Il6 (interleukin 6) - Rat Genome Database

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Gene: Il6 (interleukin 6) Rattus norvegicus
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Symbol: Il6
Name: interleukin 6
RGD ID: 2901
Description: Enables cytokine activity; histone H3K9ac reader activity; and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell communication; and positive regulation of metabolic process. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; hypertension (multiple); impotence; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including depressive disorder (multiple); eye disease (multiple); glucose metabolism disease (multiple); liver disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6); PARTICIPATES IN interleukin-6 signaling pathway; pro-inflammatory cytokine mediated pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifnb2; IL-6; ILg6; Interleukin 6 (interferon beta 2); Interleukin 6 (interferon, beta 2); interleukin-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Il6em1Yona
Genetic Models: SD-Il6em1Yona-/-
Is Marker For: Strains:   SHR.BN-(Il6-Npy) ; BN.SHR-(Il6-Cd36)/Cub
QTLs:   Bp33   Scl23   Bp79   Plsm1   Stl2   Bp330  
Candidate Gene For: Plsm1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl45,889,999 - 5,894,610 (-)EnsemblGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensemblrn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera45,093,593 - 5,098,169 (+)NCBICelera
RGSC_v3.14456,798 - 461,376 (-)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (IEP,ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (IDA)
Acute Lung Injury  (IEP,ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IDA,IEP)
Acute-Phase Reaction  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcohol use disorder  (IEP,ISO)
alcohol-associated liver disease  (IEP)
alcoholic gastritis  (IEP)
alcoholic hepatitis  (IEP)
alcoholic liver cirrhosis  (IEP,ISO)
allergic asthma  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (IDA)
amnestic disorder  (ISO)
amphetamine abuse  (IEP)
anemia  (ISO)
Aneurysm  (ISO)
Animal Toxoplasmosis  (ISO)
ankylosing spondylitis  (ISO)
anogenital venereal wart  (ISO)
aortic valve disease 1  (ISO)
arteriovenous malformations of the brain  (ISO)
Ascorbic Acid Deficiency  (IEP)
aseptic meningitis  (ISO)
asthma  (IEP,ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
beta thalassemia  (ISO)
Bile Duct Neoplasms  (ISO)
biliary tract benign neoplasm  (ISO)
Binge Drinking  (IEP)
Brain Concussion  (IDA)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Burns  (ISO)
Cachexia  (IEP,ISO)
Cadmium Poisoning  (IEP)
Carbon Tetrachloride Poisoning  (IEP)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
Castleman disease  (ISO)
celiac disease  (ISO)
central nervous system disease  (ISO)
Cerebral Hemorrhage  (IEP)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chemical Burns  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
chorioamnionitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Rhinosinusitis  (ISO)
cochlear disease  (IEP)
colitis  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (IEP)
Colorectal Neoplasms  (IEP)
congestive heart failure  (IDA,IEP,ISO)
conjunctival disease  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Coxsackievirus Infections  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
depressive disorder  (IEP,ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
disseminated intravascular coagulation  (IDA,IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Eales Disease  (ISO)
eclampsia  (IDA)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IDA,IEP)
Entamoebiasis  (ISO)
epididymitis  (IEP)
epilepsy  (IEP)
Experimental Arthritis  (IDA,IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Myocarditis  (IDA)
Experimental Colitis  (IDA,IEP,ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial Mediterranean fever  (ISO)
Femoral Fractures  (IEP)
Fetal Inflammatory Response Syndrome  (ISO)
Fever  (IEP,ISO)
Foot Injuries  (IEP)
gastric adenocarcinoma  (ISO)
gastric dilatation  (ISO)
gestational diabetes  (ISO)
gingivitis  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Headache  (ISO)
Hearing Loss, Noise-Induced  (IEP)
Heart Injuries  (ISO)
Heat Stress Disorders  (IEP)
Heat Stroke  (ISO)
Helicobacter Infections  (ISO)
hemarthrosis  (ISO)
Hemifacial Spasm  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (IEP,ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IEP,ISO)
heroin dependence  (IEP)
HIV Wasting Syndrome  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IEP,ISO)
hypercalcemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
Hyperoxia  (IEP)
hypertension  (ISO)
Hypoalbuminemia  (ISO)
hypogonadism  (ISO)
Hypotension  (ISO)
idiopathic interstitial pneumonia  (IEP)
impotence  (IEP,IMP)
Inflammation  (IDA,ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (IDA,IEP)
Intestinal Reperfusion Injury  (IDA,IEP)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
Intraventricular Hemorrhage  (ISO)
iron deficiency anemia  (IEP)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kaposi's sarcoma  (ISO)
keratitis  (ISO)
keratoconjunctivitis sicca  (ISO)
Kidney Reperfusion Injury  (ISO)
Klebsiella Infections  (IDA)
Kuhnt-Junius degeneration  (ISO)
learning disability  (ISO)
left ventricular failure  (ISO)
leishmaniasis  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IDA,IEP)
Liver Reperfusion Injury  (IDA,IEP,ISO)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
lymphoplasmacytic lymphoma  (ISO)
macular retinal edema  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP,ISO)
Middle East respiratory syndrome  (ISO)
mitochondrial myopathy  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
myocarditis  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
neurodegenerative disease  (ISO)
neuromyelitis optica  (ISO)
nicotine dependence  (ISO)
nodular goiter  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
opiate withdrawal syndrome  (IEP)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
osteoporosis  (ISO)
otitis media  (IEP,ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
perinatal necrotizing enterocolitis  (IEP)
periodontal disease  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (IEP)
