conazole antifungal drug - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	conazole antifungal drug	go back to main search page
Accession:	CHEBI:87071	browse the term
Definition:	Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans.
Synonyms:	related_synonym:	conazole antifungal drugs

show annotations for term's descendants Sort by:
Rat (1613) Mouse (1618) Human (1614) Chinchilla (0) Bonobo (0) Dog (4) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (1613)

butoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

butoconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity

butoconazole results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

climbazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

climbazole results in increased expression of CYP2B1 mRNA; climbazole results in increased expression of CYP2B1 protein

PMID:11552297 PMID:11824557

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

climbazole results in increased expression of CYP3A2 protein

PMID:11552297 PMID:11824557

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

climbazole results in increased expression of CYP4A1 protein

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

clotrimazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Clotrimazole results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects binding
multiple interactions
increases expression

Clotrimazole binds to ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
Clotrimazole results in increased expression of ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]

PMID:8632764 PMID:8917702 PMID:12235267

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

increases expression

Clotrimazole results in increased expression of ABCC2 mRNA; Clotrimazole results in increased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

acid phosphatase 2, lysosomal

increases expression

Clotrimazole results in increased expression of ACP2 mRNA

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

ADAM metallopeptidase domain 22

decreases expression

Clotrimazole results in decreased expression of ADAM22 mRNA

NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

Clotrimazole results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

ADAM metallopeptidase with thrombospondin type 1 motif, 7

increases expression

Clotrimazole results in increased expression of ADAMTS7 mRNA

NCBI chr 8:90,704,727...90,744,333
Ensembl chr 8:90,704,727...90,744,328

G

ADAMTS-like 5

decreases expression

Clotrimazole results in decreased expression of ADAMTSL5 mRNA

NCBI chr 7:9,362,623...9,371,248
Ensembl chr 7:9,363,237...9,370,285

G

adenosine deaminase, RNA-specific

decreases expression

Clotrimazole results in decreased expression of ADAR mRNA

NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282

G

adenylate cyclase 9

decreases activity

Clotrimazole results in decreased activity of ADCY9 protein

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

adenosine A2a receptor

increases expression

Clotrimazole results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

AE binding protein 1

increases expression

Clotrimazole results in increased expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

ArfGAP with FG repeats 1

increases expression

Clotrimazole results in increased expression of AGFG1 mRNA

NCBI chr 9:84,124,845...84,182,615
Ensembl chr 9:84,125,120...84,178,128

G

aryl hydrocarbon receptor

increases activity

Clotrimazole results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 6

increases expression

Clotrimazole results in increased expression of AK6 mRNA

NCBI chr 2:31,794,316...31,806,375
Ensembl chr 2:31,794,519...31,806,371
Ensembl chr20:31,794,519...31,806,371

G

aldehyde dehydrogenase 9 family, member A1

increases expression

Clotrimazole results in increased expression of ALDH9A1 mRNA

NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568

G

aldolase, fructose-bisphosphate B

affects localization

Clotrimazole affects the localization of ALDOB protein

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

ankyrin repeat domain 40

increases expression

Clotrimazole results in increased expression of ANKRD40 mRNA

NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320

G

apolipoprotein E

decreases expression

Clotrimazole results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

arrestin domain containing 1

decreases expression

Clotrimazole results in decreased expression of ARRDC1 mRNA

NCBI chr 3:7,735,002...7,742,195
Ensembl chr 3:7,735,011...7,742,197

G

activating transcription factor 3

increases expression
multiple interactions

Clotrimazole results in increased expression of ATF3 mRNA
SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA]

PMID:27507784 PMID:27965148

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATP synthase F1 subunit gamma

increases expression

Clotrimazole results in increased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Clotrimazole results in increased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATP synthase peripheral stalk subunit d

increases expression

Clotrimazole results in increased expression of ATP5PD mRNA

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase mitochondrial F1 complex assembly factor 2

increases expression

Clotrimazole results in increased expression of ATPAF2 mRNA

NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026

G

5-azacytidine induced 2

increases expression

Clotrimazole results in increased expression of AZI2 mRNA

NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847

G

basic leucine zipper ATF-like transcription factor 3

increases expression

Clotrimazole results in increased expression of BATF3 mRNA

NCBI chr13:102,689,657...102,701,241
Ensembl chr13:102,689,657...102,701,139

G

Bardet-Biedl syndrome 4

decreases expression

Clotrimazole results in decreased expression of BBS4 mRNA

NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

Clotrimazole results in decreased expression of BCKDHA mRNA

NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862

G

basic helix-loop-helix family, member e22

decreases expression

Clotrimazole results in decreased expression of BHLHE22 mRNA

NCBI chr 2:100,486,400...100,489,510
Ensembl chr 2:100,486,400...100,489,510

G

BICD cargo adaptor 2

increases expression

Clotrimazole results in increased expression of BICD2 mRNA

NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889

G

Bri3 binding protein

increases expression

Clotrimazole results in increased expression of BRI3BP mRNA

NCBI chr12:31,176,742...31,188,563
Ensembl chr12:31,173,971...31,188,572

G

basic transcription factor 3

decreases expression

Clotrimazole results in decreased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879

G

C1q and TNF related 1

decreases expression

Clotrimazole results in decreased expression of C1QTNF1 mRNA

NCBI chr10:103,660,319...103,681,662
Ensembl chr10:103,660,327...103,681,660

G

C1q and TNF related 5

increases expression

Clotrimazole results in increased expression of C1QTNF5 mRNA

NCBI chr 8:44,450,934...44,453,075
Ensembl chr 8:44,451,154...44,453,074

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Clotrimazole results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calreticulin

increases expression

Clotrimazole results in increased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 12

decreases expression

Clotrimazole results in decreased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions

Clotrimazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 mRNA]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP3 protein]

PMID:22033380 PMID:24239969

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Clotrimazole inhibits the reaction [lead acetate results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 17

decreases expression

Clotrimazole results in decreased expression of CCDC17 mRNA

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

G

coiled-coil domain containing 28A

decreases expression

Clotrimazole results in decreased expression of CCDC28A mRNA

NCBI chr 1:12,857,668...12,872,944
Ensembl chr 1:12,857,666...12,873,003

G

centriole, cilia and spindle-associated protein

decreases expression

Clotrimazole results in decreased expression of CCSAP mRNA

NCBI chr19:51,824,954...51,843,469
Ensembl chr19:51,826,994...51,842,753

G

Cd81 molecule

increases expression

Clotrimazole results in increased expression of CD81 mRNA

NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660

G

CD93 molecule

increases expression

Clotrimazole results in increased expression of CD93 mRNA

NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378

G

cell death-inducing p53 target 1

decreases expression

Clotrimazole results in decreased expression of CDIP1 mRNA

NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980

G

cyclin-dependent kinase 1

decreases expression

Clotrimazole results in decreased expression of CDK1

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

decreases expression

Clotrimazole results in decreased expression of CDK4

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Clotrimazole results in decreased expression of CDKN1A

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Clotrimazole results in increased expression of CDKN1B

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

decreases expression

Clotrimazole results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

centromere protein J

decreases expression

Clotrimazole results in decreased expression of CENPJ mRNA

NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791

G

coiled-coil-helix-coiled-coil-helix domain containing 1

increases expression

Clotrimazole results in increased expression of CHCHD1 mRNA

NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901

G

chromodomain helicase DNA binding protein 2

decreases expression

Clotrimazole results in decreased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

G

carbohydrate sulfotransferase 1

increases expression

Clotrimazole results in increased expression of CHST1 mRNA

NCBI chr 3:78,552,059...78,574,740
Ensembl chr 3:78,548,525...78,574,883

G

ciliary microtubule associated protein 1C

increases expression

Clotrimazole results in increased expression of CIMAP1C mRNA

NCBI chr 8:57,248,746...57,281,084
Ensembl chr 8:57,248,746...57,281,004

G

CDGSH iron sulfur domain 2

increases expression

Clotrimazole results in increased expression of CISD2 mRNA

NCBI chr 2:223,828,937...223,853,768
Ensembl chr 2:223,828,937...223,868,946

G

chloride voltage-gated channel 3

increases expression

Clotrimazole results in increased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

CDC-like kinase 2

decreases expression

Clotrimazole results in decreased expression of CLK2 mRNA

NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985

G

calponin 2

increases expression

Clotrimazole results in increased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

collagen type I alpha 1 chain

decreases expression

Clotrimazole results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type VI alpha 2 chain

increases expression

Clotrimazole results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VII alpha 1 chain

decreases expression

Clotrimazole results in decreased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

collagen type IX alpha 2 chain

decreases expression

Clotrimazole results in decreased expression of COL9A2 mRNA

NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677

G

COMM domain containing 2

increases expression

Clotrimazole results in increased expression of COMMD2 mRNA

NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888

G

coronin 2B

increases expression

Clotrimazole results in increased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

cytochrome c oxidase subunit 7A2

increases expression

Clotrimazole results in increased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 8A

increases expression

Clotrimazole results in increased expression of COX8A mRNA

NCBI chr 1:204,402,118...204,404,439

G

carboxypeptidase Z

decreases expression

Clotrimazole results in decreased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

cAMP responsive element binding protein 3-like 2

increases expression

Clotrimazole results in increased expression of CREB3L2 mRNA

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

G

cysteine-rich secretory protein 1

decreases expression

Clotrimazole results in decreased expression of CRISP1 mRNA

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

Clotrimazole results in increased expression of CYP1A1 protein
Clotrimazole results in decreased activity of CYP1A1 protein

