GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | multiple interactions | EXP | | 6480464 | CTD | [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with Quercetin analog] results in decreased secretion of IL6 protein; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of IL6 mRNA; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of IL6 protein; Quercetin inhibits the reaction [17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of IL6 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Quercetin inhibits the reaction [AGT protein results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]; Quercetin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lead acetate results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] | PMID:17059008 PMID:21439094 PMID:22426011 PMID:22728154 PMID:22989100 PMID:23770986 PMID:23907460 PMID:25995762 PMID:26873426 PMID:27224288 PMID:27527349 PMID:27634381 PMID:34748891 PMID:34922902 PMID:35876585 PMID:35906875 | Il6 | decreases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Quercetin results in decreased expression of IL6 mRNA | PMID:22185406 PMID:24465016 | Il6 | decreases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased expression of IL6 mRNA; Quercetin results in decreased expression of IL6 protein | PMID:17191106 PMID:21756928 PMID:25830055 PMID:37147755 | Il6 | decreases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased secretion of IL6 protein | PMID:17191106 PMID:27279714 PMID:37147755 | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Quercetin results in increased expression of IL6 | PMID:22064046 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased expression of IL6 mRNA | PMID:36982678 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | [Quercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Klebsiella O3 lipopolysaccharide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Klebsiella O3 lipopolysaccharide results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [perfluorooctanoic acid results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [TLR7 protein results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [TLR7 protein results in increased expression of IL6]; Quercetin inhibits the reaction [TNF protein results in increased expression of IL6 protein]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [Klebsiella O3 lipopolysaccharide results in increased expression of IL6 mRNA]]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [Klebsiella O3 lipopolysaccharide results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TLR7 protein results in increased expression of IL6 mRNA]]; TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]] | PMID:11123379 PMID:12619901 PMID:15630180 PMID:18720166 PMID:20579867 PMID:22185406 PMID:22210036 PMID:22698256 PMID:22915297 PMID:22919443 PMID:23353651 PMID:23735482 PMID:24465016 PMID:25413579 PMID:26054880 PMID:26329008 PMID:35822592 PMID:37880698 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with Quercetin metabolite] results in increased expression of IL6 mRNA; [bisphenol A co-treated with Quercetin] results in increased expression of IL6 mRNA; [Quercetin co-treated with IL6 protein] results in decreased expression of CCND1 mRNA; [Quercetin co-treated with IL6 protein] results in decreased expression of CCND1 protein; [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; Quercetin inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; Quercetin inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of CRP mRNA]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 protein]; Quercetin inhibits the reaction [IL1A protein results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to CCND1 promoter]]; Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of IL6ST protein]; Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of RB1 protein]; Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [IL6 protein results in increased secretion of MMP2 protein]; Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Quercetin inhibits the reaction [ochratoxin A results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Palmitates results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]; Quercetin inhibits the reaction [TNF protein results in increased secretion of IL6 protein] | PMID:11893605 PMID:16426496 PMID:16532021 PMID:16797527 PMID:17388968 PMID:17588137 PMID:18958421 PMID:20438634 PMID:21282043 PMID:21756928 PMID:22394507 PMID:23504962 PMID:24134915 PMID:25532488 PMID:25830055 PMID:26066604 PMID:30016632 PMID:36982678 | | ||||||||||||||||||||||
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