNA; Berberine results in decreased expression of PPARG protein
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA
CTD PMID:20564506 PMID:26478571 PMID:29408570 PMID:37511356 PMID:37839514 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity
EXP arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt2 protein arginine methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643
JBrowse link
G Prmt5 protein arginine methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Prmt8 protein arginine methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 4:160,535,813...160,618,193
Ensembl chr 4:160,535,813...160,617,930
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Berberine results in increased expression of PTEN protein
CTD PMID:29408570 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein]; Berberine results in increased expression of and results in increased activity of RAC2 protein CTD PMID:36070022 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]
CTD PMID:23523906 PMID:34427876 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions
EXP Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr 1:227,079,960...227,082,960
Ensembl chr 1:227,079,966...227,082,882
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
increases expression
ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489
JBrowse link
G Setd3 SET domain containing 3, actin N3(tau)-histidine methyltransferase increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr 6:127,023,058...127,090,020
Ensembl chr 6:127,023,058...127,090,008
JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894
JBrowse link
G Setd6 SET domain containing 6, protein lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr19:9,343,309...9,350,477
Ensembl chr19:9,347,458...9,350,453
JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506
JBrowse link
G Setdb2 SET domain bifurcated histone lysine methyltransferase 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470
JBrowse link
G Si sucrase-isomaltase decreases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein]
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 PMID:35121005 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469 PMID:27311644 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Slc27a5 solute carrier family 27 member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc6a19 solute carrier family 6 member 19 multiple interactions EXP Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962
JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 mRNA]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 protein] CTD PMID:37839514 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA]
Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of SOD1 protein]
CTD PMID:21095217 PMID:22775417 PMID:35439518 PMID:37839514 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417 PMID:24751971 PMID:33460233 PMID:37350525 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sparc secreted protein acidic and cysteine rich increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Berberine results in increased expression of SQSTM1 protein CTD PMID:36070022 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506 PMID:26478571 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP
ISO
Berberine inhibits the reaction [Bortezomib results in increased expression of STAT3 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of STAT3 mRNA]
CTD PMID:35121005 PMID:37839514 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of TGFB1 mRNA]
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934 PMID:23523906 PMID:30138605 PMID:37839514 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
Berberine inhibits the reaction [Bortezomib results in increased expression of TLR4 protein]
CTD PMID:21963898 PMID:30240693 PMID:35121005 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO
EXP
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Dietary Fats results in increased secretion of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]
CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
affects response to substance
ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010 PMID:26712469 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Trim21 tripartite motif-containing 21 multiple interactions ISO Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein] CTD PMID:36822301 NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
JBrowse link
G Tstd1 thiosulfate sulfurtransferase like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr13:83,853,421...83,854,875
Ensembl chr13:83,822,035...83,854,885
JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:116,114,339...116,125,076
Ensembl chr  X:116,113,875...116,125,070
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]
Berberine results in increased expression of UCP2 mRNA
CTD PMID:28533128 PMID:37511356 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Berberine results in decreased expression of VEGFA protein CTD PMID:33325633 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
JBrowse link
beta-Funaltrexamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP
ISO
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:8884884 PMID:15778877 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
bicuculline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP Bicuculline inhibits the reaction [Propofol results in decreased expression of ARC protein] CTD PMID:18946287 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bicuculline co-treated with Ethanol] results in increased cleavage of CASP3 protein CTD PMID:29044621 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP Bicuculline results in increased phosphorylation of CREB1 protein CTD PMID:22534176 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Bicuculline co-treated with Ethanol] results in increased phosphorylation of ERN1 protein CTD PMID:29044621 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
EXP
ISO
Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]
Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]; Bicuculline results in decreased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]
Bicuculline results in decreased expression of GABRA1 mRNA
CTD PMID:1977069 PMID:9600394 PMID:27720918 PMID:29038840 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Bicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form] CTD PMID:29038840 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]
Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:27720918 PMID:29038840 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]
Bicuculline results in decreased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB1 binds to GABRG2 protein alternative form]
CTD PMID:1977069 PMID:29038840 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]; Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]
Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]
CTD PMID:27720918 PMID:29038840 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 decreases expression
multiple interactions
EXP
ISO
Bicuculline results in decreased expression of GABRB3 mRNA
Bicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:9600394 PMID:29038840 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 decreases expression EXP Bicuculline results in decreased expression of GABRG1 mRNA CTD PMID:9600394 NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]]; Bicuculline inhibits the reaction [methylmercuric chloride promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein]]]
Bicuculline promotes the reaction [tetramethylenedisulfotetramine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]]; Bicuculline results in decreased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Bicuculline results in decreased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:27720918 PMID:29038840 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Bicuculline affects the reaction [bisphenol A affects the secretion of GNRH1 protein]; Bicuculline promotes the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:18603625 PMID:26950200 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Bicuculline promotes the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:29044621 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Bicuculline results in decreased expression of and results in decreased localization of GRIA1 protein CTD PMID:19674091 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
decreases expression
EXP
ISO
Bicuculline promotes the reaction [MECP2 protein binds to GRIA2 promoter]; Bicuculline results in decreased expression of and results in decreased localization of GRIA2 protein; MECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]
Bicuculline results in decreased expression of GRIA2 mRNA; Bicuculline results in decreased expression of GRIA2 protein
CTD PMID:19674091 PMID:22262897 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO [Bicuculline co-treated with Ethanol] results in increased expression of MAP3K5 protein CTD PMID:29044621 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK1 protein]
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:19344668 PMID:19911010 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Bicuculline inhibits the reaction [methyl tert-butyl ether results in decreased phosphorylation of MAPK3 protein]
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:19344668 PMID:19911010 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Bicuculline co-treated with Ethanol] results in increased expression of MAPK8 protein CTD PMID:29044621 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions
increases phosphorylation
increases expression
ISO
EXP
MECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]
Bicuculline promotes the reaction [MECP2 protein binds to GRIA2 promoter]; MECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]
Bicuculline results in increased phosphorylation of MECP2 protein
Bicuculline results in increased expression of MECP2 mRNA
CTD PMID:22262897 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Bicuculline CTD PMID:14960011 NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Bicuculline inhibits the reaction [Propofol inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]] CTD PMID:11991087 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Oxtr oxytocin receptor multiple interactions EXP Bicuculline inhibits the reaction [oxytocin, Thr(4)-Gly(7)- results in increased activity of OXTR protein] CTD PMID:11069593 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Ryr1 ryanodine receptor 1 increases response to substance EXP RYR1 results in increased susceptibility to Bicuculline CTD PMID:22534176 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Ryr2 ryanodine receptor 2 increases response to substance EXP RYR2 results in increased susceptibility to Bicuculline CTD PMID:22534176 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1981253 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
Boldine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP boldine results in increased expression of ABCB11 mRNA; boldine results in increased expression of ABCB11 protein CTD PMID:25771127 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP boldine results in increased expression of ABCC2 mRNA CTD PMID:25771127 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Aqp8 aquaporin 8 increases expression EXP boldine results in increased expression of AQP8 mRNA CTD PMID:25771127 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Cat catalase multiple interactions ISO boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein] CTD PMID:32531310 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Drd1 dopamine receptor D1 affects binding
multiple interactions
EXP boldine analog binds to DRD1 protein
boldine analog inhibits the reaction [SCH 23390 binds to DRD1 protein]
CTD PMID:10785418 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein] CTD PMID:32531310 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP boldine results in increased expression of NR0B2 mRNA CTD PMID:25771127 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP boldine results in increased expression of NR1H4 mRNA CTD PMID:25771127 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Slc4a2 solute carrier family 4 member 2 increases expression EXP boldine results in increased expression of SLC4A2 mRNA CTD PMID:25771127 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
JBrowse link
G Tert telomerase reverse transcriptase affects splicing
decreases activity
ISO boldine affects the splicing of TERT mRNA
boldine results in decreased activity of TERT protein
CTD PMID:25746354 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein] CTD PMID:32531310 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP boldine results in increased expression of UGT1A1 mRNA CTD PMID:25771127 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:25683329 PMID:32113805 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein
CTD PMID:12756210 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein
CTD PMID:12756210 PMID:15966752 PMID:16010532 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein
CTD PMID:7562497 PMID:16010532 PMID:21866885 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity
ISO
EXP
Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein
CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
canadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO canadine results in increased expression of CYP1A2 mRNA; canadine results in increased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO canadine results in increased expression of CYP2E1 mRNA; canadine results in increased expression of CYP2E1 protein CTD PMID:28257954 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
cephaeline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO cephaelin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO cephaelin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO cephaelin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO cephaelin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO cephaelin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
cepharanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO cepharanthine results in decreased activity of ABCB1 protein CTD PMID:15958061 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO cepharanthine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO cepharanthine results in increased expression of MCL1 protein CTD PMID:31255635 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO cepharanthine results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO cepharanthine results in decreased expression of PARP1 protein CTD PMID:31255635 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tp53 tumor protein p53 increases expression ISO cepharanthine results in increased expression of TP53 protein CTD PMID:31255635 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
chelerythrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO chelerythrine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
chelerythrine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] CTD PMID:10037446 PMID:15364539 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in increased expression of BAX protein]] CTD PMID:12690470 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
chelerythrine inhibits the reaction [sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
chelerythrine inhibits the reaction [Resveratrol affects the expression of BCL2 protein]
CTD PMID:12690470 PMID:31151226 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of CALCA protein] CTD PMID:18752301 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp2 caspase 2 increases cleavage ISO chelerythrine results in increased cleavage of CASP2 protein CTD PMID:26124276 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
EXP
ISO
malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP3 protein]
Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]
CTD PMID:21664962 PMID:26124276 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases cleavage ISO chelerythrine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 increases cleavage ISO chelerythrine results in increased cleavage of CASP7 protein CTD PMID:26124276 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
EXP
ISO
malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]; Rotenone inhibits the reaction [chelerythrine results in increased activity of CASP9 protein]
chelerythrine results in increased cleavage of CASP9 protein
CTD PMID:21664962 PMID:26124276 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO chelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA] CTD PMID:15117851 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO chelerythrine results in decreased activity of CFTR protein CTD PMID:14744818 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:16901605 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chelerythrine inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; chelerythrine promotes the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]] CTD PMID:10037446 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egf epidermal growth factor multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; chelerythrine inhibits the reaction [EGF protein results in decreased susceptibility to Acetaldehyde] CTD PMID:17991733 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP chelerythrine results in decreased activity of G6PD protein CTD PMID:19429815 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chelerythrine inhibits the reaction [Acrolein results in increased secretion of GPT protein]; chelerythrine inhibits the reaction [allyl alcohol results in increased secretion of GPT protein] CTD PMID:12755590 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP chelerythrine inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein] CTD PMID:12690470 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP chelerythrine inhibits the reaction [Adenosine Triphosphate results in increased expression of HSPD1 protein] CTD PMID:16178011 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Igf1 insulin-like growth factor 1 affects activity EXP chelerythrine affects the activity of IGF1 protein CTD PMID:11548882 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL1B mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein] CTD PMID:34006824 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [Acids results in increased secretion of IL6 protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein]
CTD PMID:19074641 PMID:24300194 PMID:34006824 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of JAK2 protein CTD PMID:15746188 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 multiple interactions ISO chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form] CTD PMID:11709419 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
JBrowse link
G Lmna lamin A/C increases cleavage ISO chelerythrine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16713447 PMID:19854188 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
chelerythrine inhibits the reaction [CXCL8 protein results in increased phosphorylation of MAPK3 protein]
chelerythrine inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
chelerythrine inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; chelerythrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD PMID:10037446 PMID:14511371 PMID:15831558 PMID:16581537 PMID:16713447 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [AG 1879 co-treated with chelerythrine] inhibits the reaction [CXCL8 protein results in increased secretion of MMP9 protein] CTD PMID:15831558 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:24300194 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO chelerythrine inhibits the reaction [Resveratrol affects the expression of MYC protein] CTD PMID:31151226 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl1 myosin, light chain 1 multiple interactions EXP chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein] CTD PMID:37963515 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased degradation of NFKBIA protein] CTD PMID:34006824 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [chelerythrine co-treated with tyrphostin 47] inhibits the reaction [Quercetin results in increased expression of NOS3 protein] CTD PMID:22557973 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:16787574 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nts neurotensin increases activity ISO chelerythrine results in increased activity of NTS protein CTD PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chelerythrine inhibits the reaction [Testosterone results in increased expression of PCNA mRNA] CTD PMID:21374593 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R14A protein] CTD PMID:37963515 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein] CTD PMID:18752301 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO
EXP
chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine
CTD PMID:12700091 PMID:21562303 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO chelerythrine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chelerythrine inhibits the reaction [Acids results in increased activity of RELA protein]; chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein]
chelerythrine inhibits the reaction [Ethanol results in increased expression of RELA protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]
CTD PMID:12388107 PMID:19074641 PMID:24300194 PMID:34006824 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP chelerythrine results in decreased activity of SLC1A1 protein
chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; chelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO chelerythrine results in increased cleavage of SPTAN1 protein CTD PMID:26124276 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP chelerythrine results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:15746188 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP chelerythrine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]; chelerythrine inhibits the reaction [HU 211 results in decreased expression of TH mRNA] CTD PMID:18992715 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]] CTD PMID:17991733 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chelerythrine inhibits the reaction [Ethanol results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; chelerythrine inhibits the reaction [lead acetate results in increased expression of TNF protein]; chelerythrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; chelerythrine inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Chlorides]; chelerythrine inhibits the reaction [TNF protein results in increased transport of Potassium] CTD PMID:10783394 PMID:15302094 PMID:16581537 PMID:24300194 PMID:34006824 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNI3 protein] CTD PMID:12003851 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein] CTD PMID:12003851 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP chelerythrine inhibits the reaction [Capsaicin results in increased expression of TRPV1 protein] CTD PMID:18752301 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
chelidonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO chelidonine affects the expression of BAX mRNA CTD PMID:25265580 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO chelidonine affects the expression of BCL2 mRNA CTD PMID:25265580 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog CTD PMID:31102647 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of chelidonine
[CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog
CTD PMID:31102647 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of chelidonine
[CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog
CTD PMID:31102647 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP3A4 protein results in increased metabolism of chelidonine
[CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog
CTD PMID:31102647 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dapk1 death associated protein kinase 1 affects expression ISO chelidonine affects the expression of DAPK1 mRNA CTD PMID:25265580 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO chelidonine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO chelidonine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases expression
ISO chelidonine results in decreased activity of TERT protein
chelidonine results in decreased expression of TERT mRNA
CTD PMID:25265580 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CTD PMID:15286053 PMID:16595712 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
codeinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein
CTD PMID:12606908 PMID:12894543 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
columbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh5 cadherin 5 increases expression ISO columbamine results in increased expression of CDH5 mRNA CTD PMID:23124089 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO columbamine results in decreased expression of CDK6 mRNA; columbamine results in decreased expression of CDK6 protein CTD PMID:23124089 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Xiao-Ke-An results in increased abundance of columbamine] which results in decreased activity of DPP4 protein CTD PMID:32535096 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Ephb2 Eph receptor B2 decreases expression ISO columbamine results in decreased expression of EPHB2 mRNA CTD PMID:23124089 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO columbamine results in increased phosphorylation of GSK3B protein CTD PMID:32535096 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Maged1 MAGE family member D1 decreases expression ISO columbamine results in decreased expression of MAGED1 mRNA CTD PMID:23124089 NCBI chr  X:59,422,715...59,429,381
