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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3caincreases response to substanceISOPik3ca (Mus musculus)6480464CTDPIK3CA protein results in increased susceptibility to resveratrolPMID:20542495
Pik3camultiple interactionsISOPIK3CA (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of PIK3CA mRNA; Adenosine Triphosphate inhibits the reaction [Resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]; Resveratrol inhibits the reaction [PIK3CA protein results in increased phosphorylation of AKT1 protein]; Resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]PMID:17550345 PMID:23557933
Pik3camultiple interactionsISOPik3ca (Mus musculus)6480464CTDPIK3CA protein promotes the reaction [resveratrol results in decreased susceptibility to Excitatory Amino Acid Agents]PMID:20542495
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