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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amoxapine
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Accession:CHEBI:2675 term browser browse the term
Definition:A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
Synonyms:exact_synonym: 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
 related_synonym: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine;   Desmethylloxapin;   Formula=C17H16ClN3O;   InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2;   InChIKey=QWGDMFLQWFTERH-UHFFFAOYSA-N;   SMILES=Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1;   amoxapina;   amoxapinum
 xref: Beilstein:832057;   CAS:14028-44-5;   DrugBank:DB00543;   Drug_Central:191;   KEGG:D00228;   LINCS:LSM-2021
 xref_mesh: MESH:D000657
 xref: PMID:24134630;   Patent:FR1508536;   Patent:US3663696;   Wikipedia:Amoxapine


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amoxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of Amoxapine CTD PMID:21826677 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Amoxapine binds to DRD1 protein CTD PMID:11180191 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Amoxapine binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Prl prolactin increases expression ISO Amoxapine results in increased expression of PRL protein CTD PMID:6363397 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Amoxapine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        pharmacological role 19064
          antagonist 17248
            dopaminergic antagonist 1636
              amoxapine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon group molecular entity 19741
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic polycyclic compound 17247
                                  organic tricyclic compound 15693
                                    organic heterotricyclic compound 15647
                                      dibenzooxazepine 22
                                        amoxapine 8
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