GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases expression | EXP | | 6480464 | CTD | nickel sulfate results in increased expression of IL6 mRNA | PMID:11114790 | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | nickel sulfate results in increased expression of IL6 mRNA; nickel sulfate results in increased expression of IL6 protein | PMID:16166746 PMID:26607348 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | nickel sulfate results in increased expression of IL6 mRNA; nickel sulfate results in increased expression of IL6 protein | PMID:16780908 PMID:18832182 PMID:20600219 PMID:22714537 PMID:25673294 PMID:35499276 | Il6 | increases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | nickel sulfate results in increased secretion of IL6 protein | PMID:11033066 PMID:17118622 PMID:17636246 PMID:17763283 PMID:19101624 PMID:20600219 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] | PMID:26607348 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein; [Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL6 protein; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; nickel sulfate results in increased expression of and results in increased secretion of IL6 protein; PTGS2 mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein] | PMID:17636246 PMID:18832182 PMID:19101624 PMID:20600219 PMID:24964617 PMID:25673294 PMID:35499276 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |