Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
APP protein binds to Copper; APP protein modified form binds to Copper; Copper binds to APP protein; Copper binds to APP protein alternative form; Copper binds to APP protein modified form; Copper binds to APP protein mutant form
Copper deficiency results in increased expression of APP protein modified form; Copper results in increased expression of APP mRNA; Copper results in increased expression of APP protein
Copper deficiency results in increased secretion of APP protein modified form; Copper results in increased secretion of APP protein; Copper results in increased secretion of APP protein alternative form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased expression of APP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; [APP protein modified form binds to Copper] which results in increased chemical synthesis of Hydrogen Peroxide; [APP protein modified form binds to Copper] which results in increased oxidation of Ascorbic Acid; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; [Copper binds to APP protein alternative form] which results in increased oxidation of Pyrogallol; [Copper binds to Thiosemicarbazones analog] results in decreased abundance of [APP protein modified form binds to APP protein modified form]; [Copper co-treated with APP protein modified form] results in increased abundance of Reactive Oxygen Species; [Disulfiram binds to Copper] which results in increased expression of APP mRNA; APP protein binds to and results in increased reduction of Copper; APP protein inhibits the reaction [Copper results in increased chemical synthesis of Hydrogen Peroxide]; APP protein inhibits the reaction [Copper results in increased oxidation of Ascorbic Acid]; APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; CEP-11004 inhibits the reaction [Copper results in increased expression of APP mRNA]; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Copper binds to and affects the folding of APP protein; Copper promotes the reaction [APP protein binds to APP protein]; Copper promotes the reaction [APP protein modified form results in increased oxidation of Ascorbic Acid]; Copper promotes the reaction [Heparin binds to APP protein]; Copper results in increased phosphorylation of and affects the localization of APP protein; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Hydrogen Peroxide promotes the reaction [[Copper binds to APP protein alternative form] which results in increased oxidation of Pyrogallol]; Lithium Chloride inhibits the reaction [Copper affects the localization of APP protein]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Plant Extracts inhibits the reaction [Copper results in increased expression of APP mRNA]; Plant Extracts inhibits the reaction [Copper results in increased expression of APP protein]; Plant Extracts inhibits the reaction [Copper results in increased secretion of APP protein]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; SB 203580 inhibits the reaction [Copper results in increased expression of APP mRNA]; SB 216763 inhibits the reaction [Copper affects the localization of APP protein]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Zinc inhibits the reaction [APP protein modified form results in increased reduction of Copper]; Zinc inhibits the reaction [APP protein results in increased reduction of Copper]
[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of Copper; [APP protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form; [APP protein co-treated with Copper] results in increased degradation of GPC1 protein modified form; [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of APP mRNA; [Copper co-treated with Cholesterol] results in increased expression of APP mRNA; Copper inhibits the reaction [APP protein modified form results in increased phosphorylation of SYK protein]; Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX1 protein]; Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein]; Copper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of IL1B protein]; Copper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of IL6 protein]; Copper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of TNF protein]
