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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtordecreases expressionISOMTOR (Homo sapiens)6480464CTDvorinostat results in decreased expression of MTOR protein; vorinostat results in decreased expression of MTOR protein modified formPMID:18850582
Mtordecreases phosphorylationISOMTOR (Homo sapiens)6480464CTDvorinostat results in decreased phosphorylation of MTOR proteinPMID:20543569 PMID:20962572
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTDvorinostat results in decreased phosphorylation of and results in decreased activity of MTOR proteinPMID:17881280
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