PMID:7986207 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
multiple interactions

Clotrimazole results in increased expression of CYP1A2 protein
Clotrimazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]

PMID:7986207 PMID:19858067

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Clotrimazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases activity
increases expression

Clotrimazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]
Clotrimazole results in increased activity of CYP2B1 protein
Clotrimazole results in increased expression of CYP2B1 mRNA; Clotrimazole results in increased expression of CYP2B1 protein

PMID:1372805 PMID:7986207 PMID:19858067 PMID:36356836

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Clotrimazole results in increased expression of CYP2B2 mRNA; Clotrimazole results in increased expression of CYP2B2 protein

PMID:7986207 PMID:12971794

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression
increases activity

Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]
NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]
Clotrimazole results in increased expression of CYP2B6 protein
Clotrimazole results in increased activity of CYP2B6 protein

PMID:12049174 PMID:12571232 PMID:12695351 PMID:14977870

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

Clotrimazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Clotrimazole results in decreased expression of CYP2C11 protein

PMID:7986207 PMID:19858067

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

Clotrimazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

Clotrimazole results in decreased activity of CYP2C8 protein

PMID:15601807 PMID:33775687

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Clotrimazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily j, polypeptide 3

decreases expression

Clotrimazole results in decreased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
increases expression
increases activity

Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]
Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]
Clotrimazole results in decreased activity of CYP3A4 protein
Clotrimazole results in increased expression of CYP3A4 mRNA; Clotrimazole results in increased expression of CYP3A4 protein
Clotrimazole results in increased activity of CYP3A4 protein

PMID:8632764 PMID:12065438 PMID:12505310 PMID:12673034 PMID:14977870 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
multiple interactions

Clotrimazole results in increased expression of CYP3A23-3A1 mRNA
Clotrimazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]

PMID:12971794 PMID:16125621 PMID:19858067

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

Clotrimazole results in increased expression of CYP3A5 protein

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 51

decreases activity
decreases response to substance

Clotrimazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Clotrimazole

PMID:16989930 PMID:18694951

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

DAB adaptor protein 2

increases expression

Clotrimazole results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

drebrin 1

increases expression

Clotrimazole results in increased expression of DBN1 mRNA

NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984

G

dachsous cadherin-related 1

increases expression

Clotrimazole results in increased expression of DCHS1 mRNA

NCBI chr 1:160,104,931...160,138,958
Ensembl chr 1:160,104,931...160,124,808

G

doublecortin-like kinase 1

decreases expression

Clotrimazole results in decreased expression of DCLK1 mRNA

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

DExD-box helicase 39A

increases expression

Clotrimazole results in increased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Clotrimazole results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

double C2 domain beta

increases expression

Clotrimazole results in increased expression of DOC2B mRNA

NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267

G

docking protein 4

increases expression

Clotrimazole results in increased expression of DOK4 mRNA

NCBI chr19:10,146,520...10,157,187
Ensembl chr19:10,146,474...10,158,203

G

diphthamide biosynthesis 3

increases expression

Clotrimazole results in increased expression of DPH3 mRNA

NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265

G

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

increases expression

Clotrimazole results in increased expression of DPM1 mRNA

NCBI chr 3:156,919,979...156,939,522
Ensembl chr 3:156,919,979...156,939,536

G

DS cell adhesion molecule

decreases expression

Clotrimazole results in decreased expression of DSCAM mRNA

NCBI chr11:35,921,924...36,507,100
Ensembl chr11:35,926,896...36,507,415

G

EP300 interacting inhibitor of differentiation 2

increases expression

Clotrimazole results in increased expression of EID2 mRNA

NCBI chr 1:83,538,274...83,539,599

G

eukaryotic translation initiation factor 2A

multiple interactions
increases phosphorylation

[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

endoglin

increases expression

Clotrimazole results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

erythrocyte membrane protein band 4.1-like 2

increases expression

Clotrimazole results in increased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

epoxide hydrolase 1

increases activity

Clotrimazole results in increased activity of EPHX1 protein

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

EPS8-like 1

decreases expression

Clotrimazole results in decreased expression of EPS8L1 mRNA

NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

Clotrimazole results in decreased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endothelial cell adhesion molecule

increases expression

Clotrimazole results in increased expression of ESAM mRNA

NCBI chr 8:37,238,228...37,249,217
Ensembl chr 8:37,238,287...37,249,215

G

F2R like trypsin receptor 1

multiple interactions

Clotrimazole inhibits the reaction [F2RL1 protein results in increased transport of Chlorides]

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

family with sequence similarity 110, member B

decreases expression

Clotrimazole results in decreased expression of FAM110B mRNA

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828

G

family with sequence similarity 120 member B

increases expression

Clotrimazole results in increased expression of FAM120B mRNA

NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061

G

family with sequence similarity 124 member A

decreases expression

Clotrimazole results in decreased expression of FAM124A mRNA

NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683

G

family with sequence similarity 167, member B

increases expression

Clotrimazole results in increased expression of FAM167B mRNA

NCBI chr 5:141,920,695...141,922,342
Ensembl chr 5:141,920,695...141,922,340

G

FA complementation group I

increases expression

Clotrimazole results in increased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

Fas cell surface death receptor

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

four and a half LIM domains 2

increases expression

Clotrimazole results in increased expression of FHL2 mRNA

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Clotrimazole results in decreased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follistatin-like 1

increases expression

Clotrimazole results in increased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

FXYD domain-containing ion transport regulator 5

increases expression

Clotrimazole results in increased expression of FXYD5 mRNA

NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519

G

galanin receptor 2

decreases expression

Clotrimazole results in decreased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

glucosidase, alpha; neutral C

decreases expression

Clotrimazole results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

growth associated protein 43

decreases expression

Clotrimazole results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

golgi associated RAB2 interactor 5A

decreases expression

Clotrimazole results in decreased expression of FAM71E1 mRNA

NCBI chr 1:94,988,959...94,995,971
Ensembl chr 1:94,988,613...94,993,539

G

gem (nuclear organelle) associated protein 7-like 1

increases expression

Clotrimazole results in increased expression of GEMIN7L1 mRNA

NCBI chr 4:78,269,910...78,270,681
Ensembl chr 4:78,269,888...78,270,669

G

glial fibrillary acidic protein

increases expression

Clotrimazole results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gliomedin

decreases expression

Clotrimazole results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

glutaredoxin 2

increases expression

Clotrimazole results in increased expression of GLRX2 mRNA

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

glutamic-oxaloacetic transaminase 1

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glypican 3

decreases expression

Clotrimazole results in decreased expression of GPC3 mRNA

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

G protein-coupled receptor 62

decreases expression

Clotrimazole results in decreased expression of GPR62 mRNA

NCBI chr 8:107,103,225...107,105,311
Ensembl chr 8:107,103,980...107,105,056

G

glutamic--pyruvic transaminase

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

GRAM domain containing 1A

decreases expression

Clotrimazole results in decreased expression of GRAMD1A mRNA

NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

Clotrimazole results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

Gse1 coiled-coil protein

decreases expression

Clotrimazole results in decreased expression of GSE1 mRNA

NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458

G

glutathione S-transferase alpha 2

increases expression

Clotrimazole results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 2

decreases expression

Clotrimazole results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions

Clotrimazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

guanylate cyclase activator 1A

increases expression

Clotrimazole results in increased expression of GUCA1A mRNA

NCBI chr 9:13,588,988...13,598,566
Ensembl chr 9:13,588,525...13,598,565

G

guanylate cyclase 1 soluble subunit alpha 1

increases expression

Clotrimazole results in increased expression of GUCY1A3 mRNA

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

decreases expression

Clotrimazole results in decreased expression of HERC1 mRNA

NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312

G

huntingtin interacting protein 1

increases expression

Clotrimazole results in increased expression of HIP1 mRNA

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

G

histone cluster 1 H2B family member D

increases expression

Clotrimazole results in increased expression of HIST1H2BD mRNA

NCBI chr17:42,792,887...42,793,268

G

hexokinase 2

affects localization
decreases expression

Clotrimazole affects the localization of HK2 protein
Clotrimazole results in decreased expression of HK2 mRNA

PMID:20724915 PMID:25863232

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

increases expression

Clotrimazole results in increased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

HPS4, biogenesis of lysosomal organelles complex 3 subunit 2

decreases expression

Clotrimazole results in decreased expression of HPS4 mRNA

NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632

G

heat shock transcription factor 1

increases activity

Clotrimazole results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 4

increases expression

Clotrimazole results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family E (Hsp10) member 1

increases expression

Clotrimazole results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interferon-induced protein 44

decreases expression

Clotrimazole results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon alpha and beta receptor subunit 2

decreases expression

Clotrimazole results in decreased expression of IFNAR2 mRNA

NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124

G

insulin-like growth factor 2 mRNA binding protein 2

increases expression

Clotrimazole results in increased expression of IGF2BP2 mRNA

NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377

G

insulin-like growth factor binding protein 1

increases expression
increases secretion

Clotrimazole results in increased expression of IGFBP1 mRNA
Clotrimazole results in increased secretion of IGFBP1 protein

