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voriconazole - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:voriconazole
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Accession:CHEBI:10023 term browser browse the term
Definition:A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Synonyms:exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   Formula=C16H14F3N5O;   InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1;   InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N;   SMILES=C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F;   VCZ;   Vfend;   voriconazol;   voriconazolum
 alt_id: CHEBI:127308
 xref: Beilstein:7694998;   CAS:137234-62-9;   DrugBank:DB00582;   Drug_Central:2846;   KEGG:C07622;   KEGG:D00578;   LINCS:LSM-5244
 xref_mesh: MESH:D065819
 xref: PMID:12940129;   PMID:22718362;   PMID:23392902;   PMID:23527908;   PMID:23766489;   PMID:24102553;   Patent:EP440372;   Patent:US5278175;   Wikipedia:Voriconazole

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voriconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B increases expression EXP Voriconazole results in increased expression of APOB protein CTD PMID:37659626 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Voriconazole results in decreased activity of CA1 protein CTD PMID:31478295 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Voriconazole results in decreased activity of CA2 protein CTD PMID:31478295 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Voriconazole results in decreased expression of CPT1A protein CTD PMID:37659626 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Voriconazole results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing
decreases activity 		ISO CYP2C19 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP2C19 protein 		CTD PMID:15328084 PMID:15914520 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases activity 		ISO CYP3A4 protein affects the metabolism of Voriconazole
Voriconazole results in decreased activity of CYP3A4 protein 		CTD PMID:15328084 PMID:15914520 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
decreases response to substance 		ISO CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CYP51A1 gene results in decreased susceptibility to Voriconazole 		CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Voriconazole results in decreased expression of FASN protein CTD PMID:37659626 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Voriconazole results in increased activity of GPT protein CTD PMID:37659626 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression EXP Voriconazole results in increased expression of MTTP protein CTD PMID:37659626 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression 		ISO
EXP 		[NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole
Voriconazole results in decreased expression of NR1I2 protein 		CTD PMID:23274663 PMID:37659626 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I2 protein co-treated with NR1I3 protein] affects the metabolism of Voriconazole CTD PMID:23274663 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Voriconazole results in increased expression of PPARA protein CTD PMID:37659626 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Voriconazole results in decreased expression of SCD protein CTD PMID:37659626 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        antimicrobial agent 18553
          antifungal agent 17380
            conazole antifungal agent 6592
              conazole antifungal drug 1622
                voriconazole 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            organic molecule 20637
                              organic cyclic compound 20387
                                organic heterocyclic compound 19369
                                  heteroarene 17434
                                    monocyclic heteroarene 15170
                                      azole 14600
                                        triazoles 8504
                                          triazole antifungal agent 5789
                                            triazole antifungal drug 114
                                              voriconazole 15
paths to the root