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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:myxothiazol
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Accession:CHEBI:25461 term browser browse the term
Definition:A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.
Synonyms:exact_synonym: (2E,4R,5S,6E)-3,5-dimethoxy-4-methyl-7-{2'-[(2S,3E,5E)-7-methylocta-3,5-dien-2-yl]-2,4'-bi-1,3-thiazol-4-yl}hepta-2,6-dienamide
 related_synonym: Formula=C25H33N3O3S2;   InChI=1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13+/t17-,18+,21-/m0/s1;   InChIKey=XKTFQMCPGMTBMD-FYHMSGCOSA-N;   Myxothiazol A;   SMILES=CO[C@@H](\\C=C\\C1=CSC(=N1)C1=CSC(=N1)[C@@H](C)\\C=C\\C=C\\C(C)C)[C@@H](C)C(\\OC)=C/C(N)=O
 alt_id: CHEBI:44129
 xref: CAS:76706-55-3;   DrugBank:DB04741;   KEGG:C15674;   KNApSAcK:C00018319
 xref_mesh: MESH:C030517
 xref: MetaCyc:CPD0-1244;   PDBeChem:MYX;   PMID:10853768;   PMID:11134965;   PMID:11237706;   PMID:12176058;   PMID:15312779;   PMID:16081299;   PMID:18221415;   PMID:24414973;   PMID:24661880;   PMID:2753821;   PMID:2846049;   PMID:29402945;   PMID:31079230;   PMID:6274398;   PMID:6752659;   PMID:7247372;   PMID:7271921;   Wikipedia:Myxothiazol


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myxothiazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule multiple interactions ISO myxothiazol inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP myxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:23867654 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein] CTD PMID:16303854 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:19793987 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein] CTD PMID:17087917 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA] CTD PMID:23867654 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883 		JBrowse link
G Slc6a12 solute carrier family 6 member 12 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] CTD PMID:16303854 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO myxothiazol results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO myxothiazol results in increased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            protective agent 18187
              geroprotector 17357
                myxothiazol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              monocarboxylic acid amide 15662
                                                myxothiazol 12
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