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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:8633
Term: puerarin
Definition: A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4' and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
Chemical ID: MESH:C033607
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtormultiple interactionsEXP 6480464CTDpuerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]PMID:27762461
Mtorincreases phosphorylationISOMTOR (Homo sapiens)6480464CTDpuerarin results in increased phosphorylation of MTOR proteinPMID:27796870
Mtormultiple interactionsISOMTOR (Homo sapiens)6480464CTDSirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]PMID:27796870
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