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Gene: KNG1 (kininogen 1) Homo sapiens
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Symbol: KNG1
Name: kininogen 1
Description: Exhibits cysteine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and positive regulation of cytosolic calcium ion concentration. Localizes to the extracellular space. Biomarker of Henoch-Schoenlein purpura and proliferative vitreoretinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-2-thiol proteinase inhibitor; BDK; BK; bradykinin; fitzgerald factor; high molecular weight kininogen; HMWK; kininogen-1; KNG; williams-Fitzgerald-Flaujeac factor
Orthologs:
Mus musculus (house mouse) : Kng2 (kininogen 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kng2 (kininogen 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kng1 (kininogen 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KNG1 (kininogen 1)
Canis lupus familiaris (dog) : KNG1 (kininogen 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kng1 (kininogen 1)
Sus scrofa (pig) : KNG1 (kininogen 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383186,717,359 - 186,744,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373186,435,098 - 186,462,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,917,814 - 187,944,437 (+)NCBINCBI36hg18NCBI36
Celera3184,871,536 - 184,898,662 (+)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3183,844,775 - 183,871,713 (+)NCBIHuRef
CHM1_13186,399,036 - 186,425,781 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KNG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603713
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.