peripheral nervous system disease  (ISO)
peripheral vascular disease  (ISO)
peritonitis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural disease  (ISO)
pleurisy  (ISO)
Pneumococcal Meningitis  (IDA,IEP,IMP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
polyneuropathy  (ISO)
Postmenopausal Osteoporosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-eclampsia  (IEP)
pre-malignant neoplasm  (ISO)
prediabetes syndrome  (ISO)
Premature Birth  (ISO)
Premature Obstetric Labor  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
Pulmonary Contusion  (IEP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
pulmonary tuberculosis  (ISO)
quadriplegia  (ISO)
Radiation Pneumonitis  (IEP)
rectum cancer  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (IEP)
retinal artery occlusion  (ISO)
retinal detachment  (ISO)
retinal vasculitis  (ISO)
retinal vein occlusion  (IEP)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IEP)
secondary hyperparathyroidism  (ISO)
Sepsis  (IAGP,IDA,IEP,ISO)
Septic Peritonitis  (IEP)
severe acute respiratory syndrome  (IEP,ISO)
Shwartzman phenomenon  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Compression  (IEP)
spinal cord disease  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Spine Osteoarthritis  (ISO)
spondyloarthropathy  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IAGP,ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
stress-related disorder  (IEP)
stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subretinal Fibrosis  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Hearing Loss  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
transverse myelitis  (ISO)
Tympanic Membrane Perforation  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uveitis  (IEP,ISO)
Vibrio Vulnificus Infection  (IEP)
Viral Bronchiolitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-acanthoic acid  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-cotinine  (EXP)
(-)-demecolcine  (ISO)
(-)-ephedrine  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-hinokiresinol  (ISO)
(-)-matairesinol  (ISO)
(-)-quinic acid  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP,ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-roxithromycin  (ISO)
(E)-thiamethoxam  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
(Z)-PUGNAc  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,4-tetrahydroisoquinoline  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (EXP,ISO)
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-benzoquinone  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
1,8-cineole  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
11-dehydrocorticosterone  (ISO)
11-deoxycorticosterone  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-imidazole  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,5-dimethylcelecoxib  (ISO)
2,6-dichlorobenzonitrile  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methylserotonin  (ISO)
2-palmitoylglycerol  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
23-epi-26-deoxyactein  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-aminonicotinamide  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-Methoxyflavone  (ISO)
6-O-alpha-D-glucopyranosyl-D-fructofuranose  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
8-OH-DPAT  (ISO)
9-cis-retinoic acid  (ISO)
abamectin  (EXP)
acalabrutinib  (ISO)
acetaldehyde  (EXP,ISO)
acetate ester  (ISO)
acetic acid  (EXP,ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetic anhydride  (ISO)
acetoacetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylic acid  (EXP)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
ADP  (ISO)
Aeol 10150  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
afzelechin  (EXP)
agathisflavone  (EXP)
agmatine  (ISO)
AICA ribonucleotide  (EXP,ISO)
ajmalicine  (ISO)
Alamandine  (EXP)
albuterol  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldicarb  (EXP)
aldosterone  (ISO)
alendronic acid  (ISO)
Alisol B  (ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allantoin  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (EXP,ISO)
allyl alcohol  (EXP)
allyl methyl disulfide  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-methylhistamine  (ISO)
alpha-methylserotonin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (EXP)
Alpinetin  (ISO)
Alternaramide  (ISO)
alternariol  (ISO)
aluminium atom  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (EXP,ISO)
amifostine  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
amlexanox  (ISO)
ammonia  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP,ISO)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP,ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
anandamide  (ISO)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
anethole  (EXP)
angiotensin II  (ISO)
Angoline  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antigen  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apilimod  (ISO)
apocynin  (EXP,ISO)
apomorphine  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Archazolid B  (ISO)
Arctiin  (EXP)
arecoline  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
Arkin (TN)  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (ISO)
aspalathin  (ISO)
aspartame  (ISO)
asperentin  (ISO)
asperuloside  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
astressin 2B  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
Atractylenolide III  (ISO)
Atractylodin  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aucubin  (ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
aziridines  (ISO)
azithromycin  (ISO)
Azoxymethane  (EXP,ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bardoxolone methyl  (ISO)
barium chloride  (EXP)
barium sulfate  (ISO)
barium(0)  (EXP)
Bavachinin  (ISO)
BAY 60-6583  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
benzoates  (ISO)
benzofurans  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
betalain  (ISO)
betaxolol  (ISO)
betulinic acid  (EXP)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
biochanin A  (ISO)
biotin  (EXP)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
bortezomib  (EXP,ISO)
bosentan  (ISO)
Botulinum toxin type A  (ISO)