Ensembl chr  X:59,422,717...59,429,364
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO columbamine results in decreased expression of MMP2 mRNA CTD PMID:23124089 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases expression ISO columbamine results in decreased expression of SOX17 mRNA CTD PMID:23124089 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
corydaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Corydaline inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum] RGD PMID:32717192 RGD:405100728 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
corynoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]]; corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein] CTD PMID:36161741 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO corynoline results in increased phosphorylation of GSK3B protein CTD PMID:34477289 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]]; corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein] CTD PMID:34477289 PMID:36161741 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein] CTD PMID:34477289 PMID:36161741 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of MPO protein]; corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein] CTD PMID:34477289 PMID:36161741 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]]; corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFE2L2 protein]; corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein] CTD PMID:34477289 PMID:36161741 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein] CTD PMID:34477289 PMID:36161741 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein] CTD PMID:34477289 PMID:36161741 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]]; corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein] CTD PMID:36161741 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]]; corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein] CTD PMID:34477289 PMID:36161741 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
dauricine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation
multiple interactions
ISO CYP3A4 protein results in increased glutathionylation of dauricine
[CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine; [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of quinone methide; CYP3A4 protein results in increased oxidation of and results in increased activity of dauricine; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]
CTD PMID:19358519 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
dextromethorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of AKT1 protein] CTD PMID:34740715 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein] CTD PMID:28916251 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2 protein] CTD PMID:28916251 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Dextromethorphan results in decreased expression of BCL2L1 protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]
CTD PMID:28916251 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein] CTD PMID:28916251 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases secretion
ISO Dextromethorphan results in decreased expression of CCL2 protein
Dextromethorphan results in increased secretion of CCL2 protein
CTD PMID:19189960 PMID:32871113 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Dextromethorphan results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Dextromethorphan results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Dextromethorphan CTD PMID:15879494 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Dextromethorphan CTD PMID:15286053 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
EXP CYP2D2 protein results in decreased methylation of Dextromethorphan
[CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
CTD PMID:11911841 PMID:28438436 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases methylation
increases metabolic processing
multiple interactions
decreases activity
increases response to substance
ISO
EXP
CYP2D6 polymorphism affects the metabolism of Dextromethorphan; CYP2D6 protein affects the metabolism of Dextromethorphan; CYP2D6 protein polymorphism affects the metabolism of Dextromethorphan
CYP2D6 protein results in decreased methylation of Dextromethorphan
CYP2D6 mRNA results in increased metabolism of Dextromethorphan; CYP2D6 protein results in increased metabolism of Dextromethorphan
[CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]
Dextromethorphan results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
[5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan
CTD PMID:9429230 PMID:9429232 PMID:10911933 PMID:11823760 PMID:12433797 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation
increases oxidation
increases metabolic processing
multiple interactions
affects metabolic processing
ISO CYP3A4 protein results in decreased methylation of Dextromethorphan
CYP3A4 protein results in increased oxidation of Dextromethorphan
CYP3A4 protein results in increased metabolism of Dextromethorphan
Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]
CYP3A4 protein affects the metabolism of Dextromethorphan
CTD PMID:15383492 PMID:15988119 PMID:16595712 PMID:17267297 PMID:19818743 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Dextromethorphan CTD PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases oxidation
decreases methylation
ISO CYP3A5 protein affects the metabolism of Dextromethorphan
CYP3A5 protein results in increased oxidation of Dextromethorphan
CYP3A5 protein results in decreased methylation of Dextromethorphan
CTD PMID:15383492 PMID:15988119 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases methylation ISO CYP46A1 protein results in decreased methylation of Dextromethorphan CTD PMID:14640697 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]
CTD PMID:15084442 PMID:15723099 PMID:28916251 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression
multiple interactions
ISO Dextromethorphan affects the expression of GCLC mRNA
PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]
CTD PMID:34740715 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
affects expression
ISO PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLM mRNA] CTD PMID:34740715 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of GPT protein] CTD PMID:30822415 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Dextromethorphan results in increased expression of GRIN1 protein CTD PMID:28916251 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP Dextromethorphan results in increased expression of GRIN2A protein CTD PMID:28916251 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
EXP
ISO
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
CTD PMID:28916251 PMID:34740715 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions
increases secretion
ISO MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein] CTD PMID:32871113 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Il10 interleukin 10 decreases expression ISO Dextromethorphan results in decreased expression of IL10 protein CTD PMID:19189960 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 decreases expression ISO Dextromethorphan results in decreased expression of IL6 protein CTD PMID:19189960 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
CTD PMID:15084442 PMID:15723099 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dextromethorphan results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to Dextromethorphan CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Dextromethorphan results in increased phosphorylation of MAPK1 protein
rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of MAPK1 protein]
CTD PMID:34740715 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of MAPK3 protein] CTD PMID:34740715 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance
multiple interactions
affects binding
ISO MRGPRX2 protein affects the susceptibility to Dextromethorphan
MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein]
Dextromethorphan binds to MRGPRX2 protein
CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing ISO NAT2 protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; [rostafuroxin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [traxoprodil mesylate co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [Dextromethorphan results in increased activity of NFE2L2 protein]; Dextromethorphan results in increased activity of and affects the localization of NFE2L2 protein CTD PMID:34740715 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Dextromethorphan binds to OPRK1 protein
[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects response to substance
ISO [PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; Dextromethorphan results in increased expression of and results in increased phosphorylation of PRKCD protein; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein] CTD PMID:34740715 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15987631 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects activity
ISO Buthionine Sulfoximine affects the reaction [Dextromethorphan affects the activity of RELA protein] CTD PMID:34740715 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions
affects binding
EXP SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan binds to SIGMAR1 protein
CTD PMID:15723099 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextromethorphan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions EXP Dextromethorphan inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC6A4 protein] CTD PMID:31153898 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of SORD protein] CTD PMID:30822415 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA] CTD PMID:15987631 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases secretion
multiple interactions
ISO Dextromethorphan results in decreased expression of TNF protein
Dextromethorphan results in increased secretion of TNF protein
Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF protein]; Dextromethorphan inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
CTD PMID:19189960 PMID:30822415 PMID:32871113 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
dextrorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases chemical synthesis
multiple interactions
EXP CYP2D2 protein results in increased chemical synthesis of Dextrorphan
[CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
CTD PMID:28438436 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
multiple interactions
increases chemical synthesis
ISO CYP2D6 protein affects the chemical synthesis of Dextrorphan
[CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
[CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]
CTD PMID:15155557 PMID:15988119 PMID:21915887 PMID:23850985 PMID:29555536 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Dextrorphan CTD PMID:15988119 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing ISO CYP3A5 protein affects the metabolism of Dextrorphan CTD PMID:15988119 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Dextrorphan binds to OPRD1 protein
[Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
dihydrosanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO dihydrosanguinarine results in increased activity of CASP3 protein CTD PMID:19346183 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO dihydrosanguinarine results in increased activity of CASP9 protein CTD PMID:19346183 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases chemical synthesis EXP NQO1 protein results in increased chemical synthesis of dihydrosanguinarine CTD PMID:24300172 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
dimemorfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
EXP
ISO
dimemorfan results in decreased expression of CCL2 protein
dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
CTD PMID:18173806 PMID:18500357 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation ISO CYP2B6 protein results in increased oxidation of dimemorfan CTD PMID:19593786 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases oxidation ISO CYP2C19 protein results in increased oxidation of dimemorfan CTD PMID:19593786 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation
multiple interactions
ISO CYP2D6 protein results in increased oxidation of dimemorfan
Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan]
CTD PMID:19593786 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation
multiple interactions
ISO CYP3A4 protein results in increased oxidation of dimemorfan
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]
CTD PMID:19593786 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]
dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]
CTD PMID:15084442 PMID:15723099 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP dimemorfan results in decreased expression of IL1B protein CTD PMID:18173806 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO dimemorfan inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; dimemorfan inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
CTD PMID:15084442 PMID:15723099 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:18500357 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP dimemorfan affects the expression of NOS1 protein CTD PMID:18173806 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
ISO
EXP
dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
dimemorfan affects the expression of NOS2 protein
CTD PMID:18173806 PMID:18500357 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of and results in increased activity of RELA protein] CTD PMID:18500357 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions
affects binding
EXP dimemorfan binds to and results in increased activity of SIGMAR1 protein; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
dimemorfan binds to SIGMAR1 protein
CTD PMID:15723099 PMID:18173806 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects activity EXP dimemorfan affects the activity of STAT1 protein CTD PMID:18173806 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18500357 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
emetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago3 argonaute RISC catalytic component 3 multiple interactions ISO Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] CTD PMID:29576526 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
JBrowse link
G Akap9 A-kinase anchoring protein 9 multiple interactions ISO Emetine inhibits the reaction [sodium arsenite affects the localization of AKAP9 protein] CTD PMID:19073175 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Ar androgen receptor multiple interactions ISO Emetine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] CTD PMID:29576526 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO Emetine inhibits the reaction [sodium arsenite affects the localization of CAPRIN1 protein] CTD PMID:19073175 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Casp3 caspase 3 increases activity ISO Emetine results in increased activity of CASP3 protein CTD PMID:14502240 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO Emetine results in increased activity of CASP9 protein CTD PMID:14502240 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 multiple interactions ISO Emetine inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein] CTD PMID:19073175 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Emetine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Emetine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Emetine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Emetine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Emetine inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA] CTD PMID:29576526 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Emetine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Emetine binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 multiple interactions ISO IGF2BP1 protein affects the reaction [Emetine results in increased degradation of MYCN protein] CTD PMID:37246217 NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Emetine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK1 protein]
MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:15772366 PMID:26332055 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Emetine results in increased phosphorylation of and results in increased activity of MAPK14 protein; MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP2 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP9 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK1 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK3 protein] CTD PMID:16364386 PMID:26332055 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Emetine results in increased phosphorylation of MAPK3 protein
Emetine results in decreased phosphorylation of MAPK3 protein
MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK3 protein]
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK3 protein]
CTD PMID:15772366 PMID:26332055 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK8 protein] CTD PMID:15772366 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK9 protein] CTD PMID:15772366 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Emetine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
multiple interactions
decreases expression
ISO Emetine results in decreased activity of MMP2 protein
MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP2 protein]
Emetine results in decreased expression of MMP2 mRNA
CTD PMID:26332055 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
multiple interactions
decreases expression
ISO Emetine results in decreased activity of MMP9 protein
MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP9 protein]
Emetine results in decreased expression of MMP9 mRNA
CTD PMID:26332055 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor multiple interactions
increases degradation
ISO IGF2BP1 protein affects the reaction [Emetine results in increased degradation of MYCN protein] CTD PMID:37246217 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Emetine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Emetine results in increased cleavage of PARP1 protein CTD PMID:21256112 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Emetine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs decreases expression ISO Emetine results in decreased expression of RECK mRNA CTD PMID:26332055 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 multiple interactions ISO Emetine inhibits the reaction [Thapsigargin affects the localization of RICTOR mRNA] CTD PMID:29576526 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Emetine affects the reaction [TARDBP protein binds to TIA1 protein]; Emetine affects the reaction [TARDBP protein binds to TIAL1 protein] CTD PMID:19765185 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Emetine results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Emetine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Emetine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions ISO Emetine affects the reaction [TARDBP protein binds to TIA1 protein] CTD PMID:19765185 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
JBrowse link
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 multiple interactions ISO Emetine affects the reaction [TARDBP protein binds to TIAL1 protein] CTD PMID:19765185 NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Emetine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Emetine inhibits the reaction [Thapsigargin affects the localization of XIAP mRNA] CTD PMID:29576526 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
fangchinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO fangchinoline results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]
CTD PMID:28754437 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO fangchinoline results in decreased expression of BIRC5 mRNA; fangchinoline results in decreased expression of BIRC5 protein CTD PMID:28754437 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases cleavage ISO fangchinoline results in increased cleavage of CASP3 protein CTD PMID:28754437 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO fangchinoline results in increased cleavage of CASP8 protein CTD PMID:28754437 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO fangchinoline results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein]
CTD PMID:28754437 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO fangchinoline results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]
CTD PMID:28754437 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO fangchinoline results in increased cleavage of PARP1 protein CTD PMID:28754437 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
CTD PMID:17715210 PMID:25643298 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding
ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein
CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175 PMID:9169443 PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
heroin increases phosphorylation of Creb1 protein in brain
CTD
RGD
PMID:25643298 PMID:21362452 RGD:401901181 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Heroin results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Heroin results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases activity ISO Heroin results in increased activity of CYP2D6 protein CTD PMID:35914676 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723 PMID:19169671 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP heroin decreases expression of Fosb protein in brain RGD PMID:21362452 RGD:401901181 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heroin results in increased expression of GPT protein CTD PMID:36502556 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
G Pdyn prodynorphin decreases expression ISO Heroin results in decreased expression of PDYN mRNA CTD PMID:16710320 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:13,710,553...13,715,309
Ensembl chr10:13,704,998...13,715,669
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465
JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
hydromorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions EXP [Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein CTD PMID:35449307 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Hydromorphone affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity
multiple interactions
ISO
EXP
Hydromorphone results in increased activity of OPRM1 protein
[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Hydromorphone binds to and results in increased activity of OPRM1 protein
CTD PMID:32734307 PMID:35449307 PMID:35477798 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
Levallorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Levallorphan results in decreased activity of ACHE protein CTD PMID:8961166 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Levallorphan binds to OPRD1 protein
[Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Levallorphan binds to OPRK1 protein
[Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
Levorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP Levorphanol results in decreased activity of ACHE protein CTD PMID:8961166 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Levorphanol binds to OPRD1 protein
[Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Levorphanol binds to OPRK1 protein
[Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions
ISO
EXP
ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:23748253 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression ISO Morphine results in decreased expression of ABTB3 mRNA CTD PMID:21955143 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]
CTD PMID:23056601 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases chemical synthesis
ISO [ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adcy1 adenylate cyclase 1 multiple interactions ISO [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine CTD PMID:16914643 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression EXP Morphine affects the expression of ADCY6 mRNA CTD PMID:15829634 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy8 adenylate cyclase 8 affects response to substance
affects expression
multiple interactions
ISO
EXP
ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine
CTD PMID:15829634 PMID:16914643 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Morphine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550
JBrowse link
G Adora1 adenosine A1 receptor affects response to substance
increases expression
multiple interactions
ISO
EXP
ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein
CTD PMID:9407998 PMID:26478469 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
increases expression
ISO ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA
