Gene:	Pik3ca ( Rattus norvegicus ) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
Description:	expression of the human homolog is associated with increased cell proliferation and decreased apoptosis and may play a role in ovarian cancer progression
Synonyms:	MGC116320;
ArrayIDs:	6086404; 6157433; 5801925; 6230129; A_44_P698996; 5653762; 6363000; 5981413; rc_AA997895_at; 5955775; 6435436; rc_AI030797_at; 6206254; 6541584; 1379041_at; 1396411_at; 5621297; 6424400; 6051191; 1374232_at; 5684821; 6440099; 5670270; GE1148762; 1382366_at; 6329747; 6078563; 6288633; 6604237; 1389143_at; 6294026; 1393499_at; 6547607; 6423255; 5681832; 6300420; 6097004; 5951100; 5707500; 6101846; 5839031; 6729176; 5665132; 6120159; 6623058; 6219585; 5880865; rc_AA964375_at; 6586942; 6727554; 5847471; 6086931; 6070820; 6734785;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PIK3CA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pik3ca     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pik3ca Rat Celera Assembly 2 110329809 - 110360086     RGSC genome assembly v3.4 2 118640225 - 118672451     Cytogenetic 2 q25     genome assembly 3.1 2 118603330 - 118613969 Mus musculus Pik3ca Mouse genome assembly build 36.1 3 32335128 - 32361753     Cytogenetic 3 3 B Homo sapiens PIK3CA human genome assembly 3 180349012 - 180435197     Human genome assembly build 36.2 3 180349005 - 180435194     Cytogenetic 3 q26.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology phosphatidylinositol-4,5-bisphosphate 3-kinase activity,  1-phosphatidylinositol-3-kinase activity,  inositol or phosphatidylinositol kinase activity ...  (details...)
Biological Process	Gene Ontology regulation of multicellular organism growth,  protein amino acid phosphorylation,  phosphoinositide-mediated signaling ...  (details...)
Cellular Component	Gene Ontology lamellipodium,  phosphoinositide 3-kinase complex,  cytosol (details...)
Disease	Ontology Glioma,  Carcinoma, Hepatocellular,  Breast Neoplasms ...  (details...)
Pathway	Ontology altered phosphatodylinositol 3-kinase-Akt signaling pathway,  phosphatidylinositol 3-kinase-Akt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: PI3Kc IPI SMART: PI3K_rbd IPI SMART: PI3K_p85B IPI SMART: PI3Ka IPI SMART: C2 IPI SMART: PI3K_C2 IPI PROSITE: PI3_4_KINASE_1 IPI PROSITE: PI3_4_KINASE_3 IPI PROSITE: PI3_4_KINASE_2 IPI UNIPARC: UPI0000DA20B2 IPI UNIPARC: UPI0000DA20B3 IPI UNIPARC: UPI0000DA20B1 IPI UNIPARC: UPI0000DA1F06 IPI KEGG Report: rno:170911 ENTREZGENE Germonline: 620916 Pfam: PI3K_rbd IPI Pfam: PI3Ka IPI Pfam: PI3K_p85B IPI Pfam: PI3K_C2 IPI Pfam: PI3_PI4_kinase IPI KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04150 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04070 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 00562 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE InterPro: ARM-type_fold. IPI InterPro: C2_Ca-dep. IPI InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI InterPro: Kinase-like_dom. IPI InterPro: PI3/4_kinase_cat. IPI InterPro: PI3/4_kinase_CS. IPI InterPro: PI3K_C2. IPI InterPro: PI3K_ras_bd. IPI InterPro: PI3Ka. IPI InterPro: PI_Kinase. IPI InterPro: PI3K_p85_bd. IPI IPI: IPI00769166 IPI IPI: IPI00211380 IPI IPI: IPI00769069 IPI IPI: IPI00766767 IPI Ensembl Protein: ENSRNOP00000014527 IPI Gene3D-CATH: PI3/4_kinase_cat IPI Gene3D-CATH: PI3Ka IPI Entrez Gene: Pik3ca ENTREZGENE UniProt: Q91XL6_RAT IPI Ensembl Genes: ENSRNOG00000010458 IPI Superfamily-SCOP: Kinase_like IPI Superfamily-SCOP: C2_CaLB IPI Superfamily-SCOP: ARM-type_fold IPI PANTHER: PI_Kinase IPI
Sequences	Nucleotide: XM_001059407 Get FASTA Search GEO Profiles Nucleotide: AF395897 Get FASTA Search GEO Profiles Nucleotide: XM_001059350 Get FASTA Search GEO Profiles Nucleotide: BC099154 Get FASTA Search GEO Profiles Nucleotide: XM_001063573 Get FASTA Search GEO Profiles Nucleotide: XM_001059296 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: XP_001059407 Get FASTA Protein: XP_001059296 Get FASTA Protein: XP_001059350 Get FASTA Protein: Q91XL6 Get FASTA Protein: XP_001063573 Get FASTA Protein: AAK83379 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 44193
References
Curated References	9 references in RGD related to Pik3ca
Other References	4 other references at PubMed related to Pik3ca
Database Information
RGD ID	620916
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 20-JAN-05: Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide PROVISIONAL Symbol and Name status set to provisional 70820