App (amyloid beta precursor protein) - Rat Genome Database

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Gene: App (amyloid beta precursor protein) Rattus norvegicus
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Symbol: App
Name: amyloid beta precursor protein
RGD ID: 2139
Description: Enables growth factor receptor binding activity; ion binding activity; and peptidase activator activity. Involved in several processes, including cellular response to metal ion; cellular response to organonitrogen compound; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloidogenic glycoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Appem1Sage  
Genetic Models: SD-Appem1Sage
Candidate Gene For: Edcs1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-carnitine  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4-dinitrophenol  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-nitrophenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-methoxypsoralen  (ISO)
7alpha-hydroxycholesterol  (EXP)
8-epi-prostaglandin F2alpha  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetyl-CoA  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (ISO)
AICA ribonucleotide  (ISO)
aldicarb  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-D-galactose  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
aluminium atom  (EXP,ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP,ISO)
ambenonium chloride  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP)
azure B  (ISO)
baicalein  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
Bergenin  (EXP)
bethanechol  (EXP)
bexarotene  (EXP)
bilobalide  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
buten-2-one  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calycosin  (EXP)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carvedilol  (ISO)
celecoxib  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
Congo Red  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
cordycepin  (EXP)
coumestrol  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
CTP  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-penicillamine  (ISO)
DAPT  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
Didymin  (ISO)
dieldrin  (EXP)
diethyldithiocarbamic acid  (ISO)
dihydrogen  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DPCPX  (EXP)
duvoglustat  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
ethylenediaminetetraacetic acid  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
galactose  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (EXP)
glutathione  (EXP,ISO)
glycine betaine  (ISO)
glycitin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
GW 501516  (ISO)
heme b  (ISO)
heparin  (ISO)
heroin  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP,ISO)
icariin  (EXP)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucoside  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
L-methionine  (ISO)
L-serine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (ISO)
lead(0)  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
memantine  (EXP)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyllycaconitine  (EXP,ISO)
Methysticin  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mitomycin C  (ISO)
monensin A  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
orlistat  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoenolpyruvate  (ISO)
physostigmine  (EXP)
pioglitazone  (ISO)
piperidine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
poly(vinylpyrrolidone)  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
pravastatin  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
probucol  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prucalopride  (ISO)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinine  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
ruthenium red  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylates  (EXP)
sapropterin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scopolamine  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
selenomethionine  (EXP)
serotonin  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP,ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrathiomolybdate(2-)  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP)
thiethylperazine  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thymoquinone  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
tolfenamic acid  (ISO)
tolonium chloride  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
trenbolone  (EXP)
triadimefon  (EXP)
trichlorfon  (EXP,ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
triolein  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
Y-27632  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (IEA,ISO,ISS)
amyloid fibril formation  (IEA,ISO)
antibacterial humoral response  (IDA)
antifungal humoral response  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA,ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (IEA,ISO)
axo-dendritic transport  (IEA,ISO,ISS)
axon midline choice point recognition  (IEA,ISO,ISS)