CTD PMID:14756803 PMID:21955143 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP morphine increases expression of Adra2a mRNA in cerebral cortex RGD PMID:9105684 RGD:401976538 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agrp agouti related neuropeptide increases expression ISO Morphine results in increased expression of AGRP mRNA CTD PMID:20144693 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP
ISO
[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA
corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]
CTD PMID:26478469 PMID:37394652 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Ak5 adenylate kinase 5 decreases expression ISO Morphine results in decreased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression EXP Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]
CTD PMID:19239323 PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] CTD PMID:23056601 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ano3 anoctamin 3 increases expression ISO Morphine results in increased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa6 annexin A6 decreases expression EXP Morphine results in decreased expression of ANXA6 protein CTD PMID:23056601 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Morphine results in increased expression of APOA1 protein CTD PMID:23056601 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B increases expression ISO Morphine results in increased expression of APOB protein CTD PMID:18980684 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions
EXP Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]
CTD PMID:23056601 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Morphine results in increased expression of AQP1 mRNA CTD PMID:21178816 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein CTD PMID:25766885 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Morphine results in decreased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
IEP
morphine increases expression in Arc protein in nucleus accumbens
morphine increases expression of Arc mRNA in prefrontal cortex
morphine co-treated with naloxone increases expression of Arc protein in brain
Morphine increases expression of Arc protein in shell of nucleus accumbens
RGD PMID:21549764 PMID:30550948 PMID:19262551 PMID:25746394 RGD:401851922, RGD:401959617, RGD:401938601, RGD:11087075 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Morphine results in increased expression of ARL4D mRNA CTD PMID:20144693 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 multiple interactions
increases expression
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
CTD PMID:21600884 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression
decreases expression
ISO Morphine results in increased expression of ARPP21 mRNA
Morphine deficiency results in decreased expression of ARPP21 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance
multiple interactions
ISO
EXP
ARRB2 gene SNP affects the susceptibility to Morphine
[Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
CTD PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 More... NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] CTD PMID:23056601 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression ISO Morphine results in increased expression of ASIC4 mRNA CTD PMID:21178816 NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] CTD PMID:37394652 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression EXP Morphine results in decreased expression of ATIC protein CTD PMID:23056601 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Morphine results in increased expression of ATRX mRNA CTD PMID:21955143 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO Morphine results in decreased expression of AVPR1A mRNA CTD PMID:21178816 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Morphine results in increased expression of BAG3 protein CTD PMID:23056601 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Morphine results in increased expression of BAK1 protein CTD PMID:19070643 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
CTD PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Morphine results in increased expression of BBC3 mRNA CTD PMID:19397953 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 decreases expression ISO Morphine results in decreased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106
JBrowse link
G Bche butyrylcholinesterase increases chemical synthesis
multiple interactions
ISO BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression
decreases expression
ISO Morphine results in increased expression of BCL11B mRNA
Morphine deficiency results in decreased expression of BCL11B mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
CTD PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Morphine results in decreased expression of BCL2L1 mRNA CTD PMID:15183518 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Morphine results in increased expression of BCL2L11 protein CTD PMID:19292871 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein
Morphine increases expression of Bdnf mRNA in ventral tegmental area
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD
RGD
PMID:19033880 PMID:25643298 PMID:27461790 PMID:30550948 RGD:401959617 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein
CTD PMID:20190558 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Morphine results in increased expression of BEX4 mRNA CTD PMID:21178816 NCBI chr  X:99,131,985...99,133,417
Ensembl chr  X:99,131,942...99,133,531
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Morphine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G C1ql3 complement C1q like 3 increases expression ISO Morphine results in increased expression of C1QL3 mRNA CTD PMID:21178816 NCBI chr17:76,119,344...76,129,170
Ensembl chr17:76,119,447...76,128,530
JBrowse link
G Calb1 calbindin 1 increases expression ISO Morphine results in increased expression of CALB1 mRNA CTD PMID:21178816 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions
EXP
ISO
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]
CTD PMID:16935424 PMID:20359526 PMID:20568289 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
increases expression
ISO CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA
CTD PMID:20053885 PMID:21955143 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Morphine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Morphine results in increased expression of CAR2 mRNA CTD PMID:20144693 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 increases expression ISO Morphine results in increased expression of CARHSP1 mRNA CTD PMID:21178816 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Morphine results in increased expression of CARTPT mRNA CTD PMID:20144693 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 decreases expression EXP Morphine results in decreased expression of CASP1 mRNA CTD PMID:15183518 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased cleavage of CASP3 protein
Morphine results in increased expression of CASP3 protein
Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form
CTD PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein
CTD PMID:11590188 PMID:19070643 PMID:19239323 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA
CTD PMID:15183518 PMID:19292871 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] CTD PMID:14871405 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbln1 cerebellin 1 precursor decreases expression ISO Morphine results in decreased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Ccdc136 coiled-coil domain containing 136 decreases expression ISO Morphine results in decreased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646
JBrowse link
G Cck cholecystokinin decreases expression ISO Morphine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Morphine CTD PMID:11403953 PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Morphine results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Morphine results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd38 CD38 molecule affects response to substance ISO CD38 affects the susceptibility to Morphine CTD PMID:20551293 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd79b CD79b molecule increases expression ISO Morphine results in increased expression of CD79B mRNA CTD PMID:20144693 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625
JBrowse link
G Cd9 CD9 molecule increases expression EXP Morphine results in increased expression of CD9 protein CTD PMID:23056601 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdh22 cadherin 22 increases expression ISO Morphine results in increased expression of CDH22 mRNA CTD PMID:21178816 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein CTD PMID:12702572 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO Morphine results in increased expression of CEP83 mRNA CTD PMID:20144693 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
JBrowse link
G Ces2h carboxylesterase 2H increases chemical synthesis
multiple interactions
ISO CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]
CTD PMID:8930175 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance ISO CHRM5 protein affects the susceptibility to Morphine CTD PMID:12154229 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Morphine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
JBrowse link
G Cldn2 claudin 2 increases expression ISO Morphine results in increased expression of CLDN2 mRNA CTD PMID:21178816 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Morphine results in decreased expression of CMBL protein CTD PMID:23056601 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO Morphine results in increased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] CTD PMID:23056601 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine deficiency results in decreased expression of CNR1 mRNA
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
CTD PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance
multiple interactions
ISO COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine
CTD PMID:18834357 PMID:21127283 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Coq9 coenzyme Q9 decreases expression EXP Morphine results in decreased expression of COQ9 protein CTD PMID:23056601 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Morphine results in increased expression of CPE mRNA CTD PMID:20144693 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation
EXP
ISO
Morphine results in decreased expression of CREB1 mRNA
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein]
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein
CTD PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Morphine results in increased expression of CREM mRNA CTD PMID:22454534 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crp C-reactive protein increases expression ISO Morphine results in increased expression of CRP protein CTD PMID:18980684 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression
ISO
EXP
Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein
CTD PMID:21955143 PMID:23056601 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Morphine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
JBrowse link
G Cstb cystatin B decreases expression EXP Morphine results in decreased expression of CSTB protein CTD PMID:23056601 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Ctnnal1 catenin alpha-like 1 increases expression ISO Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
JBrowse link
G Ctsb cathepsin B increases expression EXP Morphine results in increased expression of CTSB mRNA CTD PMID:9429908 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cux2 cut-like homeobox 2 increases expression ISO Morphine results in increased expression of CUX2 mRNA CTD PMID:21178816 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects response to substance
increases secretion
EXP CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein
CTD PMID:15317861 PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Morphine results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxxc1 CXXC finger protein 1 affects expression ISO Morphine affects the expression of CXXC1 mRNA CTD PMID:33891991 NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions
ISO Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]
CTD PMID:14871405 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic increases secretion
decreases secretion
multiple interactions
ISO
EXP
Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]
CTD PMID:15345483 PMID:17542780 PMID:19292871 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Morphine results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Morphine results in increased expression of CYP27A1 mRNA CTD PMID:20144693 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Morphine results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
increases activity
multiple interactions
ISO CYP2D6 protein affects the chemical synthesis of Morphine
Morphine results in increased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
CTD PMID:15625333 PMID:16595712 PMID:21241245 PMID:35914676 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] CTD PMID:23056601 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] CTD PMID:23056601 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression
multiple interactions
ISO Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]
CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] CTD PMID:37394652 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Morphine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression ISO Morphine results in increased expression of DHRS7B mRNA CTD PMID:21178816 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA
CTD PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dlx5 distal-less homeobox 5 increases expression ISO Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Morphine results in decreased expression of DNAH3 mRNA CTD PMID:21178816 NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Morphine results in increased expression of DNMT1 mRNA CTD PMID:33891991 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha affects expression ISO Morphine affects the expression of DNMT3A mRNA CTD PMID:33891991 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects expression ISO Morphine affects the expression of DNMT3B mRNA CTD PMID:33891991 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Morphine results in increased expression of DOCK10 mRNA CTD PMID:21178816 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] CTD PMID:23056601 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] CTD PMID:23056601 NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
ISO Morphine results in increased expression of DRD1 mRNA
Morphine deficiency results in decreased expression of DRD1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions
affects response to substance
increases expression
EXP
ISO
Morphine results in decreased expression of DRD2 mRNA
Morphine deficiency results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA
CTD PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Morphine results in increased expression of DRD4 mRNA CTD PMID:15183518 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression ISO Morphine results in increased expression of DSCAML1 mRNA CTD PMID:20144693 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Morphine results in decreased expression of DYNC1H1 mRNA CTD PMID:21178816 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Morphine results in decreased expression of ECH1 protein CTD PMID:23056601 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eed embryonic ectoderm development increases expression ISO Morphine results in increased expression of EED mRNA CTD PMID:33891991 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Morphine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917
JBrowse link
G Egr1 early growth response 1 increases expression
increases expression
ISO
EXP
Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA
Morphine increases expression of Egr1 mRNA in ventral tegmental area and prefrontal cortex
CTD
RGD
PMID:21955143 PMID:27126842 PMID:30550948 RGD:401959617 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression ISO Morphine results in increased expression of EGR2 mRNA CTD PMID:22454534 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 increases expression ISO Morphine results in increased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Egr4 early growth response 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine
CTD PMID:22454534 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Ehd1 EH-domain containing 1 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] CTD PMID:23056601 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 affects expression ISO Morphine affects the expression of EHMT1 mRNA CTD PMID:33891991 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 affects expression ISO Morphine affects the expression of EHMT2 mRNA CTD PMID:33891991 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO Morphine results in increased expression of EIF5A mRNA CTD PMID:19397953 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Elk1 ETS transcription factor ELK1 affects response to substance
increases activity
multiple interactions
ISO ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
CTD PMID:22454534 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eml2 EMAP like 2 increases expression EXP Morphine results in increased expression of EML2 protein CTD PMID:23056601 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Morphine results in increased expression of ENPP3 protein CTD PMID:23056601 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Morphine results in increased expression of EPHX2 mRNA CTD PMID:21178816 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Morphine results in increased expression of ERP44 mRNA CTD PMID:21178816 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]
Morphine affects the expression of EZH2 mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F2 coagulation factor II, thrombin increases expression
multiple interactions
EXP Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]
CTD PMID:23056601 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F7 coagulation factor VII increases expression ISO Morphine results in increased expression of F7 protein CTD PMID:18980684 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fam107a family with sequence similarity 107, member A increases expression ISO Morphine results in increased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA
CTD PMID:12702572 PMID:16210602 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA
CTD PMID:16210602 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression
multiple interactions
EXP Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]
CTD PMID:23056601 NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Morphine results in decreased expression of FBN1 mRNA CTD PMID:21178816 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fga fibrinogen alpha chain affects secretion EXP Morphine affects the secretion of FGA protein modified form CTD PMID:24855564 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions
ISO Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Morphine results in increased expression of FGFR1 mRNA CTD PMID:15183518 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fh fumarate hydratase increases expression EXP Morphine results in increased expression of FH protein CTD PMID:23056601 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] CTD PMID:23056601 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
increases expression
ISO
EXP
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine deficiency affects the expression of FOS protein
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]
CTD PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
morphine increases expression of Fosb protein in the Brainstem
morphine increases expression of Fosb protein in brain
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form
CTD
RGD
PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 PMID:20438612 More... RGD:401900159, RGD:401851068 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxp1 forkhead box P1 increases expression
decreases expression
ISO Morphine results in increased expression of FOXP1 mRNA
Morphine deficiency results in decreased expression of FOXP1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Morphine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression
EXP Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA
CTD PMID:15183518 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Morphine results in increased expression of GABRA4 mRNA CTD PMID:21178816 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Morphine results in increased expression of GABRD mRNA CTD PMID:15183518 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Morphine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Morphine results in increased expression of GAD1 mRNA CTD PMID:15673448 PMID:18312583 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Morphine results in increased expression of GAD2 mRNA CTD PMID:21178816 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression
decreases expression
ISO Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA
CTD PMID:21178816 PMID:21955143 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Morphine results in decreased expression of GAPDH protein CTD PMID:23056601 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Morphine results in increased expression of GCNT2 mRNA
Morphine deficiency results in decreased expression of GCNT2 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA
CTD PMID:21955143 PMID:26478469 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP Morphine results in decreased expression of GFM1 protein CTD PMID:23056601 NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
JBrowse link
G Gh1 growth hormone 1 decreases expression
increases secretion
ISO
EXP
Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein
CTD PMID:7201058 PMID:21178816 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gjc2 gap junction protein, gamma 2 decreases expression ISO Morphine results in decreased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
JBrowse link
G Glra2 glycine receptor, alpha 2 increases expression ISO Morphine results in increased expression of GLRA2 mRNA CTD PMID:21178816 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:29,020,557...29,241,666
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA
CTD PMID:15183518 PMID:18652891 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnas GNAS complex locus increases expression EXP Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein CTD PMID:17893922 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Morphine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gng2 G protein subunit gamma 2 increases expression EXP Morphine results in increased expression of GNG2 mRNA CTD PMID:15183518 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Morphine results in decreased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression
decreases expression
ISO Morphine results in increased expression of GPR88 mRNA
Morphine deficiency results in decreased expression of GPR88 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO Morphine results in decreased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects response to substance
decreases phosphorylation
affects expression
increases phosphorylation
increases expression
multiple interactions
decreases expression
ISO
EXP
GRIA1 protein affects the susceptibility to Morphine
Morphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens
Morphine alters expression of Gria1 protein in prefrontal cortex membrane
Morphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density
Morphine increases expression of Gria1 protein in the striatum
Morphine increases expression of Gria1 protein in the central amygdaloid nucleus
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein
CTD
RGD
PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 More... RGD:405650198, RGD:405649863, RGD:405101691, RGD:405100728, RGD:405100238 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Morphine results in decreased expression of GRIA2 protein CTD PMID:23711322 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Morphine results in decreased expression of GRIA3 mRNA CTD PMID:15183518 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP Morphine results in decreased expression of GRIA4 mRNA CTD PMID:15183518 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions
affects response to substance
ISO GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine
CTD PMID:20359526 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
affects phosphorylation
ISO
EXP
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein
CTD PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
affects response to substance
ISO Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine
CTD PMID:12878694 PMID:33609567 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
increases phosphorylation
ISO
EXP
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]
CTD PMID:20519536 PMID:22713680 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C increases expression EXP Morphine results in increased expression of GRIN2C mRNA CTD PMID:15183518 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Morphine results in increased expression of GRK5 mRNA CTD PMID:15183518 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grm1 glutamate metabotropic receptor 1 increases expression EXP Morphine results in increased expression of GRM1 mRNA CTD PMID:15183518 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression
decreases expression
ISO Morphine results in increased expression of GRM5 mRNA
Morphine deficiency results in decreased expression of GRM5 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]
CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression EXP Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein CTD PMID:32319158 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
JBrowse link
G Hdac5 histone deacetylase 5 increases expression EXP Morphine results in increased expression of HDAC5 protein CTD PMID:35461814 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases response to substance
ISO HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine
CTD PMID:18652891 PMID:21235400 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Morphine results in decreased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Morphine results in increased expression of HMGCS2 mRNA CTD PMID:20144693 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Morphine results in increased expression of HMOX1 protein CTD PMID:14871405 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
increases activity
EXP Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein
CTD PMID:12812915 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like increases expression ISO Morphine results in increased expression of HNRNPDL mRNA CTD PMID:20144693 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L increases expression ISO Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
JBrowse link
G Homer1 homer scaffold protein 1 increases expression ISO Morphine results in increased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hp haptoglobin decreases expression EXP Morphine results in decreased expression of HP protein CTD PMID:23056601 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hpca hippocalcin increases expression
decreases expression
ISO Morphine results in increased expression of HPCA mRNA
Morphine deficiency results in decreased expression of HPCA mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases response to substance
ISO Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:12128009 PMID:14569158 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases response to substance
ISO [zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine
CTD PMID:14569158 PMID:16806305 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Morphine results in increased expression of HS6ST2 mRNA CTD PMID:21178816 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Morphine results in decreased expression of HSD11B1 mRNA CTD PMID:21955143 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Morphine results in increased expression of HSP90AB1 mRNA CTD PMID:15497504 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Morphine results in decreased expression of HSP90B1 protein CTD PMID:23056601 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein
CTD PMID:15497504 PMID:23056601 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Morphine results in increased expression of HSPA5 protein
corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]
CTD PMID:37394652 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Morphine results in increased expression of HSPA8 mRNA CTD PMID:15497504 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein CTD PMID:15497504 PMID:23056601 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Morphine results in increased expression of HSPE1 protein CTD PMID:23056601 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine CTD PMID:10640309 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases expression ISO Morphine results in increased expression of HTR3A mRNA CTD PMID:21178816 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]
CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression
multiple interactions
EXP Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]
CTD PMID:23056601 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]
CTD PMID:11590188 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Morphine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:129,069,891...129,085,331
Ensembl chr  X:129,069,896...129,085,139
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
affects expression
ISO Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein
CTD PMID:16299287 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 increases expression ISO Morphine results in increased expression of IL13 protein CTD PMID:16210602 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein
CTD PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Morphine CTD PMID:15317861 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]
CTD PMID:11590188 PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
CTD PMID:16210602 PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO
EXP
Morphine results in increased secretion of IL6 protein
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]
CTD PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ing2 inhibitor of growth family, member 2 multiple interactions EXP Morphine promotes the reaction [ING2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:19292871 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Morphine results in increased expression of JUNB mRNA CTD PMID:21955143 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Klf7 KLF transcription factor 7 increases expression
multiple interactions
ISO Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]
CTD PMID:14644156 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Morphine results in decreased expression of KLRK1 mRNA CTD PMID:20144693 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]
Morphine affects the expression of KMT2A mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Krt1 keratin 1 decreases expression EXP Morphine results in decreased expression of KRT1 protein CTD PMID:23056601 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] CTD PMID:23056601 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Krt2 keratin 2 decreases expression
multiple interactions
EXP Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]
CTD PMID:23056601 NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
JBrowse link
G Krt33a keratin 33A multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] CTD PMID:23056601 NCBI chr10:84,942,584...84,947,544
Ensembl chr10:84,942,573...84,947,478
JBrowse link
G Krt5 keratin 5 decreases expression EXP Morphine results in decreased expression of KRT5 protein CTD PMID:23056601 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt8 keratin 8 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] CTD PMID:23056601 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Morphine results in increased expression of LCN2 mRNA CTD PMID:20144693 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lepr leptin receptor increases expression ISO Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Morphine results in decreased expression of LHB protein CTD PMID:7022252 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor decreases expression ISO Morphine results in decreased expression of LITAF mRNA CTD PMID:21955143 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Morphine results in increased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Morphine results in increased expression of LMX1B mRNA CTD PMID:19397953 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Morphine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Morphine results in decreased expression of LRP1 mRNA CTD PMID:21178816 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Morphine results in increased expression of LRPPRC mRNA CTD PMID:20144693 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Morphine results in decreased expression of MAP2 mRNA CTD PMID:15183518 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
CTD PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP Morphine results in increased expression of MAPK14 protein CTD PMID:23056601 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
CTD PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau increases expression EXP Morphine results in increased expression of MAPT mRNA CTD PMID:15183518 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Morphine results in decreased expression of MARCKS protein CTD PMID:23056601 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression EXP Morphine results in increased expression of MAVS protein CTD PMID:23056601 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 affects expression ISO Morphine affects the expression of MBD1 mRNA CTD PMID:33891991 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression ISO Morphine results in decreased expression of MBD3 mRNA CTD PMID:33891991 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects expression ISO Morphine affects the expression of MBD4 mRNA CTD PMID:33891991 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Morphine results in increased expression of MCL1 mRNA CTD PMID:20144693 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Morphine results in increased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
JBrowse link
G Me3 malic enzyme 3 increases expression ISO Morphine results in increased expression of ME3 mRNA CTD PMID:21178816 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
JBrowse link
G Mir107 microRNA 107 decreases expression ISO Morphine results in decreased expression of MIR107 CTD PMID:20564181 NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
JBrowse link
G Mir132 microRNA 132 increases expression ISO Morphine results in increased expression of MIR132 CTD PMID:20564181 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir146a microRNA 146a increases expression ISO Morphine results in increased expression of MIR146A CTD PMID:20564181 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir150 microRNA 150 increases expression ISO Morphine results in increased expression of MIR150 CTD PMID:20564181 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
JBrowse link
G Mir155 microRNA 155 increases expression ISO Morphine results in increased expression of MIR155 CTD PMID:20564181 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir15b microRNA 15b increases expression ISO Morphine results in increased expression of MIR15B CTD PMID:20564181 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir191 microRNA 191 decreases expression ISO Morphine results in decreased expression of MIR191 CTD PMID:20564181 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir21 microRNA 21 decreases expression ISO Morphine results in decreased expression of MIR21 CTD PMID:20564181 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir221 microRNA 221 increases expression ISO Morphine results in increased expression of MIR221 CTD PMID:20564181 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir23a microRNA 23a increases expression ISO Morphine results in increased expression of MIR23A CTD PMID:20564181 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
JBrowse link
G Mir23b microRNA 23b increases expression ISO Morphine results in increased expression of MIR23B CTD PMID:20564181 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
JBrowse link
G Mir26a microRNA 26a decreases expression ISO Morphine results in decreased expression of MIR26A1 CTD PMID:20564181 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Mir26b microRNA 26b decreases expression ISO Morphine results in decreased expression of MIR26B CTD PMID:20564181 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
JBrowse link
G Mir320a microRNA 320a decreases expression ISO Morphine results in decreased expression of MIR320A CTD PMID:20564181 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir423 microRNA 423 decreases expression ISO Morphine results in decreased expression of MIR423 CTD PMID:20564181 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
JBrowse link
G Mir99b microRNA 99b decreases expression ISO Morphine results in decreased expression of MIR99B CTD PMID:20564181 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases activity
EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein
CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Morphine results in increased expression of MPEG1 mRNA CTD PMID:21178816 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855
JBrowse link
G Myo19 myosin XIX decreases expression ISO Morphine results in decreased expression of MYO19 mRNA CTD PMID:21178816 NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP Morphine results in increased expression of NAIP mRNA CTD PMID:15183518 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Morphine results in decreased expression of NAV1 mRNA CTD PMID:21178816 NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Morphine results in decreased expression of NCAM1 protein modified form CTD PMID:15673448 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Morphine affects the expression of NDUFAB1 mRNA CTD PMID:20144693 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Morphine results in increased expression of NDUFV2 protein CTD PMID:23056601 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Morphine results in increased expression of NEFH mRNA CTD PMID:15183518 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nes nestin decreases expression ISO Morphine results in decreased expression of NES mRNA CTD PMID:26877219 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Morphine results in increased expression of NFKB1 mRNA CTD PMID:15183518 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions
ISO
EXP
Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
CTD PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Morphine results in increased expression of NINJ1 mRNA CTD PMID:19397953 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] CTD PMID:37394652 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]
CTD PMID:16598705 PMID:20519536 PMID:20568289 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
affects response to substance
ISO Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Morphine
CTD PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression ISO Morphine results in increased expression of NPY mRNA CTD PMID:20144693 PMID:21178816 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression ISO Morphine results in decreased expression of NPY1R mRNA CTD PMID:20144693 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine CTD PMID:15014116 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Morphine results in increased expression of NR4A1 mRNA CTD PMID:21955143 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
decreases expression
affects response to substance
ISO
EXP
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]
CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form CTD PMID:16123759 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Morphine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
JBrowse link
G Nrxn3 neurexin 3 increases expression ISO Morphine results in increased expression of NRXN3 mRNA CTD PMID:21955143 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Morphine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Ntsr1 neurotensin receptor 1 affects response to substance ISO NTSR1 protein affects the susceptibility to Morphine CTD PMID:20727387 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Morphine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:239,891,142...239,908,788
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
increases expression
affects binding
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine binds to OPRD1 protein
CTD PMID:7562497 PMID:21600884 PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity
increases activity
increases expression
affects binding
multiple interactions
ISO
EXP
Morphine affects the activity of OPRK1 protein
Morphine results in increased activity of OPRK1 protein
Morphine results in increased expression of OPRK1 mRNA
Morphine binds to OPRK1 protein
Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]
CTD PMID:7562497 PMID:15979727 PMID:18385270 PMID:22661197 PMID:26476280 More... NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO [J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases phosphorylation
increases activity
decreases expression
affects response to substance
increases expression
affects binding
affects activity
decreases response to substance
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
Morphine results in increased phosphorylation of OPRM1 protein
Morphine results in increased activity of OPRM1 protein
Morphine results in decreased expression of OPRM1 mRNA
OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
Morphine results in increased expression of OPRM1 protein
Morphine binds to OPRM1 protein
OPRM1 affects the activity of Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein
OPRM1 exon SNP results in decreased susceptibility to Morphine
Morphine affects the activity of OPRM1 protein
CTD PMID:7562497 PMID:8884884 PMID:9264103 PMID:10803207 PMID:11106302 More... NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 decreases expression EXP Morphine results in decreased expression of OXCT1 protein CTD PMID:23056601 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor increases expression ISO Morphine results in increased expression of PCSK1N mRNA CTD PMID:20144693 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pdcd5 programmed cell death 5 increases expression EXP Morphine results in increased expression of PDCD5 protein CTD PMID:23056601 NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Morphine deficiency results in decreased expression of PDE10A mRNA; Morphine results in decreased expression of PDE10A mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases response to substance
ISO PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
PDGFB protein results in decreased susceptibility to Morphine
CTD PMID:21483469 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression
multiple interactions
EXP Morphine results in increased expression of PDHB protein
Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]
CTD PMID:23056601 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression EXP Morphine results in decreased expression of PDK1 protein CTD PMID:23056601 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Morphine results in decreased expression of PDK2 protein CTD PMID:23056601 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Morphine results in decreased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242
JBrowse link
G Pdyn prodynorphin increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PDYN protein alternative form
Morphine deficiency results in decreased expression of PDYN mRNA
Morphine results in decreased expression of PDYN mRNA
[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
CTD PMID:15979727 PMID:17401159 PMID:20359526 PMID:27126842 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin multiple interactions
decreases expression
EXP
ISO
Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Morphine deficiency results in decreased expression of PENK mRNA
CTD PMID:7978486 PMID:20568289 PMID:27126842 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 affects expression EXP Morphine affects the expression of PER1 mRNA CTD PMID:19383088 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 affects response to substance
affects expression
ISO
EXP
PER2 protein affects the susceptibility to Morphine
Morphine affects the expression of PER2 mRNA
CTD PMID:19383088 PMID:20434889 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of PERM1 protein] CTD PMID:23056601 NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression ISO Morphine results in decreased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:45,003,543...45,051,541
Ensembl chr 8:45,003,538...45,051,522
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Morphine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pknox1 PBX/knotted 1 homeobox 1 increases expression ISO Morphine results in increased expression of PKNOX1 mRNA CTD PMID:21178816 NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727
JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plcb1 phospholipase C beta 1 affects response to substance ISO PLCB1 protein affects the susceptibility to Morphine CTD PMID:16405873 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein] CTD PMID:23056601 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Morphine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 decreases expression ISO Morphine results in decreased expression of PLEKHG1 mRNA CTD PMID:21955143 NCBI chr 1:40,348,684...40,434,063
Ensembl chr 1:40,311,221...40,434,063
JBrowse link
G Plg plasminogen affects response to substance ISO PLG protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pllp plasmolipin decreases expression ISO Morphine results in decreased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,315,104...10,335,892
Ensembl chr19:10,315,104...10,335,892
JBrowse link
G Pnoc prepronociceptin decreases response to substance ISO PNOC protein results in decreased susceptibility to Morphine CTD PMID:17303110 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 increases expression ISO Morphine results in increased expression of PNPLA3 mRNA CTD PMID:20144693 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
Morphine deficiency results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA
Morphine results in increased expression of POMC mRNA
CTD PMID:2846107 PMID:15979727 PMID:20084599 PMID:20144693 PMID:24398105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP Morphine results in increased expression of PPIA protein CTD PMID:23056601 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects expression
multiple interactions
increases phosphorylation
EXP
ISO
Morphine affects the expression of PPP1R1B protein modified form
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:15287884 PMID:21600884 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha increases expression ISO Morphine deficiency results in increased expression of PPP3R1 mRNA; Morphine results in increased expression of PPP3R1 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein] CTD PMID:18652891 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Morphine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
increases expression
EXP
ISO
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]
Morphine results in increased expression of PRKCG protein modified form
CTD PMID:18652891 PMID:20359526 PMID:20568289 PMID:21235400 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Morphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein] CTD PMID:12620371 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Prl prolactin increases secretion EXP Morphine results in increased secretion of PRL protein CTD PMID:7201058 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Morphine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:52,400,215...52,404,309
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression EXP Morphine results in increased expression of PSMA5 protein CTD PMID:23056601 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein] CTD PMID:23056601 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression ISO Morphine results in increased expression of PTDSS2 mRNA CTD PMID:20144693 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression
multiple interactions
EXP Morphine results in decreased expression of PTGS1 mRNA
Morphine results in increased expression of PTGS1 mRNA
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]
CTD PMID:15183518 PMID:18706994 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PTGS2 protein
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine
[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]
CTD PMID:14511336 PMID:16325209 PMID:37394652 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation EXP morphine decreases phosphorylation of Ptk2 in rat ventral tegmental area neurons RGD PMID:24399412 RGD:401959321 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Pvalb parvalbumin decreases expression ISO Morphine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Pycard PYD and CARD domain containing decreases expression
increases expression
multiple interactions
ISO Morphine results in decreased expression of PYCARD mRNA
Morphine results in increased expression of PYCARD protein
corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]
CTD PMID:20144693 PMID:37394652 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Pyy peptide YY increases expression ISO Morphine results in increased expression of PYY mRNA CTD PMID:20144693 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Morphine results in increased expression of RAB11B mRNA CTD PMID:21178816 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects expression ISO Morphine affects the expression of RAB3A protein CTD PMID:16522322 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects response to substance
multiple interactions
EXP
ISO
RAF1 protein affects the susceptibility to Morphine
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]
CTD PMID:18976650 PMID:21235400 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression ISO Morphine results in decreased expression of RAMP3 mRNA CTD PMID:21955143 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression ISO Morphine results in decreased expression of RBBP5 mRNA CTD PMID:33891991 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO
