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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzooxazepine
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Accession:CHEBI:53802 term browser browse the term
Definition:An organic heterotricyclic compound consisting of two benzene rings fused to a seven-membered ring containing one oxygen and one nitrogen atom.
Synonyms:related_synonym: dibenzooxazepines;   dibenzoxazepine;   dibenzoxazepines
 alt_id: CHEBI:50840


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amoxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases chemical synthesis ISO CYP3A4 results in increased chemical synthesis of Amoxapine CTD PMID:21826677 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO Amoxapine binds to DRD1 protein CTD PMID:11180191 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 affects binding ISO Amoxapine binds to DRD2 protein CTD PMID:11180191 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Prl prolactin increases expression ISO Amoxapine results in increased expression of PRL protein CTD PMID:6363397 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Amoxapine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
imipramine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases abundance ISO CYP1A2 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases abundance ISO CYP2B6 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases abundance ISO CYP2C19 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases abundance ISO FMO3 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
loxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing ISO CYP3A4 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Drd1 dopamine receptor D1 affects binding EXP Loxapine analog binds to DRD1 protein; Loxapine binds to DRD1 protein CTD PMID:9723970 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Loxapine analog binds to DRD2 protein; Loxapine binds to DRD2 protein CTD PMID:9723970 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP Loxapine analog binds to HTR1A protein; Loxapine binds to HTR1A protein CTD PMID:9723970 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding EXP Loxapine analog binds to HTR2A protein; Loxapine binds to HTR2A protein CTD PMID:9723970 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding EXP Loxapine analog binds to HTR2C protein; Loxapine binds to HTR2C protein CTD PMID:9723970 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Loxapine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
Olopatadine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
EXP
ISO
Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]
Olopatadine Hydrochloride binds to HRH1 protein
CTD PMID:9433371 PMID:18360087 PMID:19075512 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Il4 interleukin 4 multiple interactions EXP
ISO
Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
Olopatadine Hydrochloride inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]
CTD PMID:19075512 PMID:31672514 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO Olopatadine Hydrochloride inhibits the reaction [Ovalbumin results in increased expression of TAC1 protein] CTD PMID:31672514 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Olopatadine Hydrochloride inhibits the reaction [Ovalbumin results in increased expression of TNF mRNA]; Olopatadine Hydrochloride inhibits the reaction [Ovalbumin results in increased secretion of TNF protein] CTD PMID:31672514 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
tiracizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tiracizine binds to and results in increased activity of NR1I2 protein CTD PMID:28289823 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO tiracizine binds to and results in decreased activity of NR1I3 protein CTD PMID:28289823 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      molecular entity 19768
        polyatomic entity 19686
          molecule 19534
            cyclic compound 19367
              polycyclic compound 18620
                heteropolycyclic compound 17978
                  heterotricyclic compound 14600
                    organic heterotricyclic compound 14600
                      dibenzooxazepine 22
                        2-Hydroxyiminodibenzyl 0
                        7-Hydroxyamoxapine 0
                        8-Hydroxyamoxapine 0
                        Cancentrine 0
                        Doxepin Hydrochloride 0
                        Olopatadine 0
                        Olopatadine hydrochloride 4
                        amoxapine 8
                        bermoprofen 0
                        carpipramine 0
                        clocapramine 0
                        imipramine oxide 5
                        isoxepac 0
                        loxapine + 9
                        metapramine 0
                        quinupramine 0
                        tiracizine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      dibenzooxazepine 22
                                        2-Hydroxyiminodibenzyl 0
                                        7-Hydroxyamoxapine 0
                                        8-Hydroxyamoxapine 0
                                        Cancentrine 0
                                        Doxepin Hydrochloride 0
                                        Olopatadine 0
                                        Olopatadine hydrochloride 4
                                        amoxapine 8
                                        bermoprofen 0
                                        carpipramine 0
                                        clocapramine 0
                                        imipramine oxide 5
                                        isoxepac 0
                                        loxapine + 9
                                        metapramine 0
                                        quinupramine 0
                                        tiracizine 2
paths to the root