GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mtor | decreases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in decreased phosphorylation of MTOR protein | PMID:19801490 PMID:35134463 PMID:36639017 | Mtor | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of MTOR mRNA; Doxorubicin results in increased expression of MTOR protein | PMID:34933056 | Mtor | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MTOR protein | PMID:32525084 | Mtor | multiple interactions | EXP | | 6480464 | CTD | Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR protein]; MTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]; MTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]; NRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]; SC-66 compound inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein] | PMID:19801490 PMID:32525084 PMID:34933056 PMID:35134463 PMID:36639017 | Mtor | decreases expression | ISO | MTOR (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of MTOR mRNA | PMID:34719826 | Mtor | decreases phosphorylation | ISO | Mtor (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased phosphorylation of MTOR protein | PMID:26450947 PMID:35134463 PMID:36639017 | Mtor | decreases response to substance | ISO | Mtor (Mus musculus) | 6480464 | CTD | MTOR protein results in decreased susceptibility to Doxorubicin | PMID:19103993 | Mtor | increases phosphorylation | ISO | Mtor (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MTOR protein | PMID:34296331 | Mtor | multiple interactions | ISO | MTOR (Homo sapiens) | 6480464 | CTD | Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA] | PMID:34719826 | Mtor | multiple interactions | ISO | Mtor (Mus musculus) | 6480464 | CTD | corosolic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein]; Doxorubicin results in decreased activity of and results in decreased phosphorylation of MTOR protein; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]; SC-66 compound inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein] | PMID:19103993 PMID:34296331 PMID:35134463 PMID:36639017 | | ||||||||||||||||||||||
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