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

immunoglobulin superfamily, member 10

decreases expression

Clotrimazole results in decreased expression of IGSF10 mRNA

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

interleukin 34

increases expression

Clotrimazole results in increased expression of IL34 mRNA

NCBI chr19:38,714,990...38,782,749
Ensembl chr19:38,714,991...38,764,000

G

inositol polyphosphate-5-phosphatase D

increases expression

Clotrimazole results in increased expression of INPP5D mRNA

NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746

G

integrator complex subunit 14

increases expression

Clotrimazole results in increased expression of VWA9 mRNA

NCBI chr 8:65,475,788...65,500,807
Ensembl chr 8:65,475,910...65,500,804

G

inositol hexakisphosphate kinase 2

decreases expression

Clotrimazole results in decreased expression of IP6K2 mRNA

NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166

G

integrin subunit alpha 9

increases expression

Clotrimazole results in increased expression of ITGA9 mRNA

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

G

integrin subunit beta 1

increases expression

Clotrimazole results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

inter-alpha trypsin inhibitor, heavy chain 3

increases expression

Clotrimazole results in increased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Clotrimazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 1

decreases expression

Clotrimazole results in decreased expression of KCNJ1 mRNA

NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796

G

potassium calcium-activated channel subfamily N member 4

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]
Clotrimazole results in decreased activity of KCNN4 protein

PMID:14985237 PMID:15921678 PMID:17699636 PMID:20050851 PMID:22033380

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

lysine demethylase 4A

decreases expression

Clotrimazole results in decreased expression of KDM4A mRNA

NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501

G

lecithin cholesterol acyltransferase

decreases expression

Clotrimazole results in decreased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LHFPL tetraspan subfamily member 5

decreases expression

Clotrimazole results in decreased expression of LHFPL5 mRNA

NCBI chr20:6,632,324...6,642,534
Ensembl chr20:6,632,362...6,642,532

G

LIM zinc finger domain containing 2

decreases expression

Clotrimazole results in decreased expression of LIMS2 mRNA

NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137

G

lipase G, endothelial type

decreases expression

Clotrimazole results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lysyl oxidase-like 1

increases expression

Clotrimazole results in increased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

LDL receptor related protein 1

decreases expression

Clotrimazole results in decreased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

limbic system-associated membrane protein

decreases expression

Clotrimazole results in decreased expression of LSAMP mRNA

NCBI chr11:58,547,533...60,717,328
Ensembl chr11:58,554,805...60,717,029

G

latent transforming growth factor beta binding protein 4

decreases expression

Clotrimazole results in decreased expression of LTBP4 mRNA

NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178

G

mitogen activated protein kinase 14

multiple interactions

MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

microtubule-associated protein tau

decreases expression

Clotrimazole results in decreased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

myristoylated alanine rich protein kinase C substrate

increases expression

Clotrimazole results in increased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

microtubule affinity regulating kinase 3

increases expression

Clotrimazole results in increased expression of MARK3 mRNA

NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647

G

muscleblind-like splicing regulator 1

decreases expression

Clotrimazole results in decreased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

multiple coagulation factor deficiency 2, ER cargo receptor complex subunit

increases expression

Clotrimazole results in increased expression of MCFD2 mRNA

NCBI chr 6:7,274,469...7,285,841
Ensembl chr 6:7,274,469...7,285,841

G

microfibril associated protein 2

decreases expression

Clotrimazole results in decreased expression of MFAP2 mRNA

NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259

G

mirror-image polydactyly 1

decreases expression

Clotrimazole results in decreased expression of MIPOL1 mRNA

NCBI chr 6:74,755,293...75,090,403
Ensembl chr 6:74,755,395...75,086,811

G

microRNA 96

increases expression

Clotrimazole results in increased expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

G

MLLT3, super elongation complex subunit

increases expression

Clotrimazole results in increased expression of MLLT3 mRNA

NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361

G

maturin, neural progenitor differentiation regulator homolog

decreases expression

Clotrimazole results in decreased expression of MTURN mRNA

NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950

G

matrix remodeling associated 8

decreases expression

Clotrimazole results in decreased expression of MXRA8 mRNA

NCBI chr 5:166,448,919...166,453,645
Ensembl chr 5:166,449,154...166,453,636

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Clotrimazole results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myc target 1

increases expression

Clotrimazole results in increased expression of MYCT1 mRNA

NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:42,018,137...42,029,410

G

myelin expression factor 2

increases expression

Clotrimazole results in increased expression of MYEF2 mRNA

NCBI chr 3:112,338,241...112,374,122
Ensembl chr 3:112,338,241...112,374,181

G

myosin light chain 9

increases expression

Clotrimazole results in increased expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin XVI

increases expression

Clotrimazole results in increased expression of MYO16 mRNA

NCBI chr16:78,884,405...79,364,445
Ensembl chr16:78,884,406...79,248,388

G

myosin Ib

increases expression

Clotrimazole results in increased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

N-acetylated alpha-linked acidic dipeptidase-like 2

decreases expression

Clotrimazole results in decreased expression of NAALADL2 mRNA

NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689

G

NACC family member 2

decreases expression

Clotrimazole results in decreased expression of NACC2 mRNA

NCBI chr 3:8,879,952...8,946,660
Ensembl chr 3:8,883,065...8,946,660

G

nuclear receptor coactivator 1

multiple interactions

Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]

PMID:17998298 PMID:18973326 PMID:21924250

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor co-repressor 1

multiple interactions

Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

Nedd4 family interacting protein 2

increases expression

Clotrimazole results in increased expression of NDFIP2 mRNA

NCBI chr15:82,032,366...82,087,043
Ensembl chr15:82,032,366...82,086,317

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

Clotrimazole results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase complex assembly factor 7

increases expression

Clotrimazole results in increased expression of NDUFAF7 mRNA

NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810

G

NADH:ubiquinone oxidoreductase subunit B5

increases expression

Clotrimazole results in increased expression of NDUFB5 mRNA

NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589

G

NADH:ubiquinone oxidoreductase core subunit S3

increases expression

Clotrimazole results in increased expression of NDUFS3 mRNA

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

NADH:ubiquinone oxidoreductase subunit S6

increases expression

Clotrimazole results in increased expression of NDUFS6 mRNA

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

Clotrimazole results in decreased expression of NEDD4 mRNA

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

niban apoptosis regulator 1

increases expression

Clotrimazole results in increased expression of FAM129A mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

nidogen 1

increases expression

Clotrimazole results in increased expression of NID1 mRNA

NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267

G

nipsnap homolog 1

decreases expression

Clotrimazole results in decreased expression of NIPSNAP1 mRNA

NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098

G

nipsnap homolog 3A (C. elegans)

increases expression

Clotrimazole results in increased expression of NIPSNAP3B mRNA

NCBI chr 5:67,613,993...67,625,067
Ensembl chr 5:67,614,036...67,669,700

G

NIN1 (RPN12) binding protein 1 homolog

decreases expression

Clotrimazole results in decreased expression of NOB1 mRNA

NCBI chr19:35,322,803...35,335,354
Ensembl chr19:35,322,669...35,346,815

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
increases expression

Clotrimazole binds to and results in increased activity of NR1I2 protein; Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]
Clotrimazole results in increased activity of NR1I2 protein
Clotrimazole results in increased expression of NR1I2 mRNA

PMID:12049174 PMID:12065438 PMID:12695351 PMID:14977870 PMID:15548381 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
decreases activity
increases activity
affects binding

1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Clotrimazole binds to NR1I3 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; androstan-3-ol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol A inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]; Clotrimazole binds to and affects the activity of NR1I3 protein; Clotrimazole binds to and results in decreased activity of NR1I3 protein; Clotrimazole binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form; Clotrimazole binds to and results in increased activity of NR1I3 protein alternative form; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to and results in increased activity of NR1I3 protein mutant form]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole results in decreased activity of NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form
Clotrimazole results in decreased activity of NR1I3 protein; Clotrimazole results in decreased activity of NR1I3 protein alternative form
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form; Clotrimazole results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]; Clotrimazole inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; Clotrimazole inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form
Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]; NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]

PMID:12049174 PMID:15905360 PMID:16919048 PMID:18973326 PMID:20686338 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuronal cell adhesion molecule

decreases expression

Clotrimazole results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

NSFL1 cofactor

increases expression

Clotrimazole results in increased expression of NSFL1C mRNA

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

G

NudC domain containing 2

increases expression

Clotrimazole results in increased expression of NUDCD2 mRNA

NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738

G

nudix hydrolase 12

decreases expression

Clotrimazole results in decreased expression of NUDT12 mRNA

NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039

G

ornithine decarboxylase 1

increases expression

Clotrimazole results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

optineurin

increases expression

Clotrimazole results in increased expression of OPTN mRNA

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

origin recognition complex, subunit 1

increases expression

Clotrimazole results in increased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

purinergic receptor P2X 3

decreases expression

Clotrimazole results in decreased expression of P2RX3 mRNA

NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178

G

pecanex 4

decreases expression

Clotrimazole results in decreased expression of PCNXL4 mRNA

NCBI chr 6:91,125,063...91,170,423
Ensembl chr 6:91,125,063...91,170,439

G

platelet derived growth factor receptor beta

increases expression

Clotrimazole results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pyruvate dehydrogenase complex, component X

increases expression

Clotrimazole results in increased expression of PDHX mRNA

NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773

G

protein disulfide isomerase family A, member 4

increases expression

Clotrimazole results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

peroxisomal biogenesis factor 2

increases expression

Clotrimazole results in increased expression of PEX2 mRNA

NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404

G

phosphofructokinase, muscle

decreases expression

Clotrimazole results in decreased expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphofructokinase, platelet

affects localization

Clotrimazole affects the localization of PFKP protein

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

PHD finger protein 1

decreases expression

Clotrimazole results in decreased expression of PHF1 mRNA

NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871

G

protein inhibitor of activated STAT, 1

decreases expression

Clotrimazole results in decreased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