axonogenesis  (IBA,IEA,ISO,ISS)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to copper ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IMP)
central nervous system development  (IBA,IEA)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (IEA,ISO)
cognition  (ISO,ISS)
collateral sprouting in absence of injury  (IEA,ISO,ISS)
cytosolic mRNA polyadenylation  (IEA,ISO)
defense response to Gram-negative bacterium  (IDA)
defense response to Gram-positive bacterium  (IDA)
dendrite development  (IEA,ISO,ISS)
endocytosis  (IEA,ISO,ISS)
extracellular matrix organization  (IEA,ISO,ISS)
forebrain development  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
innate immune response  (IDA,ISO)
intracellular copper ion homeostasis  (IEA,ISO,ISS)
ionotropic glutamate receptor signaling pathway  (IEA,ISO,ISS)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (ISO,ISS)
low-density lipoprotein particle mediated signaling  (ISO)
mating behavior  (IEA,ISO,ISS)
memory  (ISO)
microglia development  (IEA,ISO)
microglial cell activation  (IEA,ISO)
mitotic cell cycle  (ISO)
modulation of excitatory postsynaptic potential  (IEA,ISO)
mRNA polyadenylation  (ISS)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron cellular homeostasis  (IEA,ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO,ISS)
neuron projection maintenance  (IEA,ISO)
neuron remodeling  (IEA,ISO,ISS)
Notch signaling pathway  (IEA)
positive regulation of amyloid fibril formation  (IEA,ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IGI,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene expression, epigenetic  (ISO)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (ISO,ISS)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein import  (ISO)
positive regulation of protein kinase A signaling  (ISO)
positive regulation of protein metabolic process  (IDA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (IEA,ISO)
positive regulation of Toll signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (ISO)
protein homooligomerization  (ISO)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO,ISS)
regulation of neurotransmitter uptake  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
regulation of presynapse assembly  (IEA,ISO)
regulation of response to calcium ion  (IGI)
regulation of spontaneous synaptic transmission  (IEA,ISO)
regulation of synapse structure or activity  (ISO,ISS)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (IEA,ISO,ISS)
response to auditory stimulus  (ISO)
response to interleukin-1  (IDA)
response to lead ion  (IEP)
response to oxidative stress  (IEA,ISO)
response to yeast  (IDA)
smooth endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
suckling behavior  (IEA,ISO)
synapse organization  (ISO)
synaptic assembly at neuromuscular junction  (IEA,ISO)
visual learning  (IEA,ISO,ISS)

Cellular Component
amyloid-beta complex  (ISO)
apical part of cell  (IEA,ISO)
astrocyte projection  (IDA)
axon  (IDA,ISO,ISS)
cell body  (ISO)
cell surface  (IBA,IDA,IEA,ISO)
cell-cell junction  (IEA,ISO)
ciliary rootlet  (IEA,ISO)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (IEA,ISO)
cytoplasm  (ISO,ISS)
cytoplasmic vesicle  (ISO)
dendrite  (ISO)
dendrite membrane  (ISO)
dendritic shaft  (IEA,ISO)
dendritic spine  (IEA,ISO)
early endosome  (IBA,IEA,ISO,ISS)
endoplasmic reticulum  (ISO)
endosome  (ISO)
endosome to plasma membrane transport vesicle  (ISO)
external side of plasma membrane  (ISO)
extracellular space  (IDA,IEA,ISO)
Golgi apparatus  (IBA,IEA,ISO,ISS)
Golgi-associated vesicle  (IEA,ISO,ISS)
growth cone  (IDA,IEA)
growth cone filopodium  (IDA)
growth cone lamellipodium  (IDA)
high-density lipoprotein particle  (ISO)
intermediate-density lipoprotein particle  (ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (IDA)
membrane  (ISO,ISS)
membrane raft  (IBA,IEA,ISO)
mitochondrion  (ISO)
neuromuscular junction  (IEA,ISO)
neuron projection  (ISO)
neuronal dense core vesicle  (IDA)
nuclear envelope lumen  (IEA,ISO)
nucleus  (ISO)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (IEA,ISO)
protein-containing complex  (ISO)
receptor complex  (IEA,ISO)
recycling endosome  (IEA,ISO,ISS)
smooth endoplasmic reticulum  (IEA)
spindle midzone  (IEA,ISO)
synapse  (ISO)
synaptic membrane  (ISO)
synaptic vesicle  (IDA,IEA,ISO)
terminal bouton  (HDA)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome. Abrahamson EE, etal., Exp Neurol. 2006 Feb;197(2):437-50. Epub 2005 Nov 21.
2. Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection. Ambrosius B, etal., J Neuroinflammation. 2017 Apr 26;14(1):92. doi: 10.1186/s12974-017-0864-z.
3. Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation. Basha MR, etal., FASEB J. 2005 Dec;19(14):2083-4. Epub 2005 Oct 17.
4. MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. Bell KA, etal., J Neurochem. 2004 Oct;91(2):349-61. doi: 10.1111/j.1471-4159.2004.02722.x.
5. beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Boland B and Campbell V, Neurobiol Aging 2003 Jan-Feb;24(1):179-86.
6. Glucagon-Like Peptide-1 (GLP-1) Treatment Ameliorates Cognitive Impairment by Attenuating Arc Expression in Type 2 Diabetic Rats. Cai XS, etal., Med Sci Monit. 2017 Sep 8;23:4334-4342.
7. Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating ß/¿-Secretases. Cai Z, etal., Neurochem Res. 2017 Dec;42(12):3446-3455. doi: 10.1007/s11064-017-2391-9. Epub 2017 Aug 24.
8. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
9. A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death. Chan J, etal., Epilepsia. 2015 Jun;56(6):e73-7. doi: 10.1111/epi.12993. Epub 2015 Apr 16.
10. (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. Chang CF, etal., Brain Res. 2017 Dec 15;1677:118-128. doi: 10.1016/j.brainres.2017.09.015. Epub 2017 Sep 27.
11. Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aß-related metabolism. Chen L, etal., Neurosci Lett. 2017 May 22;650:146-152. doi: 10.1016/j.neulet.2017.04.047. Epub 2017 Apr 25.
12. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. Chen Y, etal., J Cell Biol. 2003 Oct 13;163(1):27-33.
13. Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats. Ciallella JR, etal., J Neurotrauma 2002 Dec;19(12):1555-67.
14. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. Dineley KT, etal., J Neurosci. 2001 Jun 15;21(12):4125-33.
15. Effects of antioxidant treatment on blast-induced brain injury. Du X, etal., PLoS One. 2013 Nov 5;8(11):e80138. doi: 10.1371/journal.pone.0080138. eCollection 2013.
16. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, etal., Biochem J 1998 Feb 15;330 ( Pt 1):513-9.
17. A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation. Folkesson R, etal., Biochem Biophys Res Commun. 2007 Jul 6;358(3):777-82. Epub 2007 May 8.
18. Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Fombonne J, etal., Ann Neurol. 2009 Mar;65(3):294-303.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures. Holmlund L, etal., Int J Mol Med 2002 Sep;10(3):245-50.
21. Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. Ikin AF, etal., J Biol Chem. 1996 Dec 13;271(50):31783-6.
22. NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's disease. Istrate AN, etal., Biophys J. 2012 Jan 4;102(1):136-43. doi: 10.1016/j.bpj.2011.11.4006. Epub 2012 Jan 3.
23. Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1. Jiang DP, etal., Brain Res. 2016 Jul 1;1642:10-19. doi: 10.1016/j.brainres.2016.02.053. Epub 2016 Mar 10.
24. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
25. Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing. Kim YJ, etal., J Pharmacol Sci. 2018 May 29. pii: S1347-8613(18)30085-9. doi: 10.1016/j.jphs.2018.05.004.
26. Memory deficiency, cerebral amyloid angiopathy, and amyloid-ß plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. Klakotskaia D, etal., PLoS One. 2018 Apr 11;13(4):e0195469. doi: 10.1371/journal.pone.0195469. eCollection 2018.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J, etal., Nature. 2009 Feb 26;457(7233):1128-32. doi: 10.1038/nature07761.
29. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Lee RK, etal., Proc Natl Acad Sci U S A. 1997 May 13;94(10):5422-6.
30. Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals. Lee YH, etal., Neuroendocrinology. 2009;90(4):383-90. doi: 10.1159/000235555. Epub 2009 Aug 12.
31. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Lewis J, etal., Science 2001 Aug 24;293(5534):1487-91.
32. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Lin R, etal., Neurosci Lett. 2008 Aug 8;440(3):344-7. doi: 10.1016/j.neulet.2008.05.070. Epub 2008 May 24.
33. Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. Marquez-Sterling NR, etal., J Neurosci. 1997 Jan 1;17(1):140-51.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. Mishra SK, etal., Neurochem Int. 2018 Feb;113:56-68. doi: 10.1016/j.neuint.2017.11.012. Epub 2017 Nov 22.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Expression of neprilysin in periodontitis-affected gingival tissues. Nezu A, etal., Arch Oral Biol. 2017 Jul;79:35-41. doi: 10.1016/j.archoralbio.2017.03.003. Epub 2017 Mar 6.
38. Amyloid precursor protein interacts with notch receptors. Oh SY, etal., J Neurosci Res. 2005 Oct 1;82(1):32-42.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Palacios G, etal., Brain Res Mol Brain Res. 1992 Oct;15(3-4):195-206.
41. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. Pasternak SH, etal., J Biol Chem 2003 Jul 18;278(29):26687-94.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. The amyloid precursor protein derivative, APP96-110, is efficacious following intravenous administration after traumatic brain injury. Plummer SL, etal., PLoS One. 2018 Jan 10;13(1):e0190449. doi: 10.1371/journal.pone.0190449. eCollection 2018.
