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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtorincreases expressionEXP 6480464CTDGlucose results in increased expression of MTOR protein; Glucose results in increased expression of MTOR protein modified formPMID:22561310
Mtorincreases phosphorylationEXP 6480464CTDGlucose results in increased phosphorylation of MTOR proteinPMID:28713934
Mtormultiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [Glucose results in increased phosphorylation of MTOR protein]PMID:28713934
Mtordecreases uptakeISOMtor (Mus musculus)6480464CTDMTOR gene mutant form results in decreased uptake of GlucosePMID:29384525
Mtorincreases activityISOMtor (Mus musculus)6480464CTDGlucose results in increased activity of MTOR proteinPMID:19765649
Mtorincreases phosphorylationISOMTOR (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of MTOR proteinPMID:31494106
Mtorincreases phosphorylationISOMtor (Mus musculus)6480464CTDGlucose results in increased phosphorylation of MTOR proteinPMID:30459625
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTD[Glucose promotes the reaction [MTOR protein binds to YY1 protein]] which results in increased expression of YY1 protein; FOXP1 protein inhibits the reaction [Glucose results in increased phosphorylation of MTOR protein]PMID:31494106 PMID:35445903
Mtormultiple interactionsISOMtor (Mus musculus)6480464CTDHU 308 inhibits the reaction [Glucose results in increased phosphorylation of MTOR protein]; Resveratrol inhibits the reaction [Glucose results in increased activity of MTOR protein]PMID:19765649 PMID:30459625
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