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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtordecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of MTOR mRNA; Diethylhexyl Phthalate results in decreased expression of MTOR proteinPMID:35460826
Mtormultiple interactionsEXP 6480464CTD4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR mRNA]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR protein]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR mRNA]; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MTOR protein]PMID:35460826
Mtoraffects expressionISOMtor (Mus musculus)6480464CTDDiethylhexyl Phthalate affects the expression of MTOR mRNAPMID:31211961
Mtordecreases expressionISOMtor (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of MTOR mRNA; Diethylhexyl Phthalate results in decreased expression of MTOR proteinPMID:35659966
Mtorincreases expressionISOMTOR (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of MTOR mRNA; Diethylhexyl Phthalate results in increased expression of MTOR proteinPMID:23793038
Mtorincreases expressionISOMtor (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of MTOR mRNAPMID:24804967
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR protein]PMID:23793038
Mtormultiple interactionsISOMtor (Mus musculus)6480464CTDDiethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of MTOR protein]PMID:33484791
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