45. Quantitative changes in the amyloid beta A4 precursor protein in Alzheimer cerebrospinal fluid. Prior R, etal., Neurosci Lett. 1991 Mar 11;124(1):69-73.
46. Simultaneous changes in secretory amyloid precursor protein and beta-amyloid peptide release from rat hippocampus by activation of muscarinic receptors. Qiu Y, etal., Neurosci Lett. 2003 Nov 27;352(1):41-4.
47. Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels. Rakover I, etal., Neurodegener Dis. 2007;4(5):392-402. Epub 2007 May 25.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles. Ross JA, etal., Brain Res. 2019 Jan 1;1702:46-53. doi: 10.1016/j.brainres.2018.03.009. Epub 2018 Mar 22.
52. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Rovelet-Lecrux A, etal., Nat Genet. 2006 Jan;38(1):24-6. Epub 2005 Dec 20.
53. The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. Sabo SL, etal., J Neurosci. 2003 Jul 2;23(13):5407-15.
54. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Shankar GM, etal., Nat Med. 2008 Aug;14(8):837-42. doi: 10.1038/nm1782. Epub 2008 Jun 22.
55. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Simon AM, etal., Neurobiol Dis. 2009 Mar;33(3):369-78. doi: 10.1016/j.nbd.2008.11.005. Epub 2008 Nov 28.
56. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. Soscia SJ, etal., PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.
57. BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. Stern AL, etal., J Neurosci. 2018 May 2;38(18):4288-4300. doi: 10.1523/JNEUROSCI.1280-17.2018. Epub 2018 Apr 9.
58. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
59. Alzheimer amyloid-ß oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Um JW, etal., Nat Neurosci. 2012 Sep;15(9):1227-35. doi: 10.1038/nn.3178. Epub 2012 Jul 22.
60. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. Vilardo E, etal., J Biol Chem. 2010 Jun 11;285(24):18344-51. doi: 10.1074/jbc.M110.112664. Epub 2010 Apr 15.
61. Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Wakita H, etal., Brain Res. 2002 Jan 4;924(1):63-70.
62. Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. Wakutani Y, etal., J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):1039-42.
63. Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Abeta(1-40). Wang C, etal., Brain Res. 2000 May 26;865(2):157-67.
64. Blood-Brain Barrier Disruption and Perivascular Beta-Amyloid Accumulation in the Brain of Aged Rats with Spontaneous Hypertension: Evaluation with Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Wang Y, etal., Korean J Radiol. 2018 May-Jun;19(3):498-507. doi: 10.3348/kjr.2018.19.3.498. Epub 2018 Apr 6.
65. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
66. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. Wiltfang J, etal., J Biol Chem. 2001 Nov 16;276(46):42645-57. Epub 2001 Aug 28.
67. Ultrastructural localization of amyloid beta/A4 protein precursor in the normal rat brain. Yamazaki T, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;63(3):173-80.
68. Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aß1-42 CA1-injected rats. Zamani E, etal., Clin Exp Pharmacol Physiol. 2018 Aug 1. doi: 10.1111/1440-1681.13020.
69. Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats. Zhang L, etal., Hypertens Res. 2018 Jun;41(6):414-425. doi: 10.1038/s41440-018-0033-5. Epub 2018 Mar 22.
70. Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain. Zhou CC, etal., Toxicol Lett. 2018 Jun 15. pii: S0378-4274(18)31306-7. doi: 10.1016/j.toxlet.2018.06.1065.