EXP
Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein]
Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
CTD PMID:17542780 PMID:22258905 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin decreases expression ISO Morphine results in decreased expression of RELN mRNA CTD PMID:21178816 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 increases expression ISO Morphine results in increased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]; Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:42,222,248...42,324,625
Ensembl chr 1:42,227,070...42,324,609
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression
increases expression
EXP Morphine results in decreased expression of RGS4 mRNA
Morphine results in increased expression of RGS4 mRNA
CTD PMID:12270694 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rgs6 regulator of G-protein signaling 6 increases expression ISO Morphine results in increased expression of RGS6 mRNA CTD PMID:21178816 NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753
JBrowse link
G Ring1 ring finger protein 1 multiple interactions EXP Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter] CTD PMID:25643298 NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620
JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Morphine results in decreased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Morphine results in increased expression of RRM2B mRNA CTD PMID:21178816 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Morphine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Morphine deficiency results in increased expression of SDC4 mRNA; Morphine results in increased expression of SDC4 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein] CTD PMID:23056601 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sell selectin L decreases expression
multiple interactions
EXP Morphine results in decreased expression of SELL protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]
CTD PMID:10070497 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Septin7 septin 7 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein] CTD PMID:23056601 NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243
JBrowse link
G Septin8 septin 8 decreases expression ISO Morphine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Morphine results in decreased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Morphine results in decreased expression of SERPINF1 mRNA CTD PMID:21955143 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Serping1 serpin family G member 1 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of SERPING1 protein] CTD PMID:23056601 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Sertad4 SERTA domain containing 4 increases expression ISO Morphine results in increased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:104,360,307...104,371,064
Ensembl chr13:104,360,307...104,370,546
JBrowse link
G Setd1a SET domain containing 1A, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1A mRNA CTD PMID:33891991 NCBI chr 1:182,386,197...182,411,695
Ensembl chr 1:182,388,060...182,411,090
JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1B mRNA CTD PMID:33891991 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Morphine results in increased expression of SGK1 mRNA CTD PMID:21955143 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Morphine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions EXP Morphine promotes the reaction [SIN3A protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO Morphine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
JBrowse link
G Slc17a7 solute carrier family 17 member 7 affects expression ISO Morphine affects the expression of SLC17A7 protein CTD PMID:16522322 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc23a2 solute carrier family 23 member 2 decreases expression EXP Morphine results in decreased expression of SLC23A2 mRNA CTD PMID:19418264 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
JBrowse link
G Slc25a46 solute carrier family 25, member 46 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of SLC25A46 protein] CTD PMID:23056601 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314
JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
affects response to substance
ISO [NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine
SLC6A1 protein affects the susceptibility to Morphine
CTD PMID:14598306 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
JBrowse link
G Slc6a18 solute carrier family 6 member 18 increases expression ISO Morphine results in increased expression of SLC6A18 mRNA CTD PMID:20144693 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Morphine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:54,448,464...54,467,319
Ensembl chr18:54,448,464...54,467,319
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases expression
ISO Morphine affects the reaction [SMPD1 protein affects the abundance of Ceramides]; Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Smpx small muscle protein, X-linked increases expression
multiple interactions
EXP Morphine results in increased expression of SMPX protein
Morphine deficiency affects the reaction [Morphine results in increased expression of SMPX protein]
CTD PMID:23056601 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snca synuclein alpha increases expression EXP Morphine results in increased expression of SNCA mRNA CTD PMID:15183518 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO Morphine results in increased expression of SOD2 protein
Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]
CTD PMID:14871405 PMID:20564181 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Morphine results in increased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:37,641,823...37,645,390
Ensembl chr10:37,643,444...37,645,102
JBrowse link
G Srf serum response factor increases expression EXP Morphine results in increased expression of SRF mRNA CTD PMID:22454534 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Morphine results in increased expression of SRXN1 mRNA CTD PMID:20144693 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Sst somatostatin increases expression ISO Morphine results in increased expression of SST mRNA CTD PMID:21178816 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 increases expression
decreases expression
ISO Morphine results in increased expression of ST8SIA3 mRNA
Morphine deficiency results in decreased expression of ST8SIA3 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr18:57,754,349...57,760,839
Ensembl chr18:57,754,347...57,760,839
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Morphine results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects response to substance ISO STAT6 gene SNP affects the susceptibility to Morphine CTD PMID:16103897 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Strip2 striatin interacting protein 2 increases expression
decreases expression
ISO Morphine results in increased expression of STRIP2 mRNA
Morphine deficiency results in decreased expression of STRIP2 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:58,536,055...58,578,291
JBrowse link
G Stx12 syntaxin 12 increases expression EXP Morphine results in increased expression of STX12 mRNA CTD PMID:15183518 NCBI chr 5:145,062,978...145,092,423
Ensembl chr 5:145,063,587...145,092,377
JBrowse link
G Stx5 syntaxin 5 increases expression EXP Morphine results in increased expression of STX5A mRNA CTD PMID:15183518 NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression EXP Morphine results in decreased expression of SUCLG1 protein CTD PMID:23056601 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
increases expression
EXP
ISO
Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
Morphine results in increased expression of SUZ12 mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 increases expression ISO Morphine results in increased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
G Syt5 synaptotagmin 5 increases expression ISO Morphine results in increased expression of SYT5 mRNA CTD PMID:21178816 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Morphine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression
multiple interactions
ISO
EXP
Morphine deficiency results in increased expression of TAC1 mRNA; Morphine results in increased expression of TAC1 mRNA
Morphine results in increased expression of TAC1 protein
Morphine promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein]
CTD PMID:11976266 PMID:15964684 PMID:21178816 PMID:27126842 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions
decreases expression
increases expression
EXP [SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine; substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]
Morphine results in decreased expression of TACR1 protein
CTD PMID:14511336 PMID:15964684 PMID:17123731 PMID:19428329 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tacr2 tachykinin receptor 2 decreases expression EXP Morphine results in decreased expression of TACR2 protein CTD PMID:19428329 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 decreases expression ISO Morphine results in decreased expression of TET1 mRNA CTD PMID:33891991 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 affects expression ISO Morphine affects the expression of TET2 mRNA CTD PMID:33891991 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 affects expression ISO Morphine affects the expression of TET3 mRNA CTD PMID:33891991 NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Morphine results in increased expression of and results in increased localization of TGFB1 protein; TGFB1 protein affects the reaction [Morphine results in increased expression of and results in increased localization of TGFB1 protein]; TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein] CTD PMID:10809959 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
decreases expression
increases phosphorylation
EXP
ISO
Morphine results in increased expression of TH protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; Agmatine inhibits the reaction [Morphine results in increased expression of TH protein]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased expression of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:15541421 PMID:24398105 PMID:25308750 PMID:25582704 PMID:25643298 More... NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tkt transketolase decreases expression EXP Morphine results in decreased expression of TKT protein CTD PMID:23056601 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tlr2 toll-like receptor 2 increases expression
multiple interactions
ISO Morphine results in increased expression of TLR2 mRNA; Morphine results in increased expression of TLR2 protein
corilagin inhibits the reaction [Morphine results in increased expression of TLR2 mRNA]; corilagin inhibits the reaction [Morphine results in increased expression of TLR2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]]
CTD PMID:37394652 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
multiple interactions
affects response to substance
ISO
EXP
Morphine binds to TLR4 protein
Morphine results in increased expression of TLR4 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]
Morphine affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Morphine binds to TLR4 protein]
CTD PMID:20178837 PMID:24756886 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression ISO Morphine results in decreased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tmem125 transmembrane protein 125 decreases expression ISO Morphine results in decreased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:132,063,162...132,064,566
Ensembl chr 5:132,059,554...132,079,297
Ensembl chr 5:132,059,554...132,079,297
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Morphine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:38,967,913...39,141,664
Ensembl chr13:38,968,101...39,141,452
JBrowse link
G Tmem63a transmembrane protein 63a decreases expression ISO Morphine results in decreased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:92,662,872...92,696,186
Ensembl chr13:92,663,968...92,696,183
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF protein]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of TNF mRNA; Morphine results in increased expression of TNF protein
Morphine results in increased secretion of TNF protein
CTD PMID:12427855 PMID:15317861 PMID:20178837 PMID:21081778 PMID:22258905 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Morphine results in increased expression of TNFSF10 mRNA CTD PMID:16210602 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 decreases expression ISO Morphine results in decreased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Morphine results in increased phosphorylation of and results in increased activity of TP53 protein; Morphine results in increased phosphorylation of and results in increased stability of TP53 protein; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Morphine results in increased expression of TP53 mRNA
CTD PMID:12702572 PMID:12927789 PMID:19397953 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 affects expression ISO Morphine affects the expression of TRDMT1 mRNA CTD PMID:33891991 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
JBrowse link
G Trh thyrotropin releasing hormone increases expression ISO Morphine results in increased expression of TRH mRNA CTD PMID:21178816 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
JBrowse link
G Trhr thyrotropin releasing hormone receptor increases expression ISO Morphine results in increased expression of TRHR mRNA CTD PMID:21178816 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects activity
increases expression
affects response to substance
ISO
EXP
[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to Morphine
Morphine affects the activity of TRPV1 protein
Morphine results in increased expression of TRPV1; Morphine results in increased expression of TRPV1 protein
TRPV1 protein affects the susceptibility to Morphine
CTD PMID:18774343 PMID:20719804 PMID:22189556 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ttll11 tubulin tyrosine ligase like11 increases expression ISO Morphine results in increased expression of TTLL11 mRNA CTD PMID:21178816 NCBI chr 3:19,109,891...19,335,077
Ensembl chr 3:19,110,284...19,335,969
JBrowse link
G Ttr transthyretin decreases expression
multiple interactions
EXP Morphine results in decreased expression of TTR protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of TTR protein]
CTD PMID:23056601 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Morphine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Morphine results in increased expression of UGT1A5 mRNA CTD PMID:21955143 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 affects the metabolism of Morphine; UGT2B7 protein affects the metabolism of Morphine
UGT2B7 protein results in increased glucuronidation of Morphine
CTD PMID:11186130 PMID:12756209 PMID:12920162 PMID:15286053 PMID:15611481 More... NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Usp15 ubiquitin specific peptidase 15 multiple interactions
increases expression
ISO Calcium affects the reaction [Morphine results in increased expression of USP15 mRNA]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of USP15 mRNA]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of USP15 mRNA; Morphine results in increased expression of USP15 protein
CTD PMID:24068670 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Morphine results in increased expression of VEGFA protein CTD PMID:19356684 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of VIM protein] CTD PMID:23056601 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression EXP Morphine results in decreased expression of YWHAE protein CTD PMID:23056601 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zfp239 zinc finger protein 239 increases expression ISO Morphine results in increased expression of ZFP239 mRNA CTD PMID:21178816 NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:151,029,405...151,039,529
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Morphine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:91,908,548...91,918,020
Ensembl chr 8:91,908,576...91,912,731
JBrowse link
Morphine-3-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta increases expression ISO
EXP
morphine-3-glucuronide results in increased expression of IL1B protein CTD PMID:19833175 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP morphine-3-glucuronide results in increased expression of ITGAM mRNA CTD PMID:19833175 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases activity
increases expression
ISO
EXP
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [morphine-3-glucuronide results in increased activity of TLR4 protein]; Lipopolysaccharides inhibits the reaction [morphine-3-glucuronide results in increased activity of TLR4 protein]
morphine-3-glucuronide results in increased expression of TLR4 mRNA
CTD PMID:19833175 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
morphinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO morphinone results in increased activity of CASP3 protein CTD PMID:17094451 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
nalbuphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin increases expression ISO Nalbuphine results in increased expression of PRL protein CTD PMID:17391744 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nalbuphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
nalbuphine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin affects expression ISO nalbuphine hydrochloride affects expression of PRL in blood serum RGD PMID:17391744 RGD:401960113 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
Nalmefene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO nalmefene binds to and results in decreased activity of OPRK1 protein CTD PMID:9862779 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [nalmefene binds to and results in decreased activity of OPRM1 protein] which results in increased expression of Cyclic AMP; nalmefene binds to and results in decreased activity of OPRM1 protein CTD PMID:9862779 PMID:11413242 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prl prolactin multiple interactions ISO nalmefene inhibits the reaction [dynorphin (1-13) results in increased expression of PRL protein] CTD PMID:9862779 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
Nalorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin increases expression
multiple interactions
ISO Nalorphine results in increased expression of PRL protein
Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]
CTD PMID:7106173 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Naloxone results in increased expression of ABCB1 mRNA
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:17522070 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Naloxone results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Naloxone results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Naloxone inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:17989109 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions EXP naloxone co-treated with morphine increases expression of Adra2a mRNA in cerebral cortex RGD PMID:9105684 RGD:401976538 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agt angiotensinogen multiple interactions EXP Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33872574 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] CTD PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP naloxene co-treated with morphine increases expression of Arc protein in brain RGD PMID:19262551 RGD:401938601 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Naloxone results in decreased secretion of AVP protein CTD PMID:6850280 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] CTD PMID:12927789 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Naloxone results in increased expression of BCL2 protein
CTD PMID:12927789 PMID:16004788 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity
multiple interactions
EXP Naloxone affects the activity of CALCA protein
Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD PMID:7906887 PMID:10075105 PMID:27030709 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form] CTD PMID:20600172 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression EXP Naloxone results in increased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin multiple interactions EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:17084265 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
affects binding
ISO CES1 protein binds to and results in increased metabolism of Naloxone
Naloxone binds to CES1 protein
CTD PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Naloxone results in decreased expression of CRH mRNA
Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]
CTD PMID:12431775 PMID:33872574 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions
increases response to substance
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone
CRHR1 gene mutant form results in increased susceptibility to Naloxone
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 PMID:28434951 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Ctsl cathepsin L increases expression EXP Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] CTD PMID:15542745 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Naloxone results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:9041360 PMID:15196794 PMID:16935424 PMID:17549049 PMID:22590628 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Naloxene co-treated with morphine increases expression of Fosb protein in the Brainstem RGD PMID:20438612 RGD:401900159 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Naloxone results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Naloxone results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] CTD PMID:15497504 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Naloxone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases response to substance ISO Naloxone results in increased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases response to substance
ISO Freund's Adjuvant inhibits the reaction [Naloxone results in decreased susceptibility to IL2 protein] CTD PMID:12421473 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:17084265 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf7 KLF transcription factor 7 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] CTD PMID:14644156 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Naloxone results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lgals3 galectin 3 increases expression EXP Naloxone results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
affects expression
multiple interactions
ISO
EXP
Naloxone results in increased expression of LHB protein
Naloxone affects the expression of LHB protein
Naloxone affects the expression of and affects the secretion of LHB protein
CTD PMID:1794335 PMID:2745936 PMID:2880862 PMID:7629406 PMID:15905218 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Naloxone results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Ltf lactotransferrin decreases activity EXP Naloxone results in decreased activity of LTF protein CTD PMID:14563657 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK1 protein
Naloxone results in increased phosphorylation of MAPK1 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK3 protein
Naloxone results in increased phosphorylation of MAPK3 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir16 microRNA 16 increases expression EXP Naloxone results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Naloxone results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Naloxone results in increased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naloxone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naloxone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]
Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
Naloxone binds to OPRM1 protein
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine; Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Naloxone binds to and results in decreased activity of OPRM1 protein; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
CTD PMID:1528399 PMID:1654493 PMID:7562497 PMID:8383026 PMID:8987795 More... NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Naloxone results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Naloxone results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone; Naloxone binds to and results in increased activity of POMC protein alternative form
Naloxone results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
Naloxone results in increased expression of POMC protein alternative form
CTD PMID:2255747 PMID:2846107 PMID:3157294 PMID:6089027 PMID:24398105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prl prolactin affects expression
decreases expression
ISO
EXP
Naloxone affects the expression of PRL protein
Naloxone results in decreased expression of PRL protein
