RGD Reference Report - Rosemary Extract Improves Cognitive Deficits in a Rats Model of Repetitive Mild Traumatic Brain Injury Associated with Reduction of Astrocytosis and Neuronal Degeneration in Hippocampus. - Rat Genome Database

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Rosemary Extract Improves Cognitive Deficits in a Rats Model of Repetitive Mild Traumatic Brain Injury Associated with Reduction of Astrocytosis and Neuronal Degeneration in Hippocampus.

Authors: Song, H  Xu, L  Zhang, R  Cao, Z  Zhang, H  Yang, L  Guo, Z  Qu, Y  Yu, J 
Citation: Song H, etal., Neurosci Lett. 2016 Apr 22. pii: S0304-3940(16)30269-5. doi: 10.1016/j.neulet.2016.04.048.
RGD ID: 11062140
Pubmed: PMID:27113205   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2016.04.048   (Journal Full-text)

In this study, we investigated whether Rosemary extract (RE) improved cognitive deficits in repetitive mild Traumatic brain injury (rmTBI) rats and its potential mechanisms. The present results showed that rmTBI caused cognitive deficits, such as increased latency to find platform and decreased time spent in target quadrant in Morris water maze (MWM). These behavioral alterations were accompanying with the increased neuronal degeneration and glial fibrillary acidic protein (GFAP)-positive cells, increased Reactive oxygen species (ROS) generation, decreased activity of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT), elevated protein level of IL-1beta, IL-6 and TNF-alpha in hippocampus. Treatment with RE prevented these changes above. Our findings confirmed the effect of rosemary extract on improvement of cognitive deficits and suggested its mechanisms might be mediated by anti-oxidative and anti-inflammatory. Therefore, rosemary extract may be a potential treatment to improve cognitive deficits in rmTBI patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Concussion treatmentISOIl6 (Rattus norvegicus)11062140; 11062140 RGD 
Brain Concussion treatmentIDA 11062140 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Genes (Mus musculus)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL6  (interleukin 6)


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