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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:16422
Term: androst-4-ene-3,17-dione
Definition: A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Chemical ID: MESH:D000735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtoraffects activityISOMTOR (Homo sapiens)6480464CTDAndrostenedione affects the activity of MTOR proteinPMID:16033851
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTD[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]PMID:16033851
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