BQ 123  (ISO)
brefeldin A  (ISO)
brequinar  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
Brusatol  (EXP)
bucladesine  (ISO)
budesonide  (EXP,ISO)
Bufotalin  (ISO)
buspirone  (EXP)
butanal  (ISO)
butane-2,3-dione  (EXP,ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium carbonate  (EXP)
Calcium propionate  (EXP)
calcium silicate  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
calycosin  (EXP)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
Cannabidivarin  (ISO)
cannabigerol  (EXP)
capecitabine  (ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
captopril  (EXP,ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP,ISO)
CARBENOXOLONE  (ISO)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
Cardamonin  (ISO)
carmustine  (EXP,ISO)
carnosine  (EXP,ISO)
Carnosol  (EXP)
carrageenan  (EXP,ISO)
carteolol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
carveol  (ISO)
casticin  (EXP,ISO)
catalpol  (ISO)
cefoxitin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
ceric oxide  (EXP,ISO)
cerium trichloride  (ISO)
cerivastatin  (EXP,ISO)
ceruletide  (EXP,ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chalcone  (ISO)
chalcones  (EXP)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
Chikusetsusaponin-IV  (ISO)
CHIR 99021  (ISO)
chitosan  (ISO)
chloral hydrate  (EXP)
chloroethene  (ISO)
chlorogenic acid  (EXP,ISO)
chloromethylisothiazolinone  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium trioxide  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP,ISO)
ciprofloxacin  (EXP,ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
citral  (ISO)
citronellol  (EXP)
clarithromycin  (EXP,ISO)
clenbuterol  (EXP)
clodronic acid  (EXP,ISO)
clomipramine  (ISO)
clopidogrel  (ISO)
cloxacillin  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP)
Concanamycin B  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corticosterone  (EXP,ISO)
cortisol  (ISO)
cortisone  (ISO)
coumarin  (EXP,ISO)
coumarins  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP,ISO)
CU-CPT22  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyanocob(III)alamin  (EXP)
cyclizine  (ISO)
cycloastragenol  (EXP,ISO)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cyproheptadine  (EXP)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (EXP,ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
daidzein  (ISO)
danazol  (EXP)
dantrolene  (ISO)
dapagliflozin  (EXP)
DAPT  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
decane  (ISO)
Decursin  (ISO)
deguelin  (EXP)
dehydrocostus lactone  (ISO)
dehydroepiandrosterone  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
delta-tocotrienol  (ISO)
demeclocycline  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxynivalenol 3-glucoside  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (ISO)
devazepide  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyl hydrogen phosphate  (EXP)
diethyl phthalate  (ISO)
diethylcarbamazine  (EXP)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
diflorasone  (ISO)
diflunisal  (EXP)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
Dimaprit  (ISO)
dimethoate  (EXP,ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (EXP,ISO)
dinitrogen  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP,ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
diphenyl diselenide  (EXP)
diprotium oxide  (ISO)
dipyridamole  (ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (EXP,ISO)
docebenone  (ISO)
docosahexaenoic acid  (EXP)
dodecane  (EXP,ISO)
domperidone  (ISO)
donepezil hydrochloride  (ISO)
dopexamine  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
dydrogesterone  (ISO)
ebselen  (EXP)
EC 3.1.1.4 (phospholipase A2) inhibitor  (ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental boron  (EXP)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
Eleutheroside E  (ISO)
ellagic acid  (EXP)
emamectin benzoate  (ISO)
embelin  (EXP,ISO)
emodin  (EXP,ISO)
empagliflozin  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epalrestat  (ISO)
epinastine  (ISO)
eplerenone  (EXP)
eptifibatide  (ISO)
erastin  (ISO)
erdosteine  (EXP,ISO)
ergothioneine  (EXP)
erianin  (ISO)
eriodictyol  (ISO)
Erionite  (ISO)
eritoran  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin A  (ISO)
esculetin  (ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl pyruvate  (ISO)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylmalonic acid  (EXP)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
eumelanin  (ISO)
eupatilin  (EXP,ISO)
euxanthone  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
ezogabine  (EXP)
famotidine  (EXP)
Fargesin  (ISO)
farnesol  (ISO)
farrerol  (EXP)
Fast green FCF  (ISO)
fasudil  (EXP,ISO)
favipiravir  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
fentin chloride  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (EXP,ISO)
ferrostatin-1  (ISO)
ferruginol  (EXP)
ferulic acid  (ISO)
Fexaramine  (ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
finasteride  (EXP,ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
Flavokawain A  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP,ISO)
flucloxacillin  (ISO)
flufenamic acid  (EXP,ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluorometholone  (ISO)
fluoxetine  (EXP,ISO)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
formoterol fumarate  (EXP)
Forsythiaside  (ISO)
fragrance  (ISO)
fraxetin  (ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fucoidan  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
galangin  (EXP,ISO)
galaxolide  (ISO)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
gamma-tocopherol  (ISO)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
gardenoside  (EXP)
gardiquimod  (ISO)
Gastrodin  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
Genipin  (EXP,ISO)
Geniposide  (EXP)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
ghrelin  (ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
Ginkgolide A  (ISO)
Ginkgolide C  (EXP)
ginsenoside C-K  (ISO)
ginsenoside F1  (ISO)
ginsenoside Rb1  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (EXP)
gliclazide  (EXP)
glucagon  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
Gly-His-Lys  (ISO)
glyburide  (EXP,ISO)
glycerol  (ISO)