CTD PMID:1794335 PMID:7629406 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Naloxone results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ren renin increases activity ISO Naloxone results in increased activity of REN protein CTD PMID:3157294 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Sell selectin L multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Naloxone inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Naloxone results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,573...17,192,351
Ensembl chr  X:17,180,474...17,192,351
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Naloxone results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein] CTD PMID:11976266 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases phosphorylation
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25308750 PMID:25582704 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Naloxone results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Naloxone results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Naloxone affects the reaction [Methadone binds to TLR4 protein]; Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Naloxone results in decreased expression of TNF protein
CTD PMID:16004788 PMID:17084265 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Naloxone results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Naloxone results in decreased expression of TP53 mRNA
CTD PMID:12927789 PMID:17522070 PMID:19397953 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Naloxone results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 protein affects the metabolism of Naloxone
UGT2B7 protein results in increased glucuronidation of Naloxone
CTD PMID:15286053 PMID:28762043 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
naltriben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases activity ISO naltrindole benzofuran results in increased activity of TRPM7 protein CTD PMID:30770447 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
norcodeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
norlaudanosoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; [CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline CTD PMID:20729865 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:8186192 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:8186192 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8186192 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
oxycodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases expression EXP Oxycodone results in increased expression of ABCA8 mRNA CTD PMID:23439660 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Oxycodone results in increased expression of ABCB1A mRNA; Oxycodone results in increased expression of ABCB1A protein CTD PMID:23439660 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Oxycodone results in increased expression of ABCB4 mRNA CTD PMID:23439660 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP Oxycodone results in decreased expression of ABCG1 mRNA CTD PMID:23439660 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Oxycodone results in increased expression of ABCG5 mRNA CTD PMID:23439660 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase increases expression EXP Oxycodone results in increased expression of ABHD6 mRNA CTD PMID:23439660 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Oxycodone results in increased expression of ACSM2A mRNA CTD PMID:23439660 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Oxycodone results in decreased expression of ACTN1 mRNA CTD PMID:23439660 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 decreases expression EXP Oxycodone results in decreased expression of ADAM17 mRNA CTD PMID:23439660 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Oxycodone results in increased expression of ADAMTS1 mRNA CTD PMID:23439660 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Oxycodone results in decreased expression of ADGRE1 mRNA CTD PMID:23439660 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Oxycodone results in increased expression of AHR mRNA CTD PMID:23439660 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Oxycodone results in decreased expression of AKR1C3 mRNA CTD PMID:23439660 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Anxa3 annexin A3 decreases expression EXP Oxycodone results in decreased expression of ANXA3 mRNA CTD PMID:23439660 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta decreases expression EXP Oxycodone results in decreased expression of ARHGDIB mRNA CTD PMID:23439660 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Oxycodone results in increased expression of ASL mRNA CTD PMID:23439660 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP
Oxycodone results in increased expression of ATF4 protein CTD PMID:26377394 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Oxycodone results in increased expression of ATP1B1 mRNA CTD PMID:23439660 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 increases expression EXP Oxycodone results in increased expression of B4GALNT1 mRNA CTD PMID:23439660 NCBI chr 7:62,988,429...62,996,190
Ensembl chr 7:62,988,930...62,996,190
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Oxycodone results in decreased expression of BCL2A1 mRNA CTD PMID:23439660 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Blvra biliverdin reductase A decreases expression EXP Oxycodone results in decreased expression of BLVRA mRNA CTD PMID:23439660 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP Oxycodone results in decreased expression of CA3 mRNA CTD PMID:23439660 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cav2 caveolin 2 decreases expression EXP Oxycodone results in decreased expression of CAV2 mRNA CTD PMID:23439660 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression EXP Oxycodone results in decreased expression of CCL6 mRNA CTD PMID:23439660 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
JBrowse link
G Cd5l Cd5 molecule-like decreases expression EXP Oxycodone results in decreased expression of CD5L mRNA CTD PMID:23439660 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Oxycodone results in increased expression of CDKN1A mRNA CTD PMID:23439660 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H affects expression
increases expression
EXP Oxycodone affects the expression of CES2 mRNA
Oxycodone results in increased expression of CES2 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression EXP Oxycodone results in increased expression of CHD1L mRNA CTD PMID:23439660 NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 decreases expression EXP Oxycodone results in decreased expression of CMTM6 mRNA CTD PMID:23439660 NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Oxycodone results in decreased expression of CNP1 mRNA CTD PMID:23439660 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression EXP Oxycodone results in decreased expression of COTL1 mRNA CTD PMID:23439660 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP Oxycodone results in decreased expression of CSRP1 mRNA CTD PMID:23439660 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Ctsc cathepsin C decreases expression EXP Oxycodone results in decreased expression of CTSC mRNA CTD PMID:23439660 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsl cathepsin L increases expression EXP Oxycodone results in increased expression of CTSL mRNA CTD PMID:23439660 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP Oxycodone results in decreased expression of CYBA mRNA CTD PMID:23439660 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression
increases expression
EXP Oxycodone affects the expression of CYP17A1 mRNA
Oxycodone results in increased expression of CYP17A1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP27A1 mRNA CTD PMID:23439660 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2A1 mRNA CTD PMID:23439660 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression
increases expression
EXP Oxycodone affects the expression of CYP2B2 mRNA
Oxycodone results in increased expression of CYP2B2 mRNA; Oxycodone results in increased expression of CYP2B2 protein
CTD PMID:20487198 PMID:23439660 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Oxycodone results in decreased expression of CYP2C11 mRNA CTD PMID:23439660 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects expression
decreases expression
EXP Oxycodone affects the expression of CYP2C13 mRNA
Oxycodone results in decreased expression of CYP2C13 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Oxycodone results in decreased expression of CYP2C9 mRNA CTD PMID:23439660 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance
multiple interactions
ISO CYP2D6 gene polymorphism affects the susceptibility to Oxycodone
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone
CTD PMID:20590588 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2E1 mRNA CTD PMID:23439660 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression EXP Oxycodone results in increased expression of CYP2J4 mRNA CTD PMID:23439660 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
decreases expression
EXP
ISO
Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone]
CYP3A4 protein alternative form affects the metabolism of Oxycodone
telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone]
Oxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 protein
CTD PMID:19755414 PMID:20487198 PMID:33393779 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP3A23-3A1 mRNA; Oxycodone results in increased expression of CYP3A23-3A1 protein CTD PMID:23439660 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP4B1 mRNA CTD PMID:23439660 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 increases expression EXP Oxycodone results in increased expression of DBT mRNA CTD PMID:23439660 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Oxycodone results in increased expression of EHHADH mRNA CTD PMID:23439660 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO
EXP
Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression EXP Oxycodone results in increased expression of ELL2 mRNA CTD PMID:23439660 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression EXP Oxycodone affects the expression of EPHX2 mRNA CTD PMID:20487198 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Exosc5 exosome component 5 increases expression EXP Oxycodone results in increased expression of EXOSC5 mRNA CTD PMID:23439660 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Fcgr2a Fc gamma receptor 2A decreases expression EXP Oxycodone results in decreased expression of FCGR2A mRNA CTD PMID:23439660 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Oxycodone results in increased expression of FKBP5 mRNA CTD PMID:23439660 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 affects expression
increases expression
EXP Oxycodone affects the expression of FMO1 mRNA
Oxycodone results in increased expression of FMO1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Oxycodone results in increased expression of FOS protein CTD PMID:26377394 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Oxycodone results in increased expression of GPAM mRNA CTD PMID:23439660 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Oxycodone results in increased expression of GPT mRNA CTD PMID:23439660 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression EXP Oxycodone results in increased expression of GPT2 mRNA CTD PMID:23439660 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Oxycodone results in increased expression of GSTA3 mRNA CTD PMID:23439660 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Oxycodone results in increased expression of GSTA5 mRNA; Oxycodone results in increased expression of GSTA5 protein CTD PMID:20487198 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP Oxycodone results in increased expression of HACL1 mRNA CTD PMID:23439660 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP Oxycodone results in decreased expression of HAO2 mRNA CTD PMID:23439660 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression EXP Oxycodone results in decreased expression of HCK mRNA CTD PMID:23439660 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hexb hexosaminidase subunit beta increases expression EXP Oxycodone results in increased expression of HEXB mRNA CTD PMID:23439660 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Oxycodone results in increased expression of HNRNPAB mRNA CTD PMID:23439660 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Oxycodone results in increased expression of HOMER1 mRNA CTD PMID:23439660 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP Oxycodone results in decreased expression of HSD11B1 mRNA CTD PMID:23439660 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Oxycodone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP Oxycodone results in decreased expression of IGFALS mRNA CTD PMID:23439660 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Oxycodone results in increased expression of IGFBP1 mRNA CTD PMID:23439660 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il18bp interleukin 18 binding protein decreases expression EXP Oxycodone results in decreased expression of IL18BP mRNA CTD PMID:23439660 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Inhbe inhibin subunit beta E decreases expression EXP Oxycodone results in decreased expression of INHBE mRNA CTD PMID:23439660 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Oxycodone results in increased expression of IP6K2 mRNA CTD PMID:23439660 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression EXP Oxycodone results in decreased expression of ITGB2 mRNA CTD PMID:23439660 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Oxycodone results in increased expression of ITPR1 mRNA CTD PMID:23439660 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression EXP Oxycodone results in decreased expression of JCHAIN mRNA CTD PMID:23439660 NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
JBrowse link
G Klc4 kinesin light chain 4 increases expression EXP Oxycodone results in increased expression of KLC4 mRNA CTD PMID:23439660 NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 decreases expression EXP Oxycodone results in decreased expression of LCP1 mRNA CTD PMID:23439660 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Lgals3 galectin 3 decreases expression EXP Oxycodone results in decreased expression of LGALS3 mRNA CTD PMID:23439660 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression EXP Oxycodone results in increased expression of LHPP mRNA CTD PMID:23439660 NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component decreases expression EXP Oxycodone results in decreased expression of LIN7A mRNA CTD PMID:23439660 NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression EXP Oxycodone results in decreased expression of LY86 mRNA CTD PMID:23439660 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK1 protein CTD PMID:26377394 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK3 protein CTD PMID:26377394 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Masp1 MBL associated serine protease 1 decreases expression EXP Oxycodone results in decreased expression of MASP1 mRNA CTD PMID:23439660 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Mtmr7 myotubularin related protein 7 increases expression EXP Oxycodone results in increased expression of MTMR7 mRNA CTD PMID:23439660 NCBI chr16:51,641,267...51,732,212
Ensembl chr16:51,641,190...51,732,182
JBrowse link
G Myo1b myosin Ib increases expression EXP Oxycodone results in increased expression of MYO1B mRNA CTD PMID:23439660 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
JBrowse link
G Notch2 notch receptor 2 decreases expression EXP Oxycodone results in decreased expression of NOTCH2 mRNA CTD PMID:23439660 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression EXP Oxycodone results in increased expression of NR1I2 mRNA CTD PMID:23439660 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression EXP Oxycodone results in increased expression of NR1I3 mRNA CTD PMID:23439660 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP Oxycodone results in decreased expression of NREP mRNA CTD PMID:23439660 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Oxycodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Oxycodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Oxycodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Orm1 orosomucoid 1 decreases expression EXP Oxycodone results in decreased expression of ORM1 mRNA CTD PMID:23439660 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression EXP Oxycodone results in decreased expression of OSGIN1 mRNA CTD PMID:23439660 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP Oxycodone results in decreased expression of PDE4B mRNA CTD PMID:23439660 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression EXP Oxycodone results in increased expression of PDGFRA protein CTD PMID:26377394 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Oxycodone results in increased expression of PFKFB1 mRNA CTD PMID:23439660 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression EXP Oxycodone results in decreased expression of PIK3C3 mRNA CTD PMID:23439660 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases expression EXP Oxycodone results in decreased expression of PLA2G4A mRNA CTD PMID:23439660 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pld1 phospholipase D1 decreases expression EXP Oxycodone results in decreased expression of PLD1 mRNA CTD PMID:23439660 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Plscr1 phospholipid scramblase 1 decreases expression EXP Oxycodone results in decreased expression of PLSCR1 mRNA CTD PMID:23439660 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 increases expression EXP Oxycodone results in increased expression of PNPLA7 mRNA CTD PMID:23439660 NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Oxycodone results in increased expression of POR mRNA CTD PMID:23439660 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression EXP Oxycodone results in decreased expression of PRKAB1 mRNA CTD PMID:23439660 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases phosphorylation EXP Oxycodone results in increased phosphorylation of PRKACA protein CTD PMID:26377394 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prlr prolactin receptor increases expression EXP Oxycodone results in increased expression of PRLR mRNA CTD PMID:23439660 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression EXP Oxycodone results in increased expression of PTDSS2 mRNA CTD PMID:23439660 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression EXP Oxycodone results in increased expression of PTP4A1 mRNA CTD PMID:23439660 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 increases expression EXP Oxycodone results in increased expression of PXMP4 mRNA CTD PMID:23439660 NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Oxycodone results in decreased expression of PYCARD mRNA CTD PMID:23439660 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab30 RAB30, member RAS oncogene family increases expression EXP Oxycodone results in increased expression of RAB30 mRNA CTD PMID:23439660 NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181
JBrowse link
G Rab38 RAB38, member RAS oncogene family decreases expression EXP Oxycodone results in decreased expression of RAB38 mRNA CTD PMID:23439660 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Oxycodone results in decreased expression of RAC2 mRNA CTD PMID:23439660 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP Oxycodone results in decreased expression of SERPINA7 mRNA CTD PMID:23439660 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression EXP Oxycodone results in decreased expression of SKAP2 mRNA CTD PMID:23439660 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC10A2 mRNA CTD PMID:23439660 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc15a3 solute carrier family 15 member 3 decreases expression EXP Oxycodone results in decreased expression of SLC15A3 mRNA CTD PMID:23439660 NCBI chr 1:207,492,365...207,507,158
Ensembl chr 1:207,492,365...207,507,157
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Oxycodone results in decreased expression of SLC16A1 mRNA CTD PMID:23439660 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP Oxycodone results in increased expression of SLC16A10 mRNA CTD PMID:23439660 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Oxycodone results in increased expression of SLC17A5 mRNA CTD PMID:23439660 NCBI chr 8:79,394,416...79,429,387 JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP Oxycodone results in increased expression of SLC1A2 mRNA CTD PMID:23439660 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP Oxycodone results in increased expression of SLC22A5 mRNA CTD PMID:23439660 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Oxycodone results in decreased expression of SLC22A8 mRNA CTD PMID:23439660 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc25a15 solute carrier family 25 member 15 increases expression EXP Oxycodone results in increased expression of SLC25A15 mRNA CTD PMID:23439660 NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression EXP Oxycodone results in increased expression of SLC25A29 mRNA CTD PMID:23439660 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP Oxycodone results in decreased expression of SLC25A30 mRNA CTD PMID:23439660 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression EXP Oxycodone results in increased expression of SLC27A5 mRNA CTD PMID:23439660 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression EXP Oxycodone results in increased expression of SLC2A2 mRNA CTD PMID:23439660 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC34A2 mRNA CTD PMID:23439660 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc35b2 solute carrier family 35 member B2 decreases expression EXP Oxycodone results in decreased expression of SLC35B2 mRNA CTD PMID:23439660 NCBI chr 9:15,438,594...15,442,227
Ensembl chr 9:15,438,594...15,442,234
JBrowse link
G Slc37a4 solute carrier family 37 member 4 increases expression EXP Oxycodone results in increased expression of SLC37A4 mRNA CTD PMID:23439660 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc38a4 solute carrier family 38, member 4 increases expression EXP Oxycodone results in increased expression of SLC38A4 mRNA CTD PMID:23439660 NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
JBrowse link
G Slc39a4 solute carrier family 39 member 4 increases expression EXP Oxycodone results in increased expression of SLC39A4 mRNA CTD PMID:23439660 NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Slc41a2 solute carrier family 41 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC41A2 mRNA CTD PMID:23439660 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Slc49a4 solute carrier family 49 member 4 increases expression EXP Oxycodone results in increased expression of SLC49A4 mRNA CTD PMID:23439660 NCBI chr11:64,995,629...65,068,929
Ensembl chr11:64,995,679...65,068,926
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Oxycodone results in decreased expression of SLC6A9 mRNA CTD PMID:23439660 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Slc7a7 solute carrier family 7 member 7 decreases expression EXP Oxycodone results in decreased expression of SLC7A7 mRNA CTD PMID:23439660 NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression EXP Oxycodone results in increased expression of SLCO1B2 mRNA CTD PMID:23439660 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression EXP Oxycodone results in decreased expression of SLPI mRNA CTD PMID:23439660 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 increases expression EXP Oxycodone results in increased expression of SMARCD2 mRNA CTD PMID:23439660 NCBI chr10:91,193,752...91,202,817
Ensembl chr10:91,193,752...91,204,341
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Oxycodone results in decreased expression of STAC3 mRNA CTD PMID:23439660 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
JBrowse link
G Sulf2 sulfatase 2 increases expression EXP Oxycodone results in increased expression of SULF2 mRNA CTD PMID:23439660 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 decreases expression EXP Oxycodone results in decreased expression of SULT1A2 mRNA CTD PMID:23439660 NCBI chr19:51,189,287...51,204,275
Ensembl chr19:51,189,287...51,204,362
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression EXP Oxycodone results in increased expression of SYCP3 mRNA CTD PMID:23439660 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression EXP Oxycodone results in decreased expression of TARS1 mRNA CTD PMID:23439660 NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Thumpd1 THUMP domain containing 1 decreases expression EXP Oxycodone results in decreased expression of THUMPD1 mRNA CTD PMID:23439660 NCBI chr 1:174,078,875...174,084,915
Ensembl chr 1:174,078,878...174,084,937
JBrowse link
G Timm8a1 translocase of inner mitochondrial membrane 8A1 increases expression EXP Oxycodone results in increased expression of TIMM8A mRNA CTD PMID:23439660 NCBI chr  X:97,717,932...97,722,170
Ensembl chr  X:97,717,920...97,721,960
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor increases expression EXP Oxycodone results in increased expression of TLE1 mRNA CTD PMID:23439660 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
JBrowse link
G Tmem19 transmembrane protein 19 decreases expression EXP Oxycodone results in decreased expression of TMEM19 mRNA CTD PMID:23439660 NCBI chr 7:50,958,884...50,985,601
