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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:75393
Term: Y-27632
Definition: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Chemical ID: MESH:C108830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appincreases secretionEXP 6480464CTDY 27632 results in increased secretion of APP protein modified formPMID:19741129
Appmultiple interactionsEXP 6480464CTDY 27632 inhibits the reaction [aluminum maltolate results in decreased expression of and results in decreased secretion of APP protein modified form]PMID:20395307
Appaffects cleavageISOApp (Mus musculus)6480464CTDY 27632 affects the cleavage of APP proteinPMID:14615541
Appmultiple interactionsISOApp (Mus musculus)6480464CTDROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]PMID:14615541
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