glycine  (ISO)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP,ISO)
glyoxal  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
GR 113808  (ISO)
granisetron  (ISO)
graphite  (ISO)
GSK-J4  (ISO)
GSK2193874  (ISO)
guggulsterone  (ISO)
GW 3965  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (EXP)
GW 7647  (ISO)
gypenoside LXXV  (ISO)
haloperidol  (ISO)
halothane  (ISO)
Harpagide  (ISO)
Harpagoside  (ISO)
helenalin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
herbacetin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP)
hexadecane  (ISO)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (EXP)
hexane  (ISO)
hinokiflavone  (ISO)
hispidulin  (ISO)
histamine  (ISO)
homocysteine  (EXP)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hopane  (ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydralazine  (ISO)
hydrocortisone succinate  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxamic acid  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxyflutamide  (ISO)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (EXP,ISO)
hypochlorous acid  (ISO)
hypoxanthine  (EXP,ISO)
Ibotenic acid  (EXP)
ibrutinib  (ISO)
ibuprofen  (EXP,ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icatibant  (EXP)
ICI 118551  (EXP)
icosanoid  (EXP)
idelalisib  (ISO)
ifosfamide  (EXP)
Iguratimod  (EXP)
Ile(5)-angiotensin II  (ISO)
iloprost  (ISO)
imidacloprid  (EXP,ISO)
imidazopyrazole  (ISO)
imidurea  (ISO)
imiquimod  (ISO)
imisopasem manganese  (EXP)
immunological adjuvant  (ISO)
indinavir  (ISO)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indoline  (EXP)
indometacin  (EXP,ISO)
indoprofen  (ISO)
Inotodiol  (ISO)
iohexol  (ISO)
ionomycin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (EXP)
iron(III) nitrilotriacetate  (EXP,ISO)
isocyanates  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP,ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoorientin  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (EXP,ISO)
isovitexin  (EXP)
ivermectin  (ISO)
JTE-013  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (ISO)
ketamine  (EXP,ISO)
ketanserin  (ISO)
ketoconazole  (EXP,ISO)
ketoprofen  (ISO)
ketotifen  (EXP)
KN-93  (ISO)
kojic acid  (ISO)
KT 5823  (ISO)
kuwanone G  (ISO)
kynurenic acid  (ISO)
L-365260  (ISO)
L-arginine  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-citrulline  (ISO)
L-methionine  (EXP,ISO)
L-proline betaine  (ISO)
L-serine  (EXP)
lactacystin  (ISO)
lactucin  (ISO)
lactulose  (EXP)
lansoprazole  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (ISO)
lenvatinib  (ISO)
Leonurine  (ISO)
Leptin  (EXP)
leptomycin B  (ISO)
letrozole  (EXP)
leukotriene D4  (ISO)
leupeptin  (ISO)
leuprolide  (EXP)
levamisole  (ISO)
levocabastine  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
licofelone  (ISO)
lidocaine  (ISO)
Liensinine  (ISO)
lignan  (ISO)
limonene  (ISO)
limonin  (ISO)
linagliptin  (EXP)
linalool  (EXP)
linderalactone  (EXP,ISO)
linoleic acid  (EXP,ISO)
linsidomine  (ISO)
linuron  (ISO)
lipid As  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lixisenatide  (ISO)
LLY-507  (ISO)
loganin  (EXP,ISO)
loliolide  (ISO)
lopinavir  (ISO)
lorcaserin  (ISO)
lornoxicam  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
lucanthone  (ISO)
lupeol  (EXP,ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lycorine  (ISO)
Macrosphelide B  (ISO)
madecassoside  (ISO)
magnesium atom  (ISO)
malathion  (EXP,ISO)
malvidin  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
mastoparan  (ISO)
MC1568  (ISO)
mechlorethamine  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
meglumine amidotrizoate  (EXP)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
menadione  (ISO)
mepanipyrim  (ISO)
mephedrone  (EXP)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP,ISO)
metam  (ISO)
metamizole sodium  (EXP)
metformin  (EXP,ISO)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylene blue  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
methylmalonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
Methylthiouracil  (ISO)
metoprolol  (EXP)
metronidazole  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
mexiletine  (ISO)
microcystin-LR  (EXP,ISO)
midazolam  (ISO)
mifepristone  (EXP,ISO)
Miglitol  (ISO)
milrinone  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mirtazapine  (EXP)
mitogen  (EXP)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
MJN110  (ISO)
MK-2206  (EXP,ISO)
mocetinostat  (ISO)
molybdenum trichloride  (ISO)
monascin  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
montelukast  (EXP,ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
moxifloxacin  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (EXP,ISO)
myricitrin  (ISO)
myxothiazol  (ISO)
N(5)-ethyl-L-glutamine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylacetamide  (ISO)
N,N-dimethylformamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nafcillin  (ISO)
naloxone  (EXP,ISO)
naphthalenes  (EXP)
naproxen  (EXP)
Narciclasine  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP)
nelfinavir  (ISO)
neoastilbin  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
neohesperidin  (EXP,ISO)
neohesperidin dihydrochalcone  (ISO)
neomycin  (ISO)
nerolidol  (EXP)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP,ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nifuroxazide  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP)
nitrososulfamethoxazole  (ISO)
Nivalenol  (ISO)
NMS-873  (ISO)
nobiletin  (EXP)
nocodazole  (ISO)
nonane  (EXP,ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP,ISO)
norlaudanosoline  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
NSC 23766  (ISO)
nystatin  (ISO)
O-acetyl-L-carnitine  (EXP)
o-anisidine  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP,ISO)
oridonin  (EXP,ISO)
orlistat  (ISO)
oroxylin A  (EXP,ISO)
oseltamivir  (ISO)
osimertinib  (ISO)
ospemifene  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
oxybutynin  (ISO)
oxycodone  (ISO)
oxymetholone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (EXP,ISO)
Palmitic acid(d3)  (ISO)
palmitoleic acid  (ISO)
palmitoyl ethanolamide  (ISO)
pamidronate  (ISO)
Panaxytriol  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP,ISO)
parathion-methyl  (ISO)
