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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:45409
Term: ritonavir
Definition: An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
Chemical ID: MESH:D019438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionISOIl6 (Mus musculus)6480464CTDRitonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 proteinPMID:15865214
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDRitonavir results in increased expression of IL6 proteinPMID:17668557
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDRitonavir results in increased secretion of IL6 proteinPMID:20884875
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDrosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]PMID:15865214
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]PMID:15388451 PMID:17668557 PMID:20884875
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