PTEN induced kinase 1

decreases expression

Clotrimazole results in decreased expression of PINK1 mRNA

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

phospholipase A1 member A

increases expression

Clotrimazole results in increased expression of PLA1A mRNA

NCBI chr11:62,320,112...62,357,779
Ensembl chr11:62,320,493...62,357,779

G

plasminogen activator, urokinase

decreases expression

Clotrimazole results in decreased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipase C, eta 2

decreases expression

Clotrimazole results in decreased expression of PLCH2 mRNA

NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356

G

pleckstrin homology domain containing O1

increases expression

Clotrimazole results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

G

podocalyxin-like

increases expression

Clotrimazole results in increased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase epsilon 3, accessory subunit

increases expression

Clotrimazole results in increased expression of POLE3 mRNA

NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

decreases expression

Clotrimazole results in decreased expression of PPM1J mRNA

NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882

G

protein phosphatase 1, regulatory subunit 9A

decreases expression

Clotrimazole results in decreased expression of PPP1R9A mRNA

NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907

G

peroxiredoxin 2

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; Clotrimazole inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase C, eta

increases expression

Clotrimazole results in increased expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

protein kinase D2

decreases expression

Clotrimazole results in decreased expression of PRKD2 mRNA

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

paired related homeobox 1

increases expression

Clotrimazole results in increased expression of PRRX1 mRNA

NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866

G

serine protease 41

decreases expression

Clotrimazole results in decreased expression of PRSS41 mRNA

NCBI chr10:12,865,872...12,873,552
Ensembl chr10:12,865,872...12,873,552

G

PC4 and SRSF1 interacting protein 1

increases expression

Clotrimazole results in increased expression of PSIP1 mRNA

NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257

G

prostaglandin F2 receptor inhibitor

increases expression

Clotrimazole results in increased expression of PTGFRN mRNA

NCBI chr 2:188,469,521...188,544,795
Ensembl chr 2:188,469,521...188,544,795

G

RAB11 family interacting protein 4

increases expression

Clotrimazole results in increased expression of RAB11FIP4 mRNA

NCBI chr10:64,550,109...64,658,123
Ensembl chr10:64,550,177...64,654,759

G

RAB9A, member RAS oncogene family

decreases expression

Clotrimazole results in decreased expression of RAB9A mRNA

NCBI chr X:27,955,552...28,009,870
Ensembl chr X:27,952,204...28,001,622

G

RAD18 E3 ubiquitin protein ligase

increases expression

Clotrimazole results in increased expression of RAD18 mRNA

NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069

G

ralA binding protein 1

decreases expression

Clotrimazole results in decreased expression of RALBP1 mRNA

NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707

G

Ras interacting protein 1

increases expression

Clotrimazole results in increased expression of RASIP1 mRNA

NCBI chr 1:96,097,135...96,109,564
Ensembl chr 1:96,091,074...96,109,562

G

retinol binding protein 2

increases expression

Clotrimazole results in increased expression of RBP2 mRNA

NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473

G

replication factor C subunit 2

increases expression

Clotrimazole results in increased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

raftlin family member 2

decreases expression

Clotrimazole results in decreased expression of RFTN2 mRNA

NCBI chr 9:56,651,617...56,707,830
Ensembl chr 9:56,630,460...56,707,810

G

regucalcin

decreases expression

Clotrimazole results in decreased expression of RGN mRNA

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

regulator of G-protein signaling 5

increases expression

Clotrimazole results in increased expression of RGS5 mRNA

NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518

G

regulator of G protein signaling 9 binding protein

decreases expression

Clotrimazole results in decreased expression of RGS9BP mRNA

NCBI chr 1:88,249,438...88,250,151
Ensembl chr 1:88,249,438...88,250,151

G

Rab interacting lysosomal protein-like 1

decreases expression

Clotrimazole results in decreased expression of RILPL1 mRNA

NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938

G

ring finger protein 8

decreases expression

Clotrimazole results in decreased expression of RNF8 mRNA

NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491

G

ribosomal protein S27-like

increases expression

Clotrimazole results in increased expression of RPS27L mRNA

NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418

G

ribosomal protein S6 kinase B2

decreases expression

Clotrimazole results in decreased expression of RPS6KB2 mRNA

NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078

G

round spermatid basic protein 1

decreases expression

Clotrimazole results in decreased expression of RSBN1 mRNA

NCBI chr 2:191,416,631...191,470,711
Ensembl chr 2:191,416,631...191,470,711

G

schwannomin interacting protein 1

increases expression

Clotrimazole results in increased expression of SCHIP1 mRNA

NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585

G

succinate dehydrogenase complex subunit D

increases expression

Clotrimazole results in increased expression of SDHD mRNA

NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238

G

SUMO specific peptidase 7

decreases expression

Clotrimazole results in decreased expression of SENP7 mRNA

NCBI chr11:44,423,733...44,584,129
Ensembl chr11:44,423,735...44,564,711

G

SUMO peptidase family member, NEDD8 specific

decreases expression

Clotrimazole results in decreased expression of SENP8 mRNA

NCBI chr 8:60,135,446...60,148,836
Ensembl chr 8:60,121,714...60,148,928

G

serpin family F member 1

decreases expression

Clotrimazole results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

serum/glucocorticoid regulated kinase 1

increases expression

Clotrimazole results in increased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sialic acid binding Ig like lectin 1

decreases expression

Clotrimazole results in decreased expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

signal-induced proliferation-associated 1

increases expression

Clotrimazole results in increased expression of SIPA1 mRNA

NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591

G

solute carrier family 19 member 1

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Clotrimazole results in decreased activity of SLC19A1 protein

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 25 member 14

decreases expression

Clotrimazole results in decreased expression of SLC25A14 mRNA

NCBI chr X:127,807,630...127,845,823
Ensembl chr X:127,807,449...127,845,823

G

sphingomyelin phosphodiesterase 1

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

increases expression

Clotrimazole results in increased expression of SNRNP27 mRNA

NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234

G

sorting nexin 16

decreases expression

Clotrimazole results in decreased expression of SNX16 mRNA

NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619

G

sorting nexin 24

decreases expression

Clotrimazole results in decreased expression of SNX24 mRNA

NCBI chr18:46,670,987...46,826,070
Ensembl chr18:46,671,443...46,826,068

G

sorting nexin 33

decreases expression

Clotrimazole results in decreased expression of SNX33 mRNA

NCBI chr 8:57,315,861...57,328,522
Ensembl chr 8:57,317,161...57,327,538

G

sorbitol dehydrogenase

increases expression

Clotrimazole results in increased expression of SORD mRNA

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

serine palmitoyltransferase, small subunit A

increases expression

Clotrimazole results in increased expression of SPTSSA mRNA

NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214

G

signal recognition particle 9

increases expression

Clotrimazole results in increased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

G

sushi-repeat-containing protein, X-linked

decreases expression

Clotrimazole results in decreased expression of SRPX mRNA

NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882

G

sushi-repeat-containing protein, X-linked 2

increases expression

Clotrimazole results in increased expression of SRPX2 mRNA

NCBI chr X:97,106,455...97,132,197
Ensembl chr X:97,106,561...97,132,195

G

sarcospan

decreases expression

Clotrimazole results in decreased expression of SSPN mRNA

NCBI chr 4:178,890,030...178,946,267
Ensembl chr 4:178,897,147...178,931,554

G

SH3 and cysteine rich domain

increases expression

Clotrimazole results in increased expression of STAC mRNA

NCBI chr 8:111,530,800...111,653,228
Ensembl chr 8:111,530,800...111,654,008

G

stonin 1

decreases expression

Clotrimazole results in decreased expression of RAET1L mRNA

NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449

G

serine/threonine/tyrosine interacting-like 1

decreases expression

Clotrimazole results in decreased expression of STYXL1 mRNA

NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752

G

sulfotransferase family 1A member 1

decreases expression

Clotrimazole results in decreased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

decreases expression

Clotrimazole results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

SURF1, cytochrome c oxidase assembly factor

decreases expression

Clotrimazole results in decreased expression of SURF1 mRNA

NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315

G

spectrin repeat containing nuclear envelope protein 2

decreases expression

Clotrimazole results in decreased expression of SYNE2 mRNA

NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064

G

tafazzin, phospholipid-lysophospholipid transacylase

increases expression

Clotrimazole results in increased expression of TAZ mRNA

NCBI chr X:152,065,539...152,076,178
Ensembl chr X:152,065,609...152,074,001

G

transgelin

increases expression

Clotrimazole results in increased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

tet methylcytosine dioxygenase 3

decreases expression

Clotrimazole results in decreased expression of TET3 mRNA

NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193

G

transforming growth factor, beta 1

increases expression

Clotrimazole results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

decreases expression

Clotrimazole results in decreased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