paricalcitol  (ISO)
parthenolide  (EXP,ISO)
patchouli alcohol  (EXP,ISO)
pefloxacin  (ISO)
pelargonidin  (ISO)
penconazole  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perindopril  (EXP,ISO)
permethrin  (EXP,ISO)
pevonedistat  (ISO)
Pf-06840003  (ISO)
phenanthrene  (EXP,ISO)
Phenelzine  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phentermine  (ISO)
phenyl benzoate  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosalone  (EXP)
phosphatidic acid  (ISO)
phosphatidylcholine  (ISO)
phosphatidylinositol dimannoside  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phoxim  (EXP)
phthalic anhydride  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
phytoestrogen  (ISO)
Phytolaccoside E  (ISO)
picolinic acid  (ISO)
picropodophyllotoxin  (ISO)
pimobendan  (ISO)
pinitol  (EXP,ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirarubicin  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (EXP,ISO)
plumbagin  (ISO)
pluronic P-123  (ISO)
PNU-282987  (ISO)
Poloxamer  (ISO)
Polpunonic acid  (ISO)
poly(ethylene)  (ISO)
poly(I:C)  (EXP,ISO)
poly(methyl methacrylate) macromolecule  (ISO)
poly(vinyl chloride)  (ISO)
polymyxin B2  (EXP,ISO)
polyphosphates  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP,ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prilocaine  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP,ISO)
Primycin  (ISO)
proanthocyanidin  (EXP)
probenecid  (EXP)
probucol  (EXP)
procaterol  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propacetamol  (ISO)
propamocarb  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
propanil  (ISO)
propionic acid  (EXP)
propofol  (ISO)
propranolol  (EXP)
prostaglandin D2  (ISO)
prostaglandin E1  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
prostaglandins E  (ISO)
protein kinase inhibitor  (EXP,ISO)
protosappanin A  (ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
punicalagin  (EXP,ISO)
pyocyanine  (ISO)
pyrene  (ISO)
pyridaben  (EXP)
Pyridostigmine bromide  (EXP,ISO)
pyrimethamine  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinapril hydrochloride  (EXP)
quinazolines  (ISO)
quinine  (ISO)
quinolinic acid  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
raspberry ketone  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
remdesivir  (ISO)
Repaglinide  (EXP)
resiquimod  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhein  (ISO)
Rhynchophylline  (EXP)
ribavirin  (EXP)
riboflavin  (ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 31-8220  (ISO)
robinin  (EXP)
rofecoxib  (ISO)
roflumilast  (EXP)
rolipram  (ISO)
Roridin A  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rucaparib  (ISO)
Rutecarpine  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP,ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
salsalate  (EXP)
salubrinal  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP,ISO)
Sanggenon C  (EXP)
saquinavir  (ISO)
sarin  (EXP)
saroglitazar  (EXP)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 206553  (ISO)
SB 290157  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH772984  (EXP)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP)
scutellarin  (ISO)
selenium atom  (EXP,ISO)
semaglutide  (EXP,ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
silibinin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sincalide  (EXP)
sirolimus  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium aurothiosulfate  (ISO)
sodium benzoate  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium nitrite  (EXP,ISO)
sodium perchlorate  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (ISO)
Sophocarpine  (ISO)
sophoraflavanone B  (ISO)
Sophoricoside  (ISO)
sorafenib  (EXP,ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sparsentan  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP,ISO)
stattic  (ISO)
stavudine  (ISO)
StemRegenin 1  (ISO)
sterigmatocystin  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (EXP)
sucrose  (EXP,ISO)
sulfadiazine  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfoxaflor  (EXP)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP)
Sulpyrine  (EXP)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (EXP,ISO)
suramin  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
synephrine  (ISO)
syringic acid  (EXP,ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (ISO)
Talc  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tangeretin  (EXP)
tannic acid  (EXP)
Tanshinone I  (ISO)
tartrazine  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurolithocholic acid sulfate  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tepoxalin  (ISO)
terameprocol  (ISO)
terbutaline  (EXP)
terephthalic acid  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Testosterone propionate  (EXP,ISO)
tetrachloro-1,4-benzoquinone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetradecane  (ISO)
tetralin  (ISO)
tetramethylpyrazine  (ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theaflavin  (EXP)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiacloprid  (EXP)
thiamet G  (ISO)
thiamethoxam  (EXP)
thiazoles  (EXP)
thiazolidinediones  (ISO)
thiazolidines  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiophenes  (ISO)
thiourea  (ISO)
thiram  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tigecycline  (ISO)
Timosaponin b ii  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tocopherol  (ISO)
tofacitinib  (EXP,ISO)
Tolmetin glucuronide  (ISO)
tolterodine tartrate  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
Torularhodin  (ISO)
Trachelogenin  (ISO)
trans-anethole  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trelagliptin  (ISO)
tremolite asbestos  (ISO)
triamcinolone acetonide  (EXP)
triazophos  (EXP)
tributylstannane  (EXP,ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (ISO)
tridecane  (ISO)
trilobatin  (ISO)
trimellitic anhydride  (ISO)
trimethoprim  (ISO)
trimethyltin  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tungsten  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyloxapol  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
ubiquinones  (ISO)
UDP  (ISO)
umbelliferone  (EXP)
undecan-2-one  (EXP,ISO)
undecane  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (EXP,ISO)
