RGD Reference Report - Molecular mechanisms of mTOR-mediated translational control. - Rat Genome Database

Help | FTP Download | Citing RGD | Contact Us

Keyword

General

Molecular mechanisms of mTOR-mediated translational control.
Authors:	Ma, XM Blenis, J
Citation:	Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
Pubmed:	(View Article at PubMed) PMID:19339977
DOI:	Full-text: DOI:10.1038/nrm2672
The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis. Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation.

Annotation

Molecular Pathway Annotations

RGD Objects Annotated

Genes (Rattus norvegicus)

	Akt1s1 (AKT1 substrate 1 (proline-rich))
	Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1)
	Mapkap1 (mitogen-activated protein kinase associated protein 1)
	Mlst8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
	Mtor (mechanistic target of rapamycin (serine/threonine kinase))
	Rheb (Ras homolog enriched in brain)

	Rictor (RPTOR independent companion of MTOR, complex 2)
	Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)
	Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2)
	Rptor (regulatory associated protein of MTOR, complex 1)
	Rraga (Ras-related GTP binding A)
	RragB (Ras-related GTP binding B)

	Rragb_v1 (Ras-related GTP binding B, variant 1)
	Rragc (Ras-related GTP binding C)
	Rragd (Ras-related GTP binding D)
	Tsc1 (tuberous sclerosis 1)
	Tsc2 (tuberous sclerosis 2)

Genes (Mus musculus)

	Akt1s1 (AKT1 substrate 1 (proline-rich))
	Eif4ebp1 (eukaryotic translation initiation factor 4E binding protein 1)
	Mapkap1 (mitogen-activated protein kinase associated protein 1)
	Mlst8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
	Mtor (mechanistic target of rapamycin (serine/threonine kinase))
	Rheb (Ras homolog enriched in brain)

	Rictor (RPTOR independent companion of MTOR, complex 2)
	Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)
	Rps6kb2 (ribosomal protein S6 kinase, polypeptide 2)
	Rptor (regulatory associated protein of MTOR, complex 1)
	Rraga (Ras-related GTP binding A)
	Rragb (Ras-related GTP binding B)

	Rragc (Ras-related GTP binding C)
	Rragd (Ras-related GTP binding D)
	Tsc1 (tuberous sclerosis 1)
	Tsc2 (tuberous sclerosis 2)

Genes (Homo sapiens)

	AKT1S1 (AKT1 substrate 1 (proline-rich))
	EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)
	MAPKAP1 (mitogen-activated protein kinase associated protein 1)
	MLST8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
	MTOR (mechanistic target of rapamycin (serine/threonine kinase))
	RHEB (Ras homolog enriched in brain)

	RICTOR (RPTOR independent companion of MTOR, complex 2)
	RPS6KB1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1)
	RPS6KB2 (ribosomal protein S6 kinase, 70kDa, polypeptide 2)
	RPTOR (regulatory associated protein of MTOR, complex 1)
	RRAGA (Ras-related GTP binding A)
	RRAGB (Ras-related GTP binding B)

	RRAGC (Ras-related GTP binding C)
	RRAGD (Ras-related GTP binding D)
	TSC1 (tuberous sclerosis 1)
	TSC2 (tuberous sclerosis 2)

Additional Information

RGD Object Information
RGD ID:	2308795
Created:	2009-06-08
Species:	All Species
Last Modified:	2009-06-08
Status:	ACTIVE

Contact Us | About Us | Jobs at RGD

© Bioinformatics Program, HMGC at the Medical College of Wisconsin

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
NHLBI Logo