THAP domain containing 3

decreases expression

Clotrimazole results in decreased expression of THAP3 mRNA

NCBI chr 5:162,488,480...162,494,149
Ensembl chr 5:162,488,480...162,494,149

G

transmembrane p24 trafficking protein 4

increases expression

Clotrimazole results in increased expression of TMED4 mRNA

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631

G

transmembrane p24 trafficking protein 7

increases expression

Clotrimazole results in increased expression of TMED7 mRNA

NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640

G

transmembrane protein with EGF-like and two follistatin-like domains 2

multiple interactions

[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein

NCBI chr 9:50,445,947...50,733,473
Ensembl chr 9:50,436,079...50,733,475

G

transmembrane protein 116

decreases expression

Clotrimazole results in decreased expression of TMEM116 mRNA

NCBI chr12:35,021,912...35,089,409
Ensembl chr12:35,041,572...35,089,430

G

transmembrane protein 39b

decreases expression

Clotrimazole results in decreased expression of TMEM39B mRNA

NCBI chr 5:142,024,271...142,046,607
Ensembl chr 5:142,024,273...142,046,549

G

transmembrane protein 88

increases expression

Clotrimazole results in increased expression of TMEM88 mRNA

NCBI chr10:54,118,752...54,120,447
Ensembl chr10:54,118,752...54,120,447

G

transmembrane protein 97

increases expression

Clotrimazole results in increased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

transmembrane serine protease 9

decreases expression

Clotrimazole results in decreased expression of TMPRSS9 mRNA

NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177

G

tankyrase 1 binding protein 1

increases expression

Clotrimazole results in increased expression of TNKS1BP1 mRNA

NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038

G

tenascin XA, pseudogene 1

decreases expression

Clotrimazole results in decreased expression of TNXA-PS1 mRNA

NCBI chr20:4,026,471...4,027,826

G

tumor protein p53

increases expression

Clotrimazole results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 2

increases expression

Clotrimazole results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

Tnf receptor associated factor 4

increases expression

Clotrimazole results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

transient receptor potential cation channel, subfamily C, member 6

increases expression

Clotrimazole results in increased expression of TRPC6 mRNA

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]

PMID:21900507 PMID:22036725

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

thiosulfate sulfurtransferase like domain containing 2

decreases expression

Clotrimazole results in decreased expression of TSTD2 mRNA

NCBI chr 5:60,371,751...60,415,916
Ensembl chr 5:60,393,454...60,415,916

G

tetratricopeptide repeat domain 33

decreases expression

Clotrimazole results in decreased expression of TTC33 mRNA

NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:54,279,997...54,323,871

G

tubulin, beta 2A class IIa

increases expression

Clotrimazole results in increased expression of TUBB2A mRNA

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

taxilin alpha

increases expression

Clotrimazole results in increased expression of TXLNA mRNA

NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583

G

U2 snRNP-associated SURP domain containing

decreases expression

Clotrimazole results in decreased expression of U2SURP mRNA

NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691

G

UDP glucuronosyltransferase family 1 member A1

affects expression

Clotrimazole affects the expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UPF2, regulator of nonsense mediated mRNA decay

decreases expression

Clotrimazole results in decreased expression of UPF2 mRNA

NCBI chr17:72,224,575...72,335,896
Ensembl chr17:72,225,316...72,335,855

G

ubiquinol-cytochrome c reductase, complex III subunit X

increases expression

Clotrimazole results in increased expression of UQCR10 mRNA

NCBI chr14:79,566,151...79,569,017
Ensembl chr14:79,566,157...79,569,003

G

vasohibin 2

increases expression

Clotrimazole results in increased expression of VASH2 mRNA

NCBI chr13:102,529,718...102,561,204
Ensembl chr13:102,529,719...102,560,391

G

vascular endothelial growth factor A

multiple interactions
increases secretion

[Clotrimazole co-treated with Imatinib Mesylate] results in increased secretion of VEGFA protein
Clotrimazole results in increased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

Wnt family member 2

decreases expression

Clotrimazole results in decreased expression of WNT2 mRNA

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

G

exportin 4

decreases expression

Clotrimazole results in decreased expression of XPO4 mRNA

NCBI chr15:31,717,016...31,807,723
Ensembl chr15:31,716,762...31,807,908

G

zinc finger and BTB domain containing 10

decreases expression

Clotrimazole results in decreased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger protein 407

increases expression

Clotrimazole results in increased expression of ZFP407 mRNA

NCBI chr18:77,571,140...77,970,282
Ensembl chr18:77,571,204...77,974,129

G

zinc finger and SCAN domain containing 2

decreases expression

Clotrimazole results in decreased expression of ZSCAN2 mRNA

NCBI chr 1:134,833,701...134,848,957
Ensembl chr 1:134,833,871...134,848,952

econazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase 9

increases activity

Econazole results in increased activity of ADCY9 protein

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
Econazole results in increased expression of CYP3A4 mRNA
Econazole results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:17998298

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases response to substance

CYP51A1 gene results in decreased susceptibility to Econazole

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

glutathione S-transferase pi 1

multiple interactions

Econazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

potassium voltage-gated channel subfamily A member 3

multiple interactions
decreases activity

[Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions

Econazole results in decreased activity of KCNH2 protein
[Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor coactivator 1

multiple interactions

Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Econazole binds to and results in increased activity of NR1I2 protein; Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA2 protein

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 22 member 2

multiple interactions

Econazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

[Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

unc-51 like autophagy activating kinase 1

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein; dorsomorphin inhibits the reaction [[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein]

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

enilconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

enilconazole results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

decreases expression

enilconazole results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression
multiple interactions
increases expression

enilconazole results in decreased expression of ABCC3 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA
enilconazole results in increased expression of ABCC3 mRNA

PMID:29451352 PMID:33426623

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 3

decreases expression

enilconazole results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

acyl-CoA oxidase 1

decreases expression

enilconazole results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

adenosine kinase

increases expression

enilconazole results in increased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
multiple interactions
increases expression

enilconazole results in decreased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA
enilconazole results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA

PMID:32201337 PMID:33426623

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

decreases expression
multiple interactions

enilconazole results in decreased expression of ALDH2 mRNA
[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein

PMID:32201337 PMID:34830855

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

anoctamin 1

decreases expression

enilconazole results in decreased expression of ANO1 mRNA

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

annexin A10

increases expression

enilconazole results in increased expression of ANXA10 mRNA

NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648

G

androgen receptor

multiple interactions
affects binding
decreases expression

Dihydrotestosterone inhibits the reaction [enilconazole results in increased activity of AR protein]; enilconazole inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; enilconazole inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]
enilconazole binds to AR protein
enilconazole results in decreased expression of AR mRNA

PMID:15064155 PMID:18324785 PMID:21310686 PMID:30853599 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

decreases expression

enilconazole results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ATPase phospholipid transporting 8B1

increases expression

enilconazole results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

catalase

increases expression

enilconazole results in increased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 5

increases expression

enilconazole results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

carboxylesterase 2H

multiple interactions
decreases expression

[enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein
enilconazole results in decreased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

CF transmembrane conductance regulator

affects binding
decreases expression

enilconazole binds to CFTR protein
enilconazole results in decreased expression of CFTR mRNA; enilconazole results in decreased expression of CFTR protein

PMID:29106682 PMID:32814239

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

catechol-O-methyltransferase

increases expression

enilconazole results in increased expression of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome P450, family 11, subfamily a, polypeptide 1

affects expression

enilconazole affects the expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

enilconazole results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
affects secretion

enilconazole results in decreased activity of CYP19A1 protein
enilconazole affects the secretion of CYP19A1 mRNA

PMID:10806373 PMID:15554355 PMID:26141389 PMID:30853599

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
increases expression

enilconazole results in increased activity of CYP1A1 protein
enilconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
enilconazole results in increased expression of CYP1A1 mRNA; enilconazole results in increased expression of CYP1A1 protein

PMID:19070657 PMID:21762035 PMID:32194361

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
multiple interactions

enilconazole affects the expression of CYP1A2 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

enilconazole results in increased expression of CYP1B1 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

enilconazole results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

enilconazole results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression
affects expression

[enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
enilconazole results in increased expression of CYP2B10
enilconazole affects the expression of CYP2B6 mRNA

PMID:27853109 PMID:32201337

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

enilconazole results in decreased expression of CYP2C19 mRNA; enilconazole results in decreased expression of CYP2C19 protein

PMID:32194361 PMID:32201337

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases expression

[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
enilconazole results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects expression
decreases activity
multiple interactions
increases expression

enilconazole affects the expression of CYP3A4 mRNA
enilconazole results in decreased activity of CYP3A4 protein
[Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA
enilconazole results in increased expression of CYP3A4 protein