Additional References at PubMed
PMID:1673681   PMID:2218531   PMID:2648331   PMID:2900758   PMID:2968652   PMID:7593229   PMID:7737970   PMID:7744833   PMID:7758106   PMID:7913895   PMID:8001115   PMID:8083748  
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PMID:9754878   PMID:9930726   PMID:10024358   PMID:10037494   PMID:10188929   PMID:10200318   PMID:10219973   PMID:10329382   PMID:10338291   PMID:10341243   PMID:10386999   PMID:10413512  
PMID:10526140   PMID:10652580   PMID:10681545   PMID:10845772   PMID:10936190   PMID:11140684   PMID:11140685   PMID:11160457   PMID:11214319   PMID:11316806   PMID:11479316   PMID:11483588  
PMID:11689470   PMID:11740561   PMID:11823458   PMID:11880515   PMID:11918289   PMID:11939505   PMID:11959460   PMID:11988176   PMID:12054502   PMID:12054503   PMID:12074840   PMID:12093789  
PMID:12105108   PMID:12244210   PMID:12431992   PMID:12738769   PMID:12805363   PMID:12808450   PMID:12890766   PMID:12890786   PMID:12927782   PMID:12944403   PMID:12969271   PMID:12975376  
PMID:14523099   PMID:14622134   PMID:14983046   PMID:15009636   PMID:15090053   PMID:15190117   PMID:15208260   PMID:15385965   PMID:15447675   PMID:15457210   PMID:15537891   PMID:15561424  
PMID:15623526   PMID:15673661   PMID:15689559   PMID:15718043   PMID:15745965   PMID:15886206   PMID:15944124   PMID:15955598   PMID:15987691   PMID:16018997   PMID:16025111   PMID:16077187  
PMID:16153690   PMID:16162853   PMID:16183991   PMID:16193067   PMID:16196193   PMID:16227578   PMID:16259359   PMID:16286452   PMID:16301330   PMID:16314516   PMID:16478525   PMID:16492752  
PMID:16502470   PMID:16541076   PMID:16636059   PMID:16714296   PMID:16721824   PMID:16734669   PMID:17012232   PMID:17116874   PMID:17157827   PMID:17251419   PMID:17255335   PMID:17308309  
PMID:17402971   PMID:17460216   PMID:17468104   PMID:17556541   PMID:17920016   PMID:17929129   PMID:17937488   PMID:18007179   PMID:18059284   PMID:18077683   PMID:18089558   PMID:18216187  
PMID:18234671   PMID:18263584   PMID:18275940   PMID:18278038   PMID:18353773   PMID:18463498   PMID:18483195   PMID:18499799   PMID:18509662   PMID:18574238   PMID:18585048   PMID:18602473  
PMID:18602971   PMID:18648507   PMID:18694930   PMID:18723082   PMID:18728191   PMID:18759972   PMID:18761056   PMID:18800168   PMID:18805418   PMID:18922798   PMID:18940800   PMID:19057576  
PMID:19105196   PMID:19118188   PMID:19123057   PMID:19164281   PMID:19199708   PMID:19228461   PMID:19264960   PMID:19294646   PMID:19304802   PMID:19340611   PMID:19393223   PMID:19406747  
PMID:19458258   PMID:19515914   PMID:19542631   PMID:19549187   PMID:19549834   PMID:19587288   PMID:19660551   PMID:19686245   PMID:19706468   PMID:19706519   PMID:19726636   PMID:19754881  
PMID:19808651   PMID:19829160   PMID:19841277   PMID:19849849   PMID:19879263   PMID:19927172   PMID:19935655   PMID:19966784   PMID:20005821   PMID:20032460   PMID:20033317   PMID:20037574  
PMID:20037584   PMID:20043977   PMID:20045398   PMID:20127811   PMID:20133839   PMID:20141570   PMID:20145246   PMID:20164328   PMID:20212142   PMID:20333303   PMID:20346152   PMID:20403092  
PMID:20427278   PMID:20445063   PMID:20511235   PMID:20543465   PMID:20568471   PMID:20573181   PMID:20575418   PMID:20594620   PMID:20711450   PMID:20818335   PMID:20829454   PMID:20972601  
PMID:20974225   PMID:20974842   PMID:21036142   PMID:21047784   PMID:21085580   PMID:21113149   PMID:21126803   PMID:21179577   PMID:21187975   PMID:21205198   PMID:21289173   PMID:21297982  
PMID:21300137   PMID:21320494   PMID:21454701   PMID:21457712   PMID:21482827   PMID:21523435   PMID:21527912   PMID:21640074   PMID:21751079   PMID:21803450   PMID:21825135   PMID:21832049  
PMID:21843605   PMID:21852239   PMID:21857966   PMID:21883149   PMID:21903584   PMID:21915767   PMID:21949245   PMID:21989385   PMID:22036569   PMID:22086926   PMID:22138302   PMID:22139836  
PMID:22163051   PMID:22177709   PMID:22179788   PMID:22198949   PMID:22200570   PMID:22209725   PMID:22267734   PMID:22383525   PMID:22406537   PMID:22429478   PMID:22434822   PMID:22500019  
PMID:22528492   PMID:22584060   PMID:22635104   PMID:22666389   PMID:22754299   PMID:22847417   PMID:22854022   PMID:22871113   PMID:22874667   PMID:22905234   PMID:22910909   PMID:22944668  
