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tyramine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tyramine
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Accession:CHEBI:15760 term browser browse the term
Definition:A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.
Synonyms:related_synonym: 2-(p-Hydroxyphenyl)ethylamine;   4-(2-aminoethyl)phenol;   4-Hydroxy-beta-phenylethylamine;   4-Hydroxyphenylethylamine;   4-hydroxyphenethylamine;   Formula=C8H11NO;   InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2;   InChIKey=DZGWFCGJZKJUFP-UHFFFAOYSA-N;   SMILES=NCCc1ccc(O)cc1;   Tyramin;   beta-(4-Hydroxyphenyl)ethylamine;   p-(2-Aminoethyl)phenol;   p-hydroxyphenethylamine;   p-hydroxyphenylethylamine;   p-tyramine
 alt_id: CHEBI:15276;   CHEBI:27174;   CHEBI:9799
 xref: CAS:51-67-2;   Drug_Central:2784;   Gmelin:82946;   HMDB:HMDB0000306;   KEGG:C00483;   KNApSAcK:C00001435;   LINCS:LSM-19016
 xref_mesh: MESH:D014439
 xref: MetaCyc:TYRAMINE;   PDBeChem:AEF;   PMID:11361052;   PMID:11919655;   PMID:12183041;   PMID:12707242;   PMID:12811595;   PMID:15000446;   PMID:15848803;   PMID:15932098;   PMID:18422653;   PMID:18970430;   PMID:19137318;   PMID:19189084;   PMID:21570963;   PMID:21628600;   PMID:21651557;   PMID:21679153;   PMID:21850574;   PMID:21909937;   PMID:22735334;   PMID:3137238;   PMID:319927;   PMID:6501508;   PMID:9282832;   PMID:9731223;   Reaxys:1099914;   Wikipedia:Tyramine
 cyclic_relationship: is_conjugate_base_of CHEBI:327995

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show annotations for term's descendants           Sort by:
tyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum] CTD PMID:15526171 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) increases metabolic processing
multiple interactions		 EXP CYP2D6 protein results in increased metabolism of Tyramine
[CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine		 CTD PMID:26763401 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G GAST gastrin decreases cleavage ISO Tyramine results in decreased cleavage of GAST protein CTD PMID:10332097 NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969 		JBrowse link
G MAOA monoamine oxidase A increases metabolic processing EXP MAOA protein results in increased metabolism of Tyramine CTD PMID:10647887 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 multiple interactions EXP Tyramine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Tyramine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,317...19,718,979
Ensembl chr17:19,678,288...19,718,979 		JBrowse link
G SLC6A2 solute carrier family 6 member 2 multiple interactions EXP Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions EXP indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 multiple interactions EXP Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 increases sulfation EXP SULT1A3 protein results in increased sulfation of Tyramine CTD PMID:11181495 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310 		JBrowse link
G TAAR1 trace amine associated receptor 1 multiple interactions
increases activity		 EXP
ISO		 [Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,643,312...132,659,182 		JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of CXCL8 protein CTD PMID:34826398 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G GUSB glucuronidase beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HEXA hexosaminidase subunit alpha increases secretion
multiple interactions		 EXP p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]		 CTD PMID:36350155 NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420 		JBrowse link
G HEXB hexosaminidase subunit beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A increases activity ISO p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G KNG1 kininogen 1 decreases activity EXP p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 ISO atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:29402411 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MRGPRX2 MAS related GPR family member X2 affects response to substance EXP MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr11:19,054,455...19,060,717
Ensembl chr11:19,054,455...19,060,717 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G TNF tumor necrosis factor increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TPSB2 tryptase beta 2 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr16:1,228,336...1,230,184
Ensembl chr16:1,227,272...1,232,757 		JBrowse link
N,O-dimethyltyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of CXCL8 protein CTD PMID:34826398 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G GUSB glucuronidase beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HEXA hexosaminidase subunit alpha multiple interactions
increases secretion		 EXP Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] CTD PMID:36350155 NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420 		JBrowse link
G HEXB hexosaminidase subunit beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A increases activity ISO p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G KNG1 kininogen 1 decreases activity EXP p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 ISO atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:29402411 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:29402411 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MRGPRX2 MAS related GPR family member X2 affects response to substance EXP MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr11:19,054,455...19,060,717
Ensembl chr11:19,054,455...19,060,717 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G TNF tumor necrosis factor increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TPSB2 tryptase beta 2 increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr16:1,228,336...1,230,184
Ensembl chr16:1,227,272...1,232,757 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26568
    role 26394
      biological role 26373
        molecular messenger 20328
          monoamine molecular messenger 648
            tyramine 26
              3-nitrotyramine 0
              N,O-dimethyltyramine + 15
              N-acetyltyramine 0
              N-butanoyltyramine 0
              N-hexanoyltyramine 0
              N-trans-cinnamoyltyramine 0
              gamma-glutamyltyramine 0
              norbelladine + 0
              tyramine phosphate 0
              tyramine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26568
    subatomic particle 26544
      composite particle 26544
        hadron 26544
          baryon 26544
            nucleon 26544
              atomic nucleus 26544
                atom 26544
                  main group element atom 26293
                    main group molecular entity 26293
                      s-block molecular entity 25544
                        hydrogen molecular entity 24968
                          hydrides 23092
                            inorganic hydride 20594
                              pnictogen hydride 20537
                                nitrogen hydride 20275
                                  azane 20002
                                    ammonia 20001
                                      organic amino compound 20001
                                        aralkylamino compound 1104
                                          monoamine 648
                                            monoamine molecular messenger 648
                                              tyramine 26
                                                3-nitrotyramine 0
                                                N,O-dimethyltyramine + 15
                                                N-acetyltyramine 0
                                                N-butanoyltyramine 0
                                                N-hexanoyltyramine 0
                                                N-trans-cinnamoyltyramine 0
                                                gamma-glutamyltyramine 0
                                                norbelladine + 0
                                                tyramine phosphate 0
                                                tyramine sulfate 0
paths to the root