PMID:21762035 PMID:25028461 PMID:32201337 PMID:34273450

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A23-3A1 mRNA
enilconazole results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression
multiple interactions

enilconazole results in increased expression of CYP3A5 mRNA; enilconazole results in increased expression of CYP3A5 protein
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 51

decreases activity

enilconazole results in decreased activity of CYP51A1 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

enilconazole results in decreased expression of CYP7A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA
enilconazole results in decreased expression of CYP7A1 mRNA; enilconazole results in decreased expression of CYP7A1 protein

PMID:29451352 PMID:32194361 PMID:32201337 PMID:32814239 PMID:33426623

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

enilconazole results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

increases expression

enilconazole results in increased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

defensin alpha 3

decreases expression

enilconazole results in decreased expression of DEFA3 mRNA

NCBI chr16:70,533,436...70,535,592
Ensembl chr16:70,533,436...70,535,604

G

dynamin 1

decreases expression

enilconazole results in decreased expression of DNM1 mRNA

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

G

elastin

decreases expression
multiple interactions

enilconazole results in decreased expression of ELN mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

estrogen receptor 1

multiple interactions

enilconazole binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

decreases expression
multiple interactions

enilconazole results in decreased expression of ESR2 mRNA
enilconazole binds to and results in increased activity of ESR2 protein

PMID:30853599 PMID:33049310

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 6

decreases expression

enilconazole results in decreased expression of FABP6 mRNA

NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282

G

Fas cell surface death receptor

increases expression

enilconazole results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor 19

decreases expression
increases expression

enilconazole results in decreased expression of FGF15 mRNA
enilconazole results in increased expression of FGF15 mRNA

PMID:29451352 PMID:32814239

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

enilconazole results in decreased expression of G6PC1 mRNA

PMID:32194361 PMID:32201337

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutathione peroxidase 1

increases expression

enilconazole results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

enilconazole results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione-disulfide reductase

increases expression

enilconazole results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

decreases expression

enilconazole results in decreased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

H2A.X variant histone

multiple interactions

[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

enilconazole results in decreased expression of HAAO mRNA

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

3-hydroxy-3-methylglutaryl-CoA reductase

affects expression

enilconazole affects the expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

affects expression

enilconazole affects the expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hydroxysteroid (17-beta) dehydrogenase 13

decreases expression

enilconazole results in decreased expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

affects expression

enilconazole affects the expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

interferon gamma

increases expression

enilconazole results in increased expression of IFNG mRNA

PMID:27393971 PMID:32814239

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 17A

multiple interactions
increases expression

enilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
enilconazole results in increased expression of IL17A mRNA

PMID:22289359 PMID:32814239

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 alpha

increases expression

enilconazole results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

enilconazole results in increased expression of IL1B mRNA

PMID:27393971 PMID:32814239

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

enilconazole results in increased expression of IL6 mRNA

PMID:27393971 PMID:32201337 PMID:32814239

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

enilconazole results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

ketohexokinase

decreases expression

enilconazole results in decreased expression of KHK mRNA

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

KLF transcription factor 4

affects expression
decreases expression

enilconazole affects the expression of KLF4 mRNA
enilconazole results in decreased expression of KLF4 mRNA

PMID:29106682 PMID:32814239

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kyphoscoliosis peptidase

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA
enilconazole results in decreased expression of KY mRNA

NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024

G

lipocalin 2

increases expression

enilconazole results in increased expression of LCN2

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

luteinizing hormone subunit beta

decreases expression

enilconazole results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipoprotein lipase

increases expression

enilconazole results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lymphocyte antigen 6 family member D

decreases expression

enilconazole results in decreased expression of LY6D mRNA

NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733

G

mitogen-activated protein kinase 8

increases expression

enilconazole results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

multiple EGF-like-domains 11

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA
enilconazole results in decreased expression of MEGF11 mRNA

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

meprin A subunit beta

affects expression
decreases expression

enilconazole affects the expression of MEP1B mRNA
enilconazole results in decreased expression of MEP1B mRNA

PMID:29106682 PMID:32814239

NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840

G

MLX interacting protein-like

decreases expression

enilconazole results in decreased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

G

membrane metallo-endopeptidase

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA
enilconazole results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

microsomal triglyceride transfer protein

decreases expression

enilconazole results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

mucin 1, cell surface associated

affects expression
decreases expression

enilconazole affects the expression of MUC1 mRNA
enilconazole results in decreased expression of MUC1 mRNA

PMID:29106682 PMID:32814239

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 17, cell surface associated

decreases expression

enilconazole results in decreased expression of MUC17 mRNA

NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522

G

mucin 2, oligomeric mucus/gel-forming

affects expression
decreases expression

enilconazole affects the expression of MUC2 mRNA
enilconazole results in decreased expression of MUC2 mRNA

PMID:29106682 PMID:32814239

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
decreases expression

[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA
enilconazole results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression
increases expression

enilconazole results in decreased expression of NR1H4 mRNA
enilconazole results in increased expression of NR1H4 mRNA

PMID:29451352 PMID:32814239

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein; enilconazole binds to and results in increased activity of NR1I2 protein; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
enilconazole results in increased activity of NR1I2 protein

PMID:16565514 PMID:17438109 PMID:21115097 PMID:25028461 PMID:29973476 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
affects response to substance

enilconazole binds to and results in increased activity of NR1I3 protein; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]
NR1I3 protein affects the susceptibility to enilconazole

PMID:18832183 PMID:27853109

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

pyruvate dehydrogenase kinase 4

decreases expression

enilconazole results in decreased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

patatin-like phospholipase domain containing 3

decreases expression

enilconazole results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

peroxisome proliferator-activated receptor gamma

multiple interactions

enilconazole binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

decreases expression

enilconazole results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[enilconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

retinoic acid receptor, alpha

increases activity

enilconazole results in increased activity of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, gamma

increases activity

enilconazole results in increased activity of RARG protein

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

resistin like beta

affects expression

enilconazole affects the expression of RETNLB mRNA

NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368

G

regulator of cell cycle

increases expression

enilconazole results in increased expression of RGCC mRNA

NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141

G

RAR-related orphan receptor A

multiple interactions

enilconazole binds to and results in decreased activity of RORA protein

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

stearoyl-CoA desaturase

decreases expression

enilconazole results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 10 member 1

decreases expression

enilconazole results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 10 member 2

increases expression

enilconazole results in increased expression of SLC10A2 mRNA

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 12 member 2

decreases expression

enilconazole results in decreased expression of SLC12A2 mRNA; enilconazole results in decreased expression of SLC12A2 protein

PMID:29106682 PMID:32814239

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 22 member 5

decreases expression

enilconazole results in decreased expression of SLC22A5 mRNA; enilconazole results in decreased expression of SLC22A5 protein

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 26 member 3

decreases expression

enilconazole results in decreased expression of SLC26A3 mRNA; enilconazole results in decreased expression of SLC26A3 protein

PMID:29106682 PMID:32814239

NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772

G

solute carrier family 26 member 6

decreases expression

enilconazole results in decreased expression of SLC26A6 mRNA; enilconazole results in decreased expression of SLC26A6 protein

PMID:29106682 PMID:32814239

NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778

G

solute carrier family 6 member 1

multiple interactions

[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier family 9 member A3

decreases expression

enilconazole results in decreased expression of SLC9A3 mRNA

PMID:29106682 PMID:32814239

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

solute carrier organic anion transporter family, member 4a1

increases expression

enilconazole results in increased expression of SLCO4A1 mRNA

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

superoxide dismutase 1

increases expression

enilconazole results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

enilconazole results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

steroidogenic acute regulatory protein

affects expression
decreases expression

enilconazole affects the expression of STAR mRNA
enilconazole results in decreased expression of STAR mRNA

PMID:30853599 PMID:36410587

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

sulfotransferase family 1B member 1

decreases expression

enilconazole results in decreased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

sulfotransferase family 1C member 2A

increases expression

enilconazole results in increased expression of SULT1C2 mRNA

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

trefoil factor 3

decreases expression

enilconazole results in decreased expression of TFF3 mRNA

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

thyroid hormone receptor alpha

multiple interactions

enilconazole binds to and results in decreased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

tumor necrosis factor

increases expression

enilconazole results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 2 member B7

decreases expression

enilconazole results in decreased expression of UGT2B7 mRNA

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

fluconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 9

decreases expression

Fluconazole results in decreased expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Fluconazole results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

aldo-keto reductase family 7 member A3

increases expression

Fluconazole results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

apolipoprotein A4

decreases expression

Fluconazole results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

carboxylesterase 2H

increases expression

Fluconazole results in increased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects activity

Fluconazole affects the activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity

[Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Fluconazole results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

Fluconazole results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

Fluconazole results in increased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression

NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]

PMID:16730040 PMID:25656644

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

Fluconazole results in decreased expression of CYP2C mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

Fluconazole results in increased expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity
increases expression
multiple interactions
increases metabolic processing

Fluconazole results in decreased activity of CYP2C19 protein
Fluconazole results in increased expression of CYP2C29 mRNA
[Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased metabolism of Fluconazole

PMID:12464242 PMID:15843491 PMID:16730040 PMID:17702393 PMID:19328226 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily g, polypeptide 1

decreases expression

Fluconazole results in decreased expression of CYP2G1 mRNA

NCBI chr 1:82,145,635...82,156,862
Ensembl chr 1:82,145,073...82,156,828

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases expression

Fluconazole results in decreased expression of CYP2J9 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Fluconazole results in decreased activity of CYP3A4 protein

PMID:15784650 PMID:15843491

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
affects expression

Fluconazole results in increased expression of CYP3A23-3A1 mRNA
Fluconazole affects the expression of CYP3A23-3A1 mRNA

PMID:16643972 PMID:20623750

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

Fluconazole results in increased expression of CYP3A13 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 51

decreases activity
decreases response to substance
multiple interactions

Fluconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Fluconazole
CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]

PMID:16989930 PMID:18694951

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

glutathione S-transferase mu 1

increases expression

Fluconazole results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

Fluconazole results in decreased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lipocalin 2

increases expression

Fluconazole results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

microtubule affinity regulating kinase 2

increases expression

Fluconazole results in increased expression of MARK2 mRNA

NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652

G

myeloperoxidase

increases expression

Fluconazole results in increased expression of MPO mRNA

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Fluconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects response to substance
increases response to substance
multiple interactions

NR1I3 protein affects the susceptibility to Fluconazole
NR1I3 results in increased susceptibility to Fluconazole
NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP2B10 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of CYP3A11 mRNA]; NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]

PMID:23721867 PMID:25656644

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

cytochrome p450 oxidoreductase

decreases expression
multiple interactions
increases expression

Fluconazole results in decreased expression of POR mRNA
NR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]

PMID:16643972 PMID:16730040 PMID:25656644

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxisome proliferator-activated receptor gamma

increases expression

Fluconazole results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

solute carrier family 13 member 2

decreases expression

Fluconazole results in decreased expression of SLC13A2 mRNA

NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127

G

solute carrier family 6 member 13

decreases expression

Fluconazole results in decreased expression of SLC6A13 mRNA

NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152

G

solute carrier organic anion transporter family, member 1a4

increases expression

Fluconazole results in increased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

steroid 5 alpha-reductase 1

decreases expression

Fluconazole results in decreased expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

steroidogenic acute regulatory protein

increases expression

Fluconazole results in increased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

UDP glucuronosyltransferase family 1 member A9

affects expression

Fluconazole affects the expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

Fluconazole results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol]

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

isoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

isoconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

itraconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

Itraconazole results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects activity
decreases activity
multiple interactions
affects transport

Itraconazole affects the activity of ABCB1 protein
Itraconazole results in decreased activity of ABCB1 protein
Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]
ABCB1 protein affects the transport of Itraconazole

PMID:15905803 PMID:15964336 PMID:15969931 PMID:16084853

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

activin A receptor type 1C

increases expression

Itraconazole results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

aryl hydrocarbon receptor

multiple interactions

AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

amidohydrolase domain containing 1

decreases expression

Itraconazole results in decreased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

androgen receptor

multiple interactions

Itraconazole binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BicC family RNA binding protein 1

decreases expression

Itraconazole results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

C-C motif chemokine ligand 5

multiple interactions

Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

carboxypeptidase N subunit 2

decreases expression

Itraconazole results in decreased expression of CPN2 mRNA

NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472

G

C-X-C motif chemokine ligand 10

multiple interactions

Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

increases expression

Itraconazole results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

Itraconazole binds to and results in decreased activity of CYP11B1 protein

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Itraconazole binds to and results in decreased activity of CYP11B2 protein

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases activity

Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 protein
Itraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 protein
Itraconazole results in decreased activity of CYP1A1 protein

PMID:17283379 PMID:28390928

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

decreases activity

Itraconazole results in decreased activity of CYP24A1 protein

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases hydroxylation
affects activity
decreases activity
affects metabolic processing
increases metabolic processing
decreases expression

Itraconazole binds to and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Itraconazole
Itraconazole affects the activity of CYP3A4 protein
Itraconazole results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Itraconazole
CYP3A4 protein results in increased metabolism of Itraconazole
Itraconazole results in decreased expression of CYP3A4 mRNA; Itraconazole results in decreased expression of CYP3A4 protein

PMID:15328084 PMID:15383492 PMID:15447735 PMID:15684493 PMID:15784650 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases activity
decreases response to substance
multiple interactions

Itraconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Itraconazole
CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]

PMID:16989930 PMID:18694951

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

DNA cross-link repair 1C

increases expression

Itraconazole results in increased expression of DCLRE1C mRNA

NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186

G

DNA-damage inducible transcript 3

increases expression

Itraconazole results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dystrobrevin, alpha

decreases expression

Itraconazole results in decreased expression of DTNA mRNA

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

Itraconazole results in decreased expression of ENPP3 mRNA

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Itraconazole results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen related receptor, alpha

decreases expression

Itraconazole results in decreased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

fatty acid binding protein 5

increases expression

Itraconazole results in increased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Itraconazole results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

Itraconazole results in decreased expression of GFPT1 mRNA

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

gap junction protein, beta 1

decreases expression

Itraconazole results in decreased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

GLI family zinc finger 1

decreases expression

Itraconazole analog results in decreased expression of GLI1 mRNA; Itraconazole results in decreased expression of GLI1 mRNA

PMID:21936514 PMID:33905526

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glutamic-oxaloacetic transaminase 1

increases expression

Itraconazole results in increased expression of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

G protein-coupled receptor 6

decreases expression

Itraconazole results in decreased expression of GPR6 mRNA

NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624

G

glutamic--pyruvic transaminase

increases expression

Itraconazole results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione S-transferase pi 1

multiple interactions

Itraconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

GULP PTB domain containing engulfment adaptor 1

decreases expression

Itraconazole results in decreased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

G

high mobility group AT-hook 2

increases expression

Itraconazole results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Itraconazole results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Itraconazole results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Itraconazole results in decreased activity of HSD11B2 protein

PMID:28131847 PMID:29385285 PMID:33387577

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

Indian hedgehog signaling molecule

decreases expression

Itraconazole results in decreased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 12B

increases expression

Itraconazole results in increased expression of IL12B mRNA

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 4

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]

PMID:11886533 PMID:15284827 PMID:23688403

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

G

methyl-CpG binding domain protein 1

increases expression

Itraconazole results in increased expression of MBD1 mRNA

NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554

G

myelin transcription factor 1

increases expression

Itraconazole results in increased expression of MYT1 mRNA

NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341

G

nuclear receptor coactivator 1

multiple interactions

Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NFKB inhibitor alpha

multiple interactions

Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]
Itraconazole results in increased expression of NQO1 mRNA; Itraconazole results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression

Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]
Itraconazole results in increased expression of NR1I2 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

ornithine decarboxylase antizyme 3

decreases expression

Itraconazole results in decreased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

PNMA family member 2

increases expression

Itraconazole results in increased expression of PNMA2 mRNA

NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427

G

patched 1

decreases expression

Itraconazole results in decreased expression of PTCH1 mRNA

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

Rap guanine nucleotide exchange factor 4

decreases expression

Itraconazole results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

regulator of G-protein signaling 16

decreases expression

Itraconazole results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

ribonuclease P and MRP subunit p25

increases expression

Itraconazole results in increased expression of RPP25 mRNA

NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732

G

semaphorin 3E

increases expression

Itraconazole results in increased expression of SEMA3E mRNA

NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229

G

solute carrier family 25 member 36

increases expression

Itraconazole results in increased expression of SLC25A36 mRNA

NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703

G

smoothened, frizzled class receptor

decreases expression

Itraconazole results in decreased expression of SMO mRNA

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

signal transducer and activator of transcription 1

multiple interactions

Itraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

syntaxin 8

increases expression

Itraconazole results in increased expression of STX8 mRNA

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

synaptonemal complex protein 3

increases expression

Itraconazole results in increased expression of SYCP3 mRNA

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

TBC1 domain family member 9

increases expression

Itraconazole results in increased expression of TBC1D9 mRNA

NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129

G

transmembrane protein 138

decreases expression

Itraconazole results in decreased expression of TMEM138 mRNA

NCBI chr 1:207,219,113...207,226,159

G

thymosin beta 4, X-linked

decreases expression

Itraconazole results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

tumor necrosis factor

multiple interactions

Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thymic stromal lymphopoietin

multiple interactions

4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

tetraspanin 8

decreases expression

Itraconazole results in decreased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

zinc finger protein 451

increases expression

Itraconazole results in increased expression of ZFP451 mRNA

NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652

ketoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

Ketoconazole results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

aminoadipate aminotransferase

affects expression

Ketoconazole affects the expression of AADAT mRNA

NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332

G

angio-associated, migratory cell protein

increases expression

Ketoconazole results in increased expression of AAMP mRNA

NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547

G

apoptosis antagonizing transcription factor

decreases expression

Ketoconazole results in decreased expression of AATF mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

4-aminobutyrate aminotransferase

increases expression

Ketoconazole results in increased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]
Ketoconazole results in decreased expression of ABCA1 mRNA

PMID:14690017 PMID:37077353

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 3

decreases expression

Ketoconazole results in decreased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases transport
decreases expression
multiple interactions
affects expression
decreases activity

