RGD Reference Report - Preliminary Study on the Relationship Between Inflammation and Hemifacial Spasm. - Rat Genome Database

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Preliminary Study on the Relationship Between Inflammation and Hemifacial Spasm.

Authors: Chen, Ming  Yang, Min  Zhou, Wei-Ping  Li, Shi-Ting 
Citation: Chen M, etal., World Neurosurg. 2019 May;125:e214-e220. doi: 10.1016/j.wneu.2019.01.044. Epub 2019 Jan 23.
RGD ID: 14975126
Pubmed: PMID:30684712   (View Abstract at PubMed)
DOI: DOI:10.1016/j.wneu.2019.01.044   (Journal Full-text)


BACKGROUND: Complete pathogenesis of hemifacial spasm (HFS) is unknown. In some patients with HFS, thickened, opaque, and sticky arachnoid membranes have been found during microvascular decompression procedures. This phenomenon indicates a possible relationship between inflammation and HFS. The aim of this study was to explore the role of inflammation in pathogenesis of HFS.
METHODS: Levels of interferon-γ, interleukin-2 receptor, interleukin-6 (IL-6), interleukin-8, interleukin-10, and tumor necrosis factor α and white blood cell (WBC), neutrophil, and lymphocyte counts were compared between patients with HFS, patients with lumbar disc herniation, and healthy control subjects. A receiver operating characteristic curve analysis was performed to evaluate the diagnostic significance of peripheral blood inflammatory markers for HFS. All the inflammatory markers were further analyzed by single and multiple logistic regression analysis.
RESULTS: Patients with HFS had greater IL-6, interleukin-8, white blood cell count, and neutrophil count than patients with lumbar disc herniation and healthy control subjects. Area under curve values of IL-6, white blood cell count, and neutrophil count were >0.8. Multiple logistic regression analysis indicated that only interleukin-2 receptor and IL-6 were relevant to HFS.
CONCLUSIONS: Inflammation is relative to HFS. IL-6 may be 1 of many factors involved in pathogenesis of HFS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hemifacial Spasm  IEP 14975126 RGD 
Hemifacial Spasm  ISOIL6 (Homo sapiens)14975126; 14975126 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Genes (Mus musculus)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL6  (interleukin 6)


Additional Information