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PMID:26325471   PMID:26401782   PMID:26402095   PMID:26426258   PMID:26510576   PMID:26522221   PMID:26552445   PMID:26743041   PMID:26921470   PMID:27028062   PMID:27064279   PMID:27241555  
PMID:27366738   PMID:27428544   PMID:27460145   PMID:27699791   PMID:27853422   PMID:28008308   PMID:28121396   PMID:28164773   PMID:28219245   PMID:28259979   PMID:28282805   PMID:28302722  
PMID:28374012   PMID:28377502   PMID:28447730   PMID:28650319   PMID:28669260   PMID:28855300   PMID:28877993   PMID:29061364   PMID:29176823   PMID:29263141   PMID:29274751   PMID:29305263  
PMID:29371969   PMID:29436599   PMID:29466733   PMID:29518356   PMID:29572166   PMID:29572520   PMID:29624118   PMID:29624358   PMID:29990310   PMID:30158114   PMID:30989630   PMID:31084925  
PMID:31432127   PMID:32265300   PMID:32382574   PMID:32385113   PMID:32420373   PMID:32686865   PMID:32881772   PMID:34288242   PMID:34647720   PMID:34656177   PMID:34789895   PMID:34818135  
PMID:34944019   PMID:35061720   PMID:36155778   PMID:37179386   PMID:37256589  


Genomics

Comparative Map Data
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2125,880,535 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
T2T-CHM13v2.02124,238,622 - 24,529,258 (-)NCBIT2T-CHM13v2.0
App
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)EnsemblGRCm39 Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBIMGSCv36mm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
App
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540725,722,849 - 25,974,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540725,725,259 - 25,973,582 (-)NCBIChiLan1.0ChiLan1.0
APP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22222,074,135 - 22,358,605 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12116,933,539 - 17,218,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
APP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBIUU_Cfam_GSD_1.0
App
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366401,550,167 - 1,787,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13189,435,094 - 189,716,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113189,434,854 - 189,716,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213199,290,846 - 199,568,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,037,224 - 66,320,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl266,037,261 - 66,321,306 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660718,700,007 - 8,984,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
App
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474513,902,577 - 14,159,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474513,904,912 - 14,159,374 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in App
1287 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:588
Count of miRNA genes:251
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000044081, ENSRNOT00000048854
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111897620824697116Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat

Markers in Region
D11Got14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,096,935 - 24,097,059 (+)MAPPERmRatBN7.2
Rnor_6.01124,502,166 - 24,502,289NCBIRnor6.0
Rnor_5.01128,126,051 - 28,126,174UniSTSRnor5.0
RGSC_v3.41124,534,121 - 24,534,245RGDRGSC3.4
RGSC_v3.41124,534,122 - 24,534,245UniSTSRGSC3.4
RGSC_v3.11124,534,122 - 24,534,245RGD
Celera1123,929,938 - 23,930,048UniSTS
RH 3.4 Map11115.5UniSTS
RH 3.4 Map11115.5RGD
RH 2.0 Map11568.7RGD
Cytogenetic Map11q11UniSTS
BE108355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,133,377 - 24,133,555 (+)MAPPERmRatBN7.2
Rnor_6.01124,539,021 - 24,539,198NCBIRnor6.0
Rnor_5.01128,162,738 - 28,162,915UniSTSRnor5.0
RGSC_v3.41124,590,587 - 24,590,764UniSTSRGSC3.4
Celera1123,966,316 - 23,966,493UniSTS
RH 3.4 Map11103.7UniSTS
Cytogenetic Map11q11UniSTS
RH94865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,236,274 - 24,236,452 (+)MAPPERmRatBN7.2
Rnor_6.01124,641,553 - 24,641,730NCBIRnor6.0
Rnor_5.01128,264,953 - 28,265,130UniSTSRnor5.0
RGSC_v3.41124,693,697 - 24,693,874UniSTSRGSC3.4
Celera1124,068,894 - 24,069,071UniSTS
RH 3.4 Map1194.7UniSTS
Cytogenetic Map11q11UniSTS
BF388494  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,030,592 - 24,030,809 (+)MAPPERmRatBN7.2