ABCB1 protein results in increased transport of Ketoconazole
Ketoconazole results in decreased expression of ABCB1A mRNA
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]
Ketoconazole affects the expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole results in decreased activity of ABCB1 protein
[Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA]

PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCB4 protein
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA

PMID:28437613 PMID:30985903

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCC2 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]

PMID:19070657 PMID:19766108

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily D member 2

increases expression

Ketoconazole results in increased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily G member 2

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA]
Ketoconazole results in increased expression of ABCG2 mRNA

PMID:32185415 PMID:37077353

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABRA C-terminal like

decreases expression

Ketoconazole results in decreased expression of ABRACL mRNA

NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207

G

acetyl-CoA acyltransferase 1A

increases expression

Ketoconazole results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA acyltransferase 2

increases expression

Ketoconazole results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acyl-CoA dehydrogenase, long chain

increases expression

Ketoconazole results in increased expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

increases expression

Ketoconazole results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

increases expression

Ketoconazole results in increased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

angiotensin converting enzyme 2

increases expression

Ketoconazole results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 8

increases expression

Ketoconazole results in increased expression of ACOT8 mRNA

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

G

acyl-CoA synthetase long-chain family member 4

decreases expression

Ketoconazole results in decreased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

increases expression

Ketoconazole results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

Ketoconazole results in decreased expression of ACSM1 mRNA

NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495

G

ADAM metallopeptidase domain 9

affects expression

Ketoconazole affects the expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenylate cyclase 6

decreases expression

Ketoconazole results in decreased expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Ketoconazole results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

acireductone dioxygenase 1

decreases expression

Ketoconazole results in decreased expression of ADI1 mRNA

NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842

G

adiponectin, C1Q and collagen domain containing

increases expression

Ketoconazole results in increased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

increases expression

Ketoconazole results in increased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adenosine A1 receptor

increases expression

Ketoconazole results in increased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adrenoceptor beta 2

increases expression

Ketoconazole results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AE binding protein 2

decreases expression

Ketoconazole results in decreased expression of AEBP2 mRNA

NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100

G

alkylglycerone phosphate synthase

increases expression

Ketoconazole results in increased expression of AGPS mRNA

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

agouti related neuropeptide

decreases expression

Ketoconazole results in decreased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

angiotensinogen

increases expression

Ketoconazole results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions
increases expression
increases activity

AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]
Ketoconazole results in increased expression of AHR mRNA
Ketoconazole results in increased activity of AHR protein
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]

PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA
Ketoconazole results in increased expression of AHRR mRNA

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

alpha-2-HS-glycoprotein

increases expression

Ketoconazole results in increased expression of AHSG mRNA

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

A-kinase anchoring protein 12

decreases expression

Ketoconazole results in decreased expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldo-keto reductase family 1, member B7

increases expression

Ketoconazole results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldo-keto reductase family 1, member C15

increases expression

Ketoconazole results in increased expression of AKR1C15 mRNA

NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061

G

5'-aminolevulinate synthase 1

increases expression

Ketoconazole results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

affects expression

Ketoconazole affects the expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Ketoconazole affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

Ketoconazole results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

alkB homolog 7

decreases expression

Ketoconazole results in decreased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]
Ketoconazole results in increased expression of ALPL protein

PMID:21542014 PMID:31099283

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

amidohydrolase domain containing 1

decreases expression

Ketoconazole results in decreased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

anti-Mullerian hormone

increases expression

Ketoconazole results in increased expression of AMH protein

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

angiogenin

increases expression

Ketoconazole results in increased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

annexin A1

decreases expression

Ketoconazole results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

aldehyde oxidase 1

decreases expression

Ketoconazole results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Ketoconazole results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 3 subunit mu 1

decreases expression

Ketoconazole results in decreased expression of AP3M1 mRNA

NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844

G

apoptotic peptidase activating factor 1

decreases expression

Ketoconazole results in decreased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apolipoprotein A1

increases expression

Ketoconazole results in increased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A4

affects expression

Ketoconazole affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

increases expression

Ketoconazole results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

androgen receptor

multiple interactions
decreases expression
increases activity
decreases activity

[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Ketoconazole results in decreased expression of AR protein
Ketoconazole results in increased activity of AR protein
Ketoconazole results in decreased activity of AR protein

PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

increases expression

Ketoconazole results in increased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ankyrin repeat and SOCS box-containing 17

increases expression

Ketoconazole results in increased expression of ASB17 mRNA

NCBI chr 2:242,775,887...242,786,950
Ensembl chr 2:242,775,994...242,786,903

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Ketoconazole results in increased expression of ASNS mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

Ketoconazole results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 2

increases expression

Ketoconazole results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 1

multiple interactions

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

ATP synthase membrane subunit c locus 2

increases expression

Ketoconazole results in increased expression of ATP5MC2 mRNA

NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733

G

ATP synthase peripheral stalk subunit OSCP

increases expression

Ketoconazole results in increased expression of ATP5PO mRNA

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit D

increases expression

Ketoconazole results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

arginine vasopressin

increases expression

Ketoconazole results in increased expression of AVP mRNA

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

beta-secretase 1

decreases expression

Ketoconazole results in decreased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

increases expression

Ketoconazole results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA]

PMID:21542014 PMID:31629065

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA]

PMID:21542014 PMID:31629065

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

increases expression

Ketoconazole results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

beclin 1

increases expression

Ketoconazole results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

betaine-homocysteine S-methyltransferase

affects expression

Ketoconazole affects the expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

BicC family RNA binding protein 1

decreases expression

Ketoconazole results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

BH3 interacting domain death agonist

increases expression

Ketoconazole results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

increases expression

Ketoconazole results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 5

increases expression

Ketoconazole results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 2

multiple interactions

Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

decreases expression

Ketoconazole results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

increases expression

Ketoconazole results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

basonuclin zinc finger protein 1

decreases expression

Ketoconazole results in decreased expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

BCL2 interacting protein 1

increases expression

Ketoconazole results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 2

increases expression

Ketoconazole results in increased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BCL2 interacting protein 3

increases expression

Ketoconazole results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

decreases expression

Ketoconazole results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

similar to human chromosome 5 open reading frame 15

increases expression

Ketoconazole results in increased expression of C5ORF15 mRNA

NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1 mRNA

NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831

G

C1GALT1-specific chaperone 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C3

increases expression

Ketoconazole results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 1 open reading frame 174

increases expression

Ketoconazole results in increased expression of C1ORF174 mRNA

NCBI chr 5:164,515,578...164,520,022
Ensembl chr 5:164,515,559...164,520,021

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

Ketoconazole results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel subunit alpha1 I

decreases expression

Ketoconazole results in decreased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

increases expression

Ketoconazole results in increased expression of CACNA2D3 mRNA

NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

increases expression

Ketoconazole results in increased expression of CACNA2D4 mRNA

NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Ketoconazole results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit gamma 3

increases expression

Ketoconazole results in increased expression of CACNG3 mRNA

NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024

G

calcium voltage-gated channel auxiliary subunit gamma 4

decreases expression

Ketoconazole results in decreased expression of CACNG4 mRNA

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

calbindin 1

decreases expression

Ketoconazole results in decreased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calbindin 2

decreases expression

Ketoconazole results in decreased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

cyclase associated actin cytoskeleton regulatory protein 1

increases expression

Ketoconazole results in increased expression of CAP1 mRNA

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

carbonic anhydrase 2

increases expression

Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

capping protein regulator and myosin 1 linker 1

decreases expression

Ketoconazole results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

caspase 12

increases expression

Ketoconazole results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
multiple interactions

Ketoconazole results in increased activity of CASP3 protein
Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]

PMID:17936189 PMID:19631732

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

decreases expression
increases expression

Ketoconazole results in decreased expression of CASP6 mRNA
Ketoconazole results in increased expression of CASP6 mRNA

PMID:25787151 PMID:25808816

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

Ketoconazole results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8 associated protein 2

affects expression

Ketoconazole affects the expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

caspase 9

increases expression

Ketoconazole results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

Ketoconazole results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Ketoconazole results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

chromobox 7

increases expression

Ketoconazole results in increased expression of CBX7 mRNA

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

coiled-coil domain containing 8

increases expression

Ketoconazole results in increased expression of CCDC8 mRNA

NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090

G

cholecystokinin

increases expression

Ketoconazole results in increased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
Ketoconazole results in increased expression of CCL2 mRNA

PMID:16784723 PMID:37077353

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 27

multiple interactions

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 5

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole results in increased expression of CCL5 mRNA

PMID:16784723 PMID:23688403 PMID:37077353

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression
affects expression

Ketoconazole results in increased expression of CCN1 mRNA
Ketoconazole affects the expression of CCN1 mRNA

PMID:36621641 PMID:36653537

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin G1

increases expression

Ketoconazole results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd200 molecule

increases expression

Ketoconazole results in increased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

Cd247 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263

G

CD274 molecule

decreases expression

Ketoconazole results in decreased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd28 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD3 delta subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

CD3 epsilon subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

CD3 gamma subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

Cd47 molecule

increases expression

Ketoconazole results in increased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CDC42 effector protein 2

decreases expression

Ketoconazole results in decreased expression of CDC42EP2 mRNA

NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897

G

CDC42 effector protein 3

increases expression