usnic acid  (ISO)
UTP  (ISO)
vadimezan  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
verapamil  (EXP,ISO)
verrucarin A  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vincamine  (ISO)
vincristine  (EXP,ISO)
Vinpocetine  (EXP)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
vitamin K  (EXP)
vorinostat  (ISO)
VX-745  (ISO)
warfarin  (EXP,ISO)
water  (ISO)
wedelolactone  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
xanthone  (EXP)
XAV939  (ISO)
xyloglucan  (ISO)
Y-27632  (ISO)
Yangonin  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc nitrate  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP,ISO)
zingiberene  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
autocrine signaling  (ISO)
bone remodeling  (IEP)
branching involved in salivary gland morphogenesis  (ISO)
cell differentiation  (IEA)
cell redox homeostasis  (IMP)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cell surface receptor signaling pathway via STAT  (ISO)
cellular response to acetaldehyde  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to interleukin-1  (IEA,IEP,ISO)
cellular response to interleukin-17  (ISO)
cellular response to leptin stimulus  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to nutrient levels  (IEP)
cellular response to prolactin  (IEP)
cellular response to tumor necrosis factor  (IEA,IEP,ISO)
cellular response to virus  (ISO,ISS)
chromatin organization  (IEA)
cytokine-mediated signaling pathway  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (ISO)
endocrine pancreas development  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
gene expression  (ISO)
germinal center B cell differentiation  (ISO,ISS)
glucagon secretion  (ISO)
glucose homeostasis  (ISO,ISS)
hepatic immune response  (ISO)
hepatocyte proliferation  (ISO,ISS)
immune response  (IEA)
inflammatory response  (IBA,ISO)
inflammatory response to wounding  (ISO)
interleukin-6-mediated signaling pathway  (IBA,IDA,IEA,ISO,ISS)
liver regeneration  (IEP,ISO,ISS)
lymphocyte costimulation  (IEP)
muscle cell cellular homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of chemokine production  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of gluconeogenesis  (IDA)
negative regulation of hormone secretion  (ISO)
negative regulation of interleukin-1-mediated signaling pathway  (ISO)
negative regulation of membrane potential  (IMP)
negative regulation of muscle organ development  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein kinase activity  (IDA)
neuron projection development  (ISO)
neutrophil apoptotic process  (ISO)
positive regulation of acute inflammatory response  (ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of estradiol secretion  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of gliogenesis  (ISO)
positive regulation of immunoglobulin production  (ISO,ISS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-21 production  (ISO,ISS)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lymphocyte activation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuron differentiation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
positive regulation of platelet aggregation  (ISO)
positive regulation of protein import into nucleus  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA,IMP,ISO)
positive regulation of receptor signaling pathway via STAT  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of translation  (ISO)
positive regulation of transmission of nerve impulse  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (IDA)
regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
regulation of glucagon secretion  (ISO,ISS)
regulation of insulin secretion  (ISO,ISS)
regulation of protein transport  (IEA)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (ISO,ISS)
response to amino acid  (IEP)
response to amphetamine  (IEP,IMP)
response to auditory stimulus  (IEP)
response to bacterium  (IEP)
response to caffeine  (IEP)
response to calcium ion  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to glucocorticoid  (ISO)
response to Gram-positive bacterium  (IEP)
response to hydrogen sulfide  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nutrient levels  (IEP)
response to quercetin  (IEP)
response to resveratrol  (IEP)
response to stress  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
response to yeast  (IEP)
signal transduction  (IEA)
T cell activation  (ISO)
T follicular helper cell differentiation  (ISO,ISS)
T-helper 17 cell lineage commitment  (ISO,ISS)
vascular endothelial growth factor production  (ISO,ISS)

Cellular Component

Molecular Function

References

References - curated
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13. Interleukin-6-174 Promoter Polymorphism and Susceptibility to Hepatitis B Virus Infection as a Risk Factor for Hepatocellular Carcinoma in Iran. Attar M, etal., Asian Pac J Cancer Prev. 2016;17(5):2395-9.
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PMID:18214944   PMID:18223607   PMID:18255192   PMID:18261938   PMID:18270592   PMID:18280640   PMID:18299267   PMID:18299269   PMID:18303626   PMID:18344939   PMID:18345501   PMID:18348986  
PMID:18358738   PMID:18401835   PMID:18406623   PMID:18500730   PMID:18511508   PMID:18535404   PMID:18541141   PMID:18559975   PMID:18563316   PMID:18593633   PMID:18636982   PMID:18677579  
PMID:18679050   PMID:18686625   PMID:18700232   PMID:18716207   PMID:18719127   PMID:18782534   PMID:18782543   PMID:18792410   PMID:18821705   PMID:18848809   PMID:18938092   PMID:18973594  
PMID:19041259   PMID:19047410   PMID:19074435   PMID:19084916   PMID:19136380   PMID:19139201   PMID:19168699   PMID:19192484   PMID:19207862   PMID:19211730   PMID:19220679   PMID:19326443  
PMID:19330444   PMID:19342597   PMID:19363165   PMID:19383497   PMID:19390056   PMID:19396873   PMID:19404405   PMID:19497205   PMID:19500508   PMID:19551494   PMID:19563340   PMID:19567205  
PMID:19647022   PMID:19653339   PMID:19666510   PMID:19695174   PMID:19710104   PMID:19723085   PMID:19748527   PMID:19751774   PMID:19817504   PMID:19907006   PMID:19921094   PMID:19955433  
PMID:19955834   PMID:19961020   PMID:20035858   PMID:20122990   PMID:20150963   PMID:20180411   PMID:20373517   PMID:20411395   PMID:20420568   PMID:20458762   PMID:20519077   PMID:20519080  
