GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | App | affects abundance | EXP | | 6480464 | CTD | Lead affects the abundance of APP mRNA; Lead affects the abundance of APP protein | PMID:16230335 | App | increases expression | EXP | | 6480464 | CTD | Lead results in increased expression of APP protein alternative form | PMID:25288670 | App | increases localization | EXP | | 6480464 | CTD | Lead results in increased localization of APP protein | PMID:20488202 | App | multiple interactions | EXP | | 6480464 | CTD | [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]; [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [PSEN1 protein results in increased metabolism of APP protein]; [Arsenic co-treated with Cadmium co-treated with Lead] results in increased expression of APP protein alternative form; Arsenic promotes the reaction [Lead results in increased expression of APP protein alternative form]; Lead affects the reaction [APP protein binds to APP protein]; PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]] | PMID:16230335 PMID:20488202 PMID:25288670 | App | affects expression | ISO | APP (Homo sapiens) | 6480464 | CTD | Lead affects the expression of APP mRNA | PMID:28903495 | App | affects splicing | ISO | APP (Homo sapiens) | 6480464 | CTD | Lead affects the splicing of APP mRNA | PMID:28903495 | App | decreases expression | ISO | APP (Homo sapiens) | 6480464 | CTD | Lead results in decreased expression of APP protein modified form | PMID:22313790 | App | increases expression | ISO | APP (Homo sapiens) | 6480464 | CTD | Lead results in increased expression of APP mRNA; Lead results in increased expression of APP protein | PMID:19921347 PMID:21315759 PMID:22272629 PMID:25673500 | App | increases expression | ISO | App (Mus musculus) | 6480464 | CTD | Lead results in increased expression of APP protein | PMID:31539617 | App | increases secretion | ISO | APP (Homo sapiens) | 6480464 | CTD | Lead results in increased secretion of APP protein alternative form | PMID:25673500 | App | multiple interactions | ISO | APP (Homo sapiens) | 6480464 | CTD | [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [Lead co-treated with APP protein co-treated with APP protein modified form] results in increased expression of BACE1 protein; [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha; [Lead co-treated with APP protein modified form] results in increased expression of PTGS2 protein; [Lead co-treated with APP protein modified form] results in increased expression of TP53 protein | PMID:22610977 PMID:31843630 | App | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of APP protein; fisetin inhibits the reaction [Lead results in increased expression of APP protein] | PMID:31539617 PMID:31730887 PMID:32058320 | | ||||||||||||||||||||||
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