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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDUric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]PMID:33749747
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD[Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]PMID:36850003
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