PMID:20529813   PMID:20607388   PMID:20643563   PMID:20655350   PMID:20658183   PMID:20702406   PMID:20717763   PMID:20926198   PMID:20945380   PMID:20969918   PMID:20970480   PMID:21030786  
PMID:21048959   PMID:21069809   PMID:21072211   PMID:21109592   PMID:21116112   PMID:21173340   PMID:21192080   PMID:21192292   PMID:21193288   PMID:21199478   PMID:21216156   PMID:21245987  
PMID:21265103   PMID:21439977   PMID:21470923   PMID:21494199   PMID:21528066   PMID:21565410   PMID:21599899   PMID:21606371   PMID:21640816   PMID:21643979   PMID:21882482   PMID:21914363  
PMID:21945087   PMID:22133515   PMID:22144718   PMID:22152774   PMID:22157761   PMID:22164858   PMID:22201020   PMID:22326661   PMID:22426572   PMID:22432126   PMID:22480838   PMID:22507133  
PMID:22554223   PMID:22561097   PMID:22578249   PMID:22634718   PMID:22697788   PMID:22761278   PMID:22851861   PMID:22856259   PMID:22884876   PMID:22911046   PMID:22956308   PMID:22992031  
PMID:23018187   PMID:23034271   PMID:23086831   PMID:23218517   PMID:23261764   PMID:23294974   PMID:23379983   PMID:23395675   PMID:23438872   PMID:23451164   PMID:23460747   PMID:23520526  
PMID:23608380   PMID:23610142   PMID:23634725   PMID:23639820   PMID:23685388   PMID:23692924   PMID:23695883   PMID:23700204   PMID:23764358   PMID:23776175   PMID:23802625   PMID:23846262  
PMID:23869758   PMID:23870461   PMID:23892723   PMID:23948778   PMID:24037056   PMID:24048027   PMID:24091940   PMID:24139936   PMID:24210203   PMID:24311225   PMID:24332041   PMID:24338258  
PMID:24344329   PMID:24379062   PMID:24431453   PMID:24463741   PMID:24467743   PMID:24489578   PMID:24584780   PMID:24623002   PMID:24667246   PMID:24706318   PMID:24763697   PMID:24845382  
PMID:24865534   PMID:24913911   PMID:24961501   PMID:24965599   PMID:25084278   PMID:25096025   PMID:25129106   PMID:25150005   PMID:25200151   PMID:25260633   PMID:25262023   PMID:25362566  
PMID:25682689   PMID:25752645   PMID:25809226   PMID:25863030   PMID:25916550   PMID:26102301   PMID:26134658   PMID:26191141   PMID:26205888   PMID:26390417   PMID:26523620   PMID:26527061  
PMID:26583134   PMID:26587789   PMID:26591203   PMID:26760196   PMID:26825317   PMID:26846568   PMID:26914683   PMID:26927369   PMID:26927377   PMID:27009340   PMID:27038016   PMID:27049312  
PMID:27180201   PMID:27214337   PMID:27252421   PMID:27348628   PMID:27383646   PMID:27529541   PMID:27534878   PMID:27539920   PMID:27619517   PMID:27764704   PMID:27993875   PMID:28091942  
PMID:28141871   PMID:28258441   PMID:28319508   PMID:28387444   PMID:28433754   PMID:28573530   PMID:28592636   PMID:28698251   PMID:28713893   PMID:28759646   PMID:28776758   PMID:29018960  
PMID:29222114   PMID:29306260   PMID:29397206   PMID:29402223   PMID:29486618   PMID:29547593   PMID:29580751   PMID:29674256   PMID:29848725   PMID:30221360   PMID:30670152   PMID:30974824  
PMID:31077169   PMID:31144562   PMID:31200316   PMID:31252000   PMID:31335655   PMID:31507089   PMID:31703282   PMID:31886314   PMID:32024466   PMID:32026477   PMID:32039828   PMID:32196570  
PMID:32279611   PMID:32329820   PMID:32382539   PMID:32704142   PMID:32791212   PMID:32908484   PMID:33099553   PMID:33126892   PMID:33189652   PMID:33220932   PMID:33577025   PMID:33741073  
PMID:33770644   PMID:33893246   PMID:33920198   PMID:33945195   PMID:33971931   PMID:34023825   PMID:34407316   PMID:34423720   PMID:35583060   PMID:35655056   PMID:35853948   PMID:36631456  
PMID:36794521   PMID:37629166   PMID:37914358   PMID:39000275  


Genomics

Comparative Map Data
Il6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl45,889,999 - 5,894,610 (-)EnsemblGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensemblrn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera45,093,593 - 5,098,169 (+)NCBICelera
RGSC_v3.14456,798 - 461,376 (-)NCBI
Cytogenetic Map4q11NCBI
IL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,727,200 - 22,731,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,725,884 - 22,732,002 (+)Ensemblhg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
T2T-CHM13v2.0722,861,319 - 22,867,916 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
Il6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,218,112 - 30,224,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,218,112 - 30,224,979 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38530,013,114 - 30,019,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,013,114 - 30,019,981 (+)Ensemblmm10GRCm38
MGSCv37530,339,701 - 30,346,508 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36530,343,948 - 30,350,755 (+)NCBIMGSCv36mm8
Celera527,530,266 - 27,537,070 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.7NCBI
Il6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541025,079,835 - 25,084,390 (+)NCBIChiLan1.0ChiLan1.0
IL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2627,593,486 - 27,598,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,918,460 - 75,923,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,415,922 - 23,420,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,027,560 - 23,032,419 (+)NCBIPanPan1.1PanPan1.1panPan2
IL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,474,268 - 36,478,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,473,394 - 36,478,519 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1436,015,351 - 36,019,602 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01436,398,579 - 36,402,833 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,397,705 - 36,402,833 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,519,712 - 36,523,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,216,365 - 36,220,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,553,276 - 36,557,530 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,842,756 - 183,843,378 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365497,015,595 - 7,016,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,506,421 - 91,511,263 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1991,506,421 - 91,510,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,081,042 - 101,085,451 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q14-q15NCBI
