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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371 Species: Rattus norvegicus RGD Object: Gene Symbol: Mtor Name: mechanistic target of rapamycin (serine/threonine kinase)

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:68533	6480464	CTD	Estradiol results in increased activity of MTOR protein	PMID:16024245
affects activity	ISO	RGD:68533	6480464	CTD	Estradiol affects the activity of MTOR protein	PMID:16033851
multiple interactions	ISO	RGD:68533	6480464	CTD	everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein] letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]	PMID:16033851