CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dehydrocostus lactone
Accession: CHEBI:244418
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Definition: An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.
Synonyms: exact_synonym: (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione; (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione
related_synonym: (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one; Formula=C15H18O2; InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1; InChIKey=NETSQGRTUNRXEO-XUXIUFHCSA-N; SMILES=[H][C@@]12CCC(=C)[C@]1([H])[C@H]1OC(=O)C(=C)[C@@H]1CCC2=C; dehydrocostuslactone
alt_id: CHEBI:4359; CHEBI:467325
xref: Beilstein:4733740; CAS:477-43-0; KEGG:C09387; KNApSAcK:C00003245
xref_mesh: MESH:C083030
xref: PMID:10193198; PMID:12419922; PMID:14192430; PMID:15209353; PMID:15881118; PMID:17391667; PMID:19148545; PMID:19188481; PMID:19457452; PMID:19700217; PMID:21353686; PMID:21472220; PMID:21596031; PMID:22359572; PMID:23047249; PMID:6476889; PMID:8541643; PMID:9784148; PMID:9917276; Patent:CN102058579; Reaxys:4733740
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[dehydrocostus lactone co-treated with berberrubine] results in increased expression of BAX protein
CTD
PMID:37142148
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
dehydrocostus lactone results in decreased expression of BCL2 protein [dehydrocostus lactone co-treated with berberrubine] results in decreased expression of BCL2 protein
CTD
PMID:37142148
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions increases expression
ISO
[dehydrocostus lactone co-treated with berberrubine] results in increased expression of CASP3 protein dehydrocostus lactone results in increased expression of CASP3 protein
CTD
PMID:37142148
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Hmox1
heme oxygenase 1
increases expression
ISO
dehydrocostus lactone results in increased expression of HMOX1 protein
CTD
PMID:23942037
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il6
interleukin 6
multiple interactions
ISO
dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]
CTD
PMID:19457452
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]
CTD
PMID:26970604
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
CTD
PMID:26970604
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tnf
tumor necrosis factor
multiple interactions
ISO
dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:26970604
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein]
CTD
PMID:19457452
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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