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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtormultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein]; Quercetin inhibits the reaction [Levetiracetam results in decreased expression of MTOR protein]PMID:25164625 PMID:37098359
Mtordecreases phosphorylationISOMTOR (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of MTOR proteinPMID:23094058 PMID:25293876
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTD[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein; [Quercetin co-treated with Arachidonic Acid] results in decreased phosphorylation of MTOR protein; Quercetin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of MTOR protein]PMID:20551291 PMID:23094058 PMID:25380086 PMID:27470402
Mtormultiple interactionsISOMtor (Mus musculus)6480464CTDQuercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR mRNA]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of MTOR protein]PMID:24025686
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