Rnor_6.01124,435,832 - 24,436,048NCBIRnor6.0
Rnor_5.01128,059,716 - 28,059,932UniSTSRnor5.0
RGSC_v3.41124,467,785 - 24,468,001UniSTSRGSC3.4
Celera1123,863,626 - 23,863,842UniSTS
RH 3.4 Map11106.3UniSTS
Cytogenetic Map11q11UniSTS
BF389056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,108,880 - 24,109,123 (+)MAPPERmRatBN7.2
Rnor_6.01124,514,262 - 24,514,504NCBIRnor6.0
Rnor_5.01128,138,061 - 28,138,303UniSTSRnor5.0
RGSC_v3.41124,565,915 - 24,566,157UniSTSRGSC3.4
Celera1123,941,822 - 23,942,064UniSTS
RH 3.4 Map11110.5UniSTS
Cytogenetic Map11q11UniSTS
BF403704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,136,753 - 24,136,932 (+)MAPPERmRatBN7.2
Rnor_6.01124,542,397 - 24,542,575NCBIRnor6.0
Rnor_5.01128,166,114 - 28,166,292UniSTSRnor5.0
RGSC_v3.41124,593,963 - 24,594,141UniSTSRGSC3.4
Celera1123,969,692 - 23,969,870UniSTS
RH 3.4 Map1197.3UniSTS
Cytogenetic Map11q11UniSTS
RH139209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,079 - 24,020,312 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,319 - 24,425,551NCBIRnor6.0
Rnor_5.01128,049,203 - 28,049,435UniSTSRnor5.0
RGSC_v3.41124,457,272 - 24,457,504UniSTSRGSC3.4
Celera1123,853,113 - 23,853,345UniSTS
RH 3.4 Map11113.8UniSTS
Cytogenetic Map11q11UniSTS
GDB:185158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,092 - 24,020,374 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,332 - 24,425,613NCBIRnor6.0
Rnor_5.01128,049,216 - 28,049,497UniSTSRnor5.0
RGSC_v3.41124,457,285 - 24,457,566UniSTSRGSC3.4
Celera1123,853,126 - 23,853,407UniSTS
Cytogenetic Map11q11UniSTS
GDB:185159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,354 - 24,020,680 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,594 - 24,425,919NCBIRnor6.0
Rnor_5.01128,049,478 - 28,049,803UniSTSRnor5.0
RGSC_v3.41124,457,547 - 24,457,872UniSTSRGSC3.4
Celera1123,853,388 - 23,853,713UniSTS
Cytogenetic Map11q11UniSTS
APP  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,022 - 24,020,731 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,262 - 24,425,970NCBIRnor6.0
Rnor_5.01128,049,146 - 28,049,854UniSTSRnor5.0
RGSC_v3.41124,457,215 - 24,457,923UniSTSRGSC3.4
Celera1123,853,056 - 23,853,764UniSTS
Cytogenetic Map11q11UniSTS


Genetic Models
This gene App is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5 2 1 2
Medium 3 43 57 41 19 41 8 11 69 33 40 9 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF513015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS448150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS448172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000044081   ⟹   ENSRNOP00000040243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,778 - 24,236,530 (-)Ensembl
Rnor_6.0 Ensembl1124,425,813 - 24,641,820 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000048854   ⟹   ENSRNOP00000041613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,778 - 24,236,530 (-)Ensembl
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104573   ⟹   ENSRNOP00000078198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,781 - 24,236,561 (-)Ensembl
RefSeq Acc Id: NM_019288   ⟹   NP_062161
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,507,096 - 37,722,838 (-)NCBI
mRatBN7.21124,020,663 - 24,236,429 (-)NCBI
Rnor_6.01124,425,902 - 24,641,707 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
RGSC_v3.41124,457,855 - 24,693,851 (-)RGD
Celera1123,853,696 - 24,069,048 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248008   ⟹   XP_006248070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,027 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,013 - 24,641,872 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248009   ⟹   XP_006248071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,027 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,202 - 24,641,840 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248010   ⟹   XP_006248072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,023 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,013 - 24,641,872 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248011   ⟹   XP_006248073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,724,351 (-)NCBI
mRatBN7.21124,019,774 - 24,236,564 (-)NCBI
Rnor_6.01124,425,013 - 24,641,871 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248012   ⟹   XP_006248074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,023 (-)NCBI