IL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,577,513 - 35,582,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,577,939 - 35,582,237 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604269,001,958 - 69,006,830 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,957,674 - 7,962,318 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247397,957,709 - 7,963,414 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16158,438,075 - 158,442,699 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il6
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000013732
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat

Markers in Region
D4Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,218,294 - 5,218,392 (-)MAPPERmRatBN7.2
Rnor_6.043,044,017 - 3,044,114NCBIRnor6.0
Rnor_5.043,096,322 - 3,096,419UniSTSRnor5.0
RGSC_v3.44460,493 - 460,590UniSTSRGSC3.4
Celera45,094,379 - 5,094,476UniSTS
RGSC_v3.14460,492 - 460,590RGD
Cytogenetic Map4q11UniSTS
D4Arb14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,218,227 - 5,218,417 (-)MAPPERmRatBN7.2
Rnor_6.043,043,992 - 3,044,181NCBIRnor6.0
Rnor_5.043,096,297 - 3,096,486UniSTSRnor5.0
RGSC_v3.44460,426 - 460,615UniSTSRGSC3.4
RGSC_v3.44460,425 - 460,615RGDRGSC3.4
Celera45,094,354 - 5,094,543UniSTS
RGSC_v3.14460,425 - 460,615RGD
SHRSP x BN Map40.0UniSTS
SHRSP x BN Map40.0RGD
FHH x ACI Map40.0501RGD
Cytogenetic Map4q11UniSTS
RH142237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,217,991 - 5,218,160 (-)MAPPERmRatBN7.2
Rnor_6.043,044,249 - 3,044,417NCBIRnor6.0
Rnor_5.043,096,554 - 3,096,722UniSTSRnor5.0
RGSC_v3.44460,190 - 460,358UniSTSRGSC3.4
Celera45,094,611 - 5,094,779UniSTS
Cytogenetic Map4q11UniSTS
PMC209527P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,214,895 - 5,215,050 (-)MAPPERmRatBN7.2
Rnor_6.043,047,359 - 3,047,513NCBIRnor6.0
Rnor_5.043,099,664 - 3,099,818UniSTSRnor5.0
RGSC_v3.44457,093 - 457,248UniSTSRGSC3.4
Celera45,097,721 - 5,097,875UniSTS
Cytogenetic Map4q11UniSTS
PMC356028P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.043,097,263 - 3,097,347NCBIRnor5.0
RGSC_v3.44459,565 - 459,648UniSTSRGSC3.4
Cytogenetic Map4q11UniSTS
UniSTS:532119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,214,899 - 5,215,081 (-)MAPPERmRatBN7.2
Rnor_6.043,047,328 - 3,047,509NCBIRnor6.0
Rnor_5.043,099,633 - 3,099,814UniSTSRnor5.0
Celera45,097,690 - 5,097,871UniSTS
Cytogenetic Map4q11UniSTS
UniSTS:532129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,216,376 - 5,217,472 (-)MAPPERmRatBN7.2
Rnor_6.043,044,937 - 3,046,032NCBIRnor6.0
Rnor_5.043,097,242 - 3,098,337UniSTSRnor5.0
Celera45,095,299 - 5,096,394UniSTS
Cytogenetic Map4q11UniSTS


Related Rat Strains
The following Strains have been annotated to Il6
BN.SHR-(Il6-Cd36)/Cub     SHR.BN-(Il6-Npy)    


Genetic Models
This gene Il6 is modified in the following models/strains:
SD-Il6em1Yona-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 3 19 84 25 35 5 52 5 6 110 82 6 77 11 54 30 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000013732   ⟹   ENSRNOP00000013732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl45,889,999 - 5,894,610 (-)Ensembl
mRatBN7.2 Ensembl45,214,602 - 5,219,178 (-)Ensembl
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103213   ⟹   ENSRNOP00000092021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl45,891,567 - 5,894,575 (-)Ensembl
mRatBN7.2 Ensembl45,216,170 - 5,219,178 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104678   ⟹   ENSRNOP00000087590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl45,213,394 - 5,218,961 (-)Ensembl
RefSeq Acc Id: NM_012589   ⟹   NP_036721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr845,889,999 - 5,894,575 (-)NCBI
mRatBN7.245,214,602 - 5,219,178 (-)NCBI
Rnor_6.043,043,231 - 3,047,807 (+)NCBI
Rnor_5.043,095,536 - 3,100,112 (+)NCBI
RGSC_v3.44456,799 - 461,376 (-)RGD
Celera45,093,593 - 5,098,169 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41430 (Get FASTA)   NCBI Sequence Viewer  
  AAA77659 (Get FASTA)   NCBI Sequence Viewer  
  EDL86435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013732
  ENSRNOP00000013732.6
GenBank Protein P20607 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036721   ⟸   NM_012589
- Peptide Label: precursor
- UniProtKB: P20607 (UniProtKB/Swiss-Prot),   A6KJN3 (UniProtKB/TrEMBL),   A0A8I6A641 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013732   ⟸   ENSRNOT00000013732
Ensembl Acc Id: ENSRNOP00000092021   ⟸   ENSRNOT00000103213
Ensembl Acc Id: ENSRNOP00000087590   ⟸   ENSRNOT00000104678

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20607-F1-model_v2 AlphaFold P20607 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692776
Promoter ID:EPDNEW_R3300
Type:single initiation site
Name:Il6_1
Description:interleukin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.043,043,236 - 3,043,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2901 AgrOrtholog
BioCyc Gene G2FUF-46178 BioCyc
Ensembl Genes ENSRNOG00000010278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013732 ENTREZGENE
  ENSRNOT00000013732.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-6 UniProtKB/Swiss-Prot
  IL-6/GCSF/MGF UniProtKB/Swiss-Prot
  IL6/GCSF/MGF_CS UniProtKB/Swiss-Prot
KEGG Report rno:24498 UniProtKB/Swiss-Prot
NCBI Gene 24498 ENTREZGENE
PANTHER INTERLEUKIN-6 UniProtKB/Swiss-Prot
  INTERLEUKIN-6 UniProtKB/Swiss-Prot
Pfam IL6 UniProtKB/Swiss-Prot
PharmGKB IL6 RGD
PhenoGen Il6 PhenoGen
PIRSF IL6_MGF_GCSF UniProtKB/Swiss-Prot
PRINTS IL6GCSFMGF UniProtKB/Swiss-Prot
  INTERLEUKIN6 UniProtKB/Swiss-Prot
PROSITE INTERLEUKIN_6 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010278 RatGTEx
SMART IL6 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
TIGR TC209798
UniProt A0A8I6A641 ENTREZGENE
  A0A8I6AGT8_RAT UniProtKB/TrEMBL
  A6KJN3 ENTREZGENE, UniProtKB/TrEMBL
  IL6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il6  Interleukin 6 (interferon, beta 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA level dramatically increases after cyclophosphamide (CYP)-induced cystitis 625630
gene_regulation expression regulated by the cyclooxygenase 2 cascade 625680
gene_regulation expression and secretion regulated by IL-1beta in primary mixed glial cells 729230