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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtordecreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of MTOR proteinPMID:24534837 PMID:24599349
Mtorincreases expressionEXP 6480464CTDresveratrol results in increased expression of MTOR mRNAPMID:26071184
Mtormultiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased activity of MTOR protein]; Resveratrol inhibits the reaction [Glucose results in increased phosphorylation of MTOR protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of MTOR mRNA]PMID:23211629 PMID:24599349 PMID:26071184 PMID:28713934
Mtoraffects expressionISOMTOR (Homo sapiens)6480464CTDresveratrol affects the expression of MTOR mRNAPMID:18586690
Mtordecreases activityISOMTOR (Homo sapiens)6480464CTDresveratrol results in decreased activity of MTOR proteinPMID:21321189 PMID:22574221
Mtordecreases expressionISOMTOR (Homo sapiens)6480464CTDresveratrol results in decreased expression of MTOR protein modified formPMID:17825886 PMID:22234583
Mtordecreases phosphorylationISOMTOR (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of MTOR proteinPMID:21168265 PMID:21179458 PMID:23292070 PMID:24331535
Mtordecreases phosphorylationISOMtor (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of MTOR proteinPMID:20851890 PMID:26223300
Mtorincreases expressionISOMTOR (Homo sapiens)6480464CTDresveratrol results in increased expression of MTOR mRNAPMID:12002526
Mtorincreases phosphorylationISOMtor (Mus musculus)6480464CTDresveratrol results in increased phosphorylation of MTOR proteinPMID:22363816
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTD[[Resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein; [Resveratrol results in decreased activity of MTOR protein] which results in decreased expression of DDIT3 protein; [Resveratrol results in decreased activity of MTOR protein] which results in decreased expression of PKM mRNA; [Resveratrol results in decreased activity of MTOR protein] which results in decreased expression of PKM protein; [Resveratrol results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [Resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein; dorsomorphin inhibits the reaction [Resveratrol results in decreased phosphorylation of MTOR protein]; Niacinamide inhibits the reaction [Resveratrol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein]; PTEN protein promotes the reaction [Resveratrol results in decreased phosphorylation of MTOR protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]; Resveratrol promotes the reaction [Temozolomide results in decreased phosphorylation of MTOR protein]; Resveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein; Resveratrol results in decreased phosphorylation of and results in increased expression of MTOR protein; TSC2 protein promotes the reaction [[[Resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein]PMID:19928762 PMID:20169165 PMID:21168265 PMID:21321189 PMID:22530672 PMID:22574221 PMID:23363784 PMID:25895606
Mtormultiple interactionsISOMtor (Mus musculus)6480464CTD[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein; [[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]; [resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; [resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]; [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol affects the susceptibility to Lipopolysaccharides]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; [Sirolimus results in decreased activity of MTOR protein] which results in decreased susceptibility to resveratrol; resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein]; resveratrol inhibits the reaction [Glucose results in increased activity of MTOR protein]; resveratrol inhibits the reaction [TNF protein results in decreased phosphorylation of MTOR protein]; resveratrol inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; resveratrol promotes the reaction [MTOR protein binds to DEPTOR protein]; resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]; resveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein; TSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]PMID:19765649 PMID:20851890 PMID:21321189 PMID:22069489 PMID:22363816 PMID:22530672 PMID:23274061 PMID:24534773 PMID:26074695
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