Ensembl chr 7:50,958,888...50,986,809
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Oxycodone results in increased expression of TSC22D3 mRNA CTD PMID:23439660 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan increases expression EXP Oxycodone results in increased expression of TSKU mRNA CTD PMID:23439660 NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Oxycodone results in decreased expression of TUBB5 mRNA CTD PMID:23439660 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Oxycodone results in increased expression of UGT1A1 mRNA CTD PMID:23439660 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Usp12 ubiquitin specific peptidase 12 decreases expression EXP Oxycodone results in decreased expression of USP12 mRNA CTD PMID:23439660 NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656
JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP Oxycodone results in decreased expression of UST5R mRNA CTD PMID:23439660 NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:205,211,034...205,286,718
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases expression EXP Oxycodone results in decreased expression of VASP mRNA CTD PMID:23439660 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vim vimentin decreases expression EXP Oxycodone results in decreased expression of VIM mRNA CTD PMID:23439660 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Oxycodone results in increased expression of ZNF354A mRNA CTD PMID:23439660 NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
JBrowse link
Oxymorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprm1 opioid receptor, mu 1 multiple interactions ISO
EXP
Oxymorphone affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Oxymorphone binds to and affects the activity of OPRM1 protein CTD PMID:19800397 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pdyn prodynorphin increases expression EXP Oxymorphone results in increased expression of PDYN protein alternative form CTD PMID:16343768 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
palmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases export
increases expression
ISO
EXP
palmatine inhibits the reaction [ABCB1A protein results in increased export of Fluorescent Dyes]
ABCB1A protein results in increased export of palmatine
palmatine results in increased expression of ABCB1A mRNA
CTD PMID:20410605 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP palmatine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO palmatine results in increased expression of AHR mRNA CTD PMID:24583342 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO palmatine inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:36169195 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] CTD PMID:36169195 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO palmatine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO palmatine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO palmatine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO palmatine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO palmatine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnd1 cyclin D1 affects binding ISO palmatine binds to CCND1 protein CTD PMID:35997646 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc42 cell division cycle 42 affects binding ISO palmatine binds to CDC42 protein CTD PMID:35997646 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects binding ISO palmatine binds to CDK2 protein CTD PMID:35997646 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO palmatine results in increased expression of CYP1A1 mRNA CTD PMID:24583342 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO palmatine binds to ERBB2 protein CTD PMID:35997646 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G H2ax H2A.X variant histone increases expression ISO palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein] CTD PMID:36169195 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO palmatine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; palmatine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
palmatine results in increased secretion of IL1B protein
CTD PMID:35997646 PMID:36169195 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO palmatine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; palmatine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
palmatine results in increased secretion of IL6 protein
CTD PMID:35997646 PMID:36169195 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO palmatine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Mdm2 MDM2 proto-oncogene affects binding ISO palmatine binds to MDM2 protein CTD PMID:35997646 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO palmatine binds to MMP9 protein CTD PMID:35997646 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase affects binding ISO palmatine binds to MTOR protein CTD PMID:35997646 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:36169195 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects binding ISO palmatine binds to STAT3 protein CTD PMID:35997646 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO palmatine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; palmatine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:35997646 PMID:36169195 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO palmatine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO palmatine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
papaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Papaverine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Papaverine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Papaverine results in decreased expression of CLDN5 protein CTD PMID:20728510 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Papaverine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Papaverine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Papaverine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] CTD PMID:10894095 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Papaverine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ocln occludin decreases expression EXP Papaverine results in decreased expression of OCLN protein CTD PMID:20728510 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022 PMID:12411423 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
protopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO protopine results in increased expression of CYP1A1 mRNA CTD PMID:21419197 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO protopine results in increased expression of CYP1A2 mRNA CTD PMID:21419197 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
sanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO sanguinarine promotes the reaction [AHR protein binds to ARNT protein]; sanguinarine results in increased activity of and affects the localization of AHR protein; sanguinarine results in increased localization of and results in increased activity of AHR protein CTD PMID:15993743 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO sanguinarine promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:15993743 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
sanguinarine results in increased expression of BAX protein
sanguinarine results in increased expression of BAX mRNA; sanguinarine results in increased expression of BAX protein
NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]
CTD PMID:22215411 PMID:24300172 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BBC3 mRNA CTD PMID:24345465 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
sanguinarine results in decreased expression of BCL2 protein
sanguinarine results in decreased expression of BCL2 mRNA; sanguinarine results in decreased expression of BCL2 protein
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BCL2 protein
CTD PMID:22215411 PMID:23660334 PMID:24300172 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l14 Bcl2-like 14 multiple interactions
increases expression
ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BCL2L14 mRNA
sanguinarine results in increased expression of BCL2L14 mRNA
CTD PMID:24345465 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
ISO [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein] CTD PMID:23660334 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bik BCL2-interacting killer multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:23660334 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of BNIP3L mRNA CTD PMID:24345465 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Card6 caspase recruitment domain family, member 6 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA CTD PMID:24345465 NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP1 mRNA
sanguinarine results in increased expression of CASP1 mRNA
CTD PMID:24345465 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity
ISO sanguinarine results in decreased expression of CASP3 protein alternative form
[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP3 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP3 protein
sanguinarine results in increased activity of CASP3 protein
CTD PMID:19135517 PMID:19346183 PMID:20150630 PMID:22215411 PMID:23660334 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP4 mRNA CTD PMID:24345465 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO sanguinarine results in increased activity of CASP8 protein
[sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein
CTD PMID:19346183 PMID:23660334 PMID:24345465 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity
ISO sanguinarine results in decreased expression of CASP9 protein alternative form
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP9 protein
sanguinarine results in increased activity of CASP9 protein
CTD PMID:19135517 PMID:19346183 PMID:22215411 PMID:23660334 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of CAT protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of CAT protein CTD PMID:20691676 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sanguinarine results in increased expression of CDKN1A protein CTD PMID:15981203 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cldn2 claudin 2 decreases expression ISO sanguinarine results in decreased expression of CLDN2 protein CTD PMID:19063874 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cldn3 claudin 3 decreases expression ISO sanguinarine results in decreased expression of CLDN3 protein CTD PMID:19063874 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn4 claudin 4 decreases expression ISO sanguinarine results in decreased expression of CLDN4 protein CTD PMID:19063874 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Cldn5 claudin 5 decreases expression ISO sanguinarine results in decreased expression of CLDN5 protein CTD PMID:19063874 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Cryz crystallin zeta multiple interactions
decreases activity
EXP sanguinarine inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]
sanguinarine results in decreased activity of CRYZ protein
CTD PMID:19788401 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
increases expression
increases activity
ISO
EXP
sanguinarine results in decreased activity of CYP1A1 protein
sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A1 protein
sanguinarine results in increased expression of CYP1A1 mRNA; sanguinarine results in increased expression of CYP1A1 protein
sanguinarine results in increased activity of CYP1A1 protein
CTD PMID:15993743 PMID:19788401 PMID:24300172 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A2 protein CTD PMID:19788401 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases activity
ISO sanguinarine results in increased expression of CYP1B1 mRNA
sanguinarine results in increased activity of CYP1B1 protein
CTD PMID:15993743 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP sanguinarine results in decreased activity of CYP2B1 protein CTD PMID:19788401 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP sanguinarine results in decreased expression of and results in decreased activity of CYP2E1 protein CTD PMID:19788401 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP sanguinarine results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein CTD PMID:19788401 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dedd2 death effector domain containing 2 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of DEDD2 mRNA CTD PMID:24345465 NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
decreases expression
ISO sanguinarine promotes the reaction [Reactive Oxygen Species results in increased activity of EGR1 protein]
sanguinarine results in increased expression of EGR1 protein
sanguinarine results in decreased expression of EGR1 protein
CTD PMID:23660334 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of FAS mRNA CTD PMID:24345465 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of FASLG mRNA CTD PMID:24345465 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO sanguinarine results in increased expression of GGT1 protein CTD PMID:15981203 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of GSR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of GSR protein CTD PMID:20691676 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO sanguinarine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; sanguinarine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]
sanguinarine results in increased expression of GSTP1 protein
CTD PMID:15313406 PMID:15981203 PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hal histidine ammonia lyase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein CTD PMID:20691676 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO sanguinarine results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
JBrowse link
G Ltb lymphotoxin beta increases expression
multiple interactions
ISO sanguinarine results in increased expression of LTB mRNA
[sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA
CTD PMID:24345465 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO sanguinarine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]
CTD PMID:19135517 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] CTD PMID:19135517 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein] CTD PMID:19135517 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein] CTD PMID:19135517 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO sanguinarine results in decreased expression of MMP2 mRNA; sanguinarine results in decreased expression of MMP2 protein CTD PMID:19063874 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO sanguinarine results in decreased expression of MMP9 mRNA; sanguinarine results in decreased expression of MMP9 protein CTD PMID:19063874 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression ISO sanguinarine results in increased expression of NFKBIZ mRNA CTD PMID:24345465 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A multiple interactions
increases expression
ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA
sanguinarine results in increased expression of NLRP1 mRNA
CTD PMID:24345465 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
increases reduction
multiple interactions
ISO
EXP
sanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 protein
NQO1 protein results in increased reduction of sanguinarine
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]
CTD PMID:22021338 PMID:24300172 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of PMAIP1 mRNA CTD PMID:24345465 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
EXP sanguinarine inhibits the reaction [Phenobarbital results in increased activity of POR protein]; sanguinarine promotes the reaction [Methylcholanthrene results in decreased activity of POR protein]
sanguinarine results in decreased activity of POR protein
CTD PMID:19788401 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA CTD PMID:24345465 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sanguinarine results in decreased expression of SNAI1 protein CTD PMID:19063874 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA CTD PMID:24345465 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
ISO [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFSF10 mRNA; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein results in increased susceptibility to [arsenic trioxide co-treated with sanguinarine]
sanguinarine results in increased expression of TNFSF10 mRNA
CTD PMID:24345465 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tyr tyrosinase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein CTD PMID:20691676 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:23660334 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
Sinomenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:37436133 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:37436133 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arg1 arginase 1 multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in decreased expression of ARG1 mRNA] CTD PMID:37436133 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atg10 autophagy related 10 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of ATG10 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of ATG10 protein] CTD PMID:37436133 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Becn1 beclin 1 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of BECN1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of BECN1 protein] CTD PMID:37436133 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in increased expression of CCL2 mRNA] CTD PMID:37436133 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:37436133 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:37436133 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:37436133 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Ifng interferon gamma multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in decreased expression of ARG1 mRNA]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of IL10 mRNA]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of IL10 protein]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of TGFB1 mRNA]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of TGFB1 protein]; sinomenine inhibits the reaction [IFNG protein results in increased expression of CCL2 mRNA]; sinomenine inhibits the reaction [IFNG protein results in increased expression of IL1B mRNA]; sinomenine inhibits the reaction [IFNG protein results in increased expression of IL1B protein]; sinomenine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; sinomenine inhibits the reaction [IFNG protein results in increased expression of TNF protein]; sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:24066068 PMID:37436133 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in decreased expression of IL10 mRNA]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of IL10 protein] CTD PMID:37436133 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in increased expression of IL1B mRNA]; sinomenine inhibits the reaction [IFNG protein results in increased expression of IL1B protein] CTD PMID:37436133 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation EXP Sinomenine decreases phosphorylation of Jak2 protein in lumber vertebra RGD PMID:30027795 RGD:149735350 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF mRNA]; sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MAF protein] CTD PMID:24066068 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Mir155 microRNA 155 multiple interactions ISO sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MIR155 mRNA] CTD PMID:24066068 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir204 microRNA 204 increases expression ISO sinomenine results in increased expression of MIR204 mRNA CTD PMID:37436133 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
JBrowse link
G Mir29a microRNA 29a increases expression ISO sinomenine results in increased expression of MIR29A mRNA CTD PMID:37436133 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24066068 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased phosphorylation of PIK3CB protein] CTD PMID:37436133 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in decreased expression of TGFB1 mRNA]; sinomenine inhibits the reaction [IFNG protein results in decreased expression of TGFB1 protein]
sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of ATG10 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of ATG10 protein]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of BECN1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of BECN1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; sinomenine inhibits the reaction [TGFB1 protein results in increased phosphorylation of PIK3CB protein]
CTD PMID:37436133 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO sinomenine inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 mRNA]; sinomenine inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 protein] CTD PMID:37436133 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sinomenine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; sinomenine inhibits the reaction [IFNG protein results in increased expression of TNF protein]; sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; sinomenine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] CTD PMID:24066068 PMID:37436133 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
JBrowse link
G Acot9 acyl-CoA thioesterase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases expression ISO tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147
JBrowse link
G Ar androgen receptor multiple interactions EXP tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of AR mRNA] CTD PMID:37606869 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
Ensembl chr 8:75,779,523...75,802,452
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 decreases expression ISO tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G Cald1 caldesmon 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein
CTD PMID:20109541 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
JBrowse link
G Calu calumenin decreases expression ISO tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Casp3 caspase 3 increases cleavage ISO tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 5:123,353,289...123,367,343
Ensembl chr 5:123,353,292...123,367,318
JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Ckb creatine kinase B decreases secretion ISO tetrahydropalmatine results in decreased secretion of CKB protein CTD PMID:37606869 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 decreases expression ISO tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr19:54,395,746...54,398,348
Ensembl chr19:54,395,742...54,399,407
JBrowse link
G Coasy Coenzyme A synthase decreases expression ISO tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr10:86,014,566...86,018,849
Ensembl chr10:86,014,597...86,018,841
JBrowse link
G Cops2 COP9 signalosome subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr 3:113,084,174...113,110,090
Ensembl chr 3:113,084,176...113,109,947
JBrowse link
G Cops3 COP9 signalosome subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression ISO tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
JBrowse link
G Cryz crystallin zeta decreases expression ISO tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784
JBrowse link
G Cstb cystatin B increases expression ISO tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275
JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
JBrowse link
G Ddx19b DEAD-box helicase 19B decreases expression ISO tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr19:38,968,215...38,998,907
Ensembl chr19:38,968,215...38,997,259
JBrowse link
G Ddx50 DExD-box helicase 50 decreases expression ISO tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression ISO tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
JBrowse link
G Dhx8 DEAH-box helicase 8 increases expression ISO tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression ISO tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Dpp3 dipeptidylpeptidase 3 decreases expression ISO tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 affects binding EXP tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 3:56,033,882...56,085,080
Ensembl chr 3:56,033,917...56,085,080
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions
ISO
EXP
tetrahydropalmatine results in decreased expression of ESR1 mRNA
tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA]
CTD PMID:37606869 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Exoc8 exocyst complex component 8 decreases expression ISO tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr19:52,855,010...52,857,499
Ensembl chr19:52,852,578...52,857,491
JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485
JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression ISO tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 4:118,805,129...118,811,046
Ensembl chr 4:118,805,127...118,811,047
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
JBrowse link
G Flywch2 FLYWCH family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541 NCBI chr10:12,798,757...12,807,082
Ensembl chr10:12,798,762...12,806,439
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Galk1 galactokinase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695
JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
JBrowse link
