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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:48607
Term: lithium chloride
Definition: A metal chloride salt with a Li(+) counterion.
Chemical ID: MESH:D018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3caaffects response to substanceISOPIK3CA (Homo sapiens)6480464CTDPIK3CA protein affects the susceptibility to Lithium ChloridePMID:19196980
Pik3caincreases response to substanceISOPIK3CA (Homo sapiens)6480464CTDPIK3CA protein mutant form results in increased susceptibility to Lithium ChloridePMID:19196980
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTDPIK3CA protein affects the reaction [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein]PMID:19196980
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