Mtor Rat Gene (mechanistic target of rapamycin (serine/threonine kinase))

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Keyword

Gene:
Mtor ( Rattus norvegicus )
mechanistic target of rapamycin (serine/threonine kinase)
Description: binds the complex formed by the immunosuppressive drug rapamycin and its receptor FKBP12; may play a role in the cell cycle G1 to S transition
Synonyms: Frap1; mTOR; FK506 binding protein 12-rapamycin associated protein 1 ; rapamycin and FKBP12 target-1 protein; RAFT1; FK506 binding protein 12-rapamycin associated protein 1;
ArrayIDs: 6126412; 6376629; 6588697; 6273295; 5757965; 5923553; 6591300; 6174668; A_44_P191924; 5851449; 6518591; 5736535; 5742739; 5961658; 6150134; 6590522; 6319680; 5861867; 6657797; U11681_at; 5718937; 5821186; 1368019_at; 6595856; 6346926; 6547964; 6154185; 5653404; 6681248; 5741861; 6465452; 6629838; 6299716; 6171383; 5894924; 5877340; 6431960; GE21733; 6723987; 6632005; 6003596; 5787513; 5826934; 6671984; 6298579; 6454671; 6097724; 6216951; 6076507; 6586171; GE20707; 6707937; 6221876; 5976838; 5647502; 6506422; 6252135; 6661522; 5858828; 6111341; 6617157; 6335854; A_43_P12053; 6045358; 5653372; 5911020; 6061323; 6208453;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: MTOR     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Mtor     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Mtor genome assembly 3.1 5 165541594 - 165651087
Rat Celera Assembly 5 157161444 - 157270899
RGSC genome assembly v3.4 5 165531392 - 165640899
Cytogenetic 5 q36
Mus musculus Mtor Mouse genome assembly build 36.1 4 147822716 - 147931792
Cytogenetic 4 4 E1
Homo sapiens MTOR human genome assembly 1 11100857 - 11256830
Human genome assembly build 36.2 1 11089179 - 11245153
Cytogenetic 1 p36.2

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

nucleotide binding,  drug binding,  kinase activity ... (details...)
Biological Process

Gene Ontology

peptidyl-threonine phosphorylation,  negative regulation of macroautophagy,  positive regulation of protein kinase B signaling cascade ... (details...)
Cellular Component

Gene Ontology

nucleus,  mitochondrion,  soluble fraction ... (details...)
Disease

Ontology

Hypertrophy, Left Ventricular (details...)
Pathway

Ontology

mTOR signaling pathway (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: PI3Kc IPI
PROSITE: FAT IPI
PROSITE: PI3_4_KINASE_1 IPI
PROSITE: PI3_4_KINASE_3 IPI
PROSITE: PI3_4_KINASE_2 IPI
PROSITE: FATC IPI
UNIPARC: UPI000012ABD4 IPI
KEGG Report: rno:56718 ENTREZGENE
HomoloGene Group ID: 3637 ENTREZGENE
Germonline: 68371
Pfam: FAT IPI
Pfam: Rapamycin_bind IPI
Pfam: FATC IPI
Pfam: PI3_PI4_kinase IPI
KEGG Pathway: 05221 ENTREZGENE
KEGG Pathway: 05214 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04920 ENTREZGENE
KEGG Pathway: 04150 ENTREZGENE
KEGG Pathway: 04930 ENTREZGENE
KEGG Pathway: 05215 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 04910 ENTREZGENE
InterPro: ARM-like. IPI
InterPro: ARM-type_fold. IPI
InterPro: FATC. IPI
InterPro: FKBP_rapamycin-assoc_FKBP12-bd. IPI
InterPro: PIK_FAT. IPI
InterPro: PIK-rel_kinase_FAT. IPI
InterPro: PI3/4_kinase_CS. IPI
InterPro: PI3/4_kinase_cat. IPI
InterPro: Kinase-like_dom. IPI
IPI: IPI00339164 IPI
Ensembl Protein: ENSRNOP00000014167 IPI
Gene3D-CATH: FRAP_FKBP12_bd IPI
Gene3D-CATH: PI3/4_kinase_cat IPI
Gene3D-CATH: ARM-like IPI
Entrez Gene: Mtor ENTREZGENE
TIGR: TC218708
UniProt: FRAP_RAT IPI
Ensembl Genes: ENSRNOG00000009615 IPI
Superfamily-SCOP: FRAP_FKBP12_bind IPI
Superfamily-SCOP: ARM-type_fold IPI
Superfamily-SCOP: Kinase_like IPI
Sequences
Nucleotide: CH473968 Get FASTA Search GEO Profiles
Nucleotide: L37085 Get FASTA Search GEO Profiles
Nucleotide: U11681 Get FASTA Search GEO Profiles
Nucleotide: NM_019906 Get FASTA Search GEO Profiles
(View all 4 Nucleotide Accessions)
Protein: P42346 Get FASTA
Protein: NP_063971 Get FASTA
Protein: EDL81121 Get FASTA
Protein: AAA20091 Get FASTA
Protein: AAA65929 Get FASTA
(View all 5 Protein Accessions)
Clusters
UniGene: 11008

References
Curated References
18 references in RGD related to Mtor

Other References
91 other references at PubMed related to Mtor

Database Information
RGD ID 68371
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

12-JUN-09: Mtor mechanistic target of rapamycin (serine/threonine kinase) Frap1 FK506 binding protein 12-rapamycin associated protein 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

10-JUN-02: Frap1 FK506 binding protein 12-rapamycin associated protein 1 APPROVED Name updated 70584