mRatBN7.21124,019,774 - 24,236,584 (-)NCBI
Rnor_6.01124,425,013 - 24,641,871 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270722   ⟹   XP_063126792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,522,163 - 37,723,023 (-)NCBI
RefSeq Acc Id: NP_062161   ⟸   NM_019288
- Peptide Label: precursor
- UniProtKB: Q547B7 (UniProtKB/Swiss-Prot),   P08592 (UniProtKB/Swiss-Prot),   A6JL62 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248073   ⟸   XM_006248011
- Peptide Label: isoform X4
- UniProtKB: A6JL61 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248072   ⟸   XM_006248010
- Peptide Label: isoform X3
- UniProtKB: Q6P6Q5 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248071   ⟸   XM_006248009
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHW9 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248070   ⟸   XM_006248008
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y8G9 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248074   ⟸   XM_006248012
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041613   ⟸   ENSRNOT00000048854
RefSeq Acc Id: ENSRNOP00000040243   ⟸   ENSRNOT00000044081
RefSeq Acc Id: ENSRNOP00000078198   ⟸   ENSRNOT00000104573
RefSeq Acc Id: XP_063126792   ⟸   XM_063270722
- Peptide Label: isoform X6
Protein Domains
BPTI/Kunitz inhibitor   E1   E2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08592-F1-model_v2 AlphaFold P08592 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698015
Promoter ID:EPDNEW_R8540
Type:multiple initiation site
Name:App_1
Description:amyloid beta precursor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01124,641,839 - 24,641,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2139 AgrOrtholog
BioCyc Gene G2FUF-22080 BioCyc
Ensembl Genes ENSRNOG00000006997 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055002269 UniProtKB/Swiss-Prot
  ENSRNOG00060016739 UniProtKB/Swiss-Prot
  ENSRNOG00065006297 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044081.6 UniProtKB/TrEMBL
  ENSRNOT00000048854.7 UniProtKB/TrEMBL
  ENSRNOT00000104573.1 UniProtKB/TrEMBL
  ENSRNOT00055003610 UniProtKB/Swiss-Prot
  ENSRNOT00060028680 UniProtKB/Swiss-Prot
  ENSRNOT00065009663 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599880 IMAGE-MGC_LOAD
InterPro Amyloid_Cu-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Abeta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54226 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72270 IMAGE-MGC_LOAD
NCBI Gene 54226 ENTREZGENE
PANTHER PTHR23103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23103:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-APP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APP RGD
PhenoGen App PhenoGen
PRINTS AMYLOIDA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BASICPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETAAMYLOID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_INTRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPTI_KUNITZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006997 RatGTEx
  ENSRNOG00055002269 RatGTEx
  ENSRNOG00060016739 RatGTEx
  ENSRNOG00065006297 RatGTEx
SMART A4_EXTRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF109843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56491 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57362 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF89811 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLQ8 ENTREZGENE, UniProtKB/TrEMBL
  A4_RAT UniProtKB/Swiss-Prot
  A6JL61 ENTREZGENE, UniProtKB/TrEMBL
  A6JL62 ENTREZGENE, UniProtKB/TrEMBL
  P08592 ENTREZGENE
  Q547B7 ENTREZGENE
  Q6LEE8_RAT UniProtKB/TrEMBL
  Q6P6Q5 ENTREZGENE, UniProtKB/TrEMBL
  Q99NY6_RAT UniProtKB/TrEMBL
UniProt Secondary Q547B7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 App  amyloid beta precursor protein  App  amyloid beta (A4) precursor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 App  Amyloid beta (A4) precursor protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease abnormalities of the human homolog may contribute to the pathogenesis of Alzheimers disease 634664
gene_process may induce neuronal apoptosis 634664
gene_process induces calpain protease activity 634664
gene_process activates voltage dependent calcium channels 634664