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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cadecreases response to substanceISOPIK3CA (Homo sapiens)6480464CTDPIK3CA results in decreased susceptibility to CisplatinPMID:21849418
Pik3caincreases expressionISOPik3ca (Mus musculus)6480464CTDCisplatin results in increased expression of PIK3CA mRNAPMID:21151649
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTD[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PIK3CA mRNAPMID:30871063
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