G Glrx glutaredoxin decreases expression ISO tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP L-THP inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum] RGD PMID:32717192 RGD:405100728 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tetrahydropalmatine results in decreased expression of GSK3B mRNA CTD PMID:37606869 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin decreases expression ISO tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases expression ISO tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 5:57,904,613...57,906,868
Ensembl chr 5:57,904,614...57,907,097
JBrowse link
G Hk1 hexokinase 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein
CTD PMID:20109541 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr 1:205,713,431...205,725,553
Ensembl chr 1:205,711,886...205,725,553
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
JBrowse link
G Ipo9 importin 9 decreases expression ISO tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr13:46,810,460...46,862,694
Ensembl chr13:46,813,171...46,862,673
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956
JBrowse link
G Jpt2 Jupiter microtubule associated homolog 2 decreases expression ISO tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Mak16 MAK16 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 increases expression ISO tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of MMP9 mRNA CTD PMID:37606869 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression ISO tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Nelfe negative elongation factor complex member E decreases expression ISO tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr20:3,976,512...3,982,389
Ensembl chr20:3,976,518...3,982,355
JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression ISO tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373
JBrowse link
G Nipsnap1 nipsnap homolog 1 increases expression ISO tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098
JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969
JBrowse link
G Nufip2 nuclear FMR1 interacting protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr10:62,574,922...62,607,729
Ensembl chr10:62,574,882...62,600,346
JBrowse link
G Nup155 nucleoporin 155 decreases expression ISO tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 2:57,201,310...57,252,918
Ensembl chr 2:57,201,272...57,254,148
JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pds5a PDS5 cohesin associated factor A increases expression ISO tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr14:42,551,653...42,651,074
Ensembl chr14:42,552,647...42,648,669
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA] CTD PMID:37606869 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 decreases expression ISO tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:14,773,398...14,776,035
Ensembl chr  X:14,773,420...14,775,909
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor 4 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 5:75,859,934...75,873,924
Ensembl chr 5:75,859,924...75,873,919
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of PTGS2 mRNA CTD PMID:37606869 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pym1 PYM homolog 1, exon junction complex associated factor decreases expression ISO tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr 7:1,177,746...1,200,899
Ensembl chr 7:1,178,008...1,198,937
JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression ISO tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr13:39,355,698...39,429,154
Ensembl chr13:39,352,247...39,429,169
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ranbp2 RAN binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein
CTD PMID:20109541 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Reep5 receptor accessory protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr18:25,945,375...25,983,271
Ensembl chr18:25,945,381...25,976,509
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rhob ras homolog family member B decreases expression ISO tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rmnd5a required for meiotic nuclear division 5 homolog A increases expression ISO tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 4:103,375,846...103,432,890
Ensembl chr 4:103,379,908...103,433,051
JBrowse link
G Rnf40 ring finger protein 40 decreases expression ISO tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rpa2 replication protein A2 decreases expression ISO tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
Ensembl chr16:14,607,801...14,609,170
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Septin11 septin 11 decreases expression ISO tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853
JBrowse link
G Skic3 SKI3 subunit of superkiller complex decreases expression ISO tetrahydropalmatine results in decreased expression of SKIC3 protein CTD PMID:20109541 NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 PMID:24799337 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A2 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A4 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A5 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases expression ISO tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO tetrahydropalmatine results in decreased expression of SLC6A4 mRNA CTD PMID:37606869 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression ISO tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594
JBrowse link
G Sms spermine synthase decreases expression ISO tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Sncg synuclein, gamma decreases expression ISO tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression ISO tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310
JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360
JBrowse link
G Snx2 sorting nexin 2 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
JBrowse link
G Sri sorcin decreases expression ISO tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
JBrowse link
G Srp19 signal recognition particle 19 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017
JBrowse link
G Srp68 signal recognition particle 68 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr10:101,481,213...101,508,035
Ensembl chr10:101,481,212...101,508,035
JBrowse link
G Srpra SRP receptor subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 increases expression ISO tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794
JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152
JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 8:109,726,213...109,730,902
Ensembl chr 8:109,726,196...109,735,474
JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Tsnax translin-associated factor X decreases expression ISO tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878
JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression ISO tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:20,064,102...20,072,673
Ensembl chr  X:20,064,103...20,072,620
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases expression ISO tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295
JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 increases expression ISO tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr15:20,478,310...20,523,106
Ensembl chr15:20,489,291...20,523,096
JBrowse link
trabectedin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
[ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1A mRNA
CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
increases expression
ISO
EXP
[ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1B mRNA
CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Aco1 aconitase 1 increases expression ISO Trabectedin results in increased expression of ACO1 mRNA; Trabectedin results in increased expression of ACO1 protein CTD PMID:36396105 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP trabectedin results in decreased expression of CAR3 mRNA CTD PMID:12154027 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO trabectedin results in decreased expression of CCNA2 mRNA CTD PMID:15961672 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO trabectedin results in decreased expression of CCNB1 mRNA CTD PMID:15961672 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO trabectedin results in decreased expression of CCNB2 mRNA CTD PMID:15961672 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trabectedin results in increased expression of CCND1 mRNA CTD PMID:12154027 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression ISO trabectedin results in increased expression of CCNE1 mRNA CTD PMID:15961672 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP trabectedin results in increased expression of CDK1 mRNA CTD PMID:12154027 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP trabectedin results in decreased expression of CYP1A2 mRNA CTD PMID:12154027 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP trabectedin results in decreased activity of CYP2E1 protein CTD PMID:12154027 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity EXP trabectedin results in decreased activity of CYP3A2 protein CTD PMID:12154027 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:12504080 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP trabectedin results in decreased expression of CYP3A13 mRNA CTD PMID:12154027 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO trabectedin results in increased expression of E2F1 mRNA CTD PMID:15961672 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Trabectedin results in decreased expression of GPX4 mRNA; Trabectedin results in decreased expression of GPX4 protein CTD PMID:36396105 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Trabectedin results in increased expression of HIF1A mRNA; Trabectedin results in increased expression of HIF1A protein CTD PMID:36396105 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP trabectedin results in increased expression of MKI67 protein CTD PMID:12154027 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases response to substance
ISO everolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin] CTD PMID:21622721 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Trabectedin results in decreased expression of NFE2L2 protein CTD PMID:36396105 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565
JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377
JBrowse link
G Tfrc transferrin receptor increases expression ISO Trabectedin results in increased expression of TFRC mRNA; Trabectedin results in increased expression of TFRC protein CTD PMID:36396105 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO trabectedin results in decreased expression of TK1 mRNA CTD PMID:15961672 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
tubocurarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] CTD PMID:29618714 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2] CTD PMID:16644063 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] CTD PMID:19436947 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G C7 complement C7 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA
CTD PMID:16949557 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] CTD PMID:7808438 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] CTD PMID:10082212 PMID:10216184 PMID:16931985 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
CTD PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cntn1 contactin 1 increases expression
multiple interactions
decreases expression
ISO Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
Tubocurarine results in decreased expression of CNTN1 mRNA
CTD PMID:12588870 PMID:16949557 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA
CTD PMID:12588870 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Eml4 EMAP like 4 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions
decreases expression
ISO Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA
CTD PMID:12588870 NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] CTD PMID:11425648 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Golga4 golgin A4 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]
CTD PMID:16949557 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]] CTD PMID:22119045 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases activity ISO Tubocurarine results in decreased activity of KCNN1 protein CTD PMID:10696100 NCBI chr16:18,574,858...18,598,585
Ensembl chr16:18,585,992...18,597,482
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO
EXP
Tubocurarine results in decreased activity of KCNN2 protein CTD PMID:10696100 PMID:10991935 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA
CTD PMID:12588870 NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] CTD PMID:12588870 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:22119045 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:22119045 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] CTD PMID:17151781 PMID:18986645 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Nin ninein multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA
CTD PMID:16949557 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein] CTD PMID:19690163 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Tubocurarine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Ptma prothymosin alpha multiple interactions ISO Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS] CTD PMID:16644063 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] CTD PMID:12588870 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA] CTD PMID:9458815 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpc surfactant protein C multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA] CTD PMID:9458815 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA
CTD PMID:16949557 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] CTD PMID:11425648 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA
CTD PMID:16949557 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions
decreases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA
CTD PMID:16949557 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression
multiple interactions
ISO Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]
CTD PMID:12588870 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
JBrowse link
G Zfr zinc finger RNA binding protein decreases expression
multiple interactions
ISO Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]
CTD PMID:12588870 NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            alkaloid 7817
              isoquinoline alkaloid 1191
                (+)-1,2-dehydrokohatine 0
                (+)-pronuciferine 0
                (1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-3-yl)methanol 0
                (4aR,10bS)-noroxomaritidine 0
                (4aR,7aR)-9-methoxy-3-methyl-2,4,4a,5,6,7a-hexahydro-1H-benzofuro[3,2-e]isoquinolin-7-one 0
                (4aS,10bR)-noroxomaritidine 0
                (6As)-1,2,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-ol 0
                (6As)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-3-carbaldehyde 0
                (R)-Norisocorydine 0
                (R)-Roemerine 0
                (S)-3'-hydroxy-N-methylcoclaurine 0
                (S)-Autumnaline 0
                (S)-Nandigerine 0
                (S)-Neolitsine 0
                1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10-ol 0
                2,3,8,9-tetramethoxy-13-methyl-5,6,11,12-tetrahydro-5,11-epiminodibenzo[a,e][8]annulene + 0
                2,3,8,9-tetramethoxy-5,6,11,12-tetrahydro-5,11-epiminodibenzo[a,e][8]annulene + 0
                4-Hydroxynornantenine 0
                7'-O-demethylisocephaeline 0
                7-Chloro-6-demethylcepharadione B 0
                7-Formyldehydrothalicsimidine 0
                Aknadicine 0
                Androcymbine 0
                Aristolodione 0
                Cepharadione A 0
                Cepharadione B 0
                Cepharatine B 0
                Cepharatine C 0
                Cepharatine D 0
                Crebanine 0
                Cryptodorine 0
                Dehydroanonaine 0
                Dehydroaporheine 0
                Dehydronuciferine 0
                Domesticine 0
                Floribundine 0
                Hasubanonine 0
                Hernandoline 0
                Isoandrocymbine 0
                Isodomesticine 0
                Laetanine 0
                Launobine 0
                Laurotetanine 0
                Lettowianthine 0
                Litsoeine 0
                N-Acetylanonaine 0
                N-Methoxycarbonyl-N-nornuciferine 0
                N-Methoxycarbonylanonaine 0
                Nandazurine 0
                Norcorydine 0
                Norglaucin 0
                Norisocorydine 0
                Norisodomesticine 0
                Nornantenine 0
                O-Methylandrocymbine 0
                Oxoglaucine 0
                Oxopurpureine 0
                Periglaucine A 0
                Periglaucine B 0
                Periglaucine C 0
                Periglaucine D 0
                Remerin 0
                Romucosine A 0
                Romucosine C 0
                Xanthoplanine 0
                alangicine 0
                alangimarckine 0
                alangimarine 0
                alangiside 0
                amaryllisine 0
                ancistrotanzanine A 0
                ancistrotanzanine B 0
                ankorine 0
                backebergine 0
                benzophenanthridine alkaloid + 115
                benzylisoquinoline alkaloid + 216
                berberine alkaloid + 409
                bianfugenine 0
                bicuculline 31
                bidebiline C 0
                bidebiline D 0
                cassiarin A 0
                cassiarin B 0
                codeinone 5
                corydaline 1
                crinan 0
                deacetylipecoside 0
                deacetylisoipecoside 0
                dibenzazecine alkaloid + 2
                dimemorfan phosphate 0
                dioncopeltine A 0
                dioncophylline A 0
                dioncophylline C 0
                emetan + 39
                emetine + 39
                eschscholtzidine 0
                fumisoquin A 0
                fumisoquin B 0
                fumisoquin C 0
                hasubanan 0
                heliamine 0
                ipecoside 0
                klugine 0
                lindechunine A 0
                michellamine A 0
                michellamine B 0
                morphinane alkaloid + 696
                nororientaline + 0
                pancracine 0
                stepharine 0
                trabectedin 28
                tubulosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      p-block molecular entity 19759
                        carbon group molecular entity 19708
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organonitrogen compound 18783
                                alkaloid 7817
                                  isoquinoline alkaloid 1191
                                    (+)-1,2-dehydrokohatine 0
                                    (+)-pronuciferine 0
                                    (1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-3-yl)methanol 0
                                    (4aR,10bS)-noroxomaritidine 0
                                    (4aR,7aR)-9-methoxy-3-methyl-2,4,4a,5,6,7a-hexahydro-1H-benzofuro[3,2-e]isoquinolin-7-one 0
                                    (4aS,10bR)-noroxomaritidine 0
                                    (6As)-1,2,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-ol 0
                                    (6As)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-3-carbaldehyde 0
                                    (R)-Norisocorydine 0
                                    (R)-Roemerine 0
                                    (S)-3'-hydroxy-N-methylcoclaurine 0
                                    (S)-Autumnaline 0
                                    (S)-Nandigerine 0
                                    (S)-Neolitsine 0
                                    1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10-ol 0
                                    2,3,8,9-tetramethoxy-13-methyl-5,6,11,12-tetrahydro-5,11-epiminodibenzo[a,e][8]annulene + 0
                                    2,3,8,9-tetramethoxy-5,6,11,12-tetrahydro-5,11-epiminodibenzo[a,e][8]annulene + 0
                                    4-Hydroxynornantenine 0
                                    7'-O-demethylisocephaeline 0
                                    7-Chloro-6-demethylcepharadione B 0
                                    7-Formyldehydrothalicsimidine 0
                                    Aknadicine 0
                                    Androcymbine 0
                                    Aristolodione 0
                                    Cepharadione A 0
                                    Cepharadione B 0
                                    Cepharatine B 0
                                    Cepharatine C 0
                                    Cepharatine D 0
                                    Crebanine 0
                                    Cryptodorine 0
                                    Dehydroanonaine 0
                                    Dehydroaporheine 0
                                    Dehydronuciferine 0
                                    Domesticine 0
                                    Floribundine 0
                                    Hasubanonine 0
                                    Hernandoline 0
                                    Isoandrocymbine 0
                                    Isodomesticine 0
                                    Laetanine 0
                                    Launobine 0
                                    Laurotetanine 0
                                    Lettowianthine 0
                                    Litsoeine 0
                                    N-Acetylanonaine 0
                                    N-Methoxycarbonyl-N-nornuciferine 0
                                    N-Methoxycarbonylanonaine 0
                                    Nandazurine 0
                                    Norcorydine 0
                                    Norglaucin 0
                                    Norisocorydine 0
                                    Norisodomesticine 0
                                    Nornantenine 0
                                    O-Methylandrocymbine 0
                                    Oxoglaucine 0
                                    Oxopurpureine 0
                                    Periglaucine A 0
                                    Periglaucine B 0
                                    Periglaucine C 0
                                    Periglaucine D 0
                                    Remerin 0
                                    Romucosine A 0
                                    Romucosine C 0
                                    Xanthoplanine 0
                                    alangicine 0
                                    alangimarckine 0
                                    alangimarine 0
                                    alangiside 0
                                    amaryllisine 0
                                    ancistrotanzanine A 0
                                    ancistrotanzanine B 0
                                    ankorine 0
                                    backebergine 0
                                    benzophenanthridine alkaloid + 115
                                    benzylisoquinoline alkaloid + 216
                                    berberine alkaloid + 409
                                    bianfugenine 0
                                    bicuculline 31
                                    bidebiline C 0
                                    bidebiline D 0
                                    cassiarin A 0
                                    cassiarin B 0
                                    codeinone 5
                                    corydaline 1
                                    crinan 0
                                    deacetylipecoside 0
                                    deacetylisoipecoside 0
                                    dibenzazecine alkaloid + 2
                                    dimemorfan phosphate 0
                                    dioncopeltine A 0
                                    dioncophylline A 0
                                    dioncophylline C 0
                                    emetan + 39
                                    emetine + 39
                                    eschscholtzidine 0
                                    fumisoquin A 0
                                    fumisoquin B 0
                                    fumisoquin C 0
                                    hasubanan 0
                                    heliamine 0
                                    ipecoside 0
                                    klugine 0
                                    lindechunine A 0
                                    michellamine A 0
                                    michellamine B 0
                                    morphinane alkaloid + 696
                                    nororientaline + 0
                                    pancracine 0
                                    stepharine 0
                                    trabectedin 28
